Jens Overgaard

Summary

Affiliation: Aarhus University Hospital
Country: Denmark

Publications

  1. pmc Methylation of cancer related genes in tumor and peripheral blood DNA from the same breast cancer patient as two independent events
    Tomasz K Wojdacz
    The Lundbeck Foundation Centre for International Research in Radiation Oncology, Nørrebrogade 44, Building NO, 5, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Diagn Pathol 6:116. 2011
  2. pmc Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer
    Ana M Gonzalez-Angulo
    Departments of Breast Medical Oncology and Systems Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Clin Proteomics 8:11. 2011
  3. pmc A simple way to evaluate self-designed probes for tumor specific Multiplex Ligation-dependent Probe Amplification (MLPA)
    Kristina Pedersen
    Institute of Human Genetics, The Bartholin Building, Wilhelm Meyers Allé 4, University of Aarhus, DK 8000 Aarhus C, Denmark
    BMC Res Notes 3:179. 2010
  4. doi request reprint Five versus six fractions of radiotherapy per week for squamous-cell carcinoma of the head and neck (IAEA-ACC study): a randomised, multicentre trial
    Jens Overgaard
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Lancet Oncol 11:553-60. 2010
  5. ncbi request reprint Hypoxic radiosensitization: adored and ignored
    Jens Overgaard
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus C, Denmark
    J Clin Oncol 25:4066-74. 2007
  6. ncbi request reprint TP53 mutation is an independent prognostic marker for poor outcome in both node-negative and node-positive breast cancer
    J Overgaard
    Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus University Hospital
    Acta Oncol 39:327-33. 2000
  7. ncbi request reprint Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial
    Jens Overgaard
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, DK 8000 Aarhus C, Denmark
    Lancet Oncol 6:757-64. 2005
  8. ncbi request reprint Importance of overall treatment time for the response to radiotherapy in patients with squamous cell carcinoma of the head and neck
    J Overgaard
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Norrebrogade 44, Bld 5, DK 8000, Aarhus C, Denmark
    Rays 25:313-9. 2000
  9. ncbi request reprint Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6 and 7 randomised controlled trial
    Jens Overgaard
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, Building 5, DK 8000 C, Aarhus, Denmark
    Lancet 362:933-40. 2003
  10. doi request reprint Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck--a systematic review and meta-analysis
    Jens Overgaard
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Radiother Oncol 100:22-32. 2011

Detail Information

Publications98

  1. pmc Methylation of cancer related genes in tumor and peripheral blood DNA from the same breast cancer patient as two independent events
    Tomasz K Wojdacz
    The Lundbeck Foundation Centre for International Research in Radiation Oncology, Nørrebrogade 44, Building NO, 5, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Diagn Pathol 6:116. 2011
    ..In this study, we aimed to investigate a relationship between methylation of three breast cancer related genes in PB DNA, and tumor specific (somatic) methylation of these genes in the same individual...
  2. pmc Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer
    Ana M Gonzalez-Angulo
    Departments of Breast Medical Oncology and Systems Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Clin Proteomics 8:11. 2011
    ..abstract:..
  3. pmc A simple way to evaluate self-designed probes for tumor specific Multiplex Ligation-dependent Probe Amplification (MLPA)
    Kristina Pedersen
    Institute of Human Genetics, The Bartholin Building, Wilhelm Meyers Allé 4, University of Aarhus, DK 8000 Aarhus C, Denmark
    BMC Res Notes 3:179. 2010
    ..During evaluation of new self-designed reference probes, we encountered a number of problems, especially when applying the MLPA methodology to tumor samples...
  4. doi request reprint Five versus six fractions of radiotherapy per week for squamous-cell carcinoma of the head and neck (IAEA-ACC study): a randomised, multicentre trial
    Jens Overgaard
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Lancet Oncol 11:553-60. 2010
    ....
  5. ncbi request reprint Hypoxic radiosensitization: adored and ignored
    Jens Overgaard
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus C, Denmark
    J Clin Oncol 25:4066-74. 2007
    ..Ample data exist to support a high level of evidence for the benefit of hypoxic modification. However, hypoxic modification still has no impact on general clinical practice...
  6. ncbi request reprint TP53 mutation is an independent prognostic marker for poor outcome in both node-negative and node-positive breast cancer
    J Overgaard
    Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus University Hospital
    Acta Oncol 39:327-33. 2000
    ..A better understanding of the role of the p53 pathway, including analysis of different types of TP53 mutations, is required in order further to investigate the prognostic potential of this marker...
  7. ncbi request reprint Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial
    Jens Overgaard
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, DK 8000 Aarhus C, Denmark
    Lancet Oncol 6:757-64. 2005
    ..However, whether all patients benefit from such modification of hypoxia is unclear. We aimed to assess whether the concentration of plasma osteopontin could predict response to the hypoxia radiosensitiser...
  8. ncbi request reprint Importance of overall treatment time for the response to radiotherapy in patients with squamous cell carcinoma of the head and neck
    J Overgaard
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Norrebrogade 44, Bld 5, DK 8000, Aarhus C, Denmark
    Rays 25:313-9. 2000
    ....
