Leif Mosekilde

Summary

Affiliation: Aarhus University Hospital
Country: Denmark

Publications

  1. ncbi request reprint Vitamin D and the elderly
    Leif Mosekilde
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus C, Denmark
    Clin Endocrinol (Oxf) 62:265-81. 2005
  2. ncbi request reprint Has mortality after a hip fracture increased?
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    J Am Geriatr Soc 55:1720-6. 2007
  3. ncbi request reprint [Strontium ranelate: a new therapeutic principle for postmenopausal osteoporosis]
    Leif Mosekilde
    Arhus Universitetshospital, Arhus Sygehus, Medicinsk endokrinologisk Afdeling C og Osteoporoseklinikken, Arhus C
    Ugeskr Laeger 167:3485-7. 2005
  4. ncbi request reprint Fracture risk in perimenopausal women treated with beta-blockers
    Lars Rejnmark
    Dept of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    Calcif Tissue Int 75:365-72. 2004
  5. ncbi request reprint Effect of growth hormone and 17beta-oestradiol treatment on metabolism and body composition in girls with Turner syndrome
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Aarhus Sygehus, Aarhus University Hospital, Aarhus C, Denmark
    Clin Endocrinol (Oxf) 62:616-22. 2005
  6. doi request reprint BMD improvements after operation for primary hyperparathyroidism
    Lars Rolighed
    Department of Surgery P, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark
    Langenbecks Arch Surg 398:113-20. 2013
  7. ncbi request reprint Fracture risk in users of oral anticoagulants: a nationwide case-control study
    Lars Rejnmark
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, Aarhus C, Denmark
    Int J Cardiol 118:338-44. 2007
  8. doi request reprint Skeletal consequences of familial hypocalciuric hypercalcaemia vs. primary hyperparathyroidism
    Signe Engkjaer Christensen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus, Denmark
    Clin Endocrinol (Oxf) 71:798-807. 2009
  9. doi request reprint Risk of atrial fibrillation associated with use of bisphosphonates and other drugs against osteoporosis: a cohort study
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Arhus C, Denmark
    Calcif Tissue Int 86:335-42. 2010
  10. doi request reprint Large-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene (TGFB1) and osteoporosis: the GENOMOS study
    Bente L Langdahl
    Department of Endocrinology, Aarhus University Hospital, Aarhus, Denmark
    Bone 42:969-81. 2008

Detail Information

Publications100

  1. ncbi request reprint Vitamin D and the elderly
    Leif Mosekilde
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus C, Denmark
    Clin Endocrinol (Oxf) 62:265-81. 2005
    ..It seems that 800 IU (20 microg) vitamin D per day in combination with calcium reduces systolic blood pressure in elderly women...
  2. ncbi request reprint Has mortality after a hip fracture increased?
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    J Am Geriatr Soc 55:1720-6. 2007
    ..To study changes in mortality and causes of death in patients suffering a hip fracture between 1981 and 2001...
  3. ncbi request reprint [Strontium ranelate: a new therapeutic principle for postmenopausal osteoporosis]
    Leif Mosekilde
    Arhus Universitetshospital, Arhus Sygehus, Medicinsk endokrinologisk Afdeling C og Osteoporoseklinikken, Arhus C
    Ugeskr Laeger 167:3485-7. 2005
    ..There were few side effects. SR is thus suitable for reducing the risk of vertebral and hip fractures from postmenopausal osteoporosis, especially among patients with upper abdominal dyspepsia and the elderly...
  4. ncbi request reprint Fracture risk in perimenopausal women treated with beta-blockers
    Lars Rejnmark
    Dept of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    Calcif Tissue Int 75:365-72. 2004
    ..beta-Blockers may decrease the activity of bone-forming cells and thereby increase fracture risk. However, confirmative studies and studies exploring mechanisms of action are needed...
  5. ncbi request reprint Effect of growth hormone and 17beta-oestradiol treatment on metabolism and body composition in girls with Turner syndrome
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Aarhus Sygehus, Aarhus University Hospital, Aarhus C, Denmark
    Clin Endocrinol (Oxf) 62:616-22. 2005
    ..Girls with Turner syndrome (TS) receive GH treatment during childhood, and in adolescence this treatment may be combined with oestradiol. We have studied the effects of this combined treatment on metabolism and body composition...
  6. doi request reprint BMD improvements after operation for primary hyperparathyroidism
    Lars Rolighed
    Department of Surgery P, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark
    Langenbecks Arch Surg 398:113-20. 2013
    ..This study aims to quantify bone mineral density (BMD) changes following surgery in patients with primary hyperparathyroidism (PHPT) and to assess their relationship with clinical and biochemical variables...
  7. ncbi request reprint Fracture risk in users of oral anticoagulants: a nationwide case-control study
    Lars Rejnmark
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, Aarhus C, Denmark
    Int J Cardiol 118:338-44. 2007
    ..In bone, vitamin K reduces bone resorption and functions as a cofactor in the posttranslational carboxylation of several bone proteins. Discrepant results have been reported on whether VKA affects bone mineral density and fracture risk...
