Peter Schnohr

..This study aimed at assessment of the associations between leisure- time physical activity and incidence of cancer in the general population of adult men and women...

..The purpose of this study was to describe the associations between different levels of long-term physical activity in leisure time and subsequent causes of deaths...

..2 years in men and 5.6 years in women. This long-term study of joggers showed that jogging was associated with significantly lower all-cause mortality and a substantial increase in survival for both men and women...

..The optimal intensity, duration, and frequency still have to be established. The aim of this study was to examine the impact of intensity versus duration of cycling on all-cause and coronary heart disease mortality...

..64, 95% CI: 0.50, 0.81; p < 0.001). In this study, maintaining or adopting a moderate or high degree of physical activity was associated with lower risk of death across a wide range of ages in both sexes...

..g., 2-4 h of walking per week. In conclusion, we recommend that increased well-being should be a key argument in future campaigns for increased leisure-time physical activity...

..To further support these recommendations we examined the impact of walking intensity and walking duration on all-cause mortality...

..The importance of coronary heart disease risk factors may differ between individuals and community and by sex and age...

..51, 95% CI: 0.28, 0.92). Future preventive strategies may be targeted toward stress as a risk factor for premature death among middle-aged, presumably healthy men...

..The aim of this study was to examine the effect of PCSK9 R46L on low-density lipoprotein cholesterol (LDL-C), risk of ischemic heart disease (IHD), and mortality...

..To improve its grave prognosis, early identification of cardiac dysfunction is mandatory. Conventional echocardiography is not suitable for this. Tissue Doppler imaging (TDI), however, could be so...

..To test the hypothesis that echocardiographic tissue Doppler imaging (TDI) reveals reduced myocardial function in hypertension, diabetes, and ischaemic heart disease (IHD) in the general population...

..This study was designed to determine whether measurement of plasma pro-B-type natriuretic peptide (proBNP) could be used in discriminating between cardiac and pulmonary dyspnea in the general population...

..Tissue Doppler imaging (TDI) detects left ventricular dysfunction in patients with heart failure and normal ejection fraction, but the prognostic significance of left ventricular dysfunction by TDI in the general population is unknown...

..More attention has been paid to psychosocial conditions as possible risk factors for cardiovascular disease (CVD) and the impact of accumulated major life events (MLE) on the development of CVD has received little attention...

..We studied whether changes in individual alcohol intake result in corresponding changes in mortality...

..The aim of the present study was to describe whether vital exhaustion, a measure of fatigue and depression, prospectively predicts ischemic and hemorrhagic strokes in a large cohort, with particular focus on gender differences...

..For most diseases, the effect of ethanol predominates over that of substances in the beverage type, which makes the density method less relevant in alcohol analyses...

..Psychosocial stressors may mediate the effect of social status on the metabolic syndrome (MS). The paper explores this hypothesis in a random sample of the general population...

..This study was designed to test the hypotheses that single nucleotide polymorphisms (SNPs), in zinc finger protein 202 (ZNF202), predict severe atherosclerosis and ischemic heart disease (IHD)...

..We aim to assess if socioeconomic status, stress, and marital status are associated with prostate cancer risk in a population with free access to health care...

..Furthermore we calculated the odds ratio for stroke based on the level of physical activity...

..To investigate if persons with high physical activity at work have the same benefits from leisure time physical activity as persons with sedentary work...

..Recent studies indicate that anemia may also affect proBNP concentrations in patients with heart failure or stroke. However, the impact of hemoglobin status on proBNP concentrations has not been established in the general population...

..Population and interventional studies have shown that high plasma-cholesterol is a risk factor of coronary heart disease (CHD). However, in most of the studies elderly people were excluded...

..The nadir of the relation between alcohol and mortality was sensitive to the handling of non-drinkers. When non-drinkers were categorized separately we found no indication of a beneficial influence of low alcohol intake on mortality...

..18 (p = 0.01) per 0.1 increase in MPI(TDI). In conclusion, MPI(TDI) is a quick, simple, and reproducible measurement, which is increased in subjects with CHD and provides independent prognostic information in a low-risk population...

....

..Each of the risk factors was associated with estrogen. In conclusion, the risk of breast cancer was markedly lower for women with a favourable risk profile than for other women and lower estrogen levels is a possible explanation...

..One possible explanation is decreased case-fatality, and the aim of the present investigation was to study trends in case-fatality for first-ever stroke in a large population-based cohort study in Copenhagen, Denmark...

....

..The association between occupational physical activity with cardiovascular disease and all-cause mortality may also depend on leisure time physical activity...

..We therefore examined whether proBNP measurement is useful for LVH and LVSD screening in the general population...

..We tested whether heterozygosity for the K776N mutation (frequency: 0.4%) in ATP-binding cassette transporter A1 (ABCA1) predicted ischemic heart disease (IHD) in the Copenhagen City Heart Study population...

..We sought to assess the presence of time-dependent confounding in the association between physical activity and COPD development and course by comparing risk estimates between standard statistical methods and MSMs...

..Our results suggest that MBL deficiency is not a major risk factor for morbidity or death in the adult Caucasian population...

..We hypothesized that higher levels of regular physical activity could reduce the risk of COPD by modifying smoking-related lung function decline...

....

..83 (95% CI: 0.73, 0.95) and 0.82 (95% CI: 0.67, 1.00). These data suggest that health benefits are derived from the diversity of social roles, especially those involving intimate relationships...

..Benefit was found from moderate leisure time physical activity with further benefit from sports activity and bicycling as transportation. Benefit from physical activity at work was found in women only...

..Conclusion Leisure-time physical activity and a moderate weekly alcohol intake are both important to lower the risk of fatal IHD and all-cause mortality...

..Women reporting high levels of stress were at lower risk of breast cancer (hazard ratio = 0.60; 95% CI: 0.37-0.97) than women reporting low levels of stress. This association was most pronounced among women who received hormone therapy...

..Our primary hypothesis was that these SNPs associate with IHD after adjustment for HDL levels...

..Psychological stress may affect the synthesis and metabolism of estrogens and thereby be related to risk of endometrial cancer...

..The aim of this study is to describe prevalence of these symptoms in a community sample and determine whether they prospectively predict increased risk of IHD and all-cause mortality in men and women...

..Elevated nonfasting triglycerides indicate the presence of remnant lipoproteins, which may promote atherosclerosis...

..Odds ratios for venous thromboembolism (deep venous thrombosis and pulmonary embolism) derived from case-control studies range from 3 to 16 for heterozygotes compared with noncarriers and up to 79 for homozygotes compared with noncarriers...

..To assess the relation between self reported intensity and frequency of stress and first time incidence of primary breast cancer...

..In contrast, only a single common amino acid-changing polymorphism (A370T) has been reported in this gene. The association of this polymorphism with variations in lipid levels is at present unclear...

..We tested the hypothesis that a common variant in ZNF202, A154V, predicts risk of ischemic heart disease (IHD), myocardial infarction (MI), and ischemic cerebrovascular disease (ICVD)...

..LVH by ECG voltage-only was associated with no statistically increased risk, except for men treated for arterial hypertension...

..Low levels of high-density lipoprotein (HDL) cholesterol are inversely related to cardiovascular risk. Whether this is a causal effect is unclear...