Claus Christiansen

Summary

Affiliation: Center for Clinical and Basic Research
Country: Denmark

Publications

  1. ncbi request reprint Comparison of quantitative ultrasound of the phalanges with conventional bone densitometry in healthy postmenopausal women
    Peter Alexandersen
    Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Denmark
    Osteoporos Int 16:1071-8. 2005
  2. ncbi request reprint Novel associations between bioavailable estradiol and adipokines in elderly women with different phenotypes of obesity: implications for atherogenesis
    Laszlo B Tanko
    Prospective Epidemiological Risk Factor PERF study group, Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Ballerup, Denmark
    Circulation 110:2246-52. 2004
  3. ncbi request reprint Associations between aortic calcification and components of body composition in elderly men
    Peter Alexandersen
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Obesity (Silver Spring) 14:1571-8. 2006
  4. ncbi request reprint Enlarged waist combined with elevated triglycerides is a strong predictor of accelerated atherogenesis and related cardiovascular mortality in postmenopausal women
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Denmark
    Circulation 111:1883-90. 2005
  5. ncbi request reprint Trimegestone in a low-dose, continuous-combined hormone therapy regimen prevents bone loss in osteopenic postmenopausal women
    Lise Warming
    Center for Clinical and Basic Research, Ballerup, Denmark, Wyeth CR and D, USA
    Menopause 11:337-42. 2004
  6. ncbi request reprint Associated response in bone and lipids during hormone replacement therapy
    Anne Bloch Thomsen
    Center of Clinical Basic Research, Ballerup Byvej 222, 2750 Ballerup, Denmark
    Maturitas 47:39-45. 2004
  7. ncbi request reprint The implications of body fat mass and fat distribution for cognitive function in elderly women
    Yu Z Bagger
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Obes Res 12:1519-26. 2004
  8. ncbi request reprint Visceral fat is more important than peripheral fat for endometrial thickness and bone mass in healthy postmenopausal women
    Lise Warming
    Center for Clinical and Basic Research, Ballerup, Denmark
    Am J Obstet Gynecol 188:349-53. 2003
  9. ncbi request reprint Safety and efficacy of a novel salmon calcitonin (sCT) technology-based oral formulation in healthy postmenopausal women: acute and 3-month effects on biomarkers of bone turnover
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    J Bone Miner Res 19:1531-8. 2004
  10. ncbi request reprint Relationship between osteoporosis and cardiovascular disease in postmenopausal women
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    J Bone Miner Res 20:1912-20. 2005

Detail Information

Publications65

  1. ncbi request reprint Comparison of quantitative ultrasound of the phalanges with conventional bone densitometry in healthy postmenopausal women
    Peter Alexandersen
    Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Denmark
    Osteoporos Int 16:1071-8. 2005
    ..In conclusion, QUS assessment of the phalanges correlates moderately with BMD of all skeletal sites and is able to effectively discriminate fractured from non-fractured subjects...
  2. ncbi request reprint Novel associations between bioavailable estradiol and adipokines in elderly women with different phenotypes of obesity: implications for atherogenesis
    Laszlo B Tanko
    Prospective Epidemiological Risk Factor PERF study group, Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Ballerup, Denmark
    Circulation 110:2246-52. 2004
    ..Peripheral adiposity confers protection against diabetes and atherosclerosis in elderly women. The underlying mechanisms, however, remain to be elucidated...
  3. ncbi request reprint Associations between aortic calcification and components of body composition in elderly men
    Peter Alexandersen
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Obesity (Silver Spring) 14:1571-8. 2006
    ..To investigate associations among body composition, cardiovascular risk factors, and atherosclerosis in middle-aged and elderly men for the identification of potential pathogenic links...
  4. ncbi request reprint Enlarged waist combined with elevated triglycerides is a strong predictor of accelerated atherogenesis and related cardiovascular mortality in postmenopausal women
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Denmark
    Circulation 111:1883-90. 2005
    ..Whether EWET offers superior disease and event prediction in postmenopausal women, however, remains unknown...
  5. ncbi request reprint Trimegestone in a low-dose, continuous-combined hormone therapy regimen prevents bone loss in osteopenic postmenopausal women
    Lise Warming
    Center for Clinical and Basic Research, Ballerup, Denmark, Wyeth CR and D, USA
    Menopause 11:337-42. 2004
    ..To determine the efficacy of estrogen + progestogen therapy with 1 mg 17beta-estradiol and 0.125 mg trimegestone in the prevention of postmenopausal osteoporosis...
