Ole L Munk

Summary

Affiliation: Aarhus University Hospital
Country: Denmark

Publications

  1. doi request reprint Model-independent plot of dynamic PET data facilitates data interpretation and model selection
    Ole Lajord Munk
    Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark
    J Theor Biol 295:1-8. 2012
  2. ncbi request reprint Impulse-response function of splanchnic circulation with model-independent constraints: theory and experimental validation
    Ole L Munk
    Positron Emisssion Tomography Center, Aarhus University Hospital, Denmark
    Am J Physiol Gastrointest Liver Physiol 285:G671-80. 2003
  3. ncbi request reprint Capillaries within compartments: microvascular interpretation of dynamic positron emission tomography data
    Ole Lajord Munk
    PET Center, Aarhus University Hospital, Norrebrogade 44, Aarhus DK 8000, Denmark
    J Theor Biol 225:127-41. 2003
  4. ncbi request reprint Determination of regional flow by use of intravascular PET tracers: microvascular theory and experimental validation for pig livers
    Ole Lajord Munk
    PET Center, Aarhus University Hospital, Aarhus, Denmark
    J Nucl Med 44:1862-70. 2003
  5. pmc A method to estimate dispersion in sampling catheters and to calculate dispersion-free blood time-activity curves
    Ole Lajord Munk
    PET Center Aarhus University Hospital, Aarhus, Denmark
    Med Phys 35:3471-81. 2008
  6. pmc PET kinetics of radiolabeled antidepressant, [N-methyl-11C]mirtazapine, in the human brain
    Ole L Munk
    Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Nørrebrogade 44, Aarhus C 8000, Denmark
    EJNMMI Res 1:36. 2011
  7. ncbi request reprint Detection of alpha2-adrenergic receptors in brain of living pig with 11C-yohimbine
    Steen Jakobsen
    Aarhus University PET Centre and Centre for Functionally Integrative Neuroscience, Aarhus, Denmark
    J Nucl Med 47:2008-15. 2006
  8. ncbi request reprint Effect of hypercapnia on cerebral blood flow and blood volume in pigs studied by positron emission tomography
    Aage K Olsen
    PET Centre, Aarhus University Hospitals and Aarhus University, DK 8000 Aarhus, Denmark
    Comp Med 56:416-20. 2006
  9. ncbi request reprint MDMA-evoked changes in [11C]raclopride and [11C]NMSP binding in living pig brain
    Pedro Rosa-Neto
    Center for Functionally Integrative Neuroscience, Aarhus University and PET Center, Aarhus University Hospitals, Aarhus C, 8000, Denmark
    Synapse 53:222-33. 2004
  10. pmc Hepatic blood perfusion estimated by dynamic contrast-enhanced computed tomography in pigs: limitations of the slope method
    Michael Winterdahl
    Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark
    Invest Radiol 47:588-95. 2012

