Lars Rejnmark

Summary

Affiliation: Aarhus University Hospital
Country: Denmark

Publications

  1. doi request reprint Recombinant hormones in osteoporosis
    Lars Rejnmark
    Aarhus University, Aarhus University Hospital, Department of Endocrinology and Internal Medicine, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    Expert Opin Biol Ther 13:1135-47. 2013
  2. doi request reprint PTH replacement therapy of hypoparathyroidism
    L Rejnmark
    Department of Endocrinology and Internal Medicine, THG, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark
    Osteoporos Int 24:1529-36. 2013
  3. doi request reprint Further insights into the pathogenesis of primary hyperparathyroidism: a nested case-control study
    Lars Rejnmark
    Aarhus University Hospital, Department of Endocrinology and Internal Medicine, THG, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 98:87-96. 2013
  4. pmc Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials
    Lars Rejnmark
    Dr Med Sc, AssociateAarhus University, Department of Endocrinology and Internal Medicine, Aarhus Sygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 97:2670-81. 2012
  5. ncbi request reprint Cardiovascular drugs and bone
    Lars Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Sygehus, Aarhus, University Hospital, Aarhus, Denmark
    Curr Drug Saf 3:178-84. 2008
  6. ncbi request reprint No effect of vitamin K1 intake on bone mineral density and fracture risk in perimenopausal women
    L Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Sygehus, Aarhus University Hospital, Tage Hansens Gade 2, Aarhus C, 8000, Denmark
    Osteoporos Int 17:1122-32. 2006
  7. ncbi request reprint New and emerging antiresorptive treatments in osteoporosis
    Lars Rejnmark
    Department of Endocrinology and Internal Medicine, MEA, Aarhus Sygehus, Aarhus University Hospital, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Curr Drug Saf 6:75-88. 2011
  8. ncbi request reprint Treatment with beta-blockers, ACE inhibitors, and calcium-channel blockers is associated with a reduced fracture risk: a nationwide case-control study
    Lars Rejnmark
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Sygehus, Aarhus, Denmark
    J Hypertens 24:581-9. 2006
  9. ncbi request reprint Loop diuretics increase bone turnover and decrease BMD in osteopenic postmenopausal women: results from a randomized controlled study with bumetanide
    Lars Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Sygehus, Aarhus University Hospital, Aarhus, Denmark
    J Bone Miner Res 21:163-70. 2006
  10. ncbi request reprint Fracture risk in patients treated with loop diuretics
    L Rejnmark
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus C, Denmark
    J Intern Med 259:117-24. 2006

Detail Information

Publications105 found, 100 shown here

  1. doi request reprint Recombinant hormones in osteoporosis
    Lars Rejnmark
    Aarhus University, Aarhus University Hospital, Department of Endocrinology and Internal Medicine, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    Expert Opin Biol Ther 13:1135-47. 2013
    ..Both drugs are given as a daily subcutaneous injection. In the USA, only teriparatide is marketed...
  2. doi request reprint PTH replacement therapy of hypoparathyroidism
    L Rejnmark
    Department of Endocrinology and Internal Medicine, THG, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark
    Osteoporos Int 24:1529-36. 2013
    ..Further studies should assess the effects of continuous PTH exposure by pump delivery (or multiple daily injections) on BMD and bone histology, as well as the effects of PTH-RT on indices of QoL...
  3. doi request reprint Further insights into the pathogenesis of primary hyperparathyroidism: a nested case-control study
    Lars Rejnmark
    Aarhus University Hospital, Department of Endocrinology and Internal Medicine, THG, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 98:87-96. 2013
    ..The pathogenesis of primary hyperparathyroidism (PHPT) is largely unknown...
  4. pmc Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials
    Lars Rejnmark
    Dr Med Sc, AssociateAarhus University, Department of Endocrinology and Internal Medicine, Aarhus Sygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 97:2670-81. 2012
    ..Using pooled data from randomized controlled trials, we performed individual patient data (IPD) and trial level meta-analyses to assess mortality among participants randomized to either vitamin D alone or vitamin D with calcium...
  5. ncbi request reprint Cardiovascular drugs and bone
    Lars Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Sygehus, Aarhus, University Hospital, Aarhus, Denmark
    Curr Drug Saf 3:178-84. 2008
    ..In view of the conflicting results from published studies, no conclusions can be drawn on potential bone effects of treatment with oral anticoagulants, beta-blockers, and calcium channel blockers...
  6. ncbi request reprint No effect of vitamin K1 intake on bone mineral density and fracture risk in perimenopausal women
    L Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Sygehus, Aarhus University Hospital, Tage Hansens Gade 2, Aarhus C, 8000, Denmark
    Osteoporos Int 17:1122-32. 2006
    ..Vitamin K functions as a co-factor in the post-translational carboxylation of several bone proteins, including osteocalcin...
  7. ncbi request reprint New and emerging antiresorptive treatments in osteoporosis
    Lars Rejnmark
    Department of Endocrinology and Internal Medicine, MEA, Aarhus Sygehus, Aarhus University Hospital, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Curr Drug Saf 6:75-88. 2011
    ....
