Y Z Bagger

Summary

Affiliation: Center for Clinical and Basic Research
Country: Denmark

Publications

  1. ncbi request reprint The long-term predictive value of bone mineral density measurements for fracture risk is independent of the site of measurement and the age at diagnosis: results from the Prospective Epidemiological Risk Factors study
    Yu Z Bagger
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, 2750 Ballerup, Denmark
    Osteoporos Int 17:471-7. 2006
  2. ncbi request reprint Early postmenopausal hormone therapy may prevent cognitive impairment later in life
    Yu Z Bagger
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Menopause 12:12-7. 2005
  3. ncbi request reprint Alendronate has a residual effect on bone mass in postmenopausal Danish women up to 7 years after treatment withdrawal
    Yu Z Bagger
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, Ballerup, Denmark
    Bone 33:301-7. 2003
  4. pmc Links between cardiovascular disease and osteoporosis in postmenopausal women: serum lipids or atherosclerosis per se?
    Y Z Bagger
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, DK 2750, Ballerup, Denmark
    Osteoporos Int 18:505-12. 2007
  5. ncbi request reprint The implications of body fat mass and fat distribution for cognitive function in elderly women
    Yu Z Bagger
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Obes Res 12:1519-26. 2004
  6. ncbi request reprint Oral salmon calcitonin induced suppression of urinary collagen type II degradation in postmenopausal women: a new potential treatment of osteoarthritis
    Yu Z Bagger
    Center for Clinical and Basic Research, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Bone 37:425-30. 2005
  7. ncbi request reprint Radiographic measure of aorta calcification is a site-specific predictor of bone loss and fracture risk at the hip
    Y Z Bagger
    Center for Clinical and Basic Research A S, Ballerup, Denmark
    J Intern Med 259:598-605. 2006
  8. ncbi request reprint Two to three years of hormone replacement treatment in healthy women have long-term preventive effects on bone mass and osteoporotic fractures: the PERF study
    Yu Z Bagger
    Center for Clinical and Basic Research A S, Ballerup, Denmark
    Bone 34:728-35. 2004
  9. ncbi request reprint No major effect of estrogen receptor gene polymorphisms on bone mineral density or bone loss in postmenopausal Danish women
    Y Z Bagger
    Center for Clinical and Basic Research, Ballerup, Denmark
    Bone 26:111-6. 2000
  10. ncbi request reprint Dose dependent effects on bone resorption and formation of intermittently administered intravenous ibandronate
    C Christiansen
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, 2750, Ballerup, Denmark
    Osteoporos Int 14:609-13. 2003

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint The long-term predictive value of bone mineral density measurements for fracture risk is independent of the site of measurement and the age at diagnosis: results from the Prospective Epidemiological Risk Factors study
    Yu Z Bagger
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, 2750 Ballerup, Denmark
    Osteoporos Int 17:471-7. 2006
    ..Both age and prior fracture are strong predictors of future fractures. The long-term predictive value of bone mass measurement is independent of the site of measurement and the age at diagnosis...
  2. ncbi request reprint Early postmenopausal hormone therapy may prevent cognitive impairment later in life
    Yu Z Bagger
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Menopause 12:12-7. 2005
    ..The aim of this study was to investigate the impact of administration of HT for 2 to 3 years in the early postmenopausal years on the risk of cognitive impairment 5 to 15 years later...
  3. ncbi request reprint Alendronate has a residual effect on bone mass in postmenopausal Danish women up to 7 years after treatment withdrawal
    Yu Z Bagger
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, Ballerup, Denmark
    Bone 33:301-7. 2003
    ..The rate of bone loss after withdrawal of alendronate corresponded to the normal postmenopausal rate of bone loss. A residual effect on BMD was found up to 7 yr after treatment withdrawal...
  4. pmc Links between cardiovascular disease and osteoporosis in postmenopausal women: serum lipids or atherosclerosis per se?
    Y Z Bagger
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, DK 2750, Ballerup, Denmark
    Osteoporos Int 18:505-12. 2007
    ..We investigated whether serum lipids and polymorphism in the ApoE gene modifying serum lipids could be a biological linkage...
  5. ncbi request reprint The implications of body fat mass and fat distribution for cognitive function in elderly women
    Yu Z Bagger
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Obes Res 12:1519-26. 2004
    ..To investigate how body fat mass, an established source of endogenous estrogen after menopause, influences cognitive impairment in elderly women...
  6. ncbi request reprint Oral salmon calcitonin induced suppression of urinary collagen type II degradation in postmenopausal women: a new potential treatment of osteoarthritis
    Yu Z Bagger
    Center for Clinical and Basic Research, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Bone 37:425-30. 2005
    ....
  7. ncbi request reprint Radiographic measure of aorta calcification is a site-specific predictor of bone loss and fracture risk at the hip
    Y Z Bagger
    Center for Clinical and Basic Research A S, Ballerup, Denmark
    J Intern Med 259:598-605. 2006
    ..To investigate whether aorta calcification (AC) - a surrogate marker of atherosclerosis - is an independent indicator of low bone mass density (BMD), accelerated bone loss, and risk of future fractures in postmenopausal women...
