Bjørn Richelsen

Summary

Affiliation: Aarhus University Hospital
Country: Denmark

Publications

  1. doi Ethanol exerts anti-inflammatory effects in human adipose tissue in vitro
    Anne Wandler
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Aarhus C, Denmark
    Mol Cell Endocrinol 296:26-31. 2008
  2. ncbi Effect of orlistat on weight regain and cardiovascular risk factors following a very-low-energy diet in abdominally obese patients: a 3-year randomized, placebo-controlled study
    Bjørn Richelsen
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus, Denmark
    Diabetes Care 30:27-32. 2007
  3. ncbi [Why is weight loss so often followed by weight regain? Basal biological response as a possible explanation]
    Bjørn Richelsen
    Arhus Universitetshospital, Endokrinologisk Afdeling C, Arhus Sygehus, DK 8000 Arhus C
    Ugeskr Laeger 168:159-63. 2006
  4. doi Long-term weight loss decreases the nontraditional cardiovascular risk factors interleukin-18 and matrix metalloproteinase-9 in obese subjects
    Erik L Madsen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Aarhus C, Denmark
    Metabolism 58:946-53. 2009
  5. doi Weight loss larger than 10% is needed for general improvement of levels of circulating adiponectin and markers of inflammation in obese subjects: a 3-year weight loss study
    Erik L Madsen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 158:179-87. 2008
  6. ncbi Adiponectin receptors in human adipose tissue: effects of obesity, weight loss, and fat depots
    Maria S Rasmussen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Obesity (Silver Spring) 14:28-35. 2006
  7. doi Acute exercise increases circulating inflammatory markers in overweight and obese compared with lean subjects
    Tore Christiansen
    Department of Internal Medicine and Endocrinology MEA, Aarhus University Hospital, Aarhus, Denmark
    Eur J Appl Physiol 113:1635-42. 2013
  8. doi Comparable reduction of the visceral adipose tissue depot after a diet-induced weight loss with or without aerobic exercise in obese subjects: a 12-week randomized intervention study
    Tore Christiansen
    Department of Medicine and Endocrinology C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 160:759-67. 2009
  9. doi Sugar-sweetened beverages and cardio-metabolic disease risks
    Bjørn Richelsen
    Department of Internal Medicine and Endocrinology, Aarhus University Hospital, Aarhus, Denmark
    Curr Opin Clin Nutr Metab Care 16:478-84. 2013
  10. ncbi Interleukin-18 in plasma and adipose tissue: effects of obesity, insulin resistance, and weight loss
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 157:465-71. 2007