  8. ncbi request reprint Treatment with beta-blockers, ACE inhibitors, and calcium-channel blockers is associated with a reduced fracture risk: a nationwide case-control study
    Lars Rejnmark
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Sygehus, Aarhus, Denmark
    J Hypertens 24:581-9. 2006
    ..Antihypertensive drugs may increase the risk of falling. However, risk of fracture in patients treated with non-diuretic cardiovascular drugs is largely unknown...
  9. ncbi request reprint Loop diuretics increase bone turnover and decrease BMD in osteopenic postmenopausal women: results from a randomized controlled study with bumetanide
    Lars Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Sygehus, Aarhus University Hospital, Aarhus, Denmark
    J Bone Miner Res 21:163-70. 2006
    ..4% at the whole body. Levels of biochemical bone markers were lower in the placebo than in the bumetanide group. Thus, treatment with loop diuretics affects bone metabolism...
  10. ncbi request reprint Fracture risk in patients treated with loop diuretics
    L Rejnmark
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus C, Denmark
    J Intern Med 259:117-24. 2006
    ..Loop diuretics (LD) increase renal calcium excretion. Discrepant results on associations between LD and fracture risk have been reported...
  11. doi request reprint Nephrolithiasis and renal calcifications in primary hyperparathyroidism
    Lars Rejnmark
    Department of Endocrinology and Internal Medicine, Tage Hansens Gade, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 96:2377-85. 2011
    ..Renal complications in terms of hypercalciuria, nephrolithiasis, and nephrocalcinosis are well-known risks in primary hyperparathyroidism (PHPT) and may lead to impaired renal function...
  12. ncbi request reprint Statin but not non-statin lipid-lowering drugs decrease fracture risk: a nation-wide case-control study
    L Rejnmark
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, Aarhus C, DK 8000 Denmark
    Calcif Tissue Int 79:27-36. 2006
    ..Therefore, the epidemiological findings of a reduced fracture risk may be due to selections bias, e.g. a healthy drug user effect. If so, the reduced fracture risk is most likely independent of type of lipid lowering drug...
  13. ncbi request reprint Vitamin D and its binding protein Gc: long-term variability in peri- and postmenopausal women with and without hormone replacement therapy
    L Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Aarhus, Denmark
    Scand J Clin Lab Invest 66:227-38. 2006
    ..The purpose of this study was to investigate the variability in individual plasma 25OHD- and vitamin D-binding protein- (Gc) levels over a 5-year period in postmenopausal women with and without hormone replacement therapy (HRT)...
  14. doi request reprint Increased fracture risk in normocalcemic postmenopausal women with high parathyroid hormone levels: a 16-year follow-up study
    Lars Rejnmark
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade, Denmark
    Calcif Tissue Int 88:238-45. 2011
    ..In conclusion, PTH levels in the upper part or above the upper level of the reference interval increase risk of fracture in the presence of low vitamin D levels...
  15. ncbi request reprint Bone effects of glitazones and other anti-diabetic drugs
    Lars Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Sygehus, Aarhus University Hospital, Aarhus, Denmark
    Curr Drug Saf 3:194-8. 2008
    ..Studies are needed to elucidate mechanisms of action by which metformin and sulphonylureas may affect bone...
  16. doi request reprint Plasma 1,25(OH)2D levels decrease in postmenopausal women with hypovitaminosis D
    Lars Rejnmark
    Department of Endocrinology, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, DK 8000 Aarhus, Denmark
    Eur J Endocrinol 158:571-6. 2008
    ..Moreover, low levels of 25OHD have been associated with increased risk of different diseases including cancer, diabetes, and myopathy...
  17. doi request reprint Parathyroid response to vitamin D insufficiency: relations to bone, body composition and to lifestyle characteristics
    Lars Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Aarhus, Denmark
    Clin Endocrinol (Oxf) 69:29-35. 2008
    ..Vitamin D insufficiency is very common and is known to cause secondary hyperparathyroidism (SHPT). However, in some subjects the PTH response to low vitamin D levels is blunted, which has been termed functional hypoparathyroidism (FHPT)...
  18. doi request reprint Dietary intake of folate, but not vitamin B2 or B12, is associated with increased bone mineral density 5 years after the menopause: results from a 10-year follow-up study in early postmenopausal women
    L Rejnmark
    The Osteoporosis Clinic, Department of Endocrinology and Metabolism C, Aarhus Sygehus, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, DK 8000, Aarhus C, Denmark
    Calcif Tissue Int 82:1-11. 2008
    ..A high dietary intake of folate, but not vitamin B2 or B12, exerts positive effects on BMD; but further studies are needed to confirm this association...
  19. ncbi request reprint [Vitamin D and breast cancer]
    Lars Rejnmark Nielsen
    Arhus Universitetshospital, Arhus Sygehus, Medicinsk Endokrinologisk Afdeling C
    Ugeskr Laeger 169:1299-302. 2007
    ..As vitamin D insufficiency is common, it is important to clarify whether vitamin D status affects the risk and prognosis of breast cancer...
