Lise Aksglaede

Summary

Country: Denmark

Publications

  1. ncbi Primary testicular failure in Klinefelter's syndrome: the use of bivariate luteinizing hormone-testosterone reference charts
    Lise Aksglaede
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Clin Endocrinol (Oxf) 66:276-81. 2007
  2. doi Recent decline in age at breast development: the Copenhagen Puberty Study
    Lise Aksglaede
    Rigshospitalet, Department of Growth and Reproduction GR, Section 5064, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Pediatrics 123:e932-9. 2009
  3. ncbi Abnormal sex chromosome constitution and longitudinal growth: serum levels of insulin-like growth factor (IGF)-I, IGF binding protein-3, luteinizing hormone, and testosterone in 109 males with 47,XXY, 47,XYY, or sex-determining region of the Y chromosome
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 93:169-76. 2008
  4. pmc Increased basal and pulsatile secretion of FSH and LH in young men with 47,XXY or 46,XX karyotypes
    Lise Aksglaede
    University Department of Growth and Reproduction GR, Rigshospitalet, University of Copenhagen, Section 5064, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Eur J Endocrinol 158:803-10. 2008
  5. ncbi The exon 3 deleted growth hormone receptor gene is associated with small birth size and early pubertal onset in healthy boys
    Kaspar Sørensen
    Department of Growth and Reproduction, GR 5064, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 95:2819-26. 2010
  6. doi FSHB-211 and FSHR 2039 are associated with serum levels of follicle-stimulating hormone and antimüllerian hormone in healthy girls: a longitudinal cohort study
    Casper P Hagen
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Health and Medical Science, University of Copenhagen, Denmark Electronic address
    Fertil Steril 100:1089-95. 2013
  7. doi Diagnostic work-up of 449 consecutive girls who were referred to be evaluated for precocious puberty
    Signe Sloth Mogensen
    Department of Growth and Reproduction, Rigshospitalet, University Hospital of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 96:1393-401. 2011
  8. doi Androgen receptor CAG repeat length is associated with body fat and serum SHBG in boys: a prospective cohort study
    Annette Mouritsen
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 98:E605-9. 2013
  9. doi Urinary phthalate excretion in 555 healthy Danish boys with and without pubertal gynaecomastia
    Mikkel G Mieritz
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Healthy Sciences, University of Copenhagen, Copenhagen, Denmark
    Int J Androl 35:227-35. 2012
  10. doi Recent secular trends in pubertal timing: implications for evaluation and diagnosis of precocious puberty
    Kaspar Sørensen
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Horm Res Paediatr 77:137-45. 2012