  8. doi request reprint Skeletal consequences of familial hypocalciuric hypercalcaemia vs. primary hyperparathyroidism
    Signe Engkjaer Christensen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus, Denmark
    Clin Endocrinol (Oxf) 71:798-807. 2009
    ..We describe and compare biochemical and osteodensitometric variables in FHH and primary hyperparathyroidism (PHPT) and assess whether they can improve the diagnostic discrimination between the groups...
  9. doi request reprint Risk of atrial fibrillation associated with use of bisphosphonates and other drugs against osteoporosis: a cohort study
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Arhus C, Denmark
    Calcif Tissue Int 86:335-42. 2010
    ..In conclusion, oral bisphosphonates do not seem to be associated with an excess risk of atrial fibrillation. Any excess risk seen in prior studies may be due to confounding from COPD...
  10. doi request reprint Large-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene (TGFB1) and osteoporosis: the GENOMOS study
    Bente L Langdahl
    Department of Endocrinology, Aarhus University Hospital, Aarhus, Denmark
    Bone 42:969-81. 2008
    ....
  11. ncbi request reprint Effects of simvastatin on bone turnover and BMD: a 1-year randomized controlled trial in postmenopausal osteopenic women
    Lars Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    J Bone Miner Res 19:737-44. 2004
    ..The study showed no effect of simvastatin on biochemical bone markers or on BMD at the hip or spine. Thus, our results do not support a general beneficial effect of simvastatin on bone...
  12. doi request reprint Plasma 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and parathyroid hormone in familial hypocalciuric hypercalcemia and primary hyperparathyroidism
    Signe Engkjaer Christensen
    Department of Endocrinology, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, DK 8000 Arhus C, Denmark
    Eur J Endocrinol 159:719-27. 2008
    ..In PHPT, vitamin D metabolism is typically characterized by low plasma levels of 25-hydroxyvitamin D (25OHD), and high plasma levels of 1,25-dihydroxyvitamin D (1,25(OH)(2)D). In FHH, the vitamin D metabolism is not very well known...
  13. doi request reprint Plasma 1,25(OH)2D levels decrease in postmenopausal women with hypovitaminosis D
    Lars Rejnmark
    Department of Endocrinology, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, DK 8000 Aarhus, Denmark
    Eur J Endocrinol 158:571-6. 2008
    ..Moreover, low levels of 25OHD have been associated with increased risk of different diseases including cancer, diabetes, and myopathy...
  14. doi request reprint The effects of depot medroxyprogesterone acetate and intrauterine device use on fracture risk in Danish women
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, DK 8000 Aarhus, Denmark
    Contraception 78:459-64. 2008
    ..Depot medroxyprogesterone acetate (DMPA) use may be associated with an increased risk of fractures; however, nothing is known about the risk associated with intrauterine contraceptive device (IUD) use...
  15. doi request reprint Parathyroid response to vitamin D insufficiency: relations to bone, body composition and to lifestyle characteristics
    Lars Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Aarhus, Denmark
    Clin Endocrinol (Oxf) 69:29-35. 2008
    ..Vitamin D insufficiency is very common and is known to cause secondary hyperparathyroidism (SHPT). However, in some subjects the PTH response to low vitamin D levels is blunted, which has been termed functional hypoparathyroidism (FHPT)...
  16. ncbi request reprint Trends in incidence and mortality in the hospital diagnosis of atrial fibrillation or flutter in Denmark, 1980-1999
    Lars Frost
    Department of Cardiology, Aarhus Amtssygehus, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Int J Cardiol 103:78-84. 2005
    ..We undertook this study to examine recent trends in incidence and mortality in subjects with a hospital diagnosis of atrial fibrillation or flutter in Denmark from 1980 to 1999 by sex, 10-year age group and conditions of comorbidity...
  17. ncbi request reprint Patients with eating disorders. A high-risk group for fractures
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    Orthop Nurs 22:325-31. 2003
    ..To analyze fracture risk and bone mineral density in patients with eating disorders (anorexia nervosa, bulimia nervosa, and other eating disorders)...
  18. doi request reprint The effect of adding PTH(1-84) to conventional treatment of hypoparathyroidism: a randomized, placebo-controlled study
    Tanja Sikjaer
    Department of Metabolism and Internal Medicine, MEA, THG, Aarhus University Hospital, Aarhus, Denmark
    J Bone Miner Res 26:2358-70. 2011
    ..This is most likely due to the marked increased bone turnover. Accordingly, PTH-RT counteracts the state of overmineralized bone and, during long-term treatment, may cause a more physiologic bone metabolism...
  19. doi request reprint Gastric and esophagus events before and during treatment of osteoporosis
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus C, Denmark
    Calcif Tissue Int 86:110-5. 2010
    ..This points at an effect of the underlying condition being treated or comorbid conditions and drugs being provided in patients with osteoporosis, such as nonsteroidal anti-inflammatory drugs and corticosteroids...
