Marianne Nordsmark

Summary

Affiliation: Aarhus University Hospital
Country: Denmark

Publications

  1. ncbi request reprint Invasive oxygen measurements and pimonidazole labeling in human cervix carcinoma
    M Nordsmark
    Department of Experimental Clinical Oncology, Danish Cancer Society, Aarhus University Hospital, Aarhus, Denmark
    Int J Radiat Oncol Biol Phys 49:581-6. 2001
  2. ncbi request reprint Tumor hypoxia is independent of hemoglobin and prognostic for loco-regional tumor control after primary radiotherapy in advanced head and neck cancer
    Marianne Nordsmark
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Acta Oncol 43:396-403. 2004
  3. ncbi request reprint Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study
    Marianne Nordsmark
    Department of Experimental Clinical Oncology, Aarhus University Hospital, DK, Denmark
    Radiother Oncol 77:18-24. 2005
  4. ncbi request reprint The prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: a prospective international multi-center study
    Marianne Nordsmark
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 80:123-31. 2006
  5. ncbi request reprint Differential risk assessments from five hypoxia specific assays: The basis for biologically adapted individualized radiotherapy in advanced head and neck cancer patients
    Marianne Nordsmark
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 83:389-97. 2007
  6. ncbi request reprint Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas
    Marianne Nordsmark
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Radiother Oncol 67:35-44. 2003
  7. ncbi request reprint Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial
    Jens Overgaard
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, DK 8000 Aarhus C, Denmark
    Lancet Oncol 6:757-64. 2005
  8. doi request reprint Identifying hypoxia in human tumors: A correlation study between 18F-FMISO PET and the Eppendorf oxygen-sensitive electrode
    Lise Saksø Mortensen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Acta Oncol 49:934-40. 2010
  9. doi request reprint PET imaging of tumor hypoxia using 18F-labeled pimonidazole
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital AUH, Aarhus, Denmark
    Acta Oncol 52:1300-7. 2013
  10. doi request reprint FAZA PET/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: results from the DAHANCA 24 trial
    Lise Saksø Mortensen
    Aarhus University Hospital, Denmark
    Radiother Oncol 105:14-20. 2012