Collaborators

Detail Information

Publications33

  1. doi Ethanol exerts anti-inflammatory effects in human adipose tissue in vitro
    Anne Wandler
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Aarhus C, Denmark
    Mol Cell Endocrinol 296:26-31. 2008
    ..001), which correlated with the investigated adipokines (p<0.05) but not adiponectin (p>0.05). In conclusion, ethanol exerts anti-inflammatory effects in human AT, suggesting that ethanol may attenuate whole-body inflammation...
  2. ncbi Effect of orlistat on weight regain and cardiovascular risk factors following a very-low-energy diet in abdominally obese patients: a 3-year randomized, placebo-controlled study
    Bjørn Richelsen
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus, Denmark
    Diabetes Care 30:27-32. 2007
    ....
  3. ncbi [Why is weight loss so often followed by weight regain? Basal biological response as a possible explanation]
    Bjørn Richelsen
    Arhus Universitetshospital, Endokrinologisk Afdeling C, Arhus Sygehus, DK 8000 Arhus C
    Ugeskr Laeger 168:159-63. 2006
    ..These energy-conserving mechanisms may partially explain the difficulty in maintaining weight loss...
  4. doi Long-term weight loss decreases the nontraditional cardiovascular risk factors interleukin-18 and matrix metalloproteinase-9 in obese subjects
    Erik L Madsen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Aarhus C, Denmark
    Metabolism 58:946-53. 2009
    ..Orlistat treatment had no independent effects on IL-18, MMP-9, or leptin in the present study...
  5. doi Weight loss larger than 10% is needed for general improvement of levels of circulating adiponectin and markers of inflammation in obese subjects: a 3-year weight loss study
    Erik L Madsen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 158:179-87. 2008
    ..Moreover, to evaluate the effect of the lipase inhibitor, orlistat, on these parameters...
  6. ncbi Adiponectin receptors in human adipose tissue: effects of obesity, weight loss, and fat depots
    Maria S Rasmussen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Obesity (Silver Spring) 14:28-35. 2006
    ..To investigate the presence and regulatory properties of the adiponectin receptors, AdipoR1 and AdipoR2, in human adipose tissue (AT) and in isolated human adipocytes...
  7. doi Acute exercise increases circulating inflammatory markers in overweight and obese compared with lean subjects
    Tore Christiansen
    Department of Internal Medicine and Endocrinology MEA, Aarhus University Hospital, Aarhus, Denmark
    Eur J Appl Physiol 113:1635-42. 2013
    ..g., IL-6, IL-8, and TNF-α) in overweight and obese individuals...
  8. doi Comparable reduction of the visceral adipose tissue depot after a diet-induced weight loss with or without aerobic exercise in obese subjects: a 12-week randomized intervention study
    Tore Christiansen
    Department of Medicine and Endocrinology C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 160:759-67. 2009
    ....
  9. doi Sugar-sweetened beverages and cardio-metabolic disease risks
    Bjørn Richelsen
    Department of Internal Medicine and Endocrinology, Aarhus University Hospital, Aarhus, Denmark
    Curr Opin Clin Nutr Metab Care 16:478-84. 2013
    ..The purpose of this review is to summarize recent epidemiological but particularly recent human intervention studies on the metabolic effects associated/induced by SSB...
  10. ncbi Interleukin-18 in plasma and adipose tissue: effects of obesity, insulin resistance, and weight loss
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 157:465-71. 2007
    ....
  11. doi Upregulation of adipose 11-beta-hydroxysteroid dehydrogenase type 1 expression in ovariectomized rats is due to obesity rather than lack of estrogen
    Søren K Paulsen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade, Aarhus C, Denmark
    Obesity (Silver Spring) 16:731-5. 2008
    ..Estrogen suppresses hepatic and renal 11beta-HSD1 in rats; hence we investigated the in vitro effect of estrogen on human and rat AT, and the in vivo effects on rat AT 11beta-HSD1 expression...
  12. doi Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study
    Maria Maersk
    Department of Endocrinology and Internal Medicine MEA, Aarhus University Hospital, Denmark
    Am J Clin Nutr 95:283-9. 2012
    ..Too few long-term intervention studies in humans have examined the effects of soft drinks...
