O Mors

Summary

Affiliation: Aarhus University Hospital
Country: Denmark

Publications

  1. pmc The Depression Network (DeNT) Study: methodology and sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetic study
    Anne Farmer
    Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    BMC Psychiatry 4:42. 2004
  2. pmc Suicidal ideation during treatment of depression with escitalopram and nortriptyline in genome-based therapeutic drugs for depression (GENDEP): a clinical trial
    Nader Perroud
    MRC SGDP Centre, Institute of Psychiatry at King s College London, UK
    BMC Med 7:60. 2009
  3. pmc Genome-wide scans using archived neonatal dried blood spot samples
    Mads V Hollegaard
    Section of Neonatal Screening and Hormones, Statens Serum Institut, Copenhagen, Denmark
    BMC Genomics 10:297. 2009
  4. pmc Robustness of genome-wide scanning using archived dried blood spot samples as a DNA source
    Mads V Hollegaard
    Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Ørestads Boulevard, Copenhagen, DK 2300, Denmark
    BMC Genet 12:58. 2011
  5. ncbi [Status of and perspectives on psychiatric genomic medicine]
    Niels Peter Ole Mors
    Arhus Universitetshospital, Psykiatrisk Hospital i Arhus, Center for Psykiatrisk Grundforskning, Risskov
    Ugeskr Laeger 167:2191-3. 2005
  6. ncbi A population-based register study of the association between schizophrenia and rheumatoid arthritis
    O Mors
    Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, Risskov, Denmark
    Schizophr Res 40:67-74. 1999
  7. ncbi A genome-wide search for alleles and haplotypes associated with autism and related pervasive developmental disorders on the Faroe Islands
    M B Lauritsen
    Centre for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, Aarhus University Hospital, Shovagervej 2, DK 8240 Risskov, Denmark
    Mol Psychiatry 11:37-46. 2006
  8. ncbi Further evidence for a bipolar risk gene on chromosome 12q24 suggested by investigation of haplotype sharing and allelic association in patients from the Faroe Islands
    B Degn
    Department of Biological Psychiatry, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, DK-8240 Risskov, Denmark
    Mol Psychiatry 6:450-5. 2001
  9. ncbi A genome-wide search for risk genes using homozygosity mapping and microarrays with 1,494 single-nucleotide polymorphisms in 22 eastern Cuban families with bipolar disorder
    H Ewald
    Centre for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, Risskov, Denmark
    Am J Med Genet B Neuropsychiatr Genet 133:25-30. 2005
  10. ncbi A functional variant of the serotonin transporter gene in families with bipolar affective disorder
    H Ewald
    Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Risskov, Denmark
    J Affect Disord 48:135-44. 1998