  20. doi request reprint Use of bisphosphonates and risk of breast cancer
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, The Osteoporosis Clinic, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark
    Calcif Tissue Int 88:255-62. 2011
    ..Bisphosphonate treatment in women was associated with a reduced risk of breast cancer. However, no causal relationship seemed to be present...
  21. doi request reprint Increased fracture risk in normocalcemic postmenopausal women with high parathyroid hormone levels: a 16-year follow-up study
    Lars Rejnmark
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade, Denmark
    Calcif Tissue Int 88:238-45. 2011
    ..In conclusion, PTH levels in the upper part or above the upper level of the reference interval increase risk of fracture in the presence of low vitamin D levels...
  22. ncbi request reprint [Drugs with side effects affecting calcium homeostasis, bone metabolism and risk of fractures]
    Lars Rejnmark Nielsen
    Arhus Sygehus, Arhus Universitetshospital, Medicinsk Endokrinologisk Afdeling C
    Ugeskr Laeger 167:1026-30. 2005
  23. pmc Loss of life years after a hip fracture
    Peter Vestergaard
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus, Denmark
    Acta Orthop 80:525-30. 2009
    ..Patients with a hip fracture have a high mortality; however, it is not clear how large the loss of life-years is over an extended observation period...
  24. ncbi request reprint Osteoporosis is markedly underdiagnosed: a nationwide study from Denmark
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Amtssygehus, Aarhus, Denmark
    Osteoporos Int 16:134-41. 2005
    ..To compare the number of patients diagnosed with osteoporosis and osteoporotic fractures in Denmark, with the number of subjects expected to have osteoporosis...
  25. ncbi request reprint Reduced bone mineral density and increased bone turnover in Prader-Willi syndrome compared with controls matched for sex and body mass index--a cross-sectional study
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital and Faculty of Health Sciences, Aarhus University, Aarhus, Denmark
    J Pediatr 144:614-9. 2004
    ..To study bone mineral status, body composition, and biochemical markers of bone turnover in Prader-Willi syndrome (PWS)...
  26. ncbi request reprint Loop diuretics increase bone turnover and decrease BMD in osteopenic postmenopausal women: results from a randomized controlled study with bumetanide
    Lars Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Sygehus, Aarhus University Hospital, Aarhus, Denmark
    J Bone Miner Res 21:163-70. 2006
    ..4% at the whole body. Levels of biochemical bone markers were lower in the placebo than in the bumetanide group. Thus, treatment with loop diuretics affects bone metabolism...
  27. ncbi request reprint Decreased fracture risk in users of organic nitrates: a nationwide case-control study
    Lars Rejnmark
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, Aarhus C, Denmark
    J Bone Miner Res 21:1811-7. 2006
    ..Thus, organic nitrates may protect against osteoporosis...
  28. doi request reprint Further insights into the pathogenesis of primary hyperparathyroidism: a nested case-control study
    Lars Rejnmark
    Aarhus University Hospital, Department of Endocrinology and Internal Medicine, THG, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 98:87-96. 2013
    ..The pathogenesis of primary hyperparathyroidism (PHPT) is largely unknown...
  29. ncbi request reprint Molecular genetic analysis of the calcium sensing receptor gene in patients clinically suspected to have familial hypocalciuric hypercalcemia: phenotypic variation and mutation spectrum in a Danish population
    Peter H Nissen
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 92:4373-9. 2007
    ..The condition is difficult to distinguish clinically from primary hyperparathyroidism and is caused by inactivating mutations in the calcium sensing receptor (CASR) gene...
  30. ncbi request reprint The metabolic syndrome is frequent in Klinefelter's syndrome and is associated with abdominal obesity and hypogonadism
    Anders Bojesen
    Medical Department M, Endocrinology and Diabetes, Aarhus University Hospital, Noerrebrogade 42 44, DK 8000, Aarhus C, Denmark
    Diabetes Care 29:1591-8. 2006
    ..We analyzed differences between patients with untreated Klinefelter's syndrome and control subjects and subsequently analyzed differences between testosterone-treated and untreated Klinefelter's syndrome patients...
  31. ncbi request reprint [Treatment of osteoporosis with antiresorptive drugs]
    Peter Vestergaard
    Arhus Universitetshospital, Arhus Sygehus, Medicinsk Endokrinologisk Afdeling C
    Ugeskr Laeger 167:883-7. 2005
  32. ncbi request reprint Fracture reducing potential of hormone replacement therapy on a population level
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Sygehus, Aarhus University Hospital, The Osteoporosis Clinic, Aarhus Amtssygehus, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    Maturitas 54:285-93. 2006
    ....
  33. ncbi request reprint Hip fracture risk in statin users--a population-based Danish case-control study
    Lars Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark
    Osteoporos Int 15:452-8. 2004
    ..Our findings support an association between statin treatment and a reduced hip fracture risk. However, it is unclear whether this association is causal...
  34. doi request reprint Determinants of plasma PTH and their implication for defining a reference interval
    Lars Rejnmark
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Denmark
    Clin Endocrinol (Oxf) 74:37-43. 2011
    ..AIM, DESIGN AND METHODS: In a cross-sectional design, including 2316 women aged 17-84, we determined 95% reference interval using a nonparametric approach and studied the effects of potential predictors on plasma PTH levels...
