P J Larsen

Summary

Affiliation: Center for Clinical and Basic Research
Country: Denmark

Publications

  1. ncbi request reprint Peripheral adiposity exhibits an independent dominant antiatherogenic effect in elderly women
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Circulation 107:1626-31. 2003
  2. ncbi request reprint Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats
    P J Larsen
    Laboratory of Obesity Research, Center for Clinical and Basic Research, Ballerup, Denmark
    Diabetes 50:2530-9. 2001
  3. ncbi request reprint Ups and downs for neuropeptides in body weight homeostasis: pharmacological potential of cocaine amphetamine regulated transcript and pre-proglucagon-derived peptides
    Philip J Larsen
    Laboratory of Obesity Research, Center for Clinical and Basic Research, Ballerup Byvej 222, 2750, Denmark
    Eur J Pharmacol 440:159-72. 2002
  4. ncbi request reprint Glucagon-like peptide containing pathways in the regulation of feeding behaviour
    M Tang-Christensen
    Department of Medical Anatomy Sect B, University of Copenhagen, Copenhagen, Denmark
    Int J Obes Relat Metab Disord 25:S42-7. 2001
  5. ncbi request reprint New therapeutic developments in the regulation of food intake by neuropeptides
    P J Larsen
    Laboratory of Obesity Research, Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Denmark
    Ann Endocrinol (Paris) 63:171-5. 2002
  6. ncbi request reprint Novel associations between bioavailable estradiol and adipokines in elderly women with different phenotypes of obesity: implications for atherogenesis
    Laszlo B Tanko
    Prospective Epidemiological Risk Factor PERF study group, Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Ballerup, Denmark
    Circulation 110:2246-52. 2004
  7. ncbi request reprint Glucagon-related peptide 1 (GLP-1): hormone and neurotransmitter
    Philip J Larsen
    Rheoscience A S, The Panum Insitute, University of Copenhagen, Glerupvej 2, 2610 Rødovre, Denmark
    Regul Pept 128:97-107. 2005
  8. ncbi request reprint Enlarged waist combined with elevated triglycerides is a strong predictor of accelerated atherogenesis and related cardiovascular mortality in postmenopausal women
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Denmark
    Circulation 111:1883-90. 2005
  9. ncbi request reprint [Central fat deposits contribute to atherosclerosis and insulin resistance and peripheral fat deposits protect against atherosclerosis and insulin resistance in postmenopausal women--secondary publication]
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup
    Ugeskr Laeger 167:3597-601. 2005
  10. ncbi request reprint ACDC/adiponectin and PPAR-gamma gene polymorphisms: implications for features of obesity
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    Obes Res 13:2113-21. 2005