Detail Information

Publications20

  1. ncbi request reprint Invasive oxygen measurements and pimonidazole labeling in human cervix carcinoma
    M Nordsmark
    Department of Experimental Clinical Oncology, Danish Cancer Society, Aarhus University Hospital, Aarhus, Denmark
    Int J Radiat Oncol Biol Phys 49:581-6. 2001
    ..This study was designed to compare tumor hypoxia assessed by invasive O2 sensitive electrodes and pimonidazole labeling in primary human cervix carcinomas...
  2. ncbi request reprint Tumor hypoxia is independent of hemoglobin and prognostic for loco-regional tumor control after primary radiotherapy in advanced head and neck cancer
    Marianne Nordsmark
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Acta Oncol 43:396-403. 2004
    ..5 as continuous variable was independently the strongest prognostic indicator for loco-regional tumor control after definitive primary radiotherapy in advanced head and neck tumors...
  3. ncbi request reprint Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study
    Marianne Nordsmark
    Department of Experimental Clinical Oncology, Aarhus University Hospital, DK, Denmark
    Radiother Oncol 77:18-24. 2005
    ..To analyze the relationship between pre-treatment measurements of tumor oxygen tension (pO2) and survival in advanced head and neck cancer...
  4. ncbi request reprint The prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: a prospective international multi-center study
    Marianne Nordsmark
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 80:123-31. 2006
    ..Here, we present the results of a prospective international multi-centre study evaluating the prognostic value of pre-treatment tumour oxygen partial pressure (pO(2)) and the hypoxia marker pimonidazole (pimo)...
  5. ncbi request reprint Differential risk assessments from five hypoxia specific assays: The basis for biologically adapted individualized radiotherapy in advanced head and neck cancer patients
    Marianne Nordsmark
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 83:389-97. 2007
    ..Hypoxia adversely relates with prognosis in human tumours. Five hypoxia specific predictive marker assays were compared and correlated with definitive radiotherapy...
  6. ncbi request reprint Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas
    Marianne Nordsmark
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Radiother Oncol 67:35-44. 2003
    ..In this paper the aim was to study the relationship between such physiological measurements of tumour hypoxia and the labelling of tumours with the hypoxia-specific marker pimonidazole...
  7. ncbi request reprint Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial
    Jens Overgaard
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, DK 8000 Aarhus C, Denmark
    Lancet Oncol 6:757-64. 2005
    ..However, whether all patients benefit from such modification of hypoxia is unclear. We aimed to assess whether the concentration of plasma osteopontin could predict response to the hypoxia radiosensitiser...
  8. doi request reprint Identifying hypoxia in human tumors: A correlation study between 18F-FMISO PET and the Eppendorf oxygen-sensitive electrode
    Lise Saksø Mortensen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Acta Oncol 49:934-40. 2010
    ..The aim of this study was to examine the association between measures of hypoxia defined by functional imaging and Eppendorf pO(2) electrodes...
  9. doi request reprint PET imaging of tumor hypoxia using 18F-labeled pimonidazole
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital AUH, Aarhus, Denmark
    Acta Oncol 52:1300-7. 2013
    ..Pimonidazole has excellent chemical properties for hypoxia imaging, but labeling for non- invasive assay has not been attempted. Here we labeled pimonidazole with (18)F ([(18)F]FPIMO)...
  10. doi request reprint FAZA PET/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: results from the DAHANCA 24 trial
    Lise Saksø Mortensen
    Aarhus University Hospital, Denmark
    Radiother Oncol 105:14-20. 2012
    ..The purpose of this study was to evaluate (18)F-fluoroazomycin arabinoside (FAZA) positron emission tomography (PET)/computed tomography (CT) hypoxia imaging as a prognostic factor in HNSCC patients receiving radiotherapy...
  11. doi request reprint Increased intratumoral FOXP3-positive regulatory immune cells during interleukin-2 treatment in metastatic renal cell carcinoma
    Hanne Krogh Jensen
    Department of Oncology and Experimental Clinical Oncology, Aarhus University Hospital, Noerrebrogade 44, Aarhus C, Denmark
    Clin Cancer Res 15:1052-8. 2009
    ..The impact of IL-2-based therapy on the accumulation of FOXP3-positive immune cells in the tumor microenvironment in metastatic renal cell carcinoma is unknown...
  12. doi request reprint Development of a hypoxia gene expression classifier with predictive impact for hypoxic modification of radiotherapy in head and neck cancer
    Kasper Toustrup
    Department of Experimental Clinical Oncology, Aarhus University Hospital and Bioinformatics Research Centre, Aarhus University, Aarhus C, Denmark
    Cancer Res 71:5923-31. 2011
    ..Thus, findings show that the classifier attained both prognostic and predictive impact, and its pretherapeutic use may provide a method to identify those patients who will benefit from hypoxic modification of radiotherapy...
  13. doi request reprint Accessing radiation response using hypoxia PET imaging and oxygen sensitive electrodes: a preclinical study
    Lise Saksø Mortensen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 99:418-23. 2011
    ..The aim of this study was to investigate the prognostic value of hypoxia measured by (18)F-fluoroazomycin arabinoside ((18)F-FAZA) PET or the Eppendorf oxygen electrode in a pre-clinical tumor model...
  14. doi request reprint Presence of intratumoral neutrophils is an independent prognostic factor in localized renal cell carcinoma
    Hanne Krogh Jensen
    Department of Oncology, Aarhus University Hospital, 8000 Aarhus C, Denmark
    J Clin Oncol 27:4709-17. 2009
    ..We have previously demonstrated a significant negative impact of intratumoral neutrophils in metastatic renal cell carcinoma. This study assessed intratumoral neutrophils in localized clear cell renal cell carcinoma (RCC)...
  15. doi request reprint Hypoxia-regulated gene expression and prognosis in loco-regional gastroesophageal cancer
    Mette Winther
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Acta Oncol 52:1327-35. 2013
    ..The aim of this study was to evaluate potential prognostic factors in terms of a subset of hypoxia-responsive genes and clinicopathological parameters in patients with gastroesophageal cancer...
  16. ncbi request reprint Tumour oxygenation assessed by 18F-fluoromisonidazole PET and polarographic needle electrodes in human soft tissue tumours
    Lise Bentzen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Noerrebrogade 4, DK 8000 Aarhus C, Denmark
    Radiother Oncol 67:339-44. 2003
    ..The aim of the study was to identify hypoxia in human soft tissue sarcomas (STS) by PET scanning using the hypoxia marker [18F]-fluoromisonidazole ([18F]FMISO) and invasive oxygen sensitive probes (Eppendorf pO2 Histograph, Germany)...
  17. doi request reprint Daily cone-beam computed tomography used to determine tumour shrinkage and localisation in lung cancer patients
    Marianne Marquard Knap
    Aarhus University Hospital, Department of Oncology, Aarhus, Denmark
    Acta Oncol 49:1077-84. 2010
    ..Daily Cone-beam computed tomography (CBCT) in room imaging is used to determine tumour shrinkage during a full radiotherapy (RT) course. In addition, relative interfractional tumour and lymph node motion is determined for each RT fraction...
  18. doi request reprint Immunohistochemical expression of carbonic anhydrase IX assessed over time and during treatment in renal cell carcinoma
    Hanne Krogh Jensen
    Department of Oncology, Aarhus University Hospital, Aarhus C, Denmark
    BJU Int 101:41-4. 2008
  19. pmc Germline mutation in RNASEL predicts increased risk of head and neck, uterine cervix and breast cancer
    Bo Eskerod Madsen
    Bioinformatics Research Center, University of Aarhus, Aarhus, Denmark
    PLoS ONE 3:e2492. 2008
    ..A genetic predisposition could explain why some viral infections persist and induce cancer, while others disappear spontaneously. This points at RNASEL as a strong susceptibility gene...
  20. pmc Advanced hepatocellular carcinoma in adolescence associated with congenital cholestasis: a case description
    Morten Ladekarl
    Department of Oncology, Aarhus University Hospital, Aarhus, Denmark, Norway
    Case Rep Oncol 6:98-103. 2013
    ..The disease was thought to be caused by a congenital cholestatic syndrome associated with intermittent oedema in childhood, resembling the rare Aagenaes syndrome. Treatment choices in advanced HCC arising in adolescence are discussed...