  20. ncbi request reprint Fracture risk in patients treated with amiodarone or digoxin for cardiac arrhythmias: a nation-wide case-control study
    L Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, 8000, Aarhus C, Denmark
    Osteoporos Int 18:409-17. 2007
    ..Cardiac arrhythmias and osteoporotic fractures are common in the elderly...
  21. ncbi request reprint Fracture risk in users of oral anticoagulants: a nationwide case-control study
    Lars Rejnmark
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, Aarhus C, Denmark
    Int J Cardiol 118:338-44. 2007
    ..In bone, vitamin K reduces bone resorption and functions as a cofactor in the posttranslational carboxylation of several bone proteins. Discrepant results have been reported on whether VKA affects bone mineral density and fracture risk...
  22. doi request reprint Determinants of plasma PTH and their implication for defining a reference interval
    Lars Rejnmark
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Denmark
    Clin Endocrinol (Oxf) 74:37-43. 2011
    ..AIM, DESIGN AND METHODS: In a cross-sectional design, including 2316 women aged 17-84, we determined 95% reference interval using a nonparametric approach and studied the effects of potential predictors on plasma PTH levels...
  23. ncbi request reprint [Drugs with side effects affecting calcium homeostasis, bone metabolism and risk of fractures]
    Lars Rejnmark Nielsen
    Arhus Sygehus, Arhus Universitetshospital, Medicinsk Endokrinologisk Afdeling C
    Ugeskr Laeger 167:1026-30. 2005
  24. ncbi request reprint Reduced fracture risk in users of thiazide diuretics
    L Rejnmark
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    Calcif Tissue Int 76:167-75. 2005
    ..Therefore, use of more than 2000 DDD was associated with a 19% (95% CI 10% to 27%) decreased hip fracture risk. We conclude that use of TD is associated with a significantly reduced fracture risk...
  25. ncbi request reprint No effect of vitamin A intake on bone mineral density and fracture risk in perimenopausal women
    L Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus, Denmark
    Osteoporos Int 15:872-80. 2004
    ..Thus, in a Danish population, average vitamin A intake is lower than in Sweden and the United States and not associated with detrimental effects on bone...
  26. ncbi request reprint Loop diuretics alter the diurnal rhythm of endogenous parathyroid hormone secretion. A randomized-controlled study on the effects of loop- and thiazide-diuretics on the diurnal rhythms of calcitropic hormones and biochemical bone markers in postmenopausal
    L Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus, University Hospital, Aarhus, Denmark
    Eur J Clin Invest 31:764-72. 2001
    ..Thiazide diuretics (TD) reduce urinary calcium, bone loss and fracture risk. Loop diuretics (LD) may have opposite effects. These effects could depend on induced rhythmic changes in bone and calcium homeostasis...
  27. ncbi request reprint [Denosumab--a new efficient osteoporosis therapy]
    Lars Rejnmark
    Medicinsk endokrinologisk afdeling, Arhus Universitetshospital, Arhus Sygehus, THG, Aarhus C, Denmark
    Ugeskr Laeger 173:346-9. 2011
    ..In men with iatrogenic hypogonadism due to prostate cancer, the risk of vertebral fractures is decreased by 62%. Side effects are few, but the treatment may increase risk of infections...
  28. ncbi request reprint Vitamin D insufficiency in Greenlanders on a westernized fare: ethnic differences in calcitropic hormones between Greenlanders and Danes
    L Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    Calcif Tissue Int 74:255-63. 2004
    ..Changes from a traditional to a westernized fare are associated with a reduced vitamin D status in Greenlanders. Vitamin D supplementation should be considered...
  29. ncbi request reprint Statins decrease bone turnover in postmenopausal women: a cross-sectional study
    L Rejnmark
    Department of Endocrinology and Metabloism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus University, Aarhus, Denmark
    Eur J Clin Invest 32:581-9. 2002
    ..We studied the effects of treatment with statins on calcium homeostasis, bone turnover and bone mineral density...
  30. ncbi request reprint Diurnal rhythm of plasma 1,25-dihydroxyvitamin D and vitamin D-binding protein in postmenopausal women: relationship to plasma parathyroid hormone and calcium and phosphate metabolism
    Lars Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Denmark
    Eur J Endocrinol 146:635-42. 2002
    ..We have studied whether plasma levels of 1,25(OH)(2)D and vitamin D-binding protein (DBP) vary in a diurnal rhythm in postmenopausal women...
  31. ncbi request reprint Effects of simvastatin on bone turnover and BMD: a 1-year randomized controlled trial in postmenopausal osteopenic women
    Lars Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    J Bone Miner Res 19:737-44. 2004
    ..The study showed no effect of simvastatin on biochemical bone markers or on BMD at the hip or spine. Thus, our results do not support a general beneficial effect of simvastatin on bone...