  6. ncbi request reprint Associated response in bone and lipids during hormone replacement therapy
    Anne Bloch Thomsen
    Center of Clinical Basic Research, Ballerup Byvej 222, 2750 Ballerup, Denmark
    Maturitas 47:39-45. 2004
    ..In postmenopausal women, we investigated if the response in bone mineral density (BMD) was associated with the response in the atherogenic lipid profile during hormone replacement therapy...
  7. ncbi request reprint The implications of body fat mass and fat distribution for cognitive function in elderly women
    Yu Z Bagger
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Obes Res 12:1519-26. 2004
    ..To investigate how body fat mass, an established source of endogenous estrogen after menopause, influences cognitive impairment in elderly women...
  8. ncbi request reprint Visceral fat is more important than peripheral fat for endometrial thickness and bone mass in healthy postmenopausal women
    Lise Warming
    Center for Clinical and Basic Research, Ballerup, Denmark
    Am J Obstet Gynecol 188:349-53. 2003
    ..The purpose of this study was to investigate the influence of body mass index and body composition on endometrial thickness and bone mass...
  9. ncbi request reprint Safety and efficacy of a novel salmon calcitonin (sCT) technology-based oral formulation in healthy postmenopausal women: acute and 3-month effects on biomarkers of bone turnover
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    J Bone Miner Res 19:1531-8. 2004
    ..The results show (1) effective enteral absorption, (2) marked inhibition of bone resorption with minimal alteration of formation, and (3) reproducibility of responses over 3 months...
  10. ncbi request reprint Relationship between osteoporosis and cardiovascular disease in postmenopausal women
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    J Bone Miner Res 20:1912-20. 2005
    ..Accordingly, treatment of postmenopausal osteoporosis should include consideration of measures to prevent adverse cardiovascular outcomes...
  11. ncbi request reprint The effect on cartilage of different forms of application of postmenopausal estrogen therapy: comparison of oral and transdermal therapy
    Pernille Ravn
    Center for Clinical and Basic Research, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Bone 35:1216-21. 2004
    ..However, long-term clinical trials are needed to further investigate this issue...
  12. ncbi request reprint Effective doses of ibandronate do not influence the 3-year progression of aortic calcification in elderly osteoporotic women
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    Osteoporos Int 16:184-90. 2005
    ..These findings thus suggest that 3-year treatment with effective doses of ibandronate does not pose any cardiovascular risk in terms of altering vascular calcification...
  13. ncbi request reprint Pulsed estrogen therapy in prevention of postmenopausal osteoporosis. A 2-year randomized, double blind, placebo-controlled study
    Therese F Nielsen
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, DK 2750, Ballerup, Denmark
    Osteoporos Int 15:168-74. 2004
    ..This study demonstrates that pulsed estrogen therapy at the dose of 150 microg and 300-microg per day prevents bone loss in a dose-dependant manner at each site studied, and normalizes bone turnover markers to premenopausal levels...
  14. ncbi request reprint Peripheral adiposity exhibits an independent dominant antiatherogenic effect in elderly women
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Circulation 107:1626-31. 2003
    ..Although several lines of evidence point to an atherogenic role of central fat mass (CFM), few data are available to address the specific role played by peripheral fat mass (PFM)...
  15. doi request reprint Long-term prevention with hormone-replacement therapy after the menopause: which women should be targeted?
    Peter Alexandersen
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Womens Health (Lond Engl) 5:637-47. 2009
    ....
  16. ncbi request reprint Optimising antiresorptive therapies in postmenopausal women: why do we need to give due consideration to the degree of suppression?
    Morten A Karsdal
    Center for Clinical and Basic Research, Ballerup, Denmark
    Drugs 66:1909-18. 2006
    ....
  17. ncbi request reprint ACDC/adiponectin and PPAR-gamma gene polymorphisms: implications for features of obesity
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    Obes Res 13:2113-21. 2005
    ....
  18. ncbi request reprint Oral salmon calcitonin induced suppression of urinary collagen type II degradation in postmenopausal women: a new potential treatment of osteoarthritis
    Yu Z Bagger
    Center for Clinical and Basic Research, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Bone 37:425-30. 2005
    ....