Collaborators

Detail Information

Publications35

  1. pmc The Depression Network (DeNT) Study: methodology and sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetic study
    Anne Farmer
    Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    BMC Psychiatry 4:42. 2004
    ..This study presents the method and socio-demographic details of the first 470 affected sibling pairs recruited from 8 different sites in Europe and the United States of America...
  2. pmc Suicidal ideation during treatment of depression with escitalopram and nortriptyline in genome-based therapeutic drugs for depression (GENDEP): a clinical trial
    Nader Perroud
    MRC SGDP Centre, Institute of Psychiatry at King s College London, UK
    BMC Med 7:60. 2009
    ..The aim of the present study is to investigate the course and predictors of emergence and worsening of suicidal ideation during tricyclic antidepressant and serotonin reuptake inhibitor treatment...
  3. pmc Genome-wide scans using archived neonatal dried blood spot samples
    Mads V Hollegaard
    Section of Neonatal Screening and Hormones, Statens Serum Institut, Copenhagen, Denmark
    BMC Genomics 10:297. 2009
    ..Whole-genome amplified DNA from 24 neonatal dried blood spot samples stored between 15 to 25 years was tested, and high-quality genomic DNA from 8 of the same individuals was used as reference...
  4. pmc Robustness of genome-wide scanning using archived dried blood spot samples as a DNA source
    Mads V Hollegaard
    Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Ørestads Boulevard, Copenhagen, DK 2300, Denmark
    BMC Genet 12:58. 2011
    ..We examined the robustness of using DBS samples for whole-genome amplification following genome-wide scanning, using arrays from Illumina and Affymetrix...
  5. ncbi [Status of and perspectives on psychiatric genomic medicine]
    Niels Peter Ole Mors
    Arhus Universitetshospital, Psykiatrisk Hospital i Arhus, Center for Psykiatrisk Grundforskning, Risskov
    Ugeskr Laeger 167:2191-3. 2005
  6. ncbi A population-based register study of the association between schizophrenia and rheumatoid arthritis
    O Mors
    Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, Risskov, Denmark
    Schizophr Res 40:67-74. 1999
    ..Clinicians are reminded of the difficulties in detecting medical illness among individuals with schizophrenia...
  7. ncbi A genome-wide search for alleles and haplotypes associated with autism and related pervasive developmental disorders on the Faroe Islands
    M B Lauritsen
    Centre for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, Aarhus University Hospital, Shovagervej 2, DK 8240 Risskov, Denmark
    Mol Psychiatry 11:37-46. 2006
    ..Our data suggest that markers in these regions are in linkage disequilibrium with genes involved in the etiology of autism, and we hypothesize susceptibility genes for autism and related PDDs to be localized within these regions...
  8. ncbi Further evidence for a bipolar risk gene on chromosome 12q24 suggested by investigation of haplotype sharing and allelic association in patients from the Faroe Islands
    B Degn
    Department of Biological Psychiatry, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, DK-8240 Risskov, Denmark
    Mol Psychiatry 6:450-5. 2001
    ..This area contains the minimum interesting region between D12S342 and D12S1658 suggested by the previously reported haplotypes in the two Danish families with bipolar affective disorder...
  9. ncbi A genome-wide search for risk genes using homozygosity mapping and microarrays with 1,494 single-nucleotide polymorphisms in 22 eastern Cuban families with bipolar disorder
    H Ewald
    Centre for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, Risskov, Denmark
    Am J Med Genet B Neuropsychiatr Genet 133:25-30. 2005
    ..When analyzing 19 additional microsatellite markers on chromosome 17q the maximum parametric multipoint LOD score was 2.08, 1.5 cM proximal to D17S668. The present study replicates a recent significant linkage finding...
  10. ncbi A functional variant of the serotonin transporter gene in families with bipolar affective disorder
    H Ewald
    Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Risskov, Denmark
    J Affect Disord 48:135-44. 1998
    ..Recently a functionally important 44 basepair deletion in the regulatory region of the SERT gene was described. Association between this variant and affective disorder has been suggested...
  11. ncbi Possible evidence for a common risk locus for bipolar affective disorder and schizophrenia on chromosome 4p16 in patients from the Faroe Islands
    T D Als
    Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, Aarhus University Hospital, Risskov, Denmark
    Mol Psychiatry 9:93-8. 2004
