Filip F Fratev

Summary

Affiliation: Center for Biological Sequence Analysis
Country: Denmark

Publications

  1. doi request reprint A combination of 3D-QSAR, docking, local-binding energy (LBE) and GRID study of the species differences in the carcinogenicity of benzene derivatives chemicals
    Filip Fratev
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Mol Graph Model 27:147-60. 2008
  2. doi request reprint Molecular basis of inactive B-RAF(WT) and B-RAF(V600E) ligand inhibition, selectivity and conformational stability: an in silico study
    Filip Fratev
    Department of Systems Biology, Technical University of Denmark, DK 2800 Kongens Lyngby, Denmark
    Mol Pharm 6:144-57. 2009
  3. pmc An in silico study of the molecular basis of B-RAF activation and conformational stability
    Filip F Fratev
    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, Building 208, DK 2800 Kongens Lyngby, Denmark
    BMC Struct Biol 9:47. 2009
  4. doi request reprint The phosphorylation specificity of B-RAF WT, B-RAF D594V, B-RAF V600E and B-RAF K601E kinases: an in silico study
    Filip Fratev
    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, Building 208, DK 2800 Kongens Lyngby, Denmark
    J Mol Graph Model 28:598-603. 2010

Detail Information

Publications4

  1. doi request reprint A combination of 3D-QSAR, docking, local-binding energy (LBE) and GRID study of the species differences in the carcinogenicity of benzene derivatives chemicals
    Filip Fratev
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Mol Graph Model 27:147-60. 2008
    ..Comparing GRID, 3D-QSAR maps and LBE results, a similarity was identified, indicating a relationship between P450 metabolic processes and the differences in the carcinogenicity...
  2. doi request reprint Molecular basis of inactive B-RAF(WT) and B-RAF(V600E) ligand inhibition, selectivity and conformational stability: an in silico study
    Filip Fratev
    Department of Systems Biology, Technical University of Denmark, DK 2800 Kongens Lyngby, Denmark
    Mol Pharm 6:144-57. 2009
    ..Overall data revealed the important role of Lys601 for ligand activity, selectivity and protein stabilization, proposing an explanation of the observed strong kinase activation in the K601E mutated form...
  3. pmc An in silico study of the molecular basis of B-RAF activation and conformational stability
    Filip F Fratev
    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, Building 208, DK 2800 Kongens Lyngby, Denmark
    BMC Struct Biol 9:47. 2009
    ..B-RAF kinase plays an important role both in tumour induction and maintenance in several cancers and it is an attractive new drug target. However, the structural basis of the B-RAF activation is still not well understood...
  4. doi request reprint The phosphorylation specificity of B-RAF WT, B-RAF D594V, B-RAF V600E and B-RAF K601E kinases: an in silico study
    Filip Fratev
    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, Building 208, DK 2800 Kongens Lyngby, Denmark
    J Mol Graph Model 28:598-603. 2010
    ..The overall results can be helpful for the understanding of the B-RAF phosphorylation processes on a molecular level...