Detail Information

Publications38

  1. ncbi Primary testicular failure in Klinefelter's syndrome: the use of bivariate luteinizing hormone-testosterone reference charts
    Lise Aksglaede
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Clin Endocrinol (Oxf) 66:276-81. 2007
    ..The combined evaluation of serum LH and testosterone levels in the evaluation of testicular failure has not been widely advocated...
  2. doi Recent decline in age at breast development: the Copenhagen Puberty Study
    Lise Aksglaede
    Rigshospitalet, Department of Growth and Reproduction GR, Section 5064, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Pediatrics 123:e932-9. 2009
    ..Here we present new European data systematically collected from the same region and by 1 research group at the beginning and end of the recent 15-year period...
  3. ncbi Abnormal sex chromosome constitution and longitudinal growth: serum levels of insulin-like growth factor (IGF)-I, IGF binding protein-3, luteinizing hormone, and testosterone in 109 males with 47,XXY, 47,XYY, or sex-determining region of the Y chromosome
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 93:169-76. 2008
    ..Growth is a highly complex process regulated by the interaction between sex steroids and the GH IGF-axis. However, other factors such as sex chromosome-related genes play independent roles...
  4. pmc Increased basal and pulsatile secretion of FSH and LH in young men with 47,XXY or 46,XX karyotypes
    Lise Aksglaede
    University Department of Growth and Reproduction GR, Rigshospitalet, University of Copenhagen, Section 5064, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Eur J Endocrinol 158:803-10. 2008
    ..The aim of this study was to investigate the neuroendocrine integrity of the pituitary-gonadal axis in patients with primary testicular failure due to supernumerary X chromosomes...
  5. ncbi The exon 3 deleted growth hormone receptor gene is associated with small birth size and early pubertal onset in healthy boys
    Kaspar Sørensen
    Department of Growth and Reproduction, GR 5064, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 95:2819-26. 2010
    ..The GH/IGF-I axis influences gonadal development and function. Recently, a deletion of exon 3 in the GH receptor gene (GHRd3) has been linked to increased responsiveness to GH...
  6. doi FSHB-211 and FSHR 2039 are associated with serum levels of follicle-stimulating hormone and antimüllerian hormone in healthy girls: a longitudinal cohort study
    Casper P Hagen
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Health and Medical Science, University of Copenhagen, Denmark Electronic address
    Fertil Steril 100:1089-95. 2013
    ..AMH is a marker of ovarian function and is negatively correlated with FSH in prepubertal girls...
  7. doi Diagnostic work-up of 449 consecutive girls who were referred to be evaluated for precocious puberty
    Signe Sloth Mogensen
    Department of Growth and Reproduction, Rigshospitalet, University Hospital of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 96:1393-401. 2011
    ..The aim of this study was to describe a large cohort of Caucasian girls referred with signs of early puberty according to etiology and compare biochemical characteristics...
  8. doi Androgen receptor CAG repeat length is associated with body fat and serum SHBG in boys: a prospective cohort study
    Annette Mouritsen
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 98:E605-9. 2013
    ..Furthermore, short AR (CAG)n have been associated with premature adrenarche...
  9. doi Urinary phthalate excretion in 555 healthy Danish boys with and without pubertal gynaecomastia
    Mikkel G Mieritz
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Healthy Sciences, University of Copenhagen, Copenhagen, Denmark
    Int J Androl 35:227-35. 2012
    ..However, longitudinal studies are needed to evaluate possible perinatal or long-term postnatal effects of phthalates on healthy boys...
  10. doi Recent secular trends in pubertal timing: implications for evaluation and diagnosis of precocious puberty
    Kaspar Sørensen
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Horm Res Paediatr 77:137-45. 2012
    ....
  11. ncbi Recent changes in pubertal timing in healthy Danish boys: associations with body mass index
    Kaspar Sørensen
    Department of Growth and Reproduction, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 95:263-70. 2010
    ..In the 1990s, the American population-based study NHANES III renewed the focus on possible secular trends in male puberty. However, no conclusions could be made on pubertal onset due to the lack of compatible data...
  12. doi The physiology and timing of male puberty
    Jeanette Tinggaard
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Denmark
    Curr Opin Endocrinol Diabetes Obes 19:197-203. 2012
    ..To describe available markers of male puberty, discuss associations between adiposity and pubertal timing and to review recent evidence of a possible secular trend in male pubertal timing...
  13. pmc Sex hormone-binding globulin levels predict insulin sensitivity, disposition index, and cardiovascular risk during puberty
    Kaspar Sørensen
    Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
    Diabetes Care 32:909-14. 2009
    ..The aim of the present study was to evaluate SHBG as a predictor of glucose metabolism and metabolic risk during puberty...
  14. doi Serum concentrations of Anti-Müllerian Hormone (AMH) in 95 patients with Klinefelter syndrome with or without cryptorchidism
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Acta Paediatr 100:839-45. 2011
    ..We therefore aimed at determining circulating AMH concentrations in patients with 47,XXY Klinefelter syndrome (KS) with or without cryptorchidism...
  15. ncbi Elevated serum levels of free triiodothyronine in adolescent boys with gynaecomastia compared with controls
    Mikkel G Mieritz
    Departments of Growth and ReproductionSection 5064Clinical BiochemistryRigshospitalet, Faculty of Medical and Health Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Eur J Endocrinol 171:193-8. 2014
    ..Little is known about the aetiology of pubertal gynaecomastia. Markedly elevated thyroid hormone levels in adults with hyperthyroidism are associated with gynaecomastia...
  16. ncbi Bisphenol A and other phenols in urine from Danish children and adolescents analyzed by isotope diluted TurboFlow-LC-MS/MS
    Hanne Frederiksen
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark Electronic address
    Int J Hyg Environ Health 216:710-20. 2013
    ..Small children were relatively more exposed to BPA than older children, while higher exposures to TCS, BP-3 and ∑DCP were seen among adolescents. ..
  17. doi Endocrine evaluation of reproductive function in girls during infancy, childhood and adolescence
    Anders Juul
    Departments of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Endocr Dev 22:24-39. 2012
    ..Changes in basal reproductive hormone levels in infancy, childhood and adolescence as well as the GnRH and ACTH test procedures in girls and adolescents are described in this chapter...
  18. doi Individual serum levels of anti-Müllerian hormone in healthy girls persist through childhood and adolescence: a longitudinal cohort study
    Casper P Hagen
    Department of Growth and Reproduction, Rigshospitalet, Section 5064, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen O, Denmark
    Hum Reprod 27:861-6. 2012
    ..However, the natural course of circulating AMH levels during female childhood and adolescence is not known...
  19. doi Serum IGF1 and insulin levels in girls with normal and precocious puberty
    Kaspar Sørensen
    Department of Growth and Reproduction, GR 5064, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Eur J Endocrinol 166:903-10. 2012
    ..However, the relationship with insulin before and during gonadal suppression is unknown. In addition, the influence of the exon 3-deleted GH receptor gene (GHRd3) on IGF1 levels was evaluated...
  20. ncbi High normal testosterone levels in infants with non-mosaic Klinefelter's syndrome
    Lise Aksglaede
    University Department of Growth and Reproduction GR, Rigshospitalet, University of Copenhagen, Section 5064, Blegdamsvej 9, DK 2100, Copenhagen Ø, Denmark
    Eur J Endocrinol 157:345-50. 2007
    ..The aim of this study was to evaluate the HPG axis in KS infants...
  21. doi The pubertal transition in 179 healthy Danish children: associations between pubarche, adrenarche, gonadarche, and body composition
    Annette Mouritsen
    Department of Growth and Reproduction, GR 5064, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Eur J Endocrinol 168:129-36. 2013
    ..Pubarche is preceded by a gradual increase in production of adrenal androgens, DHEA and Δ4-androstenedione (Adione), a process termed adrenarche...
  22. ncbi Insulin sensitivity and lipid profiles in girls with central precocious puberty before and during gonadal suppression
    Kaspar Sørensen
    Department of Growth and Reproduction, GR 5064, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 95:3736-44. 2010
    ..Early menarche is associated with increased risk of cardiovascular disease in adulthood. It is unknown whether metabolic risk factors are adversely affected in girls with central precocious puberty (CPP) already at time of diagnosis...
  23. pmc Age at puberty and the emerging obesity epidemic
    Lise Aksglaede
    Department of Growth and Reproduction, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 4:e8450. 2009
    ....
  24. doi Serum levels of anti-Müllerian hormone as a marker of ovarian function in 926 healthy females from birth to adulthood and in 172 Turner syndrome patients
    Casper P Hagen
    Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 95:5003-10. 2010
    ..In adult women, anti-Müllerian hormone (AMH) is related to the ovarian follicle pool. Little is known about AMH in girls...
  25. ncbi Longitudinal Changes in Circulating Testosterone Levels Determined by LC-MS/MS and by a Commercially Available Radioimmunoassay in Healthy Girls and Boys during the Pubertal Transition
    Annette Mouritsen
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
    Horm Res Paediatr 82:12-7. 2014
    ..Accurate and selective assessment of testosterone requires use of a sensitive LC-MS/MS method, especially at low levels as those seen in young children...