  9. ncbi request reprint Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6 and 7 randomised controlled trial
    Jens Overgaard
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, Building 5, DK 8000 C, Aarhus, Denmark
    Lancet 362:933-40. 2003
    ..We aimed to find out whether shortening of treatment time by use of six instead of five radiotherapy fractions per week improves the tumour response in squamous-cell carcinoma...
  10. doi request reprint Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck--a systematic review and meta-analysis
    Jens Overgaard
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Radiother Oncol 100:22-32. 2011
    ..The present meta-analysis was, therefore, performed utilising the results from all clinical trials addressing the specific question of hypoxic modification in HNSCC undergoing curative intended primary radiotherapy alone...
  11. pmc Carbonic anhydrase IX and response to postmastectomy radiotherapy in high-risk breast cancer: a subgroup analysis of the DBCG82 b and c trials
    Marianne Kyndi
    Department of Experimental Clinical Oncology, Arhus University Hospital, Nørrebrogade, 8000 Arhus C, Denmark
    Breast Cancer Res 10:R24. 2008
    ..The purpose of the present study was to examine the importance of CA IX to response to postmastectomy radiotherapy in the larger scaled DBCG82 b and c studies...
  12. doi request reprint High local recurrence risk is not associated with large survival reduction after postmastectomy radiotherapy in high-risk breast cancer: a subgroup analysis of DBCG 82 b&c
    Marianne Kyndi
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 90:74-9. 2009
    ..International consensus reports recommend postmastectomy radiotherapy only to patients at high risk of a local recurrence (LR)...
  13. doi request reprint Proteins upregulated by mild and severe hypoxia in squamous cell carcinomas in vitro identified by proteomics
    Brita Singers Sørensen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 92:443-9. 2009
    ..In this in vitro study we have studied the proteome of cells under intermediate hypoxia (1% O2) and anoxia and compared these to normoxic (21% O2) cells to identify proteins upregulated by mild and severe hypoxia...
  14. ncbi request reprint Differential risk assessments from five hypoxia specific assays: The basis for biologically adapted individualized radiotherapy in advanced head and neck cancer patients
    Marianne Nordsmark
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 83:389-97. 2007
    ..Hypoxia adversely relates with prognosis in human tumours. Five hypoxia specific predictive marker assays were compared and correlated with definitive radiotherapy...
  15. ncbi request reprint Is the benefit of postmastectomy irradiation limited to patients with four or more positive nodes, as recommended in international consensus reports? A subgroup analysis of the DBCG 82 b&c randomized trials
    Marie Overgaard
    Department of Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 82:247-53. 2007
    ..A subgroup analysis of the DBCG 82 b&c trials was performed to evaluate the loco-regional recurrence rate and survival in relation to number of positive nodes...
  16. doi request reprint Does transfusion improve the outcome for HNSCC patients treated with radiotherapy? - results from the randomized DAHANCA 5 and 7 trials
    Camilla Molich Hoff
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Acta Oncol 50:1006-14. 2011
    ..Aim of the current analysis was to gain additional power by adding patients from the continued subrandomization in the DAHANCA 7 trial, now including a total of almost 1200 patients...
  17. doi request reprint Can hypoxia-PET map hypoxic cell density heterogeneity accurately in an animal tumor model at a clinically obtainable image contrast?
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital AUH, Aarhus, Denmark
    Radiother Oncol 92:429-36. 2009
    ....
  18. doi request reprint Estrogen receptor, progesterone receptor, HER-2, and response to postmastectomy radiotherapy in high-risk breast cancer: the Danish Breast Cancer Cooperative Group
    Marianne Kyndi
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Arhus Sygehus, Noerrebrogade 44, Building 5, 2, DK 8000 Aarhus C, Denmark
    J Clin Oncol 26:1419-26. 2008
    ....
  19. ncbi request reprint The role of epidermal growth factor receptor and E-cadherin for the outcome of reduction in the overall treatment time of radiotherapy of supraglottic larynx squamous cell carcinoma
    Jesper Grau Eriksen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Acta Oncol 44:50-8. 2005
    ....
  20. ncbi request reprint Does stage at diagnosis explain the difference in survival after breast cancer in Denmark and Sweden?
    Anni Ravnsbaek Jensen
    Centre for Cancer Documentation, Department of Experimental Clinical Oncology, Danish Cancer Society, Aarhus University Hospital, Denmark
    Acta Oncol 43:719-26. 2004
    ..001). Reanalysis without screening-detected patients only slightly affected the impact of region. It was concluded that early detection had significant impact on survival but other regional differences might be of importance...
  21. doi request reprint HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer
    Pernille Lassen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Noerrebrogade 44, DK 8000 Aarhus C, Denmark
    Radiother Oncol 94:30-5. 2010
    ..Using p16-status as a retrospective stratification parameter, we aimed to assess the influence of p16-expression on the response to nimorazole in HNSCC...