  8. ncbi request reprint Two to three years of hormone replacement treatment in healthy women have long-term preventive effects on bone mass and osteoporotic fractures: the PERF study
    Yu Z Bagger
    Center for Clinical and Basic Research A S, Ballerup, Denmark
    Bone 34:728-35. 2004
    ..In conclusion, limited HRT administered in the early postmenopausal years offers long-lasting benefits for the prevention of postmenopausal bone loss and osteoporotic fracture...
  9. ncbi request reprint No major effect of estrogen receptor gene polymorphisms on bone mineral density or bone loss in postmenopausal Danish women
    Y Z Bagger
    Center for Clinical and Basic Research, Ballerup, Denmark
    Bone 26:111-6. 2000
    ..In conclusion, we could not demonstrate any major effect of the ER gene polymorphisms on BMD or rate of bone loss in healthy postmenopausal Danish women...
  10. ncbi request reprint Dose dependent effects on bone resorption and formation of intermittently administered intravenous ibandronate
    C Christiansen
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, 2750, Ballerup, Denmark
    Osteoporos Int 14:609-13. 2003
    ....
  11. ncbi request reprint Efficacy of levormeloxifene in the prevention of postmenopausal bone loss and on the lipid profile compared to low dose hormone replacement therapy
    P Alexandersen
    Center for Clinical and Basic Research, 2750 Ballerup, Denmark
    J Clin Endocrinol Metab 86:755-60. 2001
    ..Levormeloxifene at the doses tested had an estrogen-like effect on endometrium and no effect on hot flushes. The study was unable to differentiate between the effects of the different doses of levormeloxifene...
  12. pmc Cartilage turnover assessed with a newly developed assay measuring collagen type II degradation products: influence of age, sex, menopause, hormone replacement therapy, and body mass index
    U Mouritzen
    Centre for Clinical and Basic Research A S, Ballerup, Denmark
    Ann Rheum Dis 62:332-6. 2003
    ..Cartilage normally has a slow turnover but in arthritis increased metabolism results in degradation of the tissue...
  13. ncbi request reprint Safety and efficacy of drospirenone used in a continuous combination with 17beta-estradiol for prevention of postmenopausal osteoporosis
    L Warming
    Center for Clinical and Basic Research A S, Ballerup, Denmark
    Climacteric 7:103-11. 2004
    ..To evaluate the combination of 17beta-estradiol and continuous drospirenone for the prevention of postmenopausal osteoporosis...
  14. ncbi request reprint Natural androgens inhibit male atherosclerosis: a study in castrated, cholesterol-fed rabbits
    P Alexandersen
    Center for Clinical and Basic Research, Ballerup, Denmark
    Circ Res 84:813-9. 1999
    ..Natural androgens inhibit aortic atherosclerosis in castrated male rabbits only partly through a lipid-mediated effect...
  15. doi request reprint The influence of smoking on bone loss and response to nasal estradiol
    N H Bjarnason
    Center for Clinical and Basic Research, Ballerup
    Climacteric 12:59-65. 2009
    ..In addition, to observe the consequences of smoking on bone in untreated women...
  16. ncbi request reprint Monofluorophosphate combined with hormone replacement therapy induces a synergistic effect on bone mass by dissociating bone formation and resorption in postmenopausal women: a randomized study
    P Alexandersen
    Center for Clinical and Basic Research, Ballerup, Denmark
    J Clin Endocrinol Metab 84:3013-20. 1999
    ..Furthermore, the synergistic effects of relatively low doses of the compounds suggested statistically and clinically significant increases in trabecular and probably also cortical bone. Adverse effects were relatively rare and mild...
  17. ncbi request reprint Six and twelve month changes in bone turnover are related to reduction in vertebral fracture risk during 3 years of raloxifene treatment in postmenopausal osteoporosis
    N H Bjarnason
    Center for Clinical and Basic Research, Ballerup, Denmark
    Osteoporos Int 12:922-30. 2001
    ..In contrast the change in BMD is not related to fracture risk. The strongest predictor for vertebral fracture is prevalent vertebral fracture...
  18. ncbi request reprint The efficacy of 48-week oral ibandronate treatment in postmenopausal osteoporosis when taken 30 versus 60 minutes before breakfast
    L B Tanko
    Center for Clinical and Basic Research A S, Ballerup and Aalborg, Denmark
    Bone 32:421-6. 2003
    ..Another potential solution for improving the convenience with bisphosphonate treatment is expected from weekly or monthly dosing regimens currently under clinical investigations...
  19. ncbi request reprint Oral ibandronate: changes in markers of bone turnover during adequately dosed continuous and weekly therapy and during different suboptimally dosed treatment regimens
    L B Tanko
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, 2750 Ballerup, Denmark
    Bone 32:687-93. 2003
    ..These observations suggest that serial measurements of s-CTX may provide a useful diagnostic tool for the early revelation of suboptimal dosing or noncompliance to already optimized therapies with antiresorptive agents...