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Peripheral adiposity exhibits an independent dominant antiatherogenic effect in elderly women
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Circulation 107:1626-31. 2003
    ..Although several lines of evidence point to an atherogenic role of central fat mass (CFM), few data are available to address the specific role played by peripheral fat mass (PFM)...
  2. ncbi request reprint Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats
    P J Larsen
    Laboratory of Obesity Research, Center for Clinical and Basic Research, Ballerup, Denmark
    Diabetes 50:2530-9. 2001
    ..Thus, long-acting GLP-1 derivatives may prove efficient as weight-reducing therapeutic agents for overweight patients with type 2 diabetes...
  3. ncbi request reprint Ups and downs for neuropeptides in body weight homeostasis: pharmacological potential of cocaine amphetamine regulated transcript and pre-proglucagon-derived peptides
    Philip J Larsen
    Laboratory of Obesity Research, Center for Clinical and Basic Research, Ballerup Byvej 222, 2750, Denmark
    Eur J Pharmacol 440:159-72. 2002
    ..The present review summarises the available evidence that both families of peptides constitute endogenous transmitters mediating satiety and touch upon potential pharmacological exploitation of this knowledge...
  4. ncbi request reprint Glucagon-like peptide containing pathways in the regulation of feeding behaviour
    M Tang-Christensen
    Department of Medical Anatomy Sect B, University of Copenhagen, Copenhagen, Denmark
    Int J Obes Relat Metab Disord 25:S42-7. 2001
    ..Future experiments will elucidate whether or not GLP-1 and GLP-2 are involved in the long-term or short-term regulation of feeding behaviour and hence have an impact on bodyweight...
  5. ncbi request reprint New therapeutic developments in the regulation of food intake by neuropeptides
    P J Larsen
    Laboratory of Obesity Research, Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Denmark
    Ann Endocrinol (Paris) 63:171-5. 2002
  6. ncbi request reprint Novel associations between bioavailable estradiol and adipokines in elderly women with different phenotypes of obesity: implications for atherogenesis
    Laszlo B Tanko
    Prospective Epidemiological Risk Factor PERF study group, Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Ballerup, Denmark
    Circulation 110:2246-52. 2004
    ..Peripheral adiposity confers protection against diabetes and atherosclerosis in elderly women. The underlying mechanisms, however, remain to be elucidated...
  7. ncbi request reprint Glucagon-related peptide 1 (GLP-1): hormone and neurotransmitter
    Philip J Larsen
    Rheoscience A S, The Panum Insitute, University of Copenhagen, Glerupvej 2, 2610 Rødovre, Denmark
    Regul Pept 128:97-107. 2005
    ....
  8. ncbi request reprint Enlarged waist combined with elevated triglycerides is a strong predictor of accelerated atherogenesis and related cardiovascular mortality in postmenopausal women
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Denmark
    Circulation 111:1883-90. 2005
    ..Whether EWET offers superior disease and event prediction in postmenopausal women, however, remains unknown...
  9. ncbi request reprint [Central fat deposits contribute to atherosclerosis and insulin resistance and peripheral fat deposits protect against atherosclerosis and insulin resistance in postmenopausal women--secondary publication]
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup
    Ugeskr Laeger 167:3597-601. 2005
    ..In postmenopausal women, body fat distribution has more critical implications for metabolic and cardiovascular risk than overall obesity per se...
  10. ncbi request reprint ACDC/adiponectin and PPAR-gamma gene polymorphisms: implications for features of obesity
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    Obes Res 13:2113-21. 2005
    ....
  11. ncbi request reprint The role of CART in body weight homeostasis
    Philip J Larsen
    Rheoscience A S, The Panum Institute, University of Copenhagen, Glerupvej 2, 2610 Rødovre, Denmark
    Peptides 27:1981-6. 2006
    ..Research to date has demonstrated a role for CART in the control of food intake at a number of levels within the brain of both animals and man...
  12. ncbi request reprint Differential influences of peroxisome proliferator-activated receptors gamma and -alpha on food intake and energy homeostasis
    Philip J Larsen
    Rheoscience, Rødovre, Denmark
    Diabetes 52:2249-59. 2003
    ....
  13. ncbi request reprint Central and peripheral fat mass have contrasting effect on the progression of aortic calcification in postmenopausal women
    Laszlo B Tanko
    Center for Clinical and Basic Research A S, Ballerup, Denmark
    Eur Heart J 24:1531-7. 2003
    ..To investigate the long-term effects of central fat mass (CFM) and peripheral fat mass (PFM) on atherogenic risk profile and the progression of aortic calcification (AC) in postmenopausal women...
  14. doi request reprint The once-daily human GLP-1 analog, liraglutide, reduces olanzapine-induced weight gain and glucose intolerance
    Kirsten Lykkegaard
    Rheoscience A S, Glerupvej 2, DK 2610 Roedovre, Denmark
    Schizophr Res 103:94-103. 2008
    ..It may therefore be relevant to study these effects of liraglutide in patients treated with atypically antipsychotics...
  15. ncbi request reprint Central pre-proglucagon derived peptides: opportunities for treatment of obesity
    Philip J Larsen
    Rheoscience, Glerupvej 2, 2610 Rødovre, Denmark
    Curr Pharm Des 9:1373-82. 2003
    ..This and other aspects of the current state of the role of central pre-proglucagon in energy homeostasis are reviewed...
  16. ncbi request reprint Variations in percentage of body fat within different BMI groups in young, middle-aged and old women
    Lusine Movsesyan
    Center for Clinical and Basic Research A S, Ballerup Byvej, Ballerup, Denmark
    Clin Physiol Funct Imaging 23:130-3. 2003
    ..The objective of the present study was to characterize age-dependent variations in percentage of body fat within different body mass index (BMI) classes in healthy Danish women...
  17. ncbi request reprint Hypothalamic cocaine-amphetamine regulated transcript (CART) is regulated by glucocorticoids
    Niels Vrang
    Rheoscience, Glerupvej 2, 2610, Rodovre, Denmark
    Brain Res 965:45-50. 2003
    ..Unlike CART mRNA levels hypothalamic POMC expression was unaltered by adrenenalectomy. The present results show that the CART gene is influenced by glucocorticoids, presumably via a GR dependent mechanism...
  18. ncbi request reprint Cocaine-amphetamine regulated transcript (CART) expression is not regulated by amphetamine
    Niels Vrang
    Rheoscience, Glerupvej 2, 2610 Rodovre, Denmark
    Neuroreport 13:1215-8. 2002
    ..The present results question the acronym chosen for this predominantly hyopthalamic neuropeptide...
  19. ncbi request reprint [Molecular pathogenesis in monogenic and polygenic obesity]
    Philip J Larsen
    Steno Diabetes Center, DK 2820 Gentofte
    Ugeskr Laeger 168:152-5. 2006
    ..These insights have brought us closer to the development of rational therapies of obesity, the epidemic of which is continuing in the post-industrial society, which is characterised by sedentary behaviour patterns...
  20. ncbi request reprint Light-induced c-Fos expression in suprachiasmatic nuclei neurons targeting the paraventricular nucleus of the hamster hypothalamus: phase dependence and immunochemical identification
    Inger Christine Munch
    Department of Medical Anatomy, University of Copenhagen, 2200 Copenhagen, Denmark
    J Comp Neurol 442:48-62. 2002
    ..The present findings provide functional evidence of light activation of central pathways involved in the regulation of circadian output rhythms...
  21. ncbi request reprint Projections from the raphe nuclei to the suprachiasmatic nucleus of the rat
    Anders Hay-Schmidt
    Department of Medical Anatomy, The Panum Institute, 18 2, University of Copenhagen, Blegdamsvej 3, DK 2200 N, Copenhagen, Denmark
    J Chem Neuroanat 25:293-310. 2003
    ..PHA-L injections into RMg gave rise to labelling of a few processes within the SCN. In conclusion, the main serotonergic input to the rat SCN originates from a few neurones in the MnR...