  22. ncbi request reprint TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer
    Christian Nicolaj Andreassen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, DK 8000 Aarhus, Denmark
    Radiother Oncol 75:18-21. 2005
    ..005) as well as the TGFB1 position -509 T allele (P=0.018) and increased risk of altered breast appearance. No significant associations were found for the remaining SNPs...
  23. doi request reprint FAZA PET/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: results from the DAHANCA 24 trial
    Lise Saksø Mortensen
    Aarhus University Hospital, Denmark
    Radiother Oncol 105:14-20. 2012
    ..The purpose of this study was to evaluate (18)F-fluoroazomycin arabinoside (FAZA) positron emission tomography (PET)/computed tomography (CT) hypoxia imaging as a prognostic factor in HNSCC patients receiving radiotherapy...
  24. doi request reprint Tumourigenicity and radiation resistance of mesenchymal stem cells
    Filippo P D'Andrea
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, Aarhus C, Denmark
    Acta Oncol 51:669-79. 2012
    ..It is not known, however, whether normal nontransformed adult stem cells share the same radioresistance as their cancerous counterpart...
  25. ncbi request reprint Study of failure pattern among high-risk breast cancer patients with or without postmastectomy radiotherapy in addition to adjuvant systemic therapy: long-term results from the Danish Breast Cancer Cooperative Group DBCG 82 b and c randomized studies
    Hanne M Nielsen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus C, Denmark
    J Clin Oncol 24:2268-75. 2006
    ..The aim of this analysis was to examine the overall disease recurrence pattern among patients randomly assigned to receive treatment with or without RT...
  26. doi request reprint Imaging hypoxia in xenografted and murine tumors with 18F-fluoroazomycin arabinoside: a comparative study involving microPET, autoradiography, PO2-polarography, and fluorescence microscopy
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Int J Radiat Oncol Biol Phys 70:1202-12. 2008
    ..The aim of this study was to examine the in vivo hypoxia selectivity of fluoroazomycin arabinoside ([18F]-FAZA), a promising tracer with improved washout kinetics from oxygenated tissue...
  27. ncbi request reprint LOH rather than genotypes of TP53 codon 72 is associated with disease-free survival in primary breast cancer
    Marianne Kyndi
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Acta Oncol 45:602-9. 2006
    ..05). In conclusion, we find a highly significant prognostic value of TP53 mutations but find a possible prognostic value of the Arg72Pro polymorphism only related to LOH...
  28. doi request reprint Tumour microenvironment and radiation response in sarcomas originating from tumourigenic human mesenchymal stem cells
    Filippo P D'Andrea
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Int J Radiat Biol 88:457-65. 2012
    ....
  29. doi request reprint Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole in squamous cell carcinomas of the head and neck
    Kasper Toustrup
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Arahus C, Denmark
    Radiother Oncol 102:122-9. 2012
    ..To validate the predictive impact of a hypoxia gene expression classifier in identifying patients with head and neck squamous cell carcinoma (HNSCC) having benefit from hypoxic modification of radiotherapy...
  30. pmc In vivo identification and specificity assessment of mRNA markers of hypoxia in human and mouse tumors
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    BMC Cancer 11:63. 2011
    ..g., low pH). Here we describe a new technique that by exploiting intratumoral oxygenation heterogeneity allows us to identify and objectively rank the most robust mRNA hypoxia biomarkers...
  31. ncbi request reprint Lack of association between level of Plasminogen Activator Inhibitor-1 and estimates of tumor angiogenesis in early breast cancer
    Birgitte Vrou Offersen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus C, Denmark
    Acta Oncol 46:782-91. 2007
    ..This study confirms high PAI-1 or high Chalkley counts as markers of poor prognosis in breast cancer patients, and suggests that the prognostic impact of PAI-1 is independent of its supposed involvement in tumor angiogenesis...
  32. ncbi request reprint Lack of prognostic and predictive value of CA IX in radiotherapy of squamous cell carcinoma of the head and neck with known modifiable hypoxia: an evaluation of the DAHANCA 5 study
    Jesper Grau Eriksen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 83:383-8. 2007
    ....
  33. ncbi request reprint Loco-regional recurrence after mastectomy in high-risk breast cancer--risk and prognosis. An analysis of patients from the DBCG 82 b&c randomization trials
    Hanne M Nielsen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 79:147-55. 2006
    ..The aim of the present study was to identify risk factors for loco-regional recurrence (LRR), to evaluate the treatment of LRR and to examine the prognosis after LRR...
  34. doi request reprint A comparison among HER2, TP53, PAI-1, angiogenesis, and proliferation activity as prognostic variables in tumours from 408 patients diagnosed with early breast cancer
    Birgitte Vrou Offersen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Acta Oncol 47:618-32. 2008
    ..One hundred and sixty seven patients (41%) died from breast cancer...
  35. doi request reprint Cellular uptake of PET tracers of glucose metabolism and hypoxia and their linkage
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus C, Denmark
    Eur J Nucl Med Mol Imaging 35:2294-303. 2008
    ..Here, we compare the oxygenation-dependent retention of fluoroazomycin arabinoside ([(18)F]FAZA), a promising but not well-characterised hypoxia-specific tracer, and fluorodeoxyglucose ([(18)F]FDG) in four carcinoma cell lines...
