Jimmi Nielsen

Summary

Affiliation: Aarhus University Hospital
Country: Denmark

Publications

  1. ncbi request reprint Termination of clozapine treatment due to medical reasons: when is it warranted and how can it be avoided?
    Jimmi Nielsen
    Centre for Schizophrenia, Aalborg Psychiatric Hospital, Brandevej 5, 9210 Aalborg, N A 9000, Denmark
    J Clin Psychiatry 74:603-13; quiz 613. 2013
  2. doi request reprint Real-world effectiveness of clozapine in patients with bipolar disorder: results from a 2-year mirror-image study
    Jimmi Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Aalborg, Denmark
    Bipolar Disord 14:863-9. 2012
  3. ncbi request reprint Predictors of clozapine response in patients with treatment-refractory schizophrenia: results from a Danish Register Study
    Jimmi Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Aalborg, Denmark
    J Clin Psychopharmacol 32:678-83. 2012
  4. doi request reprint Geographical and temporal variations in clozapine prescription for schizophrenia
    Jimmi Nielsen
    Centre for Schizophrenia, Aalborg Psychiatric Hospital, Aarhus University Hospital, Denmark
    Eur Neuropsychopharmacol 22:818-24. 2012
  5. doi request reprint Hematological clozapine monitoring with a point-of-care device: a randomized cross-over trial
    Jimmi Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Denmark
    Eur Neuropsychopharmacol 22:401-5. 2012
  6. pmc Risk factors for ileus in patients with schizophrenia
    Jimmi Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Mølleparkvej 10, PO Box 210, DK 9100 Aalborg, Denmark
    Schizophr Bull 38:592-8. 2012
  7. doi request reprint Augmenting clozapine with sertindole: a double-blind, randomized, placebo-controlled study
    Jimmi Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Aalborg, Denmark
    J Clin Psychopharmacol 32:173-8. 2012
  8. doi request reprint Optimizing clozapine treatment
    J Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Denmark
    Acta Psychiatr Scand 123:411-22. 2011
  9. doi request reprint Assessing QT interval prolongation and its associated risks with antipsychotics
    Jimmi Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Aalborg, Denmark
    CNS Drugs 25:473-90. 2011
  10. doi request reprint Do we agree about when patients are psychotic?
    J Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aalborg, Denmark
    Acta Psychiatr Scand 118:330-3. 2008