  32. ncbi request reprint Dose-effect relations of loop- and thiazide-diuretics on calcium homeostasis: a randomized, double-blinded Latin-square multiple cross-over study in postmenopausal osteopenic women
    L Rejnmark
    Department of Endocrinology anf Metabolism C, Aarhus Amtssygehus, University Hospital, Aarhus University, Tage Hansens Gade 2, DK 80000 Aarhus C, Denmark
    Eur J Clin Invest 33:41-50. 2003
    ..Thiazide diuretics (TDs) reduce whereas loop diuretics (LDs) increase urinary calcium. We studied the effects of different doses of a TD and LD on electrolytes, calcitropic hormones and biochemical bone markers...
  33. ncbi request reprint Effects of long-term treatment with loop diuretics on bone mineral density, calcitropic hormones and bone turnover
    L Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Sygehus, Aarhus University Hospital, Aarhus, Denmark
    J Intern Med 257:176-84. 2005
    ..Loop diuretics (LD) are widely used in the treatment of cardiovascular diseases and disorders with fluid accumulation. LD are known to increase renal calcium losses and may thereby affect calcium homeostasis and bone metabolism...
  34. ncbi request reprint Fracture risk in perimenopausal women treated with beta-blockers
    Lars Rejnmark
    Dept of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    Calcif Tissue Int 75:365-72. 2004
    ..beta-Blockers may decrease the activity of bone-forming cells and thereby increase fracture risk. However, confirmative studies and studies exploring mechanisms of action are needed...
  35. ncbi request reprint Response rates to oestrogen treatment in perimenopausal women: 5-year data from the Danish Osteoporosis Prevention Study (DOPS)
    L Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    Maturitas 48:307-20. 2004
    ..To characterise women with no response or with a good response to hormone replacement therapy (HRT), evaluated by change in bone mineral density (BMD). Design: Nested case-control study within a comprehensive cohort study...
  36. ncbi request reprint Effects of thiazide- and loop-diuretics, alone or in combination, on calcitropic hormones and biochemical bone markers: a randomized controlled study
    L Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus, Denmark
    J Intern Med 250:144-53. 2001
    ..We evaluated the effects of loop diuretics (LD) and thiazide diuretics (TD) on calcitropic hormones and biochemical bone markers...
  37. doi request reprint Reduced prediagnostic 25-hydroxyvitamin D levels in women with breast cancer: a nested case-control study
    Lars Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Sygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    Cancer Epidemiol Biomarkers Prev 18:2655-60. 2009
    ..Accordingly, risk of breast cancer was inversely associated with 25OHD levels. Randomized controlled trials are warranted in order to assess whether a causal relationship exists...
  38. ncbi request reprint Hip fracture risk in statin users--a population-based Danish case-control study
    Lars Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark
    Osteoporos Int 15:452-8. 2004
    ..Our findings support an association between statin treatment and a reduced hip fracture risk. However, it is unclear whether this association is causal...
  39. doi request reprint Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women: randomised trial
    Louise Lind Schierbeck
    Department of Endocrinology, Hvidovre Hospital, Kettegard Alle 30, 2650 Hvidovre, Denmark
    BMJ 345:e6409. 2012
    ..To investigate the long term effect of hormone replacement therapy on cardiovascular outcomes in recently postmenopausal women...
  40. doi request reprint Skeletal consequences of familial hypocalciuric hypercalcaemia vs. primary hyperparathyroidism
    Signe Engkjaer Christensen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus, Denmark
    Clin Endocrinol (Oxf) 71:798-807. 2009
    ..We describe and compare biochemical and osteodensitometric variables in FHH and primary hyperparathyroidism (PHPT) and assess whether they can improve the diagnostic discrimination between the groups...
  41. ncbi request reprint Osteoporosis is markedly underdiagnosed: a nationwide study from Denmark
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Amtssygehus, Aarhus, Denmark
    Osteoporos Int 16:134-41. 2005
    ..To compare the number of patients diagnosed with osteoporosis and osteoporotic fractures in Denmark, with the number of subjects expected to have osteoporosis...
  42. doi request reprint BMD improvements after operation for primary hyperparathyroidism
    Lars Rolighed
    Department of Surgery P, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark
    Langenbecks Arch Surg 398:113-20. 2013
    ..This study aims to quantify bone mineral density (BMD) changes following surgery in patients with primary hyperparathyroidism (PHPT) and to assess their relationship with clinical and biochemical variables...
  43. doi request reprint Risk of atrial fibrillation associated with use of bisphosphonates and other drugs against osteoporosis: a cohort study
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Arhus C, Denmark
    Calcif Tissue Int 86:335-42. 2010
    ..In conclusion, oral bisphosphonates do not seem to be associated with an excess risk of atrial fibrillation. Any excess risk seen in prior studies may be due to confounding from COPD...
  44. doi request reprint The effect of adding PTH(1-84) to conventional treatment of hypoparathyroidism: a randomized, placebo-controlled study
    Tanja Sikjaer
    Department of Metabolism and Internal Medicine, MEA, THG, Aarhus University Hospital, Aarhus, Denmark
    J Bone Miner Res 26:2358-70. 2011
    ..This is most likely due to the marked increased bone turnover. Accordingly, PTH-RT counteracts the state of overmineralized bone and, during long-term treatment, may cause a more physiologic bone metabolism...