  35. doi request reprint Osteoarthritis and risk of fractures
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    Calcif Tissue Int 84:249-56. 2009
    ..OA seems to be associated with a decreased risk of fractures at multiple skeletal sites as well as sites far from the location of OA. This may indicate systemic effects on bone strength, especially in areas rich in cortical bone...
  36. ncbi request reprint [Cohort study on effects of parathyroid surgery in primary hyperparathyroidism]
    Peter Vestergaard
    Arhus Universitetshospital, Arhus Sygehus, Medicinsk Endokrinologisk Afdeling C
    Ugeskr Laeger 166:2807-10. 2004
  37. doi request reprint Fracture risk in very young women using combined oral contraceptives
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, DK 8000 Aarhus, Denmark
    Contraception 78:358-64. 2008
    ..Little is known on fracture risk in young women using oral contraceptives...
  38. doi request reprint Muscle function and quality of life are not impaired in familial hypocalciuric hypercalcemia: a cross-sectional study on physiological effects of inactivating variants in the calcium-sensing receptor gene (CASR)
    Niels Frederik Breum Jakobsen
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark
    Eur J Endocrinol 169:349-57. 2013
    ..In patients with primary hyperparathyroidism, the state of hyperparathyroid hypercalcemia is associated with reduced muscle strength and impaired quality of life (QoL)...
  39. doi request reprint Familial hypocalciuric hypercalcaemia: a review
    Signe E Christensen
    Department of Medicine and Endocrinology, Aarhus University Hospital, Aarhus C, Denmark
    Curr Opin Endocrinol Diabetes Obes 18:359-70. 2011
    ..Familial hypocalciuric hypercalcaemia (FHH) is a rare, lifelong, benign condition. It is important to separate this condition from other hypercalcaemic states such as hypercalcaemia of malignancy and primary hyperparathyroidism (PHPT)...
  40. ncbi request reprint [The usefulness of calcium and vitamin D supplementation after the Women's Health Initiative trial]
    Leif Mosekilde
    Arhus Sygehus, Medicinsk Endokrinologisk Afdeling C, Arhus C
    Ugeskr Laeger 169:3273-6. 2007
    ..Two recent meta-analyses including the three studies supported the continuous use of calcium and vitamin D to prevent fractures in the elderly...
  41. ncbi request reprint Vitamin D treatment in primary hyperparathyroidism
    Lars Rolighed
    Department of Surgery, Aarhus University Hospital, THG, Aarhus C, Denmark
    Curr Drug Saf 6:100-7. 2011
    ..In cases where the combination of both vitamin D insufficiency and PHPT is diagnosed, vitamin D repletion is an option. However, only limited evidence exists for this treatment...
  42. doi request reprint Effects of smoking on severity of disease in primary hyperparathyroidism
    Anne Kristine Amstrup
    Department of Endocrinology and Metabolism MEA, Aarhus Sygehus, Aarhus University Hospital, Tage Hansens Gade 2, 8000, Aarhus C, Denmark
    Calcif Tissue Int 87:406-13. 2010
    ..Smoking may compromise the correct diagnostic evaluation of borderline hyperparathyroidism. It is unknown to what extent smoking in PHPT affects fracture risk and indication for surgery...
  43. ncbi request reprint Fracture risk in patients with chronic lung diseases treated with bronchodilator drugs and inhaled and oral corticosteroids
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    Chest 132:1599-607. 2007
    ..Chronic lung diseases and drugs used to treat patients with chronic lung diseases may be associated with an increased fracture risk...
  44. ncbi request reprint Treatment with beta-blockers, ACE inhibitors, and calcium-channel blockers is associated with a reduced fracture risk: a nationwide case-control study
    Lars Rejnmark
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Sygehus, Aarhus, Denmark
    J Hypertens 24:581-9. 2006
    ..Antihypertensive drugs may increase the risk of falling. However, risk of fracture in patients treated with non-diuretic cardiovascular drugs is largely unknown...
  45. ncbi request reprint [Hyperthyroidism and risk of atrial fibrillation or flutter--secondary publication. A population-based study]
    Lars Frost
    Arhus Universitetshospital, Arhus Sygehus, Medicinsk Kardiologisk Afdeling A
    Ugeskr Laeger 167:3305-7. 2005
    ..Male sex, increasing age, ischemic heart disease, congestive heart failure and heart valve disease were associated with an increased risk of atrial fibrillation or flutter in patients with hyperthyroidism...
  46. doi request reprint Multiplex ligation-dependent probe amplification (MLPA) screening for exon copy number variation in the calcium sensing receptor gene: no large rearrangements identified in patients with calcium metabolic disorders
    Peter H Nissen
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus Sygehus, Denmark
    Clin Endocrinol (Oxf) 72:758-62. 2010
    ..Exon copy number variation is not detected by currently used molecular genetic screening methods, and might be a genetic cause of inherited forms of hyper- or hypocalcaemia caused by the CASR...