  26. ncbi The 2014 Danish references from birth to 20 years for height, weight and body mass index
    Jeanette Tinggaard
    Department of Growth and Reproduction, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
    Acta Paediatr 103:214-24. 2014
    ....
  27. ncbi Elevated serum IGF-I, but unaltered sex steroid levels, in healthy boys with pubertal gynaecomastia
    Mikkel G Mieritz
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Clin Endocrinol (Oxf) 80:691-8. 2014
    ....
  28. ncbi Clinical use of anti-Müllerian hormone (AMH) determinations in patients with disorders of sex development: importance of sex- and age-specific reference ranges
    Casper P Hagen
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark
    Pediatr Endocrinol Rev 9:525-8. 2011
    ..Furthermore, low AMH is a marker of premature ovarian failure in Turner Syndrome girls. Measurement of AMH is an important tool in assessing gonadal function in children. In this context, detailed normative data are essential...
  29. doi Increased number of sex chromosomes affects height in a nonlinear fashion: a study of 305 patients with sex chromosome aneuploidy
    Anne Marie Ottesen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Am J Med Genet A 152:1206-12. 2010
    ..0 (-3.5 to -0.8) in 49,XXXXX (n = 3). Height increased with an increasing number of extra X or Y chromosomes, except in males with five, and in females with four or five sex chromosomes, consistent with a nonlinear effect on height...
  30. doi 47,XXY Klinefelter syndrome: clinical characteristics and age-specific recommendations for medical management
    Lise Aksglaede
    Department of Growth and Reproduction GR, Rigshospitalet, Blegdamsvej, Copenhagen Ø, Denmark
    Am J Med Genet C Semin Med Genet 163:55-63. 2013
    ..The aim of this review is to present the clinical aspects of XXY and the age-specific recommendations for medical management. © 2013 Wiley Periodicals, Inc...
  31. doi The pituitary-Leydig cell axis before and after orchiectomy in patients with stage I testicular cancer
    Mikkel Bandak
    Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark
    Eur J Cancer 47:2585-91. 2011
    ..This study investigates the pituitary-Leydig cell axis in patients with stage I testicular germ cell cancer (TGCC) followed with surveillance only, in order to evaluate the risk of Leydig cell dysfunction one year after orchiectomy...
  32. pmc Pathological and incidental findings on brain MRI in a single-center study of 229 consecutive girls with early or precocious puberty
    Signe Sloth Mogensen
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e29829. 2012
    ..With the recent decline in age at pubertal onset among US and European girls, it has been suggested that only girls with CPP below 6 years of age should have brain MRI performed...
  33. ncbi Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty
    Kaspar Sørensen
    Department of Growth and Reproduction, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark
    J Clin Endocrinol Metab 94:2966-9. 2009
    ..The GH/IGF-I axis has major impact on insulin sensitivity and insulin secretion. Recently a polymorphism in the GH receptor gene (GHR), a genomic deletion of exon 3 (GHRd3), has been linked to increased responsiveness to GH...
  34. doi Clinical and biological parameters in 166 boys, adolescents and adults with nonmosaic Klinefelter syndrome: a Copenhagen experience
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Acta Paediatr 100:793-806. 2011
    ..We aimed at describing the phenotypic characteristics throughout life from clinical follow-up of our large cohort of patients with KS...
  35. pmc Forty years trends in timing of pubertal growth spurt in 157,000 Danish school children
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 3:e2728. 2008
    ..The aim of our study was to determine if the age at onset of pubertal growth spurt (OGS) and at peak height velocity (PHV) during puberty show secular trends during four decades in a large cohort of school children...
  36. doi Urinary excretion of phthalate metabolites in 129 healthy Danish children and adolescents: estimation of daily phthalate intake
    Hanne Frederiksen
    Department of Growth and Reproduction, Section 5064, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Environ Res 111:656-63. 2011
    ..They are suspected to be involved in male reproductive health problems and have also been associated with several other health problems in children including obesity and asthma...
  37. ncbi The sensitivity of the child to sex steroids: possible impact of exogenous estrogens
    Lise Aksglaede
    University Department of Growth and Reproduction, GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Hum Reprod Update 12:341-9. 2006
    ..Because no lower threshold for estrogenic action has been established, caution should be taken to avoid unnecessary exposure of fetuses and children to exogenous sex steroids and endocrine disruptors, even at very low levels...
  38. ncbi Natural history of seminiferous tubule degeneration in Klinefelter syndrome
    Lise Aksglaede
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Hum Reprod Update 12:39-48. 2006
    ....