  45. doi request reprint The effects of depot medroxyprogesterone acetate and intrauterine device use on fracture risk in Danish women
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, DK 8000 Aarhus, Denmark
    Contraception 78:459-64. 2008
    ..Depot medroxyprogesterone acetate (DMPA) use may be associated with an increased risk of fractures; however, nothing is known about the risk associated with intrauterine contraceptive device (IUD) use...
  46. ncbi request reprint Fracture risk is increased in patients with GH deficiency or untreated prolactinomas--a case-control study
    Peter Vestergaard
    Department of Endocrinology, Aarhus Amtssygehus, Medical Department M Endocrinology and Diabetes, Aarhus Kommunehospital, Aarhus, University Hospital, Aarhus, Denmark
    Clin Endocrinol (Oxf) 56:159-67. 2002
    ..The aim of this study was to examine fracture risk in patients with pituitary disorders with special reference to GH deficiency and hyperprolactinaemia...
  47. ncbi request reprint Has mortality after a hip fracture increased?
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    J Am Geriatr Soc 55:1720-6. 2007
    ..To study changes in mortality and causes of death in patients suffering a hip fracture between 1981 and 2001...
  48. doi request reprint Vitamin D deficiency in postmenopausal, healthy women predicts increased cardiovascular events: a 16-year follow-up study
    Louise Lind Schierbeck
    Department of Endocrinology, Hvidovre Hospital, afd 541, Kettegard Alle 30, 2650 Hvidovre, Denmark
    Eur J Endocrinol 167:553-60. 2012
    ..To investigate the relationship between vitamin D status in healthy women and cardiovascular outcome...
  49. ncbi request reprint Decreased fracture risk in users of organic nitrates: a nationwide case-control study
    Lars Rejnmark
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, Aarhus C, Denmark
    J Bone Miner Res 21:1811-7. 2006
    ..Thus, organic nitrates may protect against osteoporosis...
  50. ncbi request reprint PTH treatment in hypoparathyroidism
    Tanja Sikjaer
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital THG, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    Curr Drug Saf 6:89-99. 2011
    ..Furthermore, it seems that some patients with hypoPT experience an improved quality of life when treated with PTH compared with conventional treatment with 1α-hydroxylated vitamin D metabolites and calcium supplements...
  51. ncbi request reprint Ten-year prediction of osteoporosis from baseline bone mineral density: development of prognostic thresholds in healthy postmenopausal women. The Danish Osteoporosis Prevention Study
    Bo Abrahamsen
    Department of Endocrinology, Odense University Hospital, Denmark
    Osteoporos Int 17:245-51. 2006
    ..The association is strong enough to provide robust prognostic thresholds, which can be used to divide the population into two prognostic classes at menopause...
  52. doi request reprint Fracture risk in very young women using combined oral contraceptives
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, DK 8000 Aarhus, Denmark
    Contraception 78:358-64. 2008
    ..Little is known on fracture risk in young women using oral contraceptives...
  53. ncbi request reprint Fracture reducing potential of hormone replacement therapy on a population level
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Sygehus, Aarhus University Hospital, The Osteoporosis Clinic, Aarhus Amtssygehus, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    Maturitas 54:285-93. 2006
    ....
  54. doi request reprint Gastric and esophagus events before and during treatment of osteoporosis
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus C, Denmark
    Calcif Tissue Int 86:110-5. 2010
    ..This points at an effect of the underlying condition being treated or comorbid conditions and drugs being provided in patients with osteoporosis, such as nonsteroidal anti-inflammatory drugs and corticosteroids...
  55. pmc Loss of life years after a hip fracture
    Peter Vestergaard
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus, Denmark
    Acta Orthop 80:525-30. 2009
    ..Patients with a hip fracture have a high mortality; however, it is not clear how large the loss of life-years is over an extended observation period...
  56. ncbi request reprint Smoking as a risk factor for Graves' disease, toxic nodular goiter, and autoimmune hypothyroidism
    Peter Vestergaard
    The Osteoporosis Clinic, Aarhus Amtssygehus, Aarhus University Hospital, Denmark
    Thyroid 12:69-75. 2002
    ..In conclusion, smoking is a powerful risk factor for thyroid disease, especially in populations with a high smoking frequency. Oral contraceptive use is associated with a slightly lower frequency of Graves' disease...
  57. doi request reprint Plasma 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and parathyroid hormone in familial hypocalciuric hypercalcemia and primary hyperparathyroidism
    Signe Engkjaer Christensen
    Department of Endocrinology, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, DK 8000 Arhus C, Denmark
    Eur J Endocrinol 159:719-27. 2008
    ..In PHPT, vitamin D metabolism is typically characterized by low plasma levels of 25-hydroxyvitamin D (25OHD), and high plasma levels of 1,25-dihydroxyvitamin D (1,25(OH)(2)D). In FHH, the vitamin D metabolism is not very well known...