  47. doi request reprint Reduced prediagnostic 25-hydroxyvitamin D levels in women with breast cancer: a nested case-control study
    Lars Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Sygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    Cancer Epidemiol Biomarkers Prev 18:2655-60. 2009
    ..Accordingly, risk of breast cancer was inversely associated with 25OHD levels. Randomized controlled trials are warranted in order to assess whether a causal relationship exists...
  48. doi request reprint Discriminative power of three indices of renal calcium excretion for the distinction between familial hypocalciuric hypercalcaemia and primary hyperparathyroidism: a follow-up study on methods
    Signe Engkjaer Christensen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus, Denmark
    Clin Endocrinol (Oxf) 69:713-20. 2008
    ..In daily practice this discrimination is often based on the renal calcium excretion or the calcium/creatinine clearance ratio (CCCR). However, the diagnostic performance of these variables is poorly documented...
  49. doi request reprint Identification of rare and frequent variants of the CASR gene by high-resolution melting
    Peter H Nissen
    Department of Clinical Biochemistry, Aarhus University Hospital, Tage Hansens Gade, Denmark
    Clin Chim Acta 413:605-11. 2012
    ..Molecular genetic screening of the CASR is often based on DNA sequencing...
  50. doi request reprint Changes in 3-dimensional bone structure indices in hypoparathyroid patients treated with PTH(1-84): a randomized controlled study
    Tanja Sikjaer
    Department of Internal Medicine and Endocrinology, MEA, Aarhus University Hospital, Aarhus, Denmark
    J Bone Miner Res 27:781-8. 2012
    ..However, at the lumbar spine, aBMD decreased by 1.8% (p < 0.05), whereas vBMD increased by 12.8% (p = 0.02) in the PTH compared with the placebo group...
  51. doi request reprint Intake of vitamin D and risk of breast cancer--a meta-analysis
    Tina Gissel
    The Osteoporosis Clinic, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    J Steroid Biochem Mol Biol 111:195-9. 2008
    ..14. In conclusion there may be a trend towards fewer cases of breast cancer with higher intakes of vitamin D (> or =400 IU/day). However, more research is needed, preferably in the form of randomized-controlled trials...
  52. ncbi request reprint [Osteoporosis and fractures associated with drugs]
    Peter Vestergaard
    Arhus Sygehus, Osteoporoseklinikken, Arhus C
    Ugeskr Laeger 170:1550-5. 2008
    ..Pain medication varied from no effect to an increased fracture risk...
  53. doi request reprint Fracture risk associated with different types of oral corticosteroids and effect of termination of corticosteroids on the risk of fractures
    Peter Vestergaard
    The Osteoporosis Clinic, Aarhus Sygehus, Tage Hansens Gade 2, 8000, Aarhus C, Denmark
    Calcif Tissue Int 82:249-57. 2008
    ..Hydrocortisone was not associated with an increase in the risk of fractures. It may take a year from last use of prednisolone/prednisone before fracture risk returns to that of the general population...
  54. doi request reprint Primary hyperparathyroidism and the skeleton
    Leif Mosekilde
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, DK 8000, Aarhus C, Denmark
    Clin Endocrinol (Oxf) 69:1-19. 2008
    ..In symptomatic hypercalcaemic PHPT with low BMD where curative surgery is impossible or contraindicated a combination of a calcimimetic and a bisphosphonate may be an undocumented therapeutical option that needs further evaluation...
  55. ncbi request reprint Emerging anabolic treatments in osteoporosis
    Leif Mosekilde
    Department of Internal Medicine and Endocrinology, MEA, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Curr Drug Saf 6:62-74. 2011
    ..The present paper summarises the physiological background and the present evidence for these effects...
  56. doi request reprint Hypertension is a risk factor for fractures
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, The Osteoporosis Clinic, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark
    Calcif Tissue Int 84:103-11. 2009
    ..The fracture risk in hypertension may explain why antihypertensive drugs as a class effect are associated with a decreased risk of fractures. These drugs may counter some of the deleterious effects of high blood pressure...
  57. doi request reprint Effect of tamoxifen and aromatase inhibitors on the risk of fractures in women with breast cancer
    Peter Vestergaard
    The Osteoporosis Clinic, Aarhus Amtssygehus, Tage Hansens Gade 2, Aarhus C, Denmark
    Calcif Tissue Int 82:334-40. 2008
    ..Aromatase inhibitors were associated with a significant increase in the risk of fractures. In women at high risk of fractures, supplementary measures, i.e., bisphosphonates, may be considered...
  58. ncbi request reprint Female premenopausal fracture risk is associated with gc phenotype
    Anna Lis Lauridsen
    Department of Clinical Biochemistry, AKH, Aarhus University Hospital, Aarhus C, Denmark
    J Bone Miner Res 19:875-81. 2004
    ..This was concluded from a study on 595 Danish perimenopausal women 45-58 years of age (30,040 person years)...