  36. ncbi request reprint Tumor hypoxia is independent of hemoglobin and prognostic for loco-regional tumor control after primary radiotherapy in advanced head and neck cancer
    Marianne Nordsmark
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Acta Oncol 43:396-403. 2004
    ..5 as continuous variable was independently the strongest prognostic indicator for loco-regional tumor control after definitive primary radiotherapy in advanced head and neck tumors...
  37. doi request reprint Inhibition of tumor lactate oxidation: consequences for the tumor microenvironment
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 99:404-11. 2011
    ....
  38. doi request reprint Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck
    Pernille Lassen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Noerrebrogade 44, DK 8000 Aarhus C, Denmark
    J Clin Oncol 27:1992-8. 2009
    ....
  39. doi request reprint Identifying hypoxia in human tumors: A correlation study between 18F-FMISO PET and the Eppendorf oxygen-sensitive electrode
    Lise Saksø Mortensen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Acta Oncol 49:934-40. 2010
    ..The aim of this study was to examine the association between measures of hypoxia defined by functional imaging and Eppendorf pO(2) electrodes...
  40. doi request reprint High-resolution melting analysis for mutation screening of RGSL1, RGS16, and RGS8 in breast cancer
    Emilia Wiechec
    Institute of Human Genetics, University of Aarhus, Aarhus C, Denmark
    Cancer Epidemiol Biomarkers Prev 20:397-407. 2011
    ..We evaluated the use of high-resolution melting (HRM) to screen for mutations in the genes of interest and assess their clinical significance...
  41. ncbi request reprint The impact of hypoxia on the activity of lactate dehydrogenase in two different pre-clinical tumour models
    Slavka Lukacova
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Noerrebrogade 44, DK 8000 Aarhus, Denmark
    Acta Oncol 47:941-7. 2008
    ..To investigate the direct relationship between tumour hypoxia and lactate dehydrogenase (Ldh) levels in serum and tumour in two different pre-clinical murine models...
  42. ncbi request reprint Hypoxia induced expression of endogenous markers in vitro is highly influenced by pH
    Brita Singers Sørensen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Radiother Oncol 83:362-6. 2007
    ..The current study is a detailed investigation using a range of pH values from 6.3 to 7.5 in two human cell lines to establish the pH dependency of hypoxia induced gene expression...
  43. doi request reprint Genetic markers for prediction of normal tissue toxicity after radiotherapy
    Jan Alsner
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Semin Radiat Oncol 18:126-35. 2008
    ..Finally, candidate gene studies elucidating the genetic component of radiation-induced morbidity and the functional consequences of single nucleotide polymorphisms by studying intermediate phenotypes will be discussed...
  44. doi request reprint Development of a hypoxia gene expression classifier with predictive impact for hypoxic modification of radiotherapy in head and neck cancer
    Kasper Toustrup
    Department of Experimental Clinical Oncology, Aarhus University Hospital and Bioinformatics Research Centre, Aarhus University, Aarhus C, Denmark
    Cancer Res 71:5923-31. 2011
    ..Thus, findings show that the classifier attained both prognostic and predictive impact, and its pretherapeutic use may provide a method to identify those patients who will benefit from hypoxic modification of radiotherapy...
  45. doi request reprint Accessing radiation response using hypoxia PET imaging and oxygen sensitive electrodes: a preclinical study
    Lise Saksø Mortensen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 99:418-23. 2011
    ..The aim of this study was to investigate the prognostic value of hypoxia measured by (18)F-fluoroazomycin arabinoside ((18)F-FAZA) PET or the Eppendorf oxygen electrode in a pre-clinical tumor model...
  46. doi request reprint The influence of HPV-associated p16-expression on accelerated fractionated radiotherapy in head and neck cancer: evaluation of the randomised DAHANCA 6&7 trial
    Pernille Lassen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 100:49-55. 2011
    ..We aimed to assess the influence of tumour HPV-status, expressed by p16, on the response to accelerated fractionated radiotherapy in HNSCC through evaluation of the DAHANCA 6&7 trial...
  47. ncbi request reprint Prognostic factors for survival after enucleation for choroidal and ciliary body melanomas
    Peter Isager
    Department of Experimental Clinical Oncology, Arhus University Hospital, Arhus, Denmark
    Acta Ophthalmol Scand 82:517-25. 2004
    ..To evaluate prognostic factors for the survival of patients treated by enucleation for choroidal and ciliary body melanomas...
  48. doi request reprint Does the introduction of sentinel node biopsy increase the number of node positive patients with early breast cancer? A population based study form the Danish Breast Cancer Cooperative Group
    Anders Husted Madsen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Tage Hansensgade 2, Aarhus, Denmark
    Acta Oncol 47:239-47. 2008
    ..In a population-based setting, the objective of the current study was to estimate the increased risk of metastases after introduction of the sentinel lymph node biopsy technique...