  58. doi request reprint Fracture risk associated with different types of oral corticosteroids and effect of termination of corticosteroids on the risk of fractures
    Peter Vestergaard
    The Osteoporosis Clinic, Aarhus Sygehus, Tage Hansens Gade 2, 8000, Aarhus C, Denmark
    Calcif Tissue Int 82:249-57. 2008
    ..Hydrocortisone was not associated with an increase in the risk of fractures. It may take a year from last use of prednisolone/prednisone before fracture risk returns to that of the general population...
  59. doi request reprint Osteoarthritis and risk of fractures
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    Calcif Tissue Int 84:249-56. 2009
    ..OA seems to be associated with a decreased risk of fractures at multiple skeletal sites as well as sites far from the location of OA. This may indicate systemic effects on bone strength, especially in areas rich in cortical bone...
  60. doi request reprint Effects of smoking on severity of disease in primary hyperparathyroidism
    Anne Kristine Amstrup
    Department of Endocrinology and Metabolism MEA, Aarhus Sygehus, Aarhus University Hospital, Tage Hansens Gade 2, 8000, Aarhus C, Denmark
    Calcif Tissue Int 87:406-13. 2010
    ..Smoking may compromise the correct diagnostic evaluation of borderline hyperparathyroidism. It is unknown to what extent smoking in PHPT affects fracture risk and indication for surgery...
  61. doi request reprint Hip fracture patients at risk of second hip fracture: a nationwide population-based cohort study of 169,145 cases during 1977-2001
    Jesper Ryg
    Department of Endocrinology, Odense University Hospital, Odense, Denmark
    J Bone Miner Res 24:1299-307. 2009
    ..05; 5 yr: 58% versus 41%, p < 0.05). Patients with HFx are at 2-fold risk of further HFx and the subsequent mortality is highly increased. We propose that programs for secondary prevention should be developed and tested...
  62. ncbi request reprint Fracture risk in patients with chronic lung diseases treated with bronchodilator drugs and inhaled and oral corticosteroids
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    Chest 132:1599-607. 2007
    ..Chronic lung diseases and drugs used to treat patients with chronic lung diseases may be associated with an increased fracture risk...
  63. ncbi request reprint Socioeconomic aspects of fractures within universal public healthcare: a nationwide case-control study from Denmark
    Peter Vestergaard
    The Osteoporosis Clinic, Aarhus, Denmark
    Scand J Public Health 34:371-7. 2006
    ..To investigate the effects of income and other socioeconomic variables on fracture risk adjusted for disease-related confounders as fractures are a major public health problem...
  64. doi request reprint Changes in 3-dimensional bone structure indices in hypoparathyroid patients treated with PTH(1-84): a randomized controlled study
    Tanja Sikjaer
    Department of Internal Medicine and Endocrinology, MEA, Aarhus University Hospital, Aarhus, Denmark
    J Bone Miner Res 27:781-8. 2012
    ..However, at the lumbar spine, aBMD decreased by 1.8% (p < 0.05), whereas vBMD increased by 12.8% (p = 0.02) in the PTH compared with the placebo group...
  65. doi request reprint Intake of vitamin D and risk of breast cancer--a meta-analysis
    Tina Gissel
    The Osteoporosis Clinic, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    J Steroid Biochem Mol Biol 111:195-9. 2008
    ..14. In conclusion there may be a trend towards fewer cases of breast cancer with higher intakes of vitamin D (> or =400 IU/day). However, more research is needed, preferably in the form of randomized-controlled trials...
  66. ncbi request reprint Emerging anabolic treatments in osteoporosis
    Leif Mosekilde
    Department of Internal Medicine and Endocrinology, MEA, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Curr Drug Saf 6:62-74. 2011
    ..The present paper summarises the physiological background and the present evidence for these effects...
  67. ncbi request reprint Oral contraceptive use and risk of fractures
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Amtssygehus, DK 8000 Aarhus, Denmark
    Contraception 73:571-6. 2006
    ..Prior studies have suggested that oral contraceptives (OCs) may be associated with an increased fracture risk. However, the previous studies have only performed a limited adjustment for other potential risk factors...
  68. ncbi request reprint Postpartum vitamin D insufficiency and secondary hyperparathyroidism in healthy Danish women
    U K Møller
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus, Denmark
    Eur J Clin Nutr 60:1214-21. 2006
    ..To examine vitamin D status and parathyroid function in normal Danish women postpartum...
  69. doi request reprint Hypertension is a risk factor for fractures
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, The Osteoporosis Clinic, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark
    Calcif Tissue Int 84:103-11. 2009
    ..The fracture risk in hypertension may explain why antihypertensive drugs as a class effect are associated with a decreased risk of fractures. These drugs may counter some of the deleterious effects of high blood pressure...
  70. ncbi request reprint Fracture risk associated with use of antiepileptic drugs
    Peter Vestergaard
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Sygehus, Aarhus, Denmark
    Epilepsia 45:1330-7. 2004
    ..An increased fracture risk has been reported in patients with epilepsy. Classical AEDs have been associated with decreased bone mineral density. The effects of newer AEDs are unknown...