  59. ncbi request reprint Hyperthyroidism and risk of atrial fibrillation or flutter: a population-based study
    Lars Frost
    Department of Cardiology, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    Arch Intern Med 164:1675-8. 2004
    ..We examined the risk of atrial fibrillation among patients aged 20 to 89 years with hyperthyroidism diagnosed in hospitals in Denmark during a 20-year period...
  60. ncbi request reprint [Non-skeletal effects of vitamin D deficiency]
    Leif Mosekilde
    Arhus Universitetshospital, Arhus Sygehus, Medicinsk Endokrinologisk Afdeling C
    Ugeskr Laeger 167:887-91. 2005
  61. doi request reprint Anxiolytics and sedatives and risk of fractures: effects of half-life
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus University, Aarhus, Denmark
    Calcif Tissue Int 82:34-43. 2008
    ..However, the increased risk of fractures with past use may suggest an effect of the condition for which the drug was prescribed rather than the drug per se (confounding by indication)...
  62. ncbi request reprint Vitamin D and calcium supplementation prevents severe falls in elderly community-dwelling women: a pragmatic population-based 3-year intervention study
    Erik Roj Larsen
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus, Denmark
    Aging Clin Exp Res 17:125-32. 2005
    ..We evaluated the effect of two programs for the prevention of falls leading to acute hospital admission in a population of elderly community-dwelling Danish residents...
  63. ncbi request reprint [Vitamin D and breast cancer]
    Lars Rejnmark Nielsen
    Arhus Universitetshospital, Arhus Sygehus, Medicinsk Endokrinologisk Afdeling C
    Ugeskr Laeger 169:1299-302. 2007
    ..As vitamin D insufficiency is common, it is important to clarify whether vitamin D status affects the risk and prognosis of breast cancer...
  64. doi request reprint Fracture risk in patients with different types of cancer
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    Acta Oncol 48:105-15. 2009
    ..Few studies on the risk of fractures in patients with cancer exist, and little is known on the mechanisms of fractures in patients with cancer. We studied the risk of fracture in patients with various types of cancer...
  65. ncbi request reprint Fracture risk associated with use of antiepileptic drugs
    Peter Vestergaard
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Sygehus, Aarhus, Denmark
    Epilepsia 45:1330-7. 2004
    ..An increased fracture risk has been reported in patients with epilepsy. Classical AEDs have been associated with decreased bone mineral density. The effects of newer AEDs are unknown...
  66. ncbi request reprint Short-term growth hormone treatment in girls with Turner syndrome decreases fat mass and insulin sensitivity: a randomized, double-blind, placebo-controlled, crossover study
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Aarhus Kommunehospital, Aarhus University Hospital, Aarhus, Denmark
    Pediatrics 110:889-96. 2002
    ..Most girls with Turner syndrome (TS) receive growth hormone (GH) treatment during childhood and adolescence, but controlled data on the effects on body composition and glucose metabolism are lacking...
  67. ncbi request reprint [Teriparatide (human recombinant 1-34 parathyroid hormone)--a new treatment regimen for severe osteoporosis]
    Peter Vestergaard
    Arhus Universitetshospital, Arhus Sygehus, Medicinsk Endokrinologisk Afdeling C
    Ugeskr Laeger 166:2653-5. 2004
  68. doi request reprint Selective serotonin reuptake inhibitors and other antidepressants and risk of fracture
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    Calcif Tissue Int 82:92-101. 2008
    ..While selective serotonin receptor uptake inhibitors were associated with an increased fracture risk, tricyclic antidepressants and the group of other antidepressants were not systematically associated with fracture risk...
  69. ncbi request reprint Fracture risk is decreased in acromegaly--a potential beneficial effect of growth hormone
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Tage Hansens Gade 2, Aarhus, DK 8000, Denmark
    Osteoporos Int 15:155-9. 2004
    ..8, 95% CI: 4.7-29.3). In conclusion, fracture risk is significantly decreased in patients with acromegaly compared to controls probably due to an anabolic effect of growth hormone on bone...
  70. pmc Cohort study on effects of parathyroid surgery on multiple outcomes in primary hyperparathyroidism
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    BMJ 327:530-4. 2003
    ..To assess the effects of surgery compared with conservative treatment (no surgery) for primary hyperparathyroidism...
  71. doi request reprint Vitamin D requirement and setting recommendation levels: long-term perspectives
    Leif Mosekilde
    The Department of Clinical Endocrinology and Metabolism C, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Nutr Rev 66:S170-7. 2008
    ..In adults, a minimum dietary intake of 17.5-25 microg/day is necessary to achieve these levels. Perspectives of future research are outlined here...
  72. ncbi request reprint Hyperthyroidism, bone mineral, and fracture risk--a meta-analysis
    Peter Vestergaard
    The Osteoporosis Clinic, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    Thyroid 13:585-93. 2003
    ..Upon normalization of the hyperthyroid state BMD return to normal even though no specific antiosteoporotic measures are taken other than normalizing the hyperthyroid state...