  49. ncbi request reprint Tumour burden and interleukin-2 dose affect the interaction between low-dose total body irradiation and interleukin 2
    Akmal Safwat
    Department of Experimental Clinical Oncology, Aarhus University Hospital, and Institute for Medical Microbiology and Immunology, Aarhus University, Denmark
    Eur J Cancer 40:1412-7. 2004
    ..It was concluded that tumour burden at the time of treatment and IL-2 dose are two crucial factors affecting the synergism between LTBI and IL-2. The combination may not only be more effective than IL-2 alone but also less toxic...
  50. ncbi request reprint Tumour oxygenation assessed by 18F-fluoromisonidazole PET and polarographic needle electrodes in human soft tissue tumours
    Lise Bentzen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Noerrebrogade 4, DK 8000 Aarhus C, Denmark
    Radiother Oncol 67:339-44. 2003
    ..The aim of the study was to identify hypoxia in human soft tissue sarcomas (STS) by PET scanning using the hypoxia marker [18F]-fluoromisonidazole ([18F]FMISO) and invasive oxygen sensitive probes (Eppendorf pO2 Histograph, Germany)...
  51. ncbi request reprint Nodal control and surgical salvage after primary radiotherapy in 1782 patients with laryngeal and pharyngeal carcinoma
    Lars Vendelbo Johansen
    Department of Experimental Clinical Oncology, ENT Department, Aarhus University Hospital, Aarhus, Denmark
    Acta Oncol 43:486-94. 2004
    ..Significant prognostic factors in multivariate analysis were gender, region of origin, N-classification, and tumor differentiation...
  52. doi request reprint Prevalence and peak incidence of acute and late normal tissue morbidity in the DAHANCA 6&7 randomised trial with accelerated radiotherapy for head and neck cancer
    Hanna R Mortensen
    Department of Oncology, Aarhus University Hospital, Aarhus, Denmark
    Radiother Oncol 103:69-75. 2012
    ..The aim of this report was to describe the incidence and prevalence of acute and late morbidity in the DAHANCA 6&7 multicentre randomised trial with accelerated radiotherapy for squamous cell carcinoma of the head and neck...
  53. doi request reprint Trends in breast cancer during three decades in Denmark: stage at diagnosis, surgical management and survival
    Anni Ravnsbaek Jensen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Acta Oncol 47:537-44. 2008
    ..This study analyses the impact of time trends in diagnostic and surgical procedures on stage at diagnosis and survival in three Danish counties in three decades...
  54. doi request reprint Aerobic glycolysis in cancers: implications for the usability of oxygen-responsive genes and fluorodeoxyglucose-PET as markers of tissue hypoxia
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Int J Cancer 122:2726-34. 2008
    ..This linkage suggests that multi-tracer imaging combining FDG and hypoxia-specific markers may provide therapeutically relevant information on tumor energetic phenotypes...
  55. ncbi request reprint Audit of the radiotherapy in the DBCG 82 b&c trials--a validation study of the 1,538 patients randomised to postmastectomy radiotherapy
    Hanne Melgaard Nielsen
    Department of Experimental Clinical Oncology, Department of Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 76:285-92. 2005
    ..The aim of the present study was to describe the delivered RT for the 1538 patients who were randomised to RT, and to evaluate the compliance with the RT guidelines...
  56. doi request reprint Matrix metalloproteinase-9 measured in urine from bladder cancer patients is an independent prognostic marker of poor survival
    Birgitte V Offersen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Acta Oncol 49:1283-7. 2010
    ..The prognostic value of these measurements has never been investigated. Using this assay we have investigated the prognostic influence of total and active MMP-9 in urine from bladder cancer patients...
  57. ncbi request reprint Stage and survival in breast cancer patients in screened and non-screened Danish and Swedish populations
    Anni R Jensen
    Centre for Cancer Documentation, Department of Experimental Clinical Oncology, Danish Cancer Society, Denmark
    Acta Oncol 42:701-9. 2003
    ..Denmark may, through early detection, approach the beneficial stage distribution and survival observed in Sweden...
  58. ncbi request reprint Differential gene expression before and after ionizing radiation of subcutaneous fibroblasts identifies breast cancer patients resistant to radiation-induced fibrosis
    Jan Alsner
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 83:261-6. 2007
    ....
  59. ncbi request reprint Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes
    Christian Nicolaj Andreassen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Noerrebrogade 44, Aarhus C DK 8000, Denmark
    Radiother Oncol 69:127-35. 2003
    ..This study investigates whether seven selected SNPs in five candidate genes influence risk of subcutaneous fibrosis and telangiectasia after radiotherapy...
  60. ncbi request reprint ATM sequence variants and risk of radiation-induced subcutaneous fibrosis after postmastectomy radiotherapy
    Christian N Andreassen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Int J Radiat Oncol Biol Phys 64:776-83. 2006
    ....
  61. ncbi request reprint Strain and tumour specific variations in the effect of hypoxia on osteopontin levels in experimental models
    Slavka Lukacova
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 80:165-71. 2006
    ..To investigate the relationship between tumour hypoxia and serum and tumour osteopontin (OPN) levels...
