Paul A C Cloos

Summary

Affiliation: Biotech Research and Innovation Centre
Country: Denmark

Publications

  1. ncbi request reprint Characterization of aged osteocalcin fragments derived from bone resorption
    Paul A C Cloos
    Nordic Bioscience A S, Herlev, Denmark
    Clin Lab 50:585-98. 2004
  2. pmc Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease
    Paul A C Cloos
    Biotech Research and Innovation Centre, University of Copenhagen, DK 2200 Copenhagen, Denmark
    Genes Dev 22:1115-40. 2008
  3. pmc Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2
    Diego Pasini
    Biotech Research and Innovation Centre BRIC and Centre for Epigenetics, University of Copenhagen, 2200 Copenhagen, Denmark
    Genes Dev 22:1345-55. 2008
  4. ncbi request reprint UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
    Karl Agger
    Biotech Research and Innovation Centre BRIC, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark
    Nature 449:731-4. 2007
  5. ncbi request reprint RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3
    Jesper Christensen
    Centre for Epigenetics, University of Copenhagen, Copenhagen, Denmark
    Cell 128:1063-76. 2007
  6. pmc The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development
    Marianne Terndrup Pedersen
    Biotech Research and Innovation Centre BRIC, University of Copenhagen, Copenhagen, Denmark
    Mol Cell Biol 34:1031-45. 2014
  7. doi request reprint JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
    Diego Pasini
    Biotech Research and Innovation Centre BRIC, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark
    Nature 464:306-10. 2010
  8. pmc The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence
    Karl Agger
    Biotech Research and Innovation Centre BRIC and Centre for Epigenetics, University of Copenhagen, DK 2200 Copenhagen, Denmark
    Genes Dev 23:1171-6. 2009
  9. pmc TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
    Kristine Williams
    Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark
    Nature 473:343-8. 2011
  10. doi request reprint The emerging functions of histone demethylases
    Karl Agger
    Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark
    Curr Opin Genet Dev 18:159-68. 2008

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Characterization of aged osteocalcin fragments derived from bone resorption
    Paul A C Cloos
    Nordic Bioscience A S, Herlev, Denmark
    Clin Lab 50:585-98. 2004
    ..OC measured in serum or plasma provides an index of bone formation. In the present study a sensitive inhibition ELISA was established that could quantify fragments derived from the OC Mid-region in human urine...
  2. pmc Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease
    Paul A C Cloos
    Biotech Research and Innovation Centre, University of Copenhagen, DK 2200 Copenhagen, Denmark
    Genes Dev 22:1115-40. 2008
    ..Here we review the emerging biochemical and biological functions of the histone demethylases and discuss their potential involvement in human diseases, including cancer...
  3. pmc Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2
    Diego Pasini
    Biotech Research and Innovation Centre BRIC and Centre for Epigenetics, University of Copenhagen, 2200 Copenhagen, Denmark
    Genes Dev 22:1345-55. 2008
    ..Taken together, these results demonstrate an elegant mechanism for repression of developmental genes by the coordinated regulation of epigenetic marks involved in repression and activation of transcription...
  4. ncbi request reprint UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
    Karl Agger
    Biotech Research and Innovation Centre BRIC, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark
    Nature 449:731-4. 2007
    ..8) supports a model in which the coordinated removal of repressive marks, polycomb group displacement, and deposition of activating marks are important for the stringent regulation of transcription during cellular differentiation...
  5. ncbi request reprint RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3
    Jesper Christensen
    Centre for Epigenetics, University of Copenhagen, Copenhagen, Denmark
    Cell 128:1063-76. 2007
    ..Taken together, these results suggest that H3K4me3/me2 demethylation regulated by the JARID1 family plays an important role during development...
  6. pmc The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development
    Marianne Terndrup Pedersen
    Biotech Research and Innovation Centre BRIC, University of Copenhagen, Copenhagen, Denmark
    Mol Cell Biol 34:1031-45. 2014
    ....
  7. doi request reprint JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
    Diego Pasini
    Biotech Research and Innovation Centre BRIC, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark
    Nature 464:306-10. 2010
    ..Thus, these results demonstrate that JARID2 is essential for the binding of PcG proteins to target genes and, consistent with this, for the proper differentiation of embryonic stem cells and normal development...
  8. pmc The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence
    Karl Agger
    Biotech Research and Innovation Centre BRIC and Centre for Epigenetics, University of Copenhagen, DK 2200 Copenhagen, Denmark
    Genes Dev 23:1171-6. 2009
    ..Additionally, inhibition of Jmjd3 expression in mouse embryonic fibroblasts results in suppression of p16Ink4a and p19Arf expression and in their immortalization...
  9. pmc TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
    Kristine Williams
    Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark
    Nature 473:343-8. 2011
    ..We propose that TET1 fine-tunes transcription, opposes aberrant DNA methylation at CpG-rich sequences and thereby contributes to the regulation of DNA methylation fidelity...
  10. doi request reprint The emerging functions of histone demethylases
    Karl Agger
    Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark
    Curr Opin Genet Dev 18:159-68. 2008
    ....
  11. pmc Posttranslational modifications of the histone 3 tail and their impact on the activity of histone lysine demethylases in vitro
    Brian Lohse
    Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 8:e67653. 2013
    ....
  12. ncbi request reprint The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3
    Paul A C Cloos
    Biotech Research and Innovation Centre, Fruebjergvej 3, 2100 Copenhagen, Denmark
    Nature 442:307-11. 2006
    ..Thus, in addition to identifying GASC1 as a histone trimethyl demethylase, we suggest a model for how this enzyme might be involved in cancer development, and propose it as a target for anti-cancer therapy...
  13. ncbi request reprint Suppression of elevated cartilage turnover in postmenopausal women and in ovariectomized rats by estrogen and a selective estrogen-receptor modulator (SERM)
    Stephan Christgau
    Nordic Bioscience, Herlev, Denmark
    Menopause 11:508-18. 2004
    ..The clinical relevance was assessed in postmenopausal women by measuring the changes in CTX-II during 12-month treatment with levormeloxifene versus placebo...
  14. ncbi request reprint Post-translational modifications of proteins: implications for aging, antigen recognition, and autoimmunity
    Paul A C Cloos
    Nordic Bioscience A S, Osteopark, Herlev Hovedgade 207, DK 2730, Denmark
    Biogerontology 5:139-58. 2004
    ..The relevance of these observations is discussed, and the implications for future prophylactic and therapeutic interventions are outlined...
  15. ncbi request reprint Current and future applications of bone turnover markers
    Stephan Christgau
    Nordic Bioscience A S, Herlev, Denmark
    Clin Lab 49:439-46. 2003
  16. ncbi request reprint An immunoassay for measuring fragments of newly synthesized collagen type I produced during metastatic invasion of bone
    Paul A C Cloos
    Nordic Bioscience, Osteopark, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    Clin Lab 50:279-89. 2004
    ..5) than beta-betaCTX (Z=3.6). In conclusion, measurement of alpha-alphaCTX fragments may provide a clinically relevant assessment of bone resorption related to bone metastases...