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Termination of clozapine treatment due to medical reasons: when is it warranted and how can it be avoided?
    Jimmi Nielsen
    Centre for Schizophrenia, Aalborg Psychiatric Hospital, Brandevej 5, 9210 Aalborg, N A 9000, Denmark
    J Clin Psychiatry 74:603-13; quiz 613. 2013
    ....
  2. doi request reprint Real-world effectiveness of clozapine in patients with bipolar disorder: results from a 2-year mirror-image study
    Jimmi Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Aalborg, Denmark
    Bipolar Disord 14:863-9. 2012
    ..Clozapine remains the drug of choice for treatment-resistant schizophrenia but the evidence for its use in severe bipolar disorder (BD) remains sparse...
  3. ncbi request reprint Predictors of clozapine response in patients with treatment-refractory schizophrenia: results from a Danish Register Study
    Jimmi Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Aalborg, Denmark
    J Clin Psychopharmacol 32:678-83. 2012
    ..Although the study design does not allow any causal inferences, all 3 models suggested a lower number of psychiatric hospitalizations and antipsychotic trials before clozapine initiation to be associated with greater clozapine response...
  4. doi request reprint Geographical and temporal variations in clozapine prescription for schizophrenia
    Jimmi Nielsen
    Centre for Schizophrenia, Aalborg Psychiatric Hospital, Aarhus University Hospital, Denmark
    Eur Neuropsychopharmacol 22:818-24. 2012
    ..7% to 16.8%, with 10.2% as the national mean. Although, the percentage of schizophrenia patients receiving clozapine increased from 1996 to 2007, the time from diagnosis of schizophrenia until first prescription of clozapine increased...
  5. doi request reprint Hematological clozapine monitoring with a point-of-care device: a randomized cross-over trial
    Jimmi Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Denmark
    Eur Neuropsychopharmacol 22:401-5. 2012
    ..05-0.7 vs. 2.3 cm 25-75 percentiles: 0.75-4.5, p<0.001). For hematological monitoring of clozapine patients a point-of-care device based on capillary blood sampling is better tolerated than traditional venous blood sampling...
  6. pmc Risk factors for ileus in patients with schizophrenia
    Jimmi Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Mølleparkvej 10, PO Box 210, DK 9100 Aalborg, Denmark
    Schizophr Bull 38:592-8. 2012
    ..Patients receiving psychotropics associated with significant anticholinergic properties should undergo proper monitoring and interventions in order to minimize the burden of constipation and the risk of ileus...
  7. doi request reprint Augmenting clozapine with sertindole: a double-blind, randomized, placebo-controlled study
    Jimmi Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Aalborg, Denmark
    J Clin Psychopharmacol 32:173-8. 2012
    ..03). Augmentation with sertindole showed no benefits compared with placebo. Psychiatrists should be aware that augmentation might not add any benefits for the patients and in some cases worsen psychosis...
  8. doi request reprint Optimizing clozapine treatment
    J Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Denmark
    Acta Psychiatr Scand 123:411-22. 2011
    ..This clinical overview aims to provide psychiatrists with knowledge about how to optimize clozapine treatment. Relevant strategies for reducing side-effects and increasing the likelihood of response are discussed...
  9. doi request reprint Assessing QT interval prolongation and its associated risks with antipsychotics
    Jimmi Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Aalborg, Denmark
    CNS Drugs 25:473-90. 2011
    ....
  10. doi request reprint Do we agree about when patients are psychotic?
    J Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aalborg, Denmark
    Acta Psychiatr Scand 118:330-3. 2008
    ..To investigate into the use of the term 'psychotic' as defined by ICD-10 or by the concept of impaired reality testing, among psychiatric staff members...
  11. ncbi request reprint The safety of atypical antipsychotics: does QTc provide all the answers?
    Jimmi Nielsen
    Expert Opin Drug Saf 10:341-4. 2011
    ..In addition to this, suboptimal treatment may result in life-shortening behaviors such as suicide. A shared decision including a thorough discussion of risks and benefits with the patients is essential...
  12. ncbi request reprint Sertindole causes distinct electrocardiographic T-wave morphology changes
    Jimmi Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Mølleparkvej 10, PO Box 210, DK 9100 Aalborg, Denmark
    Eur Neuropsychopharmacol 19:702-7. 2009
    ..92; 95% CI: 1.35-2.49) compared to the mean effect size for QTcF (ES=0.88; 95% CI: 0.52-1.24). The use of T-wave morphology analysis may become clinically relevant, particularly if shown to be associated with drug-induced arrhythmia risk...
  13. doi request reprint Determinants of poor dental care in patients with schizophrenia: a historical, prospective database study
    Jimmi Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Mølleparkvej 10, PO Box 210, DK 9100 Aalborg, Denmark
    J Clin Psychiatry 72:140-3. 2011
    ..Oral health status is poor and a disregarded health issue among patients with schizophrenia that is associated with the risk for additional social stigmatization and potentially fatal infections...
  14. doi request reprint 10-year trends in the treatment and outcomes of patients with first-episode schizophrenia
    Jimmi Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Aalborg, Denmark
    Acta Psychiatr Scand 122:356-66. 2010
    ..The first episode of schizophrenia is a critical period for illness course and outcomes. We aimed to investigate treatments and outcomes during the first year after the diagnosis of schizophrenia...
  15. pmc Antipsychotics associated with the development of type 2 diabetes in antipsychotic-naïve schizophrenia patients
    Jimmi Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Mølleparkvej 10, Aalborg, Denmark
    Neuropsychopharmacology 35:1997-2004. 2010
    ..Patients discontinuing olanzapine or mid-potency FGA had no increased risk of diabetes compared with patient not treated with the drugs at anytime...
  16. ncbi request reprint The effect of sertindole on QTD and TPTE
    J Nielsen
    Aalborg Psychiatric Hospital, Aarhus University Hospital, Denmark
    Acta Psychiatr Scand 121:385-8. 2010