  62. ncbi request reprint The prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: a prospective international multi-center study
    Marianne Nordsmark
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 80:123-31. 2006
    ..Here, we present the results of a prospective international multi-centre study evaluating the prognostic value of pre-treatment tumour oxygen partial pressure (pO(2)) and the hypoxia marker pimonidazole (pimo)...
  63. doi request reprint Resolution in PET hypoxia imaging: voxel size matters
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Acta Oncol 47:1201-10. 2008
    ....
  64. ncbi request reprint Preclinical studies on how to deal with patient intolerance to nicotinamide and carbogen
    Michael R Horsman
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, Bldg 5, DK 8000 Aarhus C, Denmark
    Radiother Oncol 70:301-9. 2004
    ..This study investigated the effect of reducing both the nicotinamide dose and carbogen CO(2) content on radiation response...
  65. doi request reprint Accelerated partial breast irradiation as part of breast conserving therapy of early breast carcinoma: a systematic review
    Birgitte V Offersen
    Department of Oncology, Aarhus University Hospital, Aarhus C, Denmark
    Radiother Oncol 90:1-13. 2009
    ..Patient selection for this therapy is pivotal and based on evidence from previous studies on patient/tumour characteristics and pattern of local recurrences we propose inclusion criteria for patients in APBI protocols...
  66. ncbi request reprint Changes from 1992 to 2002 in the pretreatment delay for patients with squamous cell carcinoma of larynx or pharynx: a Danish nationwide survey from DAHANCA
    Hanne Primdahl
    Department of Oncology, Aarhus University Hospital, Denmark
    Acta Oncol 45:156-61. 2006
    ..The prolongation was mainly related to shortage of radiotherapy capacity. The three weeks extra pretreatment delay could theoretically lead to a 10% lower tumor control probability in 2002 compared to 1992...
  67. ncbi request reprint The possible role of TP53 mutation status in the treatment of squamous cell carcinomas of the head and neck (HNSCC) with radiotherapy with different overall treatment times
    Jesper Grau Eriksen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Radiother Oncol 76:135-42. 2005
    ..Furthermore, HNSCC with mutated TP53, may have a higher proliferative potential caused by a lack of control in G1 checkpoint. Our aim of the study was to identify the role of TP53 mutations for the outcome of radiotherapy...
  68. ncbi request reprint Urokinase plasminogen activator and plasminogen activator inhibitor type-1 in nonsmall-cell lung cancer: relation to prognosis and angiogenesis
    Birgitte Vrou Offersen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, Bld 5, DK 8000 Aarhus C, Denmark
    Lung Cancer 56:43-50. 2007
    ..We investigate whether uPA and PAI-1 are prognostic markers in NSCLC and whether they are related to angiogenesis...
  69. doi request reprint The importance of haemoglobin level and effect of transfusion in HNSCC patients treated with radiotherapy--results from the randomized DAHANCA 5 study
    Camilla Molich Hoff
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 98:28-33. 2011
    ..The aim of the study was to evaluate the prognostic significance of low Hb level and its modification by transfusion in HNSCC patients treated with radiotherapy. The study was performed as a subrandomization in the DAHANCA 5 trial...
  70. ncbi request reprint Prognostic factors, pattern of recurrence and survival in a Danish bladder cancer cohort treated with radical cystectomy
    Marianne M Knap
    Department of Urology, Aarhus University Hospital, Aarhus, Denmark
    Acta Oncol 42:160-8. 2003
    ..Patients with advanced T or with perineural/vessel invasion are in need of improved treatment options. Patients with superficial tumours at high risk of progression should be offered early cystectomy...
  71. ncbi request reprint Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas
    Marianne Nordsmark
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Radiother Oncol 67:35-44. 2003
    ..In this paper the aim was to study the relationship between such physiological measurements of tumour hypoxia and the labelling of tumours with the hypoxia-specific marker pimonidazole...
  72. ncbi request reprint Relationship between radiobiological hypoxia in a C3H mouse mammary carcinoma and osteopontin levels in mouse serum
    Slavka Lukacova
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus C, Denmark
    Int J Radiat Biol 81:937-44. 2005
    ..To investigate the possible relationship between radiobiological hypoxia in a C3H mouse mammary carcinoma and osteopontin (OPN) levels measured in mouse serum...
  73. ncbi request reprint Does variability in normal tissue reactions after radiotherapy have a genetic basis--where and how to look for it?
    Christian Nicolaj Andreassen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Noerrebrogade 44, Aarhus C, Denmark
    Radiother Oncol 64:131-40. 2002
    ..However, to achieve maximum benefit from these advances, carefully designed clinical studies with an accrual of hundreds or thousands of patients are probably needed...
  74. ncbi request reprint The prognostic value of epidermal growth factor receptor is related to tumor differentiation and the overall treatment time of radiotherapy in squamous cell carcinomas of the head and neck
    Jesper Grau Eriksen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Noerrebrogade 44, Building 5, DK 8000 Aarhus, Denmark
    Int J Radiat Oncol Biol Phys 58:561-6. 2004
    ..The tumor response to variations in fractionation is heterogeneous, and the prognostic impact of EGFr and differentiation might be relative and dependent on the overall treatment time of radiotherapy...