  71. doi request reprint Effect of tamoxifen and aromatase inhibitors on the risk of fractures in women with breast cancer
    Peter Vestergaard
    The Osteoporosis Clinic, Aarhus Amtssygehus, Tage Hansens Gade 2, Aarhus C, Denmark
    Calcif Tissue Int 82:334-40. 2008
    ..Aromatase inhibitors were associated with a significant increase in the risk of fractures. In women at high risk of fractures, supplementary measures, i.e., bisphosphonates, may be considered...
  72. doi request reprint Selective serotonin reuptake inhibitors and other antidepressants and risk of fracture
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    Calcif Tissue Int 82:92-101. 2008
    ..While selective serotonin receptor uptake inhibitors were associated with an increased fracture risk, tricyclic antidepressants and the group of other antidepressants were not systematically associated with fracture risk...
  73. doi request reprint High-dose treatment with vitamin A analogues and risk of fractures
    Peter Vestergaard
    The Osteoporosis Clinic, Aarhus Amtssygehus, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    Arch Dermatol 146:478-82. 2010
    ..To study fracture risk associated with use of systemic vitamin A analogue (isotretinoin and acitretin) treatment...
  74. doi request reprint Anxiolytics and sedatives and risk of fractures: effects of half-life
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus University, Aarhus, Denmark
    Calcif Tissue Int 82:34-43. 2008
    ..However, the increased risk of fractures with past use may suggest an effect of the condition for which the drug was prescribed rather than the drug per se (confounding by indication)...
  75. ncbi request reprint Fracture risk associated with parkinsonism and anti-Parkinson drugs
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000, Aarhus C, Denmark
    Calcif Tissue Int 81:153-61. 2007
    ..Use of neuroleptics and, to some degree, levodopa was associated with increased risk of fractures...
  76. doi request reprint Fracture risk in patients with different types of cancer
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    Acta Oncol 48:105-15. 2009
    ..Few studies on the risk of fractures in patients with cancer exist, and little is known on the mechanisms of fractures in patients with cancer. We studied the risk of fracture in patients with various types of cancer...
  77. doi request reprint Are antiresorptive drugs effective against fractures in patients with diabetes?
    Peter Vestergaard
    The Osteoporosis Clinic, Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Denmark
    Calcif Tissue Int 88:209-14. 2011
    ..Therefore, patients with diabetes should receive treatment for osteoporosis in the same way as nondiabetic patients...
  78. ncbi request reprint Increased risk of osteoporotic fractures in patients with Cushing's syndrome
    Peter Vestergaard
    The Osteoporosis Clinic, Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Tage Hansens Gade 2, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 146:51-6. 2002
    ..To evaluate if fracture risk was increased in patients with Cushing's syndrome due to the increased endogenous cortisol production...
  79. doi request reprint Diabetes and its complications and their relationship with risk of fractures in type 1 and 2 diabetes
    Peter Vestergaard
    The Osteoporosis Clinic, Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark
    Calcif Tissue Int 84:45-55. 2009
    ....
  80. ncbi request reprint [Osteoporosis and fractures associated with drugs]
    Peter Vestergaard
    Arhus Sygehus, Osteoporoseklinikken, Arhus C
    Ugeskr Laeger 170:1550-5. 2008
    ..Pain medication varied from no effect to an increased fracture risk...
  81. ncbi request reprint [Strongly increasing incidence of hip fractures in Denmark from 1977 to 1999]
    Peter Vestergaard
    Aalborg Sygehus, Endokrinologisk Afdeling
    Ugeskr Laeger 170:621-3. 2008
    ..The incidence of hip fractures has been increasing throughout the world including the Nordic countries. The aim of this study was to examine if there is a similar trend in Denmark...
  82. ncbi request reprint Hip fracture prevention: cost-effective strategies
    P Vestergaard
    Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Aarhus University Hospital, Denmark
    Pharmacoeconomics 19:449-68. 2001
    ..Further studies comparing several hip fracture preventive regimens are required in order to establish the most cost-effective strategy...
  83. ncbi request reprint Fracture risk in patients treated for hyperthyroidism
    P Vestergaard
    The Osteoporosis Clinic, Aarhus Amtssygehus, Aarhus University Hospital, Denmark
    Thyroid 10:341-8. 2000
    ..To study fracture risk and risk factors for fractures in patients with hyperthyroidism...
  84. ncbi request reprint Corticosteroid use and risk of hip fracture: a population-based case-control study in Denmark
    P Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    J Intern Med 254:486-93. 2003
    ..To examine the association between cumulative CS dose and risk of hip fracture...
  85. ncbi request reprint Anxiolytics, sedatives, antidepressants, neuroleptics and the risk of fracture
    P Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, 8000, Aarhus C, Denmark
    Osteoporos Int 17:807-16. 2006
    ..Our objective was to study the association between fracture risk and the use of anxiolytics and sedatives (benzodiazepines, etc.), neuroleptics and antidepressants...
  86. ncbi request reprint Influence of hyper- and hypothyroidism, and the effects of treatment with antithyroid drugs and levothyroxine on fracture risk
    P Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, Aarhus, Denmark
    Calcif Tissue Int 77:139-44. 2005
    ..Low-dose levothyroxine was not associated with fracture risk. The effect of antithyroid drugs may be caused by the reduction in thyroid hormone levels...