Detail Information

Publications22

  1. doi request reprint Model-independent plot of dynamic PET data facilitates data interpretation and model selection
    Ole Lajord Munk
    Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark
    J Theor Biol 295:1-8. 2012
    ..The vi-plot is a model-independent and informative plot for data exploration that facilitates the selection of an appropriate method for data analysis...
  2. ncbi request reprint Impulse-response function of splanchnic circulation with model-independent constraints: theory and experimental validation
    Ole L Munk
    Positron Emisssion Tomography Center, Aarhus University Hospital, Denmark
    Am J Physiol Gastrointest Liver Physiol 285:G671-80. 2003
    ..Similarity between our parameter estimates in pigs and parameter estimates in normal humans suggests that the proposed model can be adapted for use in humans...
  3. ncbi request reprint Capillaries within compartments: microvascular interpretation of dynamic positron emission tomography data
    Ole Lajord Munk
    PET Center, Aarhus University Hospital, Norrebrogade 44, Aarhus DK 8000, Denmark
    J Theor Biol 225:127-41. 2003
    ..They are suitable for analysing dynamic PET data from any capillary bed using either intravascular or diffusible tracers, in terms of physiological parameters which include regional blood flow...
  4. ncbi request reprint Determination of regional flow by use of intravascular PET tracers: microvascular theory and experimental validation for pig livers
    Ole Lajord Munk
    PET Center, Aarhus University Hospital, Aarhus, Denmark
    J Nucl Med 44:1862-70. 2003
    ..The microvascular models, which account for concentration gradients in capillaries, are validated and compared with the standard model in a pig liver study...
  5. pmc A method to estimate dispersion in sampling catheters and to calculate dispersion-free blood time-activity curves
    Ole Lajord Munk
    PET Center Aarhus University Hospital, Aarhus, Denmark
    Med Phys 35:3471-81. 2008
    ..Once characteristic parameters are estimated, input functions can be corrected before applying kinetic models. This allows bias-free estimation of kinetic parameters such as blood flow...
  6. pmc PET kinetics of radiolabeled antidepressant, [N-methyl-11C]mirtazapine, in the human brain
    Ole L Munk
    Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Nørrebrogade 44, Aarhus C 8000, Denmark
    EJNMMI Res 1:36. 2011
    ..abstract:..
  7. ncbi request reprint Detection of alpha2-adrenergic receptors in brain of living pig with 11C-yohimbine
    Steen Jakobsen
    Aarhus University PET Centre and Centre for Functionally Integrative Neuroscience, Aarhus, Denmark
    J Nucl Med 47:2008-15. 2006
    ..As a prelude to human studies with (11)C-yohimbine, we determined the whole-body distribution of (11)C-yohimbine and calculated its dosimetry...
  8. ncbi request reprint Effect of hypercapnia on cerebral blood flow and blood volume in pigs studied by positron emission tomography
    Aage K Olsen
    PET Centre, Aarhus University Hospitals and Aarhus University, DK 8000 Aarhus, Denmark
    Comp Med 56:416-20. 2006
    ..086 ml blood/ml brain tissue (n = 6) during hypercapnia. Our observations indicate that pCO2 levels have a major influence on porcine CBF and CBV and should be controlled in studies where a constant level is crucial...
  9. ncbi request reprint MDMA-evoked changes in [11C]raclopride and [11C]NMSP binding in living pig brain
    Pedro Rosa-Neto
    Center for Functionally Integrative Neuroscience, Aarhus University and PET Center, Aarhus University Hospitals, Aarhus C, 8000, Denmark
    Synapse 53:222-33. 2004
    ..Distinct properties of MDMA such as simultaneous release of dopamine and serotonin in brain may account for the present finding of progressive decline in the availability of [11C]NMSP binding sites in striatum...
  10. pmc Hepatic blood perfusion estimated by dynamic contrast-enhanced computed tomography in pigs: limitations of the slope method
    Michael Winterdahl
    Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark
    Invest Radiol 47:588-95. 2012
    ....
  11. ncbi request reprint Distribution of PK11195 binding sites in porcine brain studied by autoradiography in vitro and by positron emission tomography
    Paul Cumming
    PET Centre and Centre for Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark
    Synapse 59:418-26. 2006
    ..Thus, [11C]PK11195 binding was not highly sensitive to constituitively expressed PBBS in brain of young Landrace pigs, and did not clearly demonstrate the expected microglial activation in the MPTP/xenograft model of minipigs...
