Research Topics
| Ole L MunkSummaryAffiliation: Aarhus University Hospital Country: Denmark Publications
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Detail Information
Publications
Model-independent plot of dynamic PET data facilitates data interpretation and model selectionOle Lajord Munk
Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark
J Theor Biol 295:1-8. 2012..The vi-plot is a model-independent and informative plot for data exploration that facilitates the selection of an appropriate method for data analysis...
Impulse-response function of splanchnic circulation with model-independent constraints: theory and experimental validationOle L Munk
Positron Emisssion Tomography Center, Aarhus University Hospital, Denmark
Am J Physiol Gastrointest Liver Physiol 285:G671-80. 2003..Similarity between our parameter estimates in pigs and parameter estimates in normal humans suggests that the proposed model can be adapted for use in humans...- Capillaries within compartments: microvascular interpretation of dynamic positron emission tomography dataOle Lajord Munk
PET Center, Aarhus University Hospital, Norrebrogade 44, Aarhus DK 8000, Denmark
J Theor Biol 225:127-41. 2003..They are suitable for analysing dynamic PET data from any capillary bed using either intravascular or diffusible tracers, in terms of physiological parameters which include regional blood flow... - Determination of regional flow by use of intravascular PET tracers: microvascular theory and experimental validation for pig liversOle Lajord Munk
PET Center, Aarhus University Hospital, Aarhus, Denmark
J Nucl Med 44:1862-70. 2003..The microvascular models, which account for concentration gradients in capillaries, are validated and compared with the standard model in a pig liver study... 
A method to estimate dispersion in sampling catheters and to calculate dispersion-free blood time-activity curvesOle Lajord Munk
PET Center Aarhus University Hospital, Aarhus, Denmark
Med Phys 35:3471-81. 2008..Once characteristic parameters are estimated, input functions can be corrected before applying kinetic models. This allows bias-free estimation of kinetic parameters such as blood flow...- PET kinetics of radiolabeled antidepressant, [N-methyl-11C]mirtazapine, in the human brainOle L Munk
Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Nørrebrogade 44, Aarhus C 8000, Denmark
EJNMMI Res 1:36. 2011..abstract:.. - Detection of alpha2-adrenergic receptors in brain of living pig with 11C-yohimbineSteen Jakobsen
Aarhus University PET Centre and Centre for Functionally Integrative Neuroscience, Aarhus, Denmark
J Nucl Med 47:2008-15. 2006..As a prelude to human studies with (11)C-yohimbine, we determined the whole-body distribution of (11)C-yohimbine and calculated its dosimetry... - Effect of hypercapnia on cerebral blood flow and blood volume in pigs studied by positron emission tomographyAage K Olsen
PET Centre, Aarhus University Hospitals and Aarhus University, DK 8000 Aarhus, Denmark
Comp Med 56:416-20. 2006..086 ml blood/ml brain tissue (n = 6) during hypercapnia. Our observations indicate that pCO2 levels have a major influence on porcine CBF and CBV and should be controlled in studies where a constant level is crucial... - MDMA-evoked changes in [11C]raclopride and [11C]NMSP binding in living pig brainPedro Rosa-Neto
Center for Functionally Integrative Neuroscience, Aarhus University and PET Center, Aarhus University Hospitals, Aarhus C, 8000, Denmark
Synapse 53:222-33. 2004..Distinct properties of MDMA such as simultaneous release of dopamine and serotonin in brain may account for the present finding of progressive decline in the availability of [11C]NMSP binding sites in striatum... - Hepatic blood perfusion estimated by dynamic contrast-enhanced computed tomography in pigs: limitations of the slope methodMichael Winterdahl
Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark
Invest Radiol 47:588-95. 2012.... - Distribution of PK11195 binding sites in porcine brain studied by autoradiography in vitro and by positron emission tomographyPaul Cumming
PET Centre and Centre for Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark
Synapse 59:418-26. 2006..Thus, [11C]PK11195 binding was not highly sensitive to constituitively expressed PBBS in brain of young Landrace pigs, and did not clearly demonstrate the expected microglial activation in the MPTP/xenograft model of minipigs... - Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow, not increased ammonia uptakeGitte Dam