  13. ncbi 11Beta-HSD type 1 expression in human adipose tissue: impact of gender, obesity, and fat localization
    Søren Kildeberg Paulsen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Obesity (Silver Spring) 15:1954-60. 2007
    ..Our objective was to compare 11beta-HSD1 gene expression in different fat depots (visceral, subcutaneous abdominal, and subcutaneous gluteal) in lean and obese men and women...
  14. doi Effects on food intake and blood lipids of cannabinoid receptor 1 antagonist treatment in lean rats
    Marianne F Bennetzen
    Department of Endocrinology, Aarhus University Hospital, Aarhus Sygehus, Aarhus, Denmark
    Obesity (Silver Spring) 16:2451-5. 2008
    ..Rimonabant treatment is associated with reduced serum levels of glycerol, NEFA, and triglyceride which seem independent of body weight changes...
  15. doi Resveratrol has inhibitory effects on the hypoxia-induced inflammation and angiogenesis in human adipose tissue in vitro
    Karina B Cullberg
    Department of Endocrinology and Internal Medicine, MEA, THG, Aarhus University Hospital, 8000 Aarhus C, Denmark
    Eur J Pharm Sci 49:251-7. 2013
    ..In addition the inhibition of hypoxia-mediated inflammation and angiogenesis might represent a novel mechanism of RSV in preventing obesity-related pathologies...
  16. doi Resveratrol up-regulates hepatic uncoupling protein 2 and prevents development of nonalcoholic fatty liver disease in rats fed a high-fat diet
    Morten Møller Poulsen
    Department of Endocrinology and Internal Medicine MEA, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Arhus C, Denmark
    Nutr Res 32:701-8. 2012
    ....
  17. ncbi Sulfatide increases adiponectin and decreases TNF-alpha, IL-6, and IL-8 in human adipose tissue in vitro
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Mol Cell Endocrinol 263:142-8. 2007
    ..Accordingly, the reported low serum levels of sulfatide in patients with type 2 diabetes might be of importance in relation to the chronic low-grade inflammatory state found in this disease...
  18. ncbi The anti-diabetic AMPK activator AICAR reduces IL-6 and IL-8 in human adipose tissue and skeletal muscle cells
    Aina S Lihn
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Sygehus, 8000 Aarhus C, Denmark
    Mol Cell Endocrinol 292:36-41. 2008
    ..In conclusion, AICAR inhibits the production of IL-6 and IL-8 human adipose tissue and in skeletal muscle cells. We suggest that decreased cytokine production might play a role for the AICAR-induced increase in insulin sensitivity...
  19. ncbi [Monogenetic obesity with special focus on the melanocortin 4 receptor gene mutations]
    Jens Meldgaard Bruun
    Arhus Universitetshospital, Arhus Sygehus, Medicinsk Endokrinologisk Afdeling C
    Ugeskr Laeger 166:3811-4. 2004
  20. doi The production and regulation of IGF and IGFBPs in human adipose tissue cultures
    Mette Faurholdt Gude
    The Medical Research Laboratories, Institute of Clinical Medicine and Department of Endocrinology and Internal Medicine, Nørrebrogade, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Growth Horm IGF Res 22:200-5. 2012
    ..Adipocytes express and secrete IGFs and IGFBPs; proteins with important effects on adipocyte homeostasis. However, the factors that control adipocyte generation of IGFs and IGFBPs are not clarified...
  21. ncbi Weight loss maintenance in severely obese adults after an intensive lifestyle intervention: 2- to 4-year follow-up
    Tore Christiansen
    Department of Medicine and Endocrinology C, Aarhus Sygehus, Aarhus University Hospital, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Obesity (Silver Spring) 15:413-20. 2007
    ..To evaluate the long-term weight loss maintenance after 2 to 4 years in severely obese subjects after a lifestyle intervention at a weight loss camp in Denmark...
  22. ncbi Human adipose tissue macrophages are enhanced but changed to an anti-inflammatory profile in obesity
    Karen Fjeldborg
    Department of Medicine and Endocrinology, MEA, Aarhus University Hospital, 8000 Aarhus, Denmark
    J Immunol Res 2014:309548. 2014
    ..Adipose tissue (AT) macrophages are increased in obesity and associated with low grade inflammation. We aimed to characterize the phenotype of AT macrophages in humans in relation to obesity and insulin resistance...