    ..Our study yields support for a common risk gene for schizophrenia and bipolar affective disorder on the short arm of chromosome 4, as suggested by previous findings in the neighbouring Scottish population...
  12. ncbi Mutational screening and association study of glutamate decarboxylase 1 as a candidate susceptibility gene for bipolar affective disorder and schizophrenia
    M D Lundorf
    Centre for Basic Psychiatric Research, Psychiatric University Hospital in Aarhus, Risskov, Denmark
    Am J Med Genet B Neuropsychiatr Genet 135:94-101. 2005
    ..Thus the results obtained from the Scottish sample suggest that the GAD1 gene variants do not play a major role in the predisposition to schizophrenia...
  13. ncbi Decreased risk of acute appendicitis in patients with schizophrenia or manic-depressive psychosis
    H Ewald
    Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, University Hospital, Skovagervej 2, DK 8240, Risskov, Denmark
    Schizophr Res 49:287-93. 2001
    ..Further studies of this relationship may help to clarify etiological or pathophysiological aspects of schizophrenia and manic-depressive psychosis...
  14. ncbi Support for the possible locus on chromosome 4p16 for bipolar affective disorder
    H Ewald
    Department of Psychiatric Demography, Psychiatric Hospital in Aarhus, Denmark
    Mol Psychiatry 3:442-8. 1998
    ..Final proof of a disease locus in the Scottish and our study has to await the identification of a DNA sequence of functional significance for bipolar disorder...
  15. ncbi A haplotype-based study of lithium responding patients with bipolar affective disorder on the Faroe Islands
    H Ewald
    Department of Psychiatric Demography, Psychiatric Hospital in Aarhus, Denmark
    Psychiatr Genet 9:23-34. 1999
    ..However, methods of genetic analysis which might provide a conclusive result are not yet available...
  16. doi Empirical support for a reclassification of eating disorders NOS
    J L Helverskov
    Eating Disorder Centre, Regional Centre of Child and Adolescent Psychiatry, Aarhus University Hospital, Risskov, Denmark
    Eur Eat Disord Rev 19:303-15. 2011
    ..To explore the empirical support for a reclassification of the eating disorders NOS (EDNOS) category...
  17. ncbi Susceptibility loci for bipolar affective disorder on chromosome 18? A review and a study of Danish families
    H Ewald
    Department of Psychiatric Demography, Psychiatric Hospital in Aarhus, Denmark
    Psychiatr Genet 7:1-12. 1997
    ..The highest lod score found was for marker D18S67, 1.83 at 0.05 recombination fraction...
  18. ncbi A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22-21, 4p16, 6q14-22, 10q26 and 16p13.3
    H Ewald
    Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, Skovagervej, Risskov, Denmark
    Mol Psychiatry 7:734-44. 2002
    ..60 (P-value 0.00079) at D1S216 further supported this finding. A number of additional loci on chromosomes 4p16, 6q14-q22, 10q26 and 16p13.3 yielded parametric lod scores around or above 2...
  19. ncbi Effects of family history and place and season of birth on the risk of schizophrenia
    P B Mortensen
    Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital, Aarhus University Hospital, Risskov, Denmark
    N Engl J Med 340:603-8. 1999
    ..Although a family history of schizophrenia is the best-established risk factor for schizophrenia, environmental factors such as the place and season of birth may also be important...
  20. ncbi No evidence of increased risk for schizophrenia or bipolar affective disorder in persons with aneuploidies of the sex chromosomes
    O Mors
    Department of Pschiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, Denmark
    Psychol Med 31:425-30. 2001
    ....
  21. ncbi Is head injury a risk factor for schizophrenia?
    A S Nielsen
    Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, Skovagervej 2, 8240 Risskov, Denmark
    Schizophr Res 55:93-8. 2002
    ..The few studies that have examined whether head injury is a risk factor for later schizophrenia have had important methodological problems...
  22. ncbi Search for common haplotypes on chromosome 22q in patients with schizophrenia or bipolar disorder from the Faroe Islands
    T H Jorgensen
    Institute for Basic Psychiatric Research, Department of Psychiatric Demography, Psychiatric Hospital in Aarhus, Aarhus University Hospital, Aarhus, Denmark
    Am J Med Genet 114:245-52. 2002
    ..We did not find this mutation in schizophrenic or bipolar patients or the controls from the Faroe Islands...
  23. doi The perceived and predicted implications of psychiatric genetic knowledge among persons with multiple cases of depression in the family
    M M Laegsgaard
    Centre for Psychiatric Research, Aarhus Psychiatric University Hospital, Risskov, Denmark
    Acta Psychiatr Scand 122:470-80. 2010
    ....
  24. doi The norepinephrine transporter gene is a candidate gene for panic disorder