  20. ncbi request reprint The influence of smoking on uterine bleeding during continuous and interrupted oral hormone therapy
    N H Bjarnason
    Center for Clinical and Basic Research, Ballerup
    Climacteric 10:480-90. 2007
    ..To study the influence of smoking on uterine bleeding patterns during continuous and interrupted oral hormone therapy (HT)...
  21. ncbi request reprint Levonorgestrel and 17beta-estradiol given transdermally for the prevention of postmenopausal osteoporosis
    L Warming
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Maturitas 50:78-85. 2005
    ..To evaluate the efficacy and safety of a new transdermal continuous combined hormone replacement therapy (HRT) for the prevention of postmenopausal osteoporosis...
  22. ncbi request reprint Ibandronate: a comparison of oral daily dosing versus intermittent dosing in postmenopausal osteoporosis
    B J Riis
    Center for Clinical and Basic Research, Ballerup, Denmark
    J Bone Miner Res 16:1871-8. 2001
    ..This supports development of new flexible dosing regimens targeted to minimize the frequency of dosing, which are expected to improve convenience and lead to enhanced long-term patient compliance...
  23. ncbi request reprint Raloxifene and estrogen reduces progression of advanced atherosclerosis--a study in ovariectomized, cholesterol-fed rabbits
    N H Bjarnason
    Center for Clinical and Basic Research, Ballerup Byvej 222, 2750, Ballerup, Denmark
    Atherosclerosis 154:97-102. 2001
    ..01 for both) as compared to placebo...
  24. ncbi request reprint The influence of smoking on uterine bleeding during sequential oral hormone therapy
    N H Bjarnason
    Center for Clinical and Basic Research, Ballerup, Denmark
    Climacteric 10:147-54. 2007
    ..To study the influence of smoking on uterine bleeding patterns during sequentially administered oral hormone therapy (HT)...
  25. ncbi request reprint Effects of 17beta-oestradiol plus different doses of drospirenone on adipose tissue, adiponectin and atherogenic metabolites in postmenopausal women
    L B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    J Intern Med 258:544-53. 2005
    ..To investigate how variation in the dose of the progestogen influence the impact of 17beta-oestradiol plus drospirenone (DRSP) treatment on adipose tissue and its secretor function with direct implications for atherogenic metabolites...
  26. ncbi request reprint Low bone mineral density in the hip as a marker of advanced atherosclerosis in elderly women
    L B Tanko
    Center for Clinical and Basic Research A S, Aalborg, Denmark
    Calcif Tissue Int 73:15-20. 2003
    ..The results further emphasize that osteoporosis in the hip and peripheral vascular disease are linked by common risk factors and pathomechanisms...
  27. ncbi request reprint Number of years since menopause: spontaneous bone loss is dependent but response to hormone replacement therapy is independent
    N H Bjarnason
    Center for Clinical and Basic Research, Ballerup, Denmark
    Bone 30:637-42. 2002
    ..Whereas bone loss was significantly related to number of years since menopause, all HRT regimens applied arrested bone loss in healthy postmenopausal women, regardless of number of years since menopause...
  28. ncbi request reprint Ipriflavone in the treatment of postmenopausal osteoporosis: a randomized controlled trial
    P Alexandersen
    Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Denmark
    JAMA 285:1482-8. 2001
    ..Data on the efficacy and safety of ipriflavone for prevention of postmenopausal bone loss are conflicting...
  29. ncbi request reprint The effect of fluvastatin on parameters of bone remodeling
    N H Bjarnason
    Center for Clinical and Basic Research, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Osteoporos Int 12:380-4. 2001
    ..We conclude that fluvastatin given in clinically relevant doses has no influence on parameters of bone remodeling. Other statins remain to be investigated...
  30. ncbi request reprint Associated response in bone mineral density and atherogenic lipid profile during treatment with two different selective estrogen receptor modulators: levormeloxifene and raloxifene
    A Bloch-Thomsen
    Center for Clinical and Basic Research, Ballerup, Denmark
    Climacteric 6:159-67. 2003
    ..Study 1 included 133 women treated with placebo or levormeloxifene in four different doses for 12 months, and study 2 included 248 women treated with raloxifene in three different doses or placebo for 24 months...
  31. ncbi request reprint The long-term impact of 2-3 years of hormone replacement therapy on cardiovascular mortality and atherosclerosis in healthy women
    P Alexandersen
    Center for Clinical and Basic Research, Ballerup, Denmark
    Climacteric 9:108-18. 2006
    ..The aim of this study was to investigate the long-term effects of HRT given for a few years on all-cause and cardiovascular mortality and the severity of atherosclerosis...
  32. ncbi request reprint Vitamin D receptor and estrogen receptor gene polymorphisms in postmenopausal Danish women: no relation to bone markers or serum lipoproteins
    Y Z Bagger
    Center for Clinical and Basic Research, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Climacteric 3:84-91. 2000
    ....
  33. doi request reprint Strontium ranelate effect in postmenopausal women with different clinical levels of osteoarthritis
    P Alexandersen
    Center for Clinical and Basic Research, Vejle, Denmark
    Climacteric 14:236-43. 2011
    ..Women were stratified according to reported symptoms of osteoarthritis and to the baseline levels of a cartilage degradation marker...