PET Centre and Department of Nuclear Medicine, Aarhus University Hospital, Aarhus, Denmark
Hepatology 57:258-65. 2013..The changes in CMRO(2) and CBF could not be linked to blood ammonia concentration or CMRA... - Hepatic uptake and metabolism of galactose can be quantified in vivo by 2-[18F]fluoro-2-deoxygalactose positron emission tomographyMichael Sørensen
PET Center, Aarhus University Hospital, DK 8000 Aarhus, Denmark
Am J Physiol Gastrointest Liver Physiol 295:G27-G36. 2008..At near-saturated kinetics, the maximal hepatic removal rate of galactose can be calculated from the net metabolic clearance of FDGal and the blood concentration of galactose... - Dynamic FDG-PET is useful for detection of cholangiocarcinoma in patients with PSC listed for liver transplantationHanne Prytz
Department of Gastroenterology, University Hospital of Lund, Lund, Sweden
Hepatology 44:1572-80. 2006..In conclusion, dynamic FDG-PET appears superior to conventional imaging techniques for both detection and exclusion of CC in advanced PSC. FDG-PET may be useful for screening for CC in the pretransplant evaluation of patients with PSC... - Peripheral benzodiazepine receptors in the brain of cirrhosis patients with manifest hepatic encephalopathyPeter Iversen
PET Centre, Aarhus University Hospital, 8000 Aarhus, Denmark
Eur J Nucl Med Mol Imaging 33:810-6. 2006..Mean values of V (d) ranged from 1.0 to 1.1 in both groups of subjects. CONCLUSION: The results do not confirm the hypothesis of an increased number of PBRs in patients with HE... - Quantification of (18)F-FDG uptake in the liver using dynamic PETOle Lajord Munk
J Nucl Med 43:439-41. 2002 - Brain metabolism of 13N-ammonia during acute hepatic encephalopathy in cirrhosis measured by positron emission tomographySusanne Keiding
Department of Medicine V Hepatology, Aarhus University Hospital, Aarhus, Denmark
Hepatology 43:42-50. 2006..In conclusion, increased cerebral trapping of ammonia in patients with cirrhosis with acute HE was primarily attributable to increased blood ammonia and to a minor extent to changed ammonia kinetics in the brain... - Effect of intratumoral heterogeneity in oxygenation status on FMISO PET, autoradiography, and electrode Po2 measurements in murine tumorsMichael Sørensen
PET Center, Aarhus University Hospital, Aarhus, Denmark
Int J Radiat Oncol Biol Phys 62:854-61. 2005..To explore conflicting results obtained when tumor hypoxia is assessed with Eppendorf electrode Po(2) measurements and with positron emission tomography (PET) by use of [(18)F]fluoromisonidazole (FMISO)... - Hepatic microcirculation assessed by positron emission tomography of first-pass ammonia metabolism in porcine liverSusanne Keiding
Department of Medicine V Hepatology and Gastroenterology, Aarhus University Hospital, DK 8000 Aarhus, Denmark
Liver Int 25:171-6. 2005..We examined the effects of these vascular variations on porcine hepatic first-pass ammonia metabolism, which is characterised by high uptake and separate periportal urea and perivenous glutamine formations... - Metabolic fate of 18F-FDG in mice bearing either SCCVII squamous cell carcinoma or C3H mammary carcinomaKatrin Kaarstad
PET Center, Aarhus University Hospital, Denmark
J Nucl Med 43:940-7. 2002..Furthermore, the rate of 18F-FDG metabolism was higher in SCCVII carcinoma than in C3H carcinoma... - 11C-methionine PET, a novel method for measuring regional salivary gland function after radiotherapy of head and neck cancerSimon Buus
PET Centre, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus C, Denmark
Radiother Oncol 73:289-96. 2004..The net metabolic clearance of 11C-methionine of salivary glands was reduced dependent on the radiation dose. Dynamic 11C-methionine PET offers a method for studying the individual response of the major salivary glands to irradiation... - Individual radiation response of parotid glands investigated by dynamic 11C-methionine PETSimon Buus
PET Centre, Department of Oncology, Aarhus University Hospital, Aarhus, Denmark
Radiother Oncol 78:262-9. 2006..The aim of this study was to investigate by dynamic 11C-methionine PET the individual radiation dose response relationship of parotid glands in head and neck cancer patients...