    H N Buttenschøn
    Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Skovagervej 2, 8240 Risskov, Denmark
    J Neural Transm 118:969-76. 2011
    ..Furthermore, the NET gene showed overall evidence for association with the disease (P = 0.000035). In conclusion, the present study indicates that NET could be a susceptibility gene for PD...
  25. doi Trans-diagnostic outcome of eating disorders: A 30-month follow-up study of 629 patients
    J L Helverskov
    Eating Disorder Centre, Regional Centre of Child and Adolescent Psychiatry, Aarhus University Hospital, Risskov, Denmark
    Eur Eat Disord Rev 18:453-63. 2010
    ..To assess the 30-month outcome and predictors of outcome in a cohort of patients with any eating disorder (ED)...
  26. ncbi Individual and familial risk factors for bipolar affective disorders in Denmark
    Preben Bo Mortensen
    National Centre for Register Based Research, Aarhus University, Aarhus, Denmark
    Arch Gen Psychiatry 60:1209-15. 2003
    ..Few population-based studies have addressed risk factors for bipolar affective disorder...
  27. ncbi Dopa decarboxylase genotypes may influence age at onset of schizophrenia
    A D Børglum
    Institute of Human Genetics and Danish Centre for Human Genome Research, University of Aarhus, Denmark
    Mol Psychiatry 6:712-7. 2001
    ..7-8.8). Thus, DDC may possibly act as a modulator of age at onset in male schizophrenics...
  28. ncbi Evidence implicating BRD1 with brain development and susceptibility to both schizophrenia and bipolar affective disorder
    J E Severinsen
    Institute of Human Genetics, University of Aarhus, Aarhus, Denmark
    Mol Psychiatry 11:1126-38. 2006
    ..The results implicate BRD1 with SZ and BPD susceptibility and provide evidence that suggests a role for BRD1 in neurodevelopment...
  29. ncbi A genome-wide linkage search for bipolar disorder susceptibility loci in a large and complex pedigree from the eastern part of Cuba
    B Marcheco-Teruel
    National Center of Medical Genetics, Reparto Cubanacán, Playa, Havana, Cuba
    Am J Med Genet B Neuropsychiatr Genet 141:833-43. 2006
    ..3-13.32 showed suggestive linkage in the complete family. Most of these potential susceptibility loci overlap with, or are close, to previous linkage findings. The locus on 5q may, however, represent a novel susceptibility locus...
  30. ncbi Association analyses suggest GPR24 as a shared susceptibility gene for bipolar affective disorder and schizophrenia
    J E Severinsen
    Institute of Human Genetics, University of Aarhus, Aarhus, Denmark
    Am J Med Genet B Neuropsychiatr Genet 141:524-33. 2006
    ..To our knowledge this is the first study reporting association between GPR24 and BPD and SZ, suggesting that GPR24 variants may confer susceptibility to both disorders...
  31. ncbi Joint multi-population analysis for genetic linkage of bipolar disorder or "wellness" to chromosome 4p
    P M Visscher
    Institute of Cell, Animal and Population Biology, University of Edinburgh, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 133:18-24. 2005
    ..Studies reporting linkage to the same region require careful scrutiny and preferably joint or meta analysis on the same basis in order to ensure that the results are truly comparable...
  32. ncbi Possible parent-of-origin effect of Dopa decarboxylase in susceptibility to bipolar affective disorder
    A D Børglum
    Institute of Human Genetics, University of Aarhus, Denmark
    Am J Med Genet B Neuropsychiatr Genet 117:18-22. 2003
    ..Increased transmission of paternal DDC alleles has also been suggested in attention deficit hyperactivity disorder. We suggest that DDC might confer susceptibility to BPAD predominantly when paternally transmitted...
  33. ncbi No association between a neuronal nitric oxide synthase (NOS1) gene polymorphism on chromosome 12q24 and bipolar disorder
    H N Buttenschön
    Am J Med Genet B Neuropsychiatr Genet 124:73-5. 2004
  34. ncbi Novel polymorphisms in the somatostatin receptor 5 (SSTR5) gene associated with bipolar affective disorder
    M Nyegaard
    Department of Clinical Biochemistry and Genetics, Odense University Hospital, Denmark
    Mol Psychiatry 7:745-54. 2002
    ..However, given the marginal statistical significance and the potential for false-positive results in association studies with candidate genes, further studies are needed to clarify this hypothesis...
  35. ncbi Head injury as a risk factor for bipolar affective disorder
    P B Mortensen
    National Centre for Register Based Research, Aarhus University, Taasingegade 1 DK 8000 Aarhus C, Denmark
    J Affect Disord 76:79-83. 2003
    ..Case reports have associated head injury with psychoses including affective disorders, but little is known regarding head injury as a risk factor for the onset of bipolar affective disorder...