  12. doi request reprint Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow, not increased ammonia uptake
    Gitte Dam
    PET Centre and Department of Nuclear Medicine, Aarhus University Hospital, Aarhus, Denmark
    Hepatology 57:258-65. 2013
    ..Arterial blood ammonia concentration decreased 20% after recovery (P < 0.05) and CMRA was unchanged (P > 0.30); both values were higher than in the control patients (both P < 0.05)...
  13. pmc Hepatic uptake and metabolism of galactose can be quantified in vivo by 2-[18F]fluoro-2-deoxygalactose positron emission tomography
    Michael Sørensen
    PET Center, Aarhus University Hospital, DK 8000 Aarhus, Denmark
    Am J Physiol Gastrointest Liver Physiol 295:G27-G36. 2008
    ..At near-saturated kinetics, the maximal hepatic removal rate of galactose can be calculated from the net metabolic clearance of FDGal and the blood concentration of galactose...
  14. ncbi request reprint Dynamic FDG-PET is useful for detection of cholangiocarcinoma in patients with PSC listed for liver transplantation
    Hanne Prytz
    Department of Gastroenterology, University Hospital of Lund, Lund, Sweden
    Hepatology 44:1572-80. 2006
    ..In conclusion, dynamic FDG-PET appears superior to conventional imaging techniques for both detection and exclusion of CC in advanced PSC. FDG-PET may be useful for screening for CC in the pretransplant evaluation of patients with PSC...
  15. ncbi request reprint Peripheral benzodiazepine receptors in the brain of cirrhosis patients with manifest hepatic encephalopathy
    Peter Iversen
    PET Centre, Aarhus University Hospital, 8000 Aarhus, Denmark
    Eur J Nucl Med Mol Imaging 33:810-6. 2006
    ....
  16. ncbi request reprint Quantification of (18)F-FDG uptake in the liver using dynamic PET
    Ole Lajord Munk
    J Nucl Med 43:439-41. 2002
  17. ncbi request reprint Brain metabolism of 13N-ammonia during acute hepatic encephalopathy in cirrhosis measured by positron emission tomography
    Susanne Keiding
    Department of Medicine V Hepatology, Aarhus University Hospital, Aarhus, Denmark
    Hepatology 43:42-50. 2006
    ..In conclusion, increased cerebral trapping of ammonia in patients with cirrhosis with acute HE was primarily attributable to increased blood ammonia and to a minor extent to changed ammonia kinetics in the brain...
  18. ncbi request reprint Effect of intratumoral heterogeneity in oxygenation status on FMISO PET, autoradiography, and electrode Po2 measurements in murine tumors
    Michael Sørensen
    PET Center, Aarhus University Hospital, Aarhus, Denmark
    Int J Radiat Oncol Biol Phys 62:854-61. 2005
    ..To explore conflicting results obtained when tumor hypoxia is assessed with Eppendorf electrode Po(2) measurements and with positron emission tomography (PET) by use of [(18)F]fluoromisonidazole (FMISO)...
  19. ncbi request reprint Hepatic microcirculation assessed by positron emission tomography of first-pass ammonia metabolism in porcine liver
    Susanne Keiding
    Department of Medicine V Hepatology and Gastroenterology, Aarhus University Hospital, DK 8000 Aarhus, Denmark
    Liver Int 25:171-6. 2005
    ..We examined the effects of these vascular variations on porcine hepatic first-pass ammonia metabolism, which is characterised by high uptake and separate periportal urea and perivenous glutamine formations...
  20. ncbi request reprint Metabolic fate of 18F-FDG in mice bearing either SCCVII squamous cell carcinoma or C3H mammary carcinoma
    Katrin Kaarstad
    PET Center, Aarhus University Hospital, Denmark
    J Nucl Med 43:940-7. 2002
    ..We therefore wished to characterize the metabolism of 18F-FDG in experimental tumors in mice...
  21. ncbi request reprint 11C-methionine PET, a novel method for measuring regional salivary gland function after radiotherapy of head and neck cancer
    Simon Buus
    PET Centre, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus C, Denmark
    Radiother Oncol 73:289-96. 2004
    ..The aim of this study was to develop a positron emission tomography (PET) method for measuring regional salivary gland function in the major salivary glands irradiated during RT...
  22. ncbi request reprint Individual radiation response of parotid glands investigated by dynamic 11C-methionine PET
    Simon Buus
    PET Centre, Department of Oncology, Aarhus University Hospital, Aarhus, Denmark
    Radiother Oncol 78:262-9. 2006
    ..The aim of this study was to investigate by dynamic 11C-methionine PET the individual radiation dose response relationship of parotid glands in head and neck cancer patients...