  19. ncbi request reprint The effect of hormone replacement therapy on appendicular lean tissue mass in early postmenopausal women
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    Menopause 9:117-21. 2002
    ..The aim of the present preliminary study was to evaluate the effect of a 3-year HRT program on appendicular lean tissue mass (LTM(A)) in early postmenopausal women aged 45-54 years...
  20. ncbi request reprint Alendronate has a residual effect on bone mass in postmenopausal Danish women up to 7 years after treatment withdrawal
    Yu Z Bagger
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, Ballerup, Denmark
    Bone 33:301-7. 2003
    ..The rate of bone loss after withdrawal of alendronate corresponded to the normal postmenopausal rate of bone loss. A residual effect on BMD was found up to 7 yr after treatment withdrawal...
  21. ncbi request reprint Early postmenopausal hormone therapy may prevent cognitive impairment later in life
    Yu Z Bagger
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Menopause 12:12-7. 2005
    ..The aim of this study was to investigate the impact of administration of HT for 2 to 3 years in the early postmenopausal years on the risk of cognitive impairment 5 to 15 years later...
  22. ncbi request reprint Strontium ranelate reduces the urinary level of cartilage degradation biomarker CTX-II in postmenopausal women
    Peter Alexandersen
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Bone 40:218-22. 2007
    ..The objective of the present study was to investigate whether strontium ranelate (2 g/day) also affects cartilage brakedown as measured by urinary marker of cartilage degradation, designated CTX-II...
  23. ncbi request reprint An update on the antiestrogenic effect of smoking: a literature review with implications for researchers and practitioners
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    Menopause 11:104-9. 2004
    ..DESIGN Summary of own research and a MEDLINE search of English-language literature on the antiestrogenic effect of smoking in pre- and postmenopausal women published during the past two decades...
  24. ncbi request reprint The long-term predictive value of bone mineral density measurements for fracture risk is independent of the site of measurement and the age at diagnosis: results from the Prospective Epidemiological Risk Factors study
    Yu Z Bagger
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, 2750 Ballerup, Denmark
    Osteoporos Int 17:471-7. 2006
    ..Both age and prior fracture are strong predictors of future fractures. The long-term predictive value of bone mass measurement is independent of the site of measurement and the age at diagnosis...
  25. ncbi request reprint Lack of difference among progestins on the anti-atherogenic effect of ethinyl estradiol: a rabbit study
    Peter Alexandersen
    Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Denmark
    Hum Reprod 18:1395-403. 2003
    ..The aim of this study was to investigate the influence of different oral contraceptive formulations on the development of experimental atherosclerosis and vascular reactivity...
  26. ncbi request reprint Serum placental protein 14: a novel marker of selective oestrogen receptor modulator action on the postmenopausal endometrium
    Laszlo B Tanko
    Centre for Clinical and Basic Research A S, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Biomarkers 7:257-66. 2002
    ....
  27. ncbi request reprint The aging male: testosterone deficiency and testosterone replacement. An up-date
    Peter Alexandersen
    CCBR, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Atherosclerosis 173:157-69. 2004
    ..The evidence clearly shows that data for the most part are conflicting, with only very few randomized studies available...
  28. ncbi request reprint Biochemical approach to the detection and monitoring of metastatic bone disease: What do we know and what questions need answers?
    Laszlo B Tanko
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, 2750, Ballerup, Denmark
    Cancer Metastasis Rev 25:659-68. 2006
    ....
  29. ncbi request reprint Pulsed estrogen therapy improves postmenopausal quality of life: a 2-year placebo-controlled study
    Therese F Nielsen
    Center for Clinical and Basic Research A S, Ballerup, Denmark
    Maturitas 53:184-90. 2006
    ....
  30. ncbi request reprint Central and peripheral fat mass have contrasting effect on the progression of aortic calcification in postmenopausal women
    Laszlo B Tanko
    Center for Clinical and Basic Research A S, Ballerup, Denmark
    Eur Heart J 24:1531-7. 2003
    ..To investigate the long-term effects of central fat mass (CFM) and peripheral fat mass (PFM) on atherogenic risk profile and the progression of aortic calcification (AC) in postmenopausal women...
  31. ncbi request reprint Two to three years of hormone replacement treatment in healthy women have long-term preventive effects on bone mass and osteoporotic fractures: the PERF study
    Yu Z Bagger
    Center for Clinical and Basic Research A S, Ballerup, Denmark
    Bone 34:728-35. 2004
    ..In conclusion, limited HRT administered in the early postmenopausal years offers long-lasting benefits for the prevention of postmenopausal bone loss and osteoporotic fracture...