  34. ncbi request reprint The influence of thinness and smoking on bone loss and response to hormone replacement therapy in early postmenopausal women
    N H Bjarnason
    Center for Clinical and Basic Research, Ballerup Byvej 222, Denmark
    J Clin Endocrinol Metab 85:590-6. 2000
    ..In conclusion, thinness and smoking are important risk factors for osteoporosis development, but are counteracted by hormone replacement therapy...
  35. ncbi request reprint Influence of female and male sex steroids on body composition in the rabbit model
    P Alexandersen
    Center for Clinical and Basic Research, Ballerup Byvej 222, DK-2750 Ballerup, Denmark
    Climacteric 4:219-27. 2001
    ..Until comparable human data are available, it is speculated that similar changes in soft body composition may occur in humans treated with sex steroids...
  36. ncbi request reprint Biochemical markers for prediction of 4-year response in bone mass during bisphosphonate treatment for prevention of postmenopausal osteoporosis
    P Ravn
    Center for Clinical and Basic Research, Ballerup, Denmark
    Bone 33:150-8. 2003
    ..In conclusion, the bone markers predicted a change in spine BMD greater than 0% with a high PPV and specificity. There was a trend toward better performance in this respect for the bone resorption markers...
  37. doi request reprint Parallel assessment of the impact of different hormone replacement therapies on breast density by radiologist- and computer-based analyses of mammograms
    P C Pettersen
    Center for Clinical and Basic Research, Ballerup, Denmark
    Climacteric 11:135-43. 2008
    ..First, to compare the impact of nasally and orally dosed estradiol on breast density; second, to investigate the utility of computer-based automated approaches to the assessment of breast density with reference to traditional methods...
  38. ncbi request reprint Dietary phytoestrogens and estrogen inhibit experimental atherosclerosis
    P Alexandersen
    Center for Clinical and Basic Research, Ballerup Byvej 222, DK-2750 Ballerup, Denmark
    Climacteric 4:151-9. 2001
    ..CONCLUSION: Dietary phytoestrogens significantly reduce aortic cholesterol content with a potency comparable to that of ERT, and seem to enhance (although mildly) the antiatherogenic effect of E2 in this model...
  39. ncbi request reprint Association between pharmacokinetics of oral ibandronate and clinical response in bone mass and bone turnover in women with postmenopausal osteoporosis
    P Ravn
    Center for Clinical and Basic Research, Ballerup, Denmark
    Bone 30:320-4. 2002
    ..The data are the first to show highly significant associations between pharmacokinetic parameters of a bisphosphonate and the clinical response in bone mass and bone turnover...
  40. ncbi request reprint A computer-based measure of irregularity in vertebral alignment is a BMD-independent predictor of fracture risk in postmenopausal women
    P C Pettersen
    Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Denmark
    Osteoporos Int 18:1525-30. 2007
    ....
  41. ncbi request reprint Smoking reduces breast tenderness during oral estrogen-progestogen therapy
    N H Bjarnason
    Center for Clinical and Basic Research, Ballerup, Denmark
    Climacteric 7:390-6. 2004
    ..We wished to study the influence of smoking upon the occurrence of breast tenderness during oral estrogen-progestogen therapy (EPT)...
  42. pmc Effect of bisphosphonates on cartilage turnover assessed with a newly developed assay for collagen type II degradation products
    H J Lehmann
    Centre for Clinical and Basic Research, Ballerup, Denmark Osteometer Biotech A S, Herlev, Denmark
    Ann Rheum Dis 61:530-3. 2002
    ..Animal studies of arthritis have suggested that bisphosphonates may have chondroprotective abilities...
  43. ncbi request reprint Effects of drospirenone/estrogen combinations on bone metabolism
    C Christiansen
    Center for Clinical and Basic Research A S, Ballerup, Denmark
    Climacteric 8:35-41. 2005
    ..001). The combination of 17beta-estradiol with drospirenone offers a safe and effective medication for decreasing bone turnover and preventing postmenopausal bone loss in postmenopausal women...
  44. ncbi request reprint Does serum cholesterol contribute to vertebral bone loss in postmenopausal women?
    L B Tanko
    The PERF Study Group, Center for Clinical and Basic Research A S, Hobrovej 42D, 9000 Aalborg, Ballerup, Denmark
    Bone 32:8-14. 2003
    ....
  45. ncbi request reprint Adipose tissue, insulin resistance and low-grade inflammation: implications for atherogenesis and the cardiovascular harm of estrogen plus progestogen therapy
    L B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    Climacteric 9:169-80. 2006
    ....
  46. ncbi request reprint Adverse effects of a SERM (Levormeloxifene). Safety parameters and bone mineral density 12 months after treatment withdrawal
    L Warming
    Center for Clinical and Basic Research, Ballerup Byvej 222, 2750, Ballerup, Denmark
    Maturitas 44:189-99. 2003
    ..This paper follow-up on the adverse events in a group of 234 women that was followed for 12 months without treatment after 12 months of treatment with levormeloxifene...