  75. ncbi request reprint Glottic carcinoma--patterns of failure and salvage treatment after curative radiotherapy in 861 consecutive patients
    Lars Vendelbo Johansen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Radiother Oncol 63:257-67. 2002
    ..The aim of this study was to evaluate the patterns of failure and the treatment of recurrences, in a series of primary irradiated patients with squamous cell carcinoma of the glottic larynx...
  76. ncbi request reprint Laryngeal carcinoma--multivariate analysis of prognostic factors in 1252 consecutive patients treated with primary radiotherapy
    Lars V Johansen
    Department of Experimental Clinical Oncology, Danish Cancer Society, Aarhus University Hospital, Aarhus, Denmark
    Acta Oncol 42:771-8. 2003
    ..Independent prognostic factors in the multivariate analyses were gender, region of origin, T-stage, nodal involvement, differentiation and hemoglobin...
  77. ncbi request reprint Intravascular contrast agent-enhanced MRI measuring contrast clearance and tumor blood volume and the effects of vascular modifiers in an experimental tumor
    Lise Bentzen
    Experimental Clinical Oncology, Arhus University Hospital, Nørrebrogade 44, Bld 5, DK 8000 Aarhus C, Denmark
    Int J Radiat Oncol Biol Phys 61:1208-15. 2005
    ....
  78. pmc The myofibroblast is the predominant plasminogen activator inhibitor-1-expressing cell type in human breast carcinomas
    Birgitte Vrou Offersen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, Building 5, DK 8000 Aarhus C, Denmark
    Am J Pathol 163:1887-99. 2003
    ..In conclusion, we have provided a robust immunohistochemical procedure for detection of PAI-1 and shown that the majority of the PAI-1-expressing cells in invasive ductal breast carcinomas are myofibroblasts...
  79. doi request reprint Long-term evaluation of postmastectomy breast reconstruction
    Bekka O Christensen
    Department of Plastic Surgery, Aarhus University Hospital, Denmark
    Acta Oncol 50:1053-61. 2011
    ..The current study examined the long-term results from three methods of breast reconstruction to assess the subjective and the objective outcome...
  80. ncbi request reprint Validity and representativity in the Danish Breast Cancer Cooperative Group--a study on protocol allocation and data validity from one county to a multi-centre database
    Anni R Jensen
    Cancer Documentation, Department of Experimental Clinical Oncology, The Danish Cancer Society, Aarhus University Hospital, Denmark
    Acta Oncol 42:179-85. 2003
    ..The DBCG database holds high-quality data, but as a population-based database, it is neither comprehensive nor representative...
  81. ncbi request reprint Assessment of hypoxia in experimental mice tumours by [18F]fluoromisonidazole PET and pO2 electrode measurements. Influence of tumour volume and carbogen breathing
    Lise Bentzen
    Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus University Hospital, Noerrebrogade 44, Bld 5, DK 8000 Aarhus C, Denmark
    Acta Oncol 41:304-12. 2002
    ..Autoradiography confirmed lower [18F]FMISO uptake in tumours of carbogen-breathing animals compared with air-breathing animals, and demonstrated the heterogeneity of the tracer uptake in small compared with larger tumours...
  82. ncbi request reprint Radiation administered as a large single dose or in a fractionated schedule: Role of the tumour vasculature as a target for influencing response
    Michael R Horsman
    Department of Experimental Clinical Oncology, Aarhus University Hospital, DK 8000, Aarhus C, Denmark
    Acta Oncol 45:876-80. 2006
    ..Our results confirm that radiation given in a large single dose is superior to the same dose given in a more conventional fractionated schedule, but vascular-mediated effects did not account for this difference in radiation sensitivity...
  83. ncbi request reprint Comparison of methods of microvascular staining and quantification in prostate carcinoma: relevance to prognosis
    Birgitte Vrou Offersen
    Department of Experimental Clinical Oncology, University Hospital of Aarhus, Denmark
    APMIS 110:177-85. 2002
    ..In conclusion, anti-CD34 antibodies are sensitive endothelial markers in prostate carcinoma, and the investigated counting methods are compatible. Moreover, high vascular scores seem to carry a poor prognosis...
  84. ncbi request reprint Chalkley estimates of angiogenesis in early breast cancer--relevance to prognosis
    Birgitte V Offersen
    Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Acta Oncol 41:695-703. 2002
    ..Thus, in a univariate analysis it was found that high Chalkley estimates of angiogenesis indicated a poor prognosis, but high Chalkley estimates were independent prognostic markers only in node-positive patients...
  85. ncbi request reprint The influence of epidermal growth factor receptor and tumor differentiation on the response to accelerated radiotherapy of squamous cell carcinomas of the head and neck in the randomized DAHANCA 6 and 7 study
    Jesper G Eriksen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Radiother Oncol 74:93-100. 2005
    ..The aim of the current study was to address the influence of EGFr and histopathological differentiation when the overall treatment time of radiotherapy was moderately reduced...