  32. ncbi request reprint The clinical potential of estrogen for the prevention of osteoarthritis: what is known and what needs to be done?
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Denmark
    Womens Health (Lond Engl) 1:125-32. 2005
    ....
  33. pmc Safety of bazedoxifene in a randomized, double-blind, placebo- and active-controlled Phase 3 study of postmenopausal women with osteoporosis
    Claus Christiansen
    Center for Clinical and Basic Research, Ballerup, Denmark
    BMC Musculoskelet Disord 11:130. 2010
    ..We report the safety findings from a 3-year phase 3 study (NCT00205777) of bazedoxifene, a novel selective estrogen receptor modulator under development for the prevention and treatment of postmenopausal osteoporosis...
  34. ncbi request reprint Appendicular lean tissue mass and the prevalence of sarcopenia among healthy women
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    Metabolism 51:69-74. 2002
    ....
  35. ncbi request reprint Norethisterone acetate in combination with estrogen: effects on the skeleton and other organs. A review
    Bente Juel Riis
    Center for Clinical and Basic Research, Ballerup, Denmark
    Am J Obstet Gynecol 187:1101-16. 2002
    ..Also, hormone replacement therapy combinations with norethisterone acetate efficiently alleviate hot flushes. Hormone replacement therapy and the risk of breast cancer and the role of progestogens are discussed...
  36. ncbi request reprint Effects of bazedoxifene on BMD and bone turnover in postmenopausal women: 2-yr results of a randomized, double-blind, placebo-, and active-controlled study
    Paul D Miller
    Colorado Center for Bone Research, Lakewood, Colorado 80227, USA
    J Bone Miner Res 23:525-35. 2008
    ..Osteoporosis is an increasingly common health concern in postmenopausal women. In a 2-yr phase III study, bazedoxifene prevented bone loss, reduced bone turnover, and was well tolerated in early postmenopausal women with normal or low BMD...
  37. ncbi request reprint Are nonresorbing osteoclasts sources of bone anabolic activity?
    Morten A Karsdal
    Nordic Bioscience A S, Herlev, Denmark
    J Bone Miner Res 22:487-94. 2007
    ..Finally, we describe the likely possibility that bone resorption can be attenuated pharmacologically without the undesirable reduction in bone formation...
  38. ncbi request reprint Cognitive performance in elderly women: significance of the 19bp insertion/deletion polymorphism in the 5' flank of the dopamine beta-hydroxylase gene, educational level, body fat measures, serum triglyceride, alcohol consumption and age
    Mads Togsverd
    Research Institute of Biological Psychiatry, H S Sct Hans Hospital, Roskilde, Copenhagen University, Denmark
    Int J Geriatr Psychiatry 22:883-9. 2007
    ..The gene encoding dopamine beta-hydroxylase (DBH) could be one such factor since this hydroxylase converts dopamine to norepinephrine both of which are involved in cognition regulation...
  39. ncbi request reprint Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
    Agnar Helgason
    deCODE Genetics, 101 Reykjavik, Iceland
    Nat Genet 39:218-25. 2007
    ....
  40. ncbi request reprint Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women
    Una L Fairbrother
    Section of Genomic Medicine, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    J Bone Miner Res 22:544-50. 2007
    ..In a population-based study of 1306 postmenopausal Danish women, nonsynonymous LEPR SNPs were associated with risk of adiposity, BMD, and vertebral fracture. Smoking exacerbates this LEPR-associated fracture risk...
  41. ncbi request reprint A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
    Valgerdur Steinthorsdottir
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:770-5. 2007
    ..The insulin response for homozygotes was approximately 20% lower than for heterozygotes or noncarriers, suggesting that this variant confers risk of T2D through reduced insulin secretion...
  42. ncbi request reprint The effect of oral calcitonin on cartilage turnover and surface erosion in an ovariectomized rat model
    Bodil Cecilie Sondergaard
    Nordic Bioscience Diagnostics, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    Arthritis Rheum 56:2674-8. 2007
    ..To investigate whether oral calcitonin treatment influences the increases in type II collagen (CII) degradation and related surface erosions of articular cartilage in ovariectomized rats...
  43. pmc The effects of tibolone in older postmenopausal women
    Steven R Cummings
    San Francisco Coordinating Center and the California Pacific Medical Center Research Institute, San Francisco, USA
    N Engl J Med 359:697-708. 2008
    ..Tibolone has estrogenic, progestogenic, and androgenic effects. Although tibolone prevents bone loss, its effects on fractures, breast cancer, and cardiovascular disease are uncertain...