  73. ncbi request reprint Fractures in patients with hyperthyroidism and hypothyroidism: a nationwide follow-up study in 16,249 patients
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aahus Amtssygehus, Aarhus University Hospital, Denmark
    Thyroid 12:411-9. 2002
    ..To study fracture risk in patients with hyperthyroidism and hypothyroidism...
  74. ncbi request reprint Marked disproportionality in bone size and mineral, and distinct abnormalities in bone markers and calcitropic hormones in adult turner syndrome: a cross-sectional study
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes, Aarhus Kommunehospital, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 87:2798-808. 2002
    ....
  75. ncbi request reprint Fracture risk in patients with celiac Disease, Crohn's disease, and ulcerative colitis: a nationwide follow-up study of 16,416 patients in Denmark
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    Am J Epidemiol 156:1-10. 2002
    ..The severity of the inflammatory process and the amount of corticosteroids given may explain the difference in fracture risk...
  76. ncbi request reprint Fracture risk associated with parkinsonism and anti-Parkinson drugs
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000, Aarhus C, Denmark
    Calcif Tissue Int 81:153-61. 2007
    ..Use of neuroleptics and, to some degree, levodopa was associated with increased risk of fractures...
  77. ncbi request reprint Fractures in patients with primary hyperparathyroidism: nationwide follow-up study of 1201 patients
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Tage Hansens Gade 2, Aarhus University Hospital, DK 8000, Aarhus C, Denmark
    World J Surg 27:343-9. 2003
    ..58, 95% CI 0.47-0.73). No differences in fracture risk could be demonstrated between those who had and those who did not have surgery, taking age, gender, and previous fractures into account...
  78. ncbi request reprint Diurnal rhythm of plasma 1,25-dihydroxyvitamin D and vitamin D-binding protein in postmenopausal women: relationship to plasma parathyroid hormone and calcium and phosphate metabolism
    Lars Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Denmark
    Eur J Endocrinol 146:635-42. 2002
    ..We have studied whether plasma levels of 1,25(OH)(2)D and vitamin D-binding protein (DBP) vary in a diurnal rhythm in postmenopausal women...
  79. ncbi request reprint [Cinacalcet--a new drug for the treatment of secondary hyperparathyroidism in patients with uraemia, parathyroid cancer or primary hyperparathyroidism]
    Peter Vestergaard
    Osteoporoseklinikken, Arhus Universitetshospital, Arhus Sygehus, Medicinsk Endokrinologisk Afdeling C, Arhus C
    Ugeskr Laeger 168:29-32. 2006
    ..Cinacalcet decreases plasma calcium and plasma PTH levels in patients with primary hyperparathyroidism or parathyroid cancer...
  80. ncbi request reprint [The vitamin D status of the Danish population needs to be improved]
    Leif Mosekilde
    Arhus Universitetshospital, Arhus Sygehus, Medicinsk Endokrinologisk Afdeling C, Sundhedsstyrelsen, København
    Ugeskr Laeger 167:895-7. 2005
  81. ncbi request reprint Increased risk of osteoporotic fractures in patients with Cushing's syndrome
    Peter Vestergaard
    The Osteoporosis Clinic, Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Tage Hansens Gade 2, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 146:51-6. 2002
    ..To evaluate if fracture risk was increased in patients with Cushing's syndrome due to the increased endogenous cortisol production...
  82. ncbi request reprint Effects of 5 years of hormonal replacement therapy on menopausal symptoms and blood pressure-a randomised controlled study
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, The Osteoporosis Clinic, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 C Aarhus, Denmark
    Maturitas 46:123-32. 2003
    ..To study the effects of hormonal replacement on hot flushes, other symptoms linked to menopause, and blood pressure...
  83. ncbi request reprint Smoking as a risk factor for Graves' disease, toxic nodular goiter, and autoimmune hypothyroidism
    Peter Vestergaard
    The Osteoporosis Clinic, Aarhus Amtssygehus, Aarhus University Hospital, Denmark
    Thyroid 12:69-75. 2002
    ..In conclusion, smoking is a powerful risk factor for thyroid disease, especially in populations with a high smoking frequency. Oral contraceptive use is associated with a slightly lower frequency of Graves' disease...
  84. ncbi request reprint Vitamin D and calcium supplementation prevents osteoporotic fractures in elderly community dwelling residents: a pragmatic population-based 3-year intervention study
    Erik Roj Larsen
    Department of Orthopaedic Surgery, Randers Central Hospital, Randers, Denmark
    J Bone Miner Res 19:370-8. 2004
    ....
  85. ncbi request reprint Socioeconomic aspects of fractures within universal public healthcare: a nationwide case-control study from Denmark
    Peter Vestergaard
    The Osteoporosis Clinic, Aarhus, Denmark
    Scand J Public Health 34:371-7. 2006
    ..To investigate the effects of income and other socioeconomic variables on fracture risk adjusted for disease-related confounders as fractures are a major public health problem...