  87. ncbi request reprint Reduced relative risk of fractures among users of lithium
    P Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Aarhus, Denmark
    Calcif Tissue Int 77:1-8. 2005
    ..Adjustment for further confounders did not change the results. Lithium treatment was associated with a decreased risk of fractures potentially pointing at bone anabolic properties...
  88. ncbi request reprint Relative fracture risk in patients with diabetes mellitus, and the impact of insulin and oral antidiabetic medication on relative fracture risk
    P Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus, Denmark
    Diabetologia 48:1292-9. 2005
    ..We studied the association between fractures and type 1 and type 2 diabetes mellitus...
  89. ncbi request reprint Fracture risk associated with systemic and topical corticosteroids
    P Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus, Denmark
    J Intern Med 257:374-84. 2005
    ..To study the fracture risk associated with the use of corticosteroids in any formulation and administration...
  90. ncbi request reprint Fracture risk associated with the use of morphine and opiates
    P Vestergaard
    Department of Endocrinology and Metabolism, Aarhus Sygehus, Aarhus University Hospital, Aarhus, Denmark
    J Intern Med 260:76-87. 2006
    ..To study the effect of morphine and opiates on fracture risk...
  91. doi request reprint Risk of femoral shaft and subtrochanteric fractures among users of bisphosphonates and raloxifene
    P Vestergaard
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
    Osteoporos Int 22:993-1001. 2011
    ..This may suggest an effect of the underlying disease rather than the drugs used...
  92. doi request reprint Use of bisphosphonates and raloxifene and risk of deep venous thromboembolism and pulmonary embolism
    P Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Arhus C, Denmark
    Osteoporos Int 21:1591-7. 2010
    ..In a cohort study, we observed an increased risk also with the bisphosphonates. However, the increase was present already before the start of bisphosphonates pointing at an effect of the underlying condition...
  93. ncbi request reprint Increased mortality in patients with a hip fracture-effect of pre-morbid conditions and post-fracture complications
    P Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    Osteoporos Int 18:1583-93. 2007
    ..The main reason for the excess mortality was linked to the trauma that caused the hip fracture...
  94. ncbi request reprint Fractures in patients with primary idiopathic hypothyroidism
    P Vestergaard
    The Osteoporosis Clinic, Aarhus Amtssygehus, Aarhus University Hospital, Denmark
    Thyroid 10:335-40. 2000
    ..To study fracture risk and risk factors for fractures in patients with primary idiopathic hypothyroidism (ICD 10: E03.9)...
  95. ncbi request reprint Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis
    P Vestergaard
    Department of Endocrinology and Metabolism, Aarhus Sygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000, Aarhus C, Denmark
    Calcif Tissue Int 79:84-94. 2006
    ..86, 95% CI 1.68-2.07). Weak analgesics may be associated with fracture risk in a varying way. The effects in most cases were small. Falls may be one reason for the increase in fracture risk with some NSAIDs...
  96. doi request reprint Stroke in relation to use of raloxifene and other drugs against osteoporosis
    P Vestergaard
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Arhus C, Denmark
    Osteoporos Int 22:1037-45. 2011
    ..In a cohort study, we found no excess risk of stroke with raloxifene; whereas, an excess risk of stroke and fatal stroke was seen with alendronate and etidronate. However, the excess risks were small...
  97. doi request reprint Risk of fractures associated with treatment for benign prostate hyperplasia in men
    P Vestergaard
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
    Osteoporos Int 22:731-7. 2011
    ..In our study, neither 5-α-reductase inhibitors nor α-blockers were associated with negative effects on fractures, α-blockers perhaps being associated with a limited decrease in fractures...
  98. ncbi request reprint Proton pump inhibitors, histamine H2 receptor antagonists, and other antacid medications and the risk of fracture
    P Vestergaard
    The Osteoporosis Clinic, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000, Aarhus C, Denmark
    Calcif Tissue Int 79:76-83. 2006
    ..In all cases, the changes in risk estimates were small and the clinical significance was limited...
  99. ncbi request reprint Methotrexate, azathioprine, cyclosporine, and risk of fracture
    P Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000, Aarhus C, Denmark
    Calcif Tissue Int 79:69-75. 2006
    ..It thus seems that the underlying disease for which the treatment is administered may be responsible for much of the increase in fracture risk rather than the drugs used to treat the disorder in question...
  100. ncbi request reprint [Osteoporosis--new therapeutic possibilities. The Danish Bone Society]
    Bente L Langdahl
    Medicinsk Endokrinologisk Afdeling C, Arhus Sygehus, Arhus Universitetshospital, DK 8000 Arhus C
    Ugeskr Laeger 170:1043. 2008
  101. ncbi request reprint Fracture risk in patients with muscular dystrophy and spinal muscular atrophy
    P Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Denmark
    J Rehabil Med 33:150-5. 2001
    ..Loss of ambulation was the major risk factor for fractures. In conclusion, fracture risk is increased in neuromuscular disease...