  44. pmc Does increased local bone resorption secondary to breast and prostate cancer result in increased cartilage degradation?
    Diana J Leeming
    Nordic Bioscience, Herlev Hovedgade 207, 2730 Herlev, Denmark
    BMC Cancer 8:180. 2008
    ....
  45. ncbi request reprint Calcitonin: a drug of the past or for the future? Physiologic inhibition of bone resorption while sustaining osteoclast numbers improves bone quality
    Morten A Karsdal
    Pharmacology Department, Nordic Bioscience A S, Herlev, Denmark
    BioDrugs 22:137-44. 2008
    ..There are promising clinical data available for this formulation from both osteoarthritis and osteoporosis clinical trials, although the antifracture efficacy is not yet known...
  46. ncbi request reprint Quantifying calcification in the lumbar aorta on X-ray images
    Lars A Conrad-Hansen
    Department of Computer Science, University of Copenhagen, Denmark
    Med Image Comput Comput Assist Interv 10:352-9. 2007
    ....
  47. doi request reprint Multiple genetic loci for bone mineral density and fractures
    Unnur Styrkarsdottir
    deCODE Genetics, Reykjavik, Iceland
    N Engl J Med 358:2355-65. 2008
    ..Bone mineral density influences the risk of osteoporosis later in life and is useful in the evaluation of the risk of fracture. We aimed to identify sequence variants associated with bone mineral density and fracture...
  48. ncbi request reprint Calcitonin affects both bone and cartilage: a dual action treatment for osteoarthritis?
    Morten A Karsdal
    Nordic Bioscience A S, Herlev, Copenhagen, Denmark
    Ann N Y Acad Sci 1117:181-95. 2007
    ..Presently there is limited availability of chondroprotective agents. Therefore, the current clinical research on calcitonin is highly anticipated, and may prove calcitonin treatment efficacious for the prevention and treatment of OA...
  49. ncbi request reprint Association of a dopamine beta-hydroxylase gene variant with depression in elderly women possibly reflecting noradrenergic dysfunction
    Mads Togsverd
    Research Institute of Biological Psychiatry, Sct Hans Hospital, Roskilde, Copenhagen University, Denmark
    J Affect Disord 106:169-72. 2008
    ..Depression has a multifactorial etiology which involves genetic factors and comorbid diseases...
  50. ncbi request reprint Disassociation of bone resorption and formation by GLP-2: a 14-day study in healthy postmenopausal women
    Dennis B Henriksen
    Sanos Bioscience, Glerupvej 2, 2610 Roedovre, Denmark
    Bone 40:723-9. 2007
    ..Osteocalcin and PINP levels were unaffected at Day 1 and Day 14, suggesting a disassociation between bone resorption and bone formation during GLP-2 treatment...
  51. pmc Linkage of osteoporosis to chromosome 20p12 and association to BMP2
    Unnur Styrkarsdottir
    deCODE Genetics, Reykjavik, Iceland
    PLoS Biol 1:E69. 2003
    ....
  52. ncbi request reprint Can confounding with fat-derived endogenous free estradiol explain the inverse correlation of bone mineral density with adiponectin?
    Laszlo B Tanko
    Bone 34:916; author reply 917. 2004
  53. ncbi request reprint An immunoassay for measuring fragments of newly synthesized collagen type I produced during metastatic invasion of bone
    Paul A C Cloos
    Nordic Bioscience, Osteopark, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    Clin Lab 50:279-89. 2004
    ..5) than beta-betaCTX (Z=3.6). In conclusion, measurement of alpha-alphaCTX fragments may provide a clinically relevant assessment of bone resorption related to bone metastases...
  54. ncbi request reprint Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis
    Charles H Chesnut III
    Osteoporosis Research Group, University of Washington, Seattle, Washington 98185, USA
    J Bone Miner Res 19:1241-9. 2004
    ..Significant reduction in incident vertebral fracture risk by 62% and 50%, respectively, was shown after 3 years. This is the first study to prospectively show antifracture efficacy for the intermittent administration of a bisphosphonate...