  47. ncbi request reprint Changes in bone mineral density with age in men and women: a longitudinal study
    L Warming
    Center for Clinical and Basic Research, Ballerup, Denmark
    Osteoporos Int 13:105-12. 2002
    ..In conclusion, the hip and forearm appear to be the sites with the best agreement between the cross-sectional estimated and the longitudinal age-related changes in BMD...
  48. ncbi request reprint Measurement precision and normal range of endometrial thickness in a postmenopausal population by transvaginal ultrasound
    L Warming
    Centre for Clinical and Basic Research, Ballerup, Denmark
    Ultrasound Obstet Gynecol 20:492-5. 2002
    ..The aim of this study was to examine the endometrial thickness (ET) in an asymptomatic postmenopausal population, and to assess the long-term variability...
  49. ncbi request reprint Effect of free plant sterols in low-fat milk on serum lipid profile in hypercholesterolemic subjects
    A B Thomsen
    Centre of Clinical and Basic Research, Ballerup Byvej, Ballerup, Denmark
    Eur J Clin Nutr 58:860-70. 2004
    ..To determine the effect of nonesterified, nonhydrogenated plant sterols solubilized in a partly vegetable oil-filled low-fat milk on serum low-density lipoprotein cholesterol (LDL) in mildly hypercholesterolemic patients...
  50. ncbi request reprint Mechanism of circadian variation in bone resorption
    N H Bjarnason
    Center for Clinical and Basic Research, Ballerup, Denmark
    Bone 30:307-13. 2002
    ..Both exogenous and endogenous insulin stimulation tests induced a reduction in bone resorption, but this was only partial when compared with the reduction observed during food intake...
  51. ncbi request reprint Two-dimensional gel analysis of human endometrial proteins: characterization of proteins with increased expression in hyperplasia and adenocarcinoma
    I Byrjalsen
    Center for Clinical and Basic Research, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Mol Hum Reprod 5:748-56. 1999
    ..The remaining unidentified proteins were either not contained in the database and must be assumed to be novel proteins, or were present in too low amounts to allow characterization...
  52. ncbi request reprint Biochemical approach to the detection and monitoring of metastatic bone disease: What do we know and what questions need answers?
    Laszlo B Tanko
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, 2750, Ballerup, Denmark
    Cancer Metastasis Rev 25:659-68. 2006
    ....
  53. ncbi request reprint Cognitive performance in elderly women: significance of the 19bp insertion/deletion polymorphism in the 5' flank of the dopamine beta-hydroxylase gene, educational level, body fat measures, serum triglyceride, alcohol consumption and age
    Mads Togsverd
    Research Institute of Biological Psychiatry, H S Sct Hans Hospital, Roskilde, Copenhagen University, Denmark
    Int J Geriatr Psychiatry 22:883-9. 2007
    ..The gene encoding dopamine beta-hydroxylase (DBH) could be one such factor since this hydroxylase converts dopamine to norepinephrine both of which are involved in cognition regulation...
  54. ncbi request reprint Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
    Agnar Helgason
    deCODE Genetics, 101 Reykjavik, Iceland
    Nat Genet 39:218-25. 2007
    ....
  55. ncbi request reprint Norethisterone acetate in combination with estrogen: effects on the skeleton and other organs. A review
    Bente Juel Riis
    Center for Clinical and Basic Research, Ballerup, Denmark
    Am J Obstet Gynecol 187:1101-16. 2002
    ..Also, hormone replacement therapy combinations with norethisterone acetate efficiently alleviate hot flushes. Hormone replacement therapy and the risk of breast cancer and the role of progestogens are discussed...
  56. ncbi request reprint Optimising antiresorptive therapies in postmenopausal women: why do we need to give due consideration to the degree of suppression?
    Morten A Karsdal
    Center for Clinical and Basic Research, Ballerup, Denmark
    Drugs 66:1909-18. 2006
    ....
  57. ncbi request reprint Disassociation of bone resorption and formation by GLP-2: a 14-day study in healthy postmenopausal women
    Dennis B Henriksen
    Sanos Bioscience, Glerupvej 2, 2610 Roedovre, Denmark
    Bone 40:723-9. 2007
    ..Osteocalcin and PINP levels were unaffected at Day 1 and Day 14, suggesting a disassociation between bone resorption and bone formation during GLP-2 treatment...
  58. ncbi request reprint Associations between aortic calcification and components of body composition in elderly men
    Peter Alexandersen
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Obesity (Silver Spring) 14:1571-8. 2006
    ..To investigate associations among body composition, cardiovascular risk factors, and atherosclerosis in middle-aged and elderly men for the identification of potential pathogenic links...
  59. ncbi request reprint Strontium ranelate reduces the urinary level of cartilage degradation biomarker CTX-II in postmenopausal women
    Peter Alexandersen
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Bone 40:218-22. 2007
    ..The objective of the present study was to investigate whether strontium ranelate (2 g/day) also affects cartilage brakedown as measured by urinary marker of cartilage degradation, designated CTX-II...