    ..While sertindole significantly prolongs the QTc interval, the effects on other markers of arrhythmia risk, such as QTc dispersion and Tpeak-Tend are unknown...
  17. ncbi request reprint Psychiatrists' attitude towards and knowledge of clozapine treatment
    J Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, 9100 Aalborg, Denmark
    J Psychopharmacol 24:965-71. 2010
    ..A reason for the low awareness of clozapine's properties might be that clozapine is now a generic drug, and therefore, the marketing and education in using the drug is sparse...
  18. doi request reprint Increased use of antibiotics in patients treated with clozapine
    Jimmi Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Mølleparkvej 10, PO Box 210, DK 9100 Aalborg, Denmark
    Eur Neuropsychopharmacol 19:483-6. 2009
    ..The findings reported here should alert clinicians to be mindful of infectious processes as yet another possible somatic manifestation of clozapine treatment...
  19. doi request reprint Schizophrenia, antipsychotics and risk of hip fracture: a population-based analysis
    Holger J Sørensen
    Centre for Schizophrenia, Aalborg Psychiatric Hospital, Aarhus University Hospital, Brandevej 5, 9220 Aalborg Øst, Denmark
    Eur Neuropsychopharmacol 23:872-8. 2013
    ..Preventive strategies should focus attention to severely ill patients with high likelihood of a receiving complex psychopharmacologic treatment and high doses of antipsychotics. ..
  20. doi request reprint The association between psychotic mania, psychotic depression and mixed affective episodes among 14,529 patients with bipolar disorder
    Søren Dinesen Ostergaard
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Aalborg, Denmark
    J Affect Disord 147:44-50. 2013
    ..The present study aimed to investigate whether the occurrence of PM, PD and MAE were associated with one another...
  21. doi request reprint Characteristics and predictors of long-term institutionalization in patients with schizophrenia
    Peter Uggerby
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Mølleparkvej 10, PO Box 210, DK 9100 Aalborg, Denmark
    Schizophr Res 131:120-6. 2011
    ..Patients with schizophrenia requiring long-term institutionalization represent those with the worst outcome, leading to personal costs for patients and relatives and constituting a large economical burden for society...
  22. ncbi request reprint Neuroleptic malignant syndrome-an 11-year longitudinal case-control study
    Rene Ernst Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Aalborg, Denmark
    Can J Psychiatry 57:512-8. 2012
    ..To describe patients with neuroleptic malignant syndrome (NMS), to establish occurrence of NMS, to investigate risk factors of NMS, and to investigate mortality associated with NMS...
  23. ncbi request reprint DAI-10 is as good as DAI-30 in schizophrenia
    Rene Ernst Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Aalborg, Denmark
    Eur Neuropsychopharmacol 22:747-50. 2012
    ..DAI is an easy-to-use self-report instrument seemingly assessing a unique clinical dimension relevant to non-adherence. DAI-10 might be preferred for its simplicity and good psychometric properties...
  24. ncbi request reprint The validity of the schizophrenia diagnosis in the Danish Psychiatric Central Research Register is good
    Peter Uggerby
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Mølleparkvej 10, 9100 Aalborg, Denmark
    Dan Med J 60:A4578. 2013
    ..The aim of this study was to investigate the validity of the International Classification of Diseases (ICD)-10 schizophrenia diagnosis in the DPCRR...
  25. ncbi request reprint Quantitative analysis of T-wave morphology increases confidence in drug-induced cardiac repolarization abnormalities: evidence from the investigational IKr inhibitor Lu 35-138
    Claus Graff
    Department of Health Science and Technology, Center for Sensory Motor Interaction, Aalborg University, Aalborg, Denmark
    J Clin Pharmacol 49:1331-42. 2009
    ..As a covariate to the assessment of QT interval liability, MCS offered important additive information to the effect of Lu 35-138 on cardiac repolarization...
  26. ncbi request reprint Risk factors for suicide among 34,671 patients with psychotic and non-psychotic severe depression
    Anne Katrine K Leadholm
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aalborg University Hospital, Aalborg, Denmark Psychiatric Research Unit, Psychiatric Center North Zealand, University of Copenhagen, Hillerød, Denmark Electronic address
    J Affect Disord 156:119-25. 2014
    ..Therefore, this study aimed to identify risk factors for suicide in non-PD and PD separately, and to investigate if the presence of psychotic symptoms is an independent risk factor for suicide in severe depression...
  27. doi request reprint The association between physical morbidity and subtypes of severe depression
    Søren Dinesen Ostergaard
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Aalborg, Denmark
    Psychother Psychosom 82:45-52. 2013
    ..This study aimed to clarify the relationship between a number of physical diseases and the nonpsychotic and psychotic subtype of severe depression...
  28. ncbi request reprint Immunomodulatory effects of clozapine and their clinical implications: what have we learned so far?
    Rasmus Røge
    Centre for Schizophrenia, Aalborg Psychiatric Hospital, Aarhus University Hospital, Denmark
    Schizophr Res 140:204-13. 2012
    ....
  29. doi request reprint Risk factors for conversion from unipolar psychotic depression to bipolar disorder
    Søren Dinesen Østergaard
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aalborg University Hospital, Aalborg, Denmark Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 16:180-9. 2014
    ..This conversion has important implications for the choice of treatment. This study, therefore, aimed to identify risk factors associated with diagnostic conversion from PD to BD...
  30. ncbi request reprint An association between autumn birth and clozapine treatment in patients with schizophrenia: A population-based analysis
    Holger J Sørensen
    Holger J Sørensen, Centre for Schizophrenia, Aalborg University Hospital, and Psychiatric Centre Copenhagen, Capital Region of Copenhagen, Denmark
    Nord J Psychiatry 68:428-32. 2014
    ..The reasons for this relationship remain to be further investigated but might be partially explained by early exposures such as winter flu season and low vitamin D levels. ..