  55. ncbi request reprint Suppression of elevated cartilage turnover in postmenopausal women and in ovariectomized rats by estrogen and a selective estrogen-receptor modulator (SERM)
    Stephan Christgau
    Nordic Bioscience, Herlev, Denmark
    Menopause 11:508-18. 2004
    ..The clinical relevance was assessed in postmenopausal women by measuring the changes in CTX-II during 12-month treatment with levormeloxifene versus placebo...
  56. ncbi request reprint Association between spine disc degeneration and type II collagen degradation in postmenopausal women: the OFELY study
    Patrick Garnero
    INSERM Research Unit 403, Synarc, Lyon, France
    Arthritis Rheum 50:3137-44. 2004
    ....
  57. ncbi request reprint Changes in bone density and turnover after alendronate or estrogen withdrawal
    Richard D Wasnich
    Radiant Research Honolulu, Honolulu, HI 96814, USA
    Menopause 11:622-30. 2004
    ..To compare bone mineral density (BMD) and bone turnover changes after therapy withdrawal in postmenopausal women treated with alendronate or estrogen-progestin...
  58. pmc Acidification of the osteoclastic resorption compartment provides insight into the coupling of bone formation to bone resorption
    Morten A Karsdal
    Nordic Bioscience A S, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    Am J Pathol 166:467-76. 2005
    ..Thus, we suggest that acidification is essential for normal bone remodeling and that attenuated acidification leads to uncoupling with decreased bone resorption and unaffected bone formation...
  59. ncbi request reprint Prevention of postmenopausal bone loss: six-year results from the Early Postmenopausal Intervention Cohort Study
    Michael R McClung
    Oregon Osteoporosis Center, 5050 Northeast Hoyt, Suite 651, Portland, Oregon 97213, USA
    J Clin Endocrinol Metab 89:4879-85. 2004
    ..5, 10.3, and 8.9% of women taking placebo, 2.5 mg alendronate, or 5 mg alendronate daily, respectively. Therapy with alendronate is an effective and promising strategy for the prevention of postmenopausal osteoporosis...
  60. ncbi request reprint Extracellular post-translational modifications of collagen are major determinants of biomechanical properties of fetal bovine cortical bone
    Patrick Garnero
    INSERM Unit 403, Hopital E Herriot, Pav F, 69437 Lyon Cedex 03, France
    Bone 38:300-9. 2006
    ..We conclude that the extent and nature of collagen cross-linking contribute to the mechanical properties of fetal bovine cortical bone independently of bone mineral density...
  61. ncbi request reprint Estrogen receptor alpha and risk for cognitive impairment in postmenopausal women
    Line Olsen
    Research Institute of Biological Psychiatry, Copenhagen University Hospital, Roskilde, Denmark
    Psychiatr Genet 16:85-8. 2006
    ..049) and this effect was reflected in executive cognitive ability. These data support that the ESR1 gene variants affect cognitive functioning in postmenopausal women...
  62. ncbi request reprint Intravenous ibandronate injections in postmenopausal women with osteoporosis: one-year results from the dosing intravenous administration study
    Pierre D Delmas
    Université Claude Bernard Lyon 1 and INSERM Research Unit 403, Lyon, France
    Arthritis Rheum 54:1838-46. 2006
    ..The aim of this study was to identify the optimal intravenous dosing regimen for ibandronate in postmenopausal women with osteoporosis...
  63. ncbi request reprint Estrogen receptor alpha and beta polymorphisms: is there an association with bone mineral density, plasma lipids, and response to postmenopausal hormone therapy?
    Sandra Silvestri
    Department of Internal Medicine, School of Medicine, University of Florence, Florence, Italy
    Menopause 13:451-61. 2006
    ..In another untreated subpopulation of 443 women, genotype influence on the prevalence of vertebral fractures and on annual rate of bone loss during a mean follow-up period of 11 years was estimated...
  64. ncbi request reprint Effects of ovariectomy and estrogen therapy on type II collagen degradation and structural integrity of articular cartilage in rats: implications of the time of initiation
    Svetlana Oestergaard
    Nordic Bioscience, Herlev, Denmark
    Arthritis Rheum 54:2441-51. 2006
    ....
  65. ncbi request reprint Variations in percentage of body fat within different BMI groups in young, middle-aged and old women
    Lusine Movsesyan
    Center for Clinical and Basic Research A S, Ballerup Byvej, Ballerup, Denmark
    Clin Physiol Funct Imaging 23:130-3. 2003
    ..The objective of the present study was to characterize age-dependent variations in percentage of body fat within different body mass index (BMI) classes in healthy Danish women...