  60. ncbi request reprint Effects of ovariectomy and estrogen therapy on type II collagen degradation and structural integrity of articular cartilage in rats: implications of the time of initiation
    Svetlana Oestergaard
    Nordic Bioscience, Herlev, Denmark
    Arthritis Rheum 54:2441-51. 2006
    ....
  61. ncbi request reprint Estrogen receptor alpha and beta polymorphisms: is there an association with bone mineral density, plasma lipids, and response to postmenopausal hormone therapy?
    Sandra Silvestri
    Department of Internal Medicine, School of Medicine, University of Florence, Florence, Italy
    Menopause 13:451-61. 2006
    ..In another untreated subpopulation of 443 women, genotype influence on the prevalence of vertebral fractures and on annual rate of bone loss during a mean follow-up period of 11 years was estimated...
  62. ncbi request reprint Are nonresorbing osteoclasts sources of bone anabolic activity?
    Morten A Karsdal
    Nordic Bioscience A S, Herlev, Denmark
    J Bone Miner Res 22:487-94. 2007
    ..Finally, we describe the likely possibility that bone resorption can be attenuated pharmacologically without the undesirable reduction in bone formation...
  63. ncbi request reprint Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women
    Una L Fairbrother
    Section of Genomic Medicine, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    J Bone Miner Res 22:544-50. 2007
    ..In a population-based study of 1306 postmenopausal Danish women, nonsynonymous LEPR SNPs were associated with risk of adiposity, BMD, and vertebral fracture. Smoking exacerbates this LEPR-associated fracture risk...
  64. ncbi request reprint A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
    Valgerdur Steinthorsdottir
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:770-5. 2007
    ..The insulin response for homozygotes was approximately 20% lower than for heterozygotes or noncarriers, suggesting that this variant confers risk of T2D through reduced insulin secretion...
  65. pmc The effects of tibolone in older postmenopausal women
    Steven R Cummings
    San Francisco Coordinating Center and the California Pacific Medical Center Research Institute, San Francisco, USA
    N Engl J Med 359:697-708. 2008
    ..Tibolone has estrogenic, progestogenic, and androgenic effects. Although tibolone prevents bone loss, its effects on fractures, breast cancer, and cardiovascular disease are uncertain...
  66. pmc Does increased local bone resorption secondary to breast and prostate cancer result in increased cartilage degradation?
    Diana J Leeming
    Nordic Bioscience, Herlev Hovedgade 207, 2730 Herlev, Denmark
    BMC Cancer 8:180. 2008
    ....
  67. ncbi request reprint Calcitonin: a drug of the past or for the future? Physiologic inhibition of bone resorption while sustaining osteoclast numbers improves bone quality
    Morten A Karsdal
    Pharmacology Department, Nordic Bioscience A S, Herlev, Denmark
    BioDrugs 22:137-44. 2008
    ..There are promising clinical data available for this formulation from both osteoarthritis and osteoporosis clinical trials, although the antifracture efficacy is not yet known...
  68. doi request reprint Multiple genetic loci for bone mineral density and fractures
    Unnur Styrkarsdottir
    deCODE Genetics, Reykjavik, Iceland
    N Engl J Med 358:2355-65. 2008
    ..Bone mineral density influences the risk of osteoporosis later in life and is useful in the evaluation of the risk of fracture. We aimed to identify sequence variants associated with bone mineral density and fracture...
  69. ncbi request reprint Effects of bazedoxifene on BMD and bone turnover in postmenopausal women: 2-yr results of a randomized, double-blind, placebo-, and active-controlled study
    Paul D Miller
    Colorado Center for Bone Research, Lakewood, Colorado 80227, USA
    J Bone Miner Res 23:525-35. 2008
    ..Osteoporosis is an increasingly common health concern in postmenopausal women. In a 2-yr phase III study, bazedoxifene prevented bone loss, reduced bone turnover, and was well tolerated in early postmenopausal women with normal or low BMD...
  70. ncbi request reprint Calcitonin affects both bone and cartilage: a dual action treatment for osteoarthritis?
    Morten A Karsdal
    Nordic Bioscience A S, Herlev, Copenhagen, Denmark
    Ann N Y Acad Sci 1117:181-95. 2007
    ..Presently there is limited availability of chondroprotective agents. Therefore, the current clinical research on calcitonin is highly anticipated, and may prove calcitonin treatment efficacious for the prevention and treatment of OA...
  71. ncbi request reprint The effect of hormone replacement therapy on appendicular lean tissue mass in early postmenopausal women
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    Menopause 9:117-21. 2002
    ..The aim of the present preliminary study was to evaluate the effect of a 3-year HRT program on appendicular lean tissue mass (LTM(A)) in early postmenopausal women aged 45-54 years...
  72. ncbi request reprint Association of a dopamine beta-hydroxylase gene variant with depression in elderly women possibly reflecting noradrenergic dysfunction
    Mads Togsverd
    Research Institute of Biological Psychiatry, Sct Hans Hospital, Roskilde, Copenhagen University, Denmark
    J Affect Disord 106:169-72. 2008
    ..Depression has a multifactorial etiology which involves genetic factors and comorbid diseases...