  23. ncbi [Surgical treatment of severe obesity. The effect of laparoscopic adjustable gastric banding]
    Steen B Pedersen
    Arhus Universitetshospital, Arhus Sygehus, Medicinsk Endokrinologisk Afdeling C
    Ugeskr Laeger 167:1942-5. 2005
  24. ncbi [Diet in the prevention of common diseases]
    Bjørn Richelsen
    Arhus Universitetshospital, Arhus Sygehus, Medicinskendokrinologisk Afdeling C
    Ugeskr Laeger 166:1557-60. 2004
  25. ncbi Plasma monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1alpha are increased in patients with polycystic ovary syndrome (PCOS) and associated with adiposity, but unaffected by pioglitazone treatment
    Dorte Glintborg
    Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervaenget 6, Odense C, Denmark
    Clin Endocrinol (Oxf) 71:652-8. 2009
    ....
  26. ncbi Growth hormone (GH) substitution in GH-deficient patients inhibits 11beta-hydroxysteroid dehydrogenase type 1 messenger ribonucleic acid expression in adipose tissue
    Søren Kildeberg Paulsen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 91:1093-8. 2006
    ..Increased tissue activity of cortisol may play a central role in the features of GH deficiency and the metabolic syndrome...
  27. doi The effect of high-dose vitamin D supplementation on calciotropic hormones and bone mineral density in obese subjects with low levels of circulating 25-hydroxyvitamin d: results from a randomized controlled study
    Louise Wamberg
    Department of Endocrinology and Internal Medicine MEA, Aarhus University Hospital, Tage Hansens Gade 2, Aarhus C, 8000, Aarhus, Denmark
    Calcif Tissue Int 93:69-77. 2013
    ....
  28. doi The macrophage-specific serum marker, soluble CD163, is increased in obesity and reduced after dietary-induced weight loss
    Karen Fjeldborg
    Department of Medicine and Endocrinology MEA, Aarhus University Hospital, Aarhus, Denmark
    Obesity (Silver Spring) 21:2437-43. 2013
    ..We investigated whether dietary intervention and moderate exercise was related to changes in sCD163 and how sCD163 is associated to insulin resistance in obesity...
  29. ncbi [Obesity in Denmark--why has it not gone so badly?]
    Henning Bay Nielsen
    H S Rigshospitalet, Anaestesiafdelingen, Center for Muskelforskning, Den Kongelige Veterinaer og Landbohøjskole, Levnedsmiddelcenteret, Institut for Human Ernaering, Arhus Universitetshospital, Arhus Sygehus, Medicinsk afdeling C
    Ugeskr Laeger 168:132-5. 2006
    ..Although several factors may be of importance, Danes are more physically active and their intake of beverages with added sugar is less than in the American population...
  30. ncbi Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects
    Jens M Bruun
    Dept of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Sygehus, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Am J Physiol Endocrinol Metab 290:E961-7. 2006
    ..Markers of inflammation were particularly reduced in AT, whereas SM does not contribute to this attenuation of whole body inflammation...
  31. ncbi Pro- and mature IGF-II during diet-induced weight loss in obese subjects
    Ulrick Espelund
    Medical Research Laboratories, Clinical Institute and Medical Department C and M, Aarhus University Hospital, Aarhus C, Denmark
    Eur J Endocrinol 153:861-9. 2005
    ..However, its regulation and biological impact remains unknown. In obese subjects, serum free and total IGF-II are increased, and we therefore investigated the impact of obesity and diet on serum pro-IGF-II...
  32. ncbi Lower expression of adiponectin mRNA in visceral adipose tissue in lean and obese subjects
    Aina S Lihn
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Mol Cell Endocrinol 219:9-15. 2004
    ..In conclusion, adiponectin gene expression is lower in visceral AT than in subcutaneous abdominal AT, suggesting subcutaneous AT to be more important for circulating adiponectin levels...
  33. ncbi Increased expression of TNF-alpha, IL-6, and IL-8 in HALS: implications for reduced adiponectin expression and plasma levels
    Aina S Lihn
    Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Tage Hansensgade 2, 8000 Aarhus C, Denmark
    Am J Physiol Endocrinol Metab 285:E1072-80. 2003
    ..Increased cytokine mRNA in AT is hypothesized to exert an inhibitory effect on adiponectin gene expression and, consequently, to play a role in the reduced plasma adiponectin levels found in HALS patients...