  86. ncbi request reprint Ten-year prediction of osteoporosis from baseline bone mineral density: development of prognostic thresholds in healthy postmenopausal women. The Danish Osteoporosis Prevention Study
    Bo Abrahamsen
    Department of Endocrinology, Odense University Hospital, Denmark
    Osteoporos Int 17:245-51. 2006
    ..The association is strong enough to provide robust prognostic thresholds, which can be used to divide the population into two prognostic classes at menopause...
  87. pmc Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    JAMA 299:1277-90. 2008
    ..Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population...
  88. ncbi request reprint Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    JAMA 292:2105-14. 2004
    ..Estrogen receptor alpha (ESR1) is a candidate gene for osteoporosis, but previous studies of ESR1 polymorphisms in this field were hampered by small sample size, lack of standardization, and inconclusive results...
  89. ncbi request reprint [Strongly increasing incidence of hip fractures in Denmark from 1977 to 1999]
    Peter Vestergaard
    Aalborg Sygehus, Endokrinologisk Afdeling
    Ugeskr Laeger 170:621-3. 2008
    ..The incidence of hip fractures has been increasing throughout the world including the Nordic countries. The aim of this study was to examine if there is a similar trend in Denmark...
  90. ncbi request reprint Age-related changes in cortical bone content of insulin-like growth factor binding protein (IGFBP)-3, IGFBP-5, osteoprotegerin, and calcium in postmenopausal osteoporosis: a cross-sectional study
    Thor Ueland
    Department of Endocrinology, and Research Institute for Internal Medicine National, University Hospital, N 0027 Oslo, Norway
    J Clin Endocrinol Metab 88:1014-8. 2003
    ..As for OPG, our findings probably represent compensatory responses to increased osteoclastic resorption...
  91. ncbi request reprint A common methylenetetrahydrofolate reductase (C677T) polymorphism is associated with low bone mineral density and increased fracture incidence after menopause: longitudinal data from the Danish osteoporosis prevention study
    Bo Abrahamsen
    Department of Endocrinology, Odense University Hospital, Odense, Denmark
    J Bone Miner Res 18:723-9. 2003
    ..The MTHFR TT genotype is associated with low BMD and increased fracture incidence in early postmenopausal women...
  92. ncbi request reprint Standardization of BMD T-Scores in the first five years after the menopause: do femoral neck-equivalent and older normative range T-Scores improve diagnostic agreement?
    Bo Abrahamsen
    Dept of Endocrinology, Odense University Hospital, Denmark
    J Clin Densitom 6:87-95. 2003
    ..To overcome this problem, risk-based diagnostic cut-offs must therefore be calculated separately for each measurement site and fracture localization...
  93. ncbi request reprint [Calcium homeostasis and normal bone remodeling]
    Peter Schwarz
    H S Hvidovre Hospital, Klinisk Biokemisk Afdeling
    Ugeskr Laeger 167:871-3. 2005
  94. ncbi request reprint Are effects of MTHFR (C677T) genotype on BMD confined to women with low folate and riboflavin intake? Analysis of food records from the Danish osteoporosis prevention study
    Bo Abrahamsen
    Department of Endocrinology, Odense University Hospital, DK 5000 Odense C, Denmark
    Bone 36:577-83. 2005
    ..Vitamin B supplementation would only be expected to benefit BMD in about 2% of the population, i.e., those with the TT genotype and low vitamin B intake...
  95. ncbi request reprint [Vitamin D deficiency in ethnic minorities]
    Aase T Jacobsen
    Ugeskr Laeger 167:33-4. 2005
  96. ncbi request reprint Correlates of falling during 24 h among elderly Danish community residents
    Erik Roj Larsen
    Department of Orthopaedic Surgery, Randers Central Hospital, Randers, Denmark
    Prev Med 39:389-98. 2004
    ..To identify dietary, medical, and environmental correlates of falling during the last 24 h among elderly community residents. The limited accuracy of recall of falls in the elderly in previous studies was the reason for a 24-h time frame...
  97. ncbi request reprint [Alendronate once a week]
    Kim T Brixen
    Endokrinologisk Afdeling M, Odense Universitetshospital, DK 5000 Odense C
    Ugeskr Laeger 165:2734-9. 2003
  98. ncbi request reprint [Incidence of primary hyperparathyroidism, frequency of surgical interventions and mortality based on the data from the National Patient Registry]
    Peter Vestergaard
    Arhus Universitetshospital, Arhus Amtssygehus, Medicinsk Endokrinologisk Afdeling C
    Ugeskr Laeger 166:41-5. 2004
  99. ncbi request reprint Increased fracture rates in Turner's syndrome: a nationwide questionnaire survey
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes, Aarhus Kommunehospital, Denmark
    Clin Endocrinol (Oxf) 59:89-96. 2003
    ..A total of 322 patients (51%) and 1169 controls (62%) returned the questionnaire...
  100. ncbi request reprint [Oesteogenesis imperfecta--genetics, diagnosis and medical treatment]
    Kim T Brixen
    Odense Universitetshospital, Endokrinologisk Afdeling M, Odense C
    Ugeskr Laeger 169:30-4. 2007
    ..Results from bone marrow transplantation and animal experiments may lead to alternative treatment in severe OI...