  73. ncbi request reprint The effect of oral calcitonin on cartilage turnover and surface erosion in an ovariectomized rat model
    Bodil Cecilie Sondergaard
    Nordic Bioscience Diagnostics, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    Arthritis Rheum 56:2674-8. 2007
    ..To investigate whether oral calcitonin treatment influences the increases in type II collagen (CII) degradation and related surface erosions of articular cartilage in ovariectomized rats...
  74. ncbi request reprint Novel associations between bioavailable estradiol and adipokines in elderly women with different phenotypes of obesity: implications for atherogenesis
    Laszlo B Tanko
    Prospective Epidemiological Risk Factor PERF study group, Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Ballerup, Denmark
    Circulation 110:2246-52. 2004
    ..Peripheral adiposity confers protection against diabetes and atherosclerosis in elderly women. The underlying mechanisms, however, remain to be elucidated...
  75. ncbi request reprint Serum placental protein 14: a novel marker of selective oestrogen receptor modulator action on the postmenopausal endometrium
    Laszlo B Tanko
    Centre for Clinical and Basic Research A S, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Biomarkers 7:257-66. 2002
    ....
  76. ncbi request reprint Intravenous ibandronate injections in postmenopausal women with osteoporosis: one-year results from the dosing intravenous administration study
    Pierre D Delmas
    Université Claude Bernard Lyon 1 and INSERM Research Unit 403, Lyon, France
    Arthritis Rheum 54:1838-46. 2006
    ..The aim of this study was to identify the optimal intravenous dosing regimen for ibandronate in postmenopausal women with osteoporosis...
  77. ncbi request reprint Visceral fat is more important than peripheral fat for endometrial thickness and bone mass in healthy postmenopausal women
    Lise Warming
    Center for Clinical and Basic Research, Ballerup, Denmark
    Am J Obstet Gynecol 188:349-53. 2003
    ..The purpose of this study was to investigate the influence of body mass index and body composition on endometrial thickness and bone mass...
  78. ncbi request reprint Associated response in bone and lipids during hormone replacement therapy
    Anne Bloch Thomsen
    Center of Clinical Basic Research, Ballerup Byvej 222, 2750 Ballerup, Denmark
    Maturitas 47:39-45. 2004
    ..In postmenopausal women, we investigated if the response in bone mineral density (BMD) was associated with the response in the atherogenic lipid profile during hormone replacement therapy...
  79. ncbi request reprint Changes in bone density and turnover after alendronate or estrogen withdrawal
    Richard D Wasnich
    Radiant Research Honolulu, Honolulu, HI 96814, USA
    Menopause 11:622-30. 2004
    ..To compare bone mineral density (BMD) and bone turnover changes after therapy withdrawal in postmenopausal women treated with alendronate or estrogen-progestin...
  80. ncbi request reprint The effect on cartilage of different forms of application of postmenopausal estrogen therapy: comparison of oral and transdermal therapy
    Pernille Ravn
    Center for Clinical and Basic Research, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Bone 35:1216-21. 2004
    ..However, long-term clinical trials are needed to further investigate this issue...
  81. ncbi request reprint An update on the antiestrogenic effect of smoking: a literature review with implications for researchers and practitioners
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    Menopause 11:104-9. 2004
    ..DESIGN Summary of own research and a MEDLINE search of English-language literature on the antiestrogenic effect of smoking in pre- and postmenopausal women published during the past two decades...
  82. ncbi request reprint Association between spine disc degeneration and type II collagen degradation in postmenopausal women: the OFELY study
    Patrick Garnero
    INSERM Research Unit 403, Synarc, Lyon, France
    Arthritis Rheum 50:3137-44. 2004
    ....
  83. ncbi request reprint Prevention of postmenopausal bone loss: six-year results from the Early Postmenopausal Intervention Cohort Study
    Michael R McClung
    Oregon Osteoporosis Center, 5050 Northeast Hoyt, Suite 651, Portland, Oregon 97213, USA
    J Clin Endocrinol Metab 89:4879-85. 2004
    ..5, 10.3, and 8.9% of women taking placebo, 2.5 mg alendronate, or 5 mg alendronate daily, respectively. Therapy with alendronate is an effective and promising strategy for the prevention of postmenopausal osteoporosis...
  84. ncbi request reprint The aging male: testosterone deficiency and testosterone replacement. An up-date
    Peter Alexandersen
    CCBR, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Atherosclerosis 173:157-69. 2004
    ..The evidence clearly shows that data for the most part are conflicting, with only very few randomized studies available...
  85. ncbi request reprint Suppression of elevated cartilage turnover in postmenopausal women and in ovariectomized rats by estrogen and a selective estrogen-receptor modulator (SERM)
    Stephan Christgau
    Nordic Bioscience, Herlev, Denmark
    Menopause 11:508-18. 2004
    ..The clinical relevance was assessed in postmenopausal women by measuring the changes in CTX-II during 12-month treatment with levormeloxifene versus placebo...