  86. ncbi request reprint Low-dose total body irradiation augments the therapeutic effect of interleukin-2 in a mouse model for metastatic malignant melanoma
    Akmal Safwat
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Institute for Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark
    J Exp Ther Oncol 3:161-8. 2003
    ..However, the use of LTBI in combination with IL-2 or other forms of immunotherapy has not been tested before...
  87. ncbi request reprint Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study
    Marianne Nordsmark
    Department of Experimental Clinical Oncology, Aarhus University Hospital, DK, Denmark
    Radiother Oncol 77:18-24. 2005
    ..To analyze the relationship between pre-treatment measurements of tumor oxygen tension (pO2) and survival in advanced head and neck cancer...
  88. ncbi request reprint Early and late treatment-related morbidity following radical cystectomy
    Marianne M Knap
    Department of Urology, Aarhus University Hospital, Denmark
    Scand J Urol Nephrol 38:153-60. 2004
    ..To evaluate treatment-related morbidity following cystectomy in a cohort of consecutive bladder cancer patients. The impact of age, comorbid condition, previous pelvic radiotherapy and type of urinary diversion was analysed...
  89. ncbi request reprint Impact of delay on diagnosis and treatment of primary lung cancer
    Anni R Jensen
    Department of Experimental Clinical Oncology, The Danish Cancer Society, Aaarhus University Hospital
    Acta Oncol 41:147-52. 2002
    ..Large-scale cohort studies within well-defined catchment areas are required both to establish the prognostic impact of delays and to understand the natural progression of lung cancers...
  90. ncbi request reprint Radiation-induced gene expression in human subcutaneous fibroblasts is predictive of radiation-induced fibrosis
    Olaug Kristin Rødningen
    Department of Genetics, Institute of Cancer Research, Rikshospitalet Radiumhospitalet Medical Centre, Oslo, Norway
    Radiother Oncol 86:314-20. 2008
    ..Our aim was to identify basal and radiation-induced transcriptional profiles in fibroblasts from breast cancer patients that might be related to the individual risk of RIF in these patients...
  91. ncbi request reprint Familial cancer associated with a polymorphism in ARLTS1
    George Adrian Calin
    Thomas Jefferson University, Philadelphia, USA
    N Engl J Med 352:1667-76. 2005
    ..The finding of hemizygous or homozygous deletions at band 14 on chromosome 13 in a variety of neoplasms suggests the presence of a tumor-suppressor locus telomeric to the RB1 gene...
  92. ncbi request reprint Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis
    Jean Bourhis
    Radiation Oncology Department, Institut Gustave Roussy, Villejuif, France
    Lancet 368:843-54. 2006
    ..The aim of this meta-analysis was to assess whether this type of radiotherapy could improve survival...
  93. ncbi request reprint Effect of adjuvant systemic treatment on cosmetic outcome and late normal-tissue reactions after breast conservation
    Jørgen Johansen
    Department of Oncology, Odense University Hospital, Odense, Denmark
    Acta Oncol 46:525-33. 2007
    ..Axillary irradiation increased the incidence of moderate to severe breast fibrosis in both premenopausal and postmenopausal patients...
  94. ncbi request reprint Influence of oxygen concentration and pH on expression of hypoxia induced genes
    Brita Singers Sørensen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 76:187-93. 2005
    ....
  95. ncbi request reprint Genetic predictors of adverse radiotherapy effects: the Gene-PARE project
    Alice Y Ho
    Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY, USA
    Int J Radiat Oncol Biol Phys 65:646-55. 2006
    ..The purpose of the Genetic Predictors of Adverse Radiotherapy Effects (Gene-PARE) project is to help achieve this goal...
  96. ncbi request reprint Microarray analysis of the transcriptional response to single or multiple doses of ionizing radiation in human subcutaneous fibroblasts
    Olaug Kristin Rødningen
    Department of Genetics, Institute of Cancer Research, Faculty Division, The Norwegian Radium Hospital, University of Oslo, Norway
    Radiother Oncol 77:231-40. 2005
    ....
  97. ncbi request reprint Prospective study of 18FDG-PET in the detection and management of patients with lymph node metastases to the neck from an unknown primary tumor. Results from the DAHANCA-13 study
    Jørgen Johansen
    Department of Oncology, Odense University Hospital, Odense, Denmark
    Head Neck 30:471-8. 2008
    ..The benefit of a complementary fluorodeoxyglucose-positron emission tomography (FDG-PET) scan to standard workup for carcinoma of unknown primary (CUP) and metastatic neck lesions was prospectively studied...
  98. ncbi request reprint retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danis
    Ann S Knoop
    Oncological Department, Odense University Hospital DK 5000, Odense C, Denmark
    J Clin Oncol 23:7483-90. 2005
    ..The aim of the study was to evaluate the predictive value of HER2 and topoisomerase IIalpha gene (TOP2A) for the efficacy of epirubicin in the adjuvant setting of breast cancer patients...