  86. ncbi request reprint Safety and efficacy of a novel salmon calcitonin (sCT) technology-based oral formulation in healthy postmenopausal women: acute and 3-month effects on biomarkers of bone turnover
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    J Bone Miner Res 19:1531-8. 2004
    ..The results show (1) effective enteral absorption, (2) marked inhibition of bone resorption with minimal alteration of formation, and (3) reproducibility of responses over 3 months...
  87. ncbi request reprint Can confounding with fat-derived endogenous free estradiol explain the inverse correlation of bone mineral density with adiponectin?
    Laszlo B Tanko
    Bone 34:916; author reply 917. 2004
  88. ncbi request reprint Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis
    Charles H Chesnut III
    Osteoporosis Research Group, University of Washington, Seattle, Washington 98185, USA
    J Bone Miner Res 19:1241-9. 2004
    ..Significant reduction in incident vertebral fracture risk by 62% and 50%, respectively, was shown after 3 years. This is the first study to prospectively show antifracture efficacy for the intermittent administration of a bisphosphonate...
  89. ncbi request reprint Effective doses of ibandronate do not influence the 3-year progression of aortic calcification in elderly osteoporotic women
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    Osteoporos Int 16:184-90. 2005
    ..These findings thus suggest that 3-year treatment with effective doses of ibandronate does not pose any cardiovascular risk in terms of altering vascular calcification...
  90. ncbi request reprint Pulsed estrogen therapy in prevention of postmenopausal osteoporosis. A 2-year randomized, double blind, placebo-controlled study
    Therese F Nielsen
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, DK 2750, Ballerup, Denmark
    Osteoporos Int 15:168-74. 2004
    ..This study demonstrates that pulsed estrogen therapy at the dose of 150 microg and 300-microg per day prevents bone loss in a dose-dependant manner at each site studied, and normalizes bone turnover markers to premenopausal levels...
  91. pmc Acidification of the osteoclastic resorption compartment provides insight into the coupling of bone formation to bone resorption
    Morten A Karsdal
    Nordic Bioscience A S, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    Am J Pathol 166:467-76. 2005
    ..Thus, we suggest that acidification is essential for normal bone remodeling and that attenuated acidification leads to uncoupling with decreased bone resorption and unaffected bone formation...
  92. ncbi request reprint Comparison of quantitative ultrasound of the phalanges with conventional bone densitometry in healthy postmenopausal women
    Peter Alexandersen
    Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Denmark
    Osteoporos Int 16:1071-8. 2005
    ..In conclusion, QUS assessment of the phalanges correlates moderately with BMD of all skeletal sites and is able to effectively discriminate fractured from non-fractured subjects...
  93. ncbi request reprint Estrogen receptor alpha and risk for cognitive impairment in postmenopausal women
    Line Olsen
    Research Institute of Biological Psychiatry, Copenhagen University Hospital, Roskilde, Denmark
    Psychiatr Genet 16:85-8. 2006
    ..049) and this effect was reflected in executive cognitive ability. These data support that the ESR1 gene variants affect cognitive functioning in postmenopausal women...
  94. ncbi request reprint ACDC/adiponectin and PPAR-gamma gene polymorphisms: implications for features of obesity
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    Obes Res 13:2113-21. 2005
    ....
  95. ncbi request reprint Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
    Struan F A Grant
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 38:320-3. 2006
    ..It is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway...
  96. ncbi request reprint Pulsed estrogen therapy improves postmenopausal quality of life: a 2-year placebo-controlled study
    Therese F Nielsen
    Center for Clinical and Basic Research A S, Ballerup, Denmark
    Maturitas 53:184-90. 2006
    ....
  97. ncbi request reprint Peripheral adiposity exhibits an independent dominant antiatherogenic effect in elderly women
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Circulation 107:1626-31. 2003
    ..Although several lines of evidence point to an atherogenic role of central fat mass (CFM), few data are available to address the specific role played by peripheral fat mass (PFM)...
  98. ncbi request reprint Variations in percentage of body fat within different BMI groups in young, middle-aged and old women
    Lusine Movsesyan
    Center for Clinical and Basic Research A S, Ballerup Byvej, Ballerup, Denmark
    Clin Physiol Funct Imaging 23:130-3. 2003
    ..The objective of the present study was to characterize age-dependent variations in percentage of body fat within different body mass index (BMI) classes in healthy Danish women...
  99. ncbi request reprint Relationship between osteoporosis and cardiovascular disease in postmenopausal women
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    J Bone Miner Res 20:1912-20. 2005
    ..Accordingly, treatment of postmenopausal osteoporosis should include consideration of measures to prevent adverse cardiovascular outcomes...
  100. ncbi request reprint Obesity susceptibility CART gene polymorphism contributes to bone remodeling in postmenopausal women
    Audrey Guerardel
    Osteoporos Int 17:156-7. 2006
  101. pmc Linkage of osteoporosis to chromosome 20p12 and association to BMP2
    Unnur Styrkarsdottir
    deCODE Genetics, Reykjavik, Iceland
    PLoS Biol 1:E69. 2003
    ....