Holger Jon Møller

Summary

Affiliation: Aarhus University Hospital
Country: Denmark

Publications

  1. pmc High mobility group box-1 protein in patients with suspected community-acquired infections and sepsis: a prospective study
    Shahin Gaïni
    Department of Infectious Diseases, Odense University Hospital, Søndre Boulevard 29, DK 5000 Odense C, Denmark
    Crit Care 11:R32. 2007
  2. pmc A comparison of high-mobility group-box 1 protein, lipopolysaccharide-binding protein and procalcitonin in severe community-acquired infections and bacteraemia: a prospective study
    Shahin Gaïni
    Department of Infectious Diseases, Odense University Hospital, Søndre Boulevard 29, DK 5000 Odense C, Denmark
    Crit Care 11:R76. 2007
  3. pmc Soluble CD163 from activated macrophages predicts mortality in acute liver failure
    Holger Jon Møller
    Department of Clinical Biochemistry AS, Aarhus University Hospital, Aarhus, Denmark
    J Hepatol 47:671-6. 2007
  4. doi Soluble macrophage-derived CD163: a homogenous ectodomain protein with a dissociable haptoglobin-hemoglobin binding
    Holger Jon Møller
    Department of Clinical Biochemistry, Aarhus University Hospital, Nørrebrogade 44, 8000 Arhus Sygehus, Denmark
    Immunobiology 215:406-12. 2010
  5. doi Efficient intracellular drug-targeting of macrophages using stealth liposomes directed to the hemoglobin scavenger receptor CD163
    Anders Etzerodt
    Department of Biomedicine, Aarhus University, Ole Worms Alle 2, Aarhus, Denmark
    J Control Release 160:72-80. 2012
  6. doi Tumor-promoting macrophages induce the expression of the macrophage-specific receptor CD163 in malignant cells
    Maciej Bogdan Maniecki
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    Int J Cancer 131:2320-31. 2012
  7. ncbi Soluble CD163 and interleukin-6 are increased in aqueous humour from patients with endothelial rejection of corneal grafts
    Mikkel Funding
    Department of Ophthalmology, Aarhus University Hospital, Aarhus, Denmark
    Acta Ophthalmol Scand 83:234-9. 2005
  8. ncbi CD163 positive subsets of blood dendritic cells: the scavenging macrophage receptors CD163 and CD91 are coexpressed on human dendritic cells and monocytes
    Maciej Bogdan Maniecki
    Department of Clinical Biochemistry, Aarhus University Hospital, Norrebrogade 44, DK 8000 Aarhus C, Denmark
    Immunobiology 211:407-17. 2006
  9. doi Comparative assessment of the recognition of domain-specific CD163 monoclonal antibodies in human monocytes explains wide discrepancy in reported levels of cellular surface CD163 expression
    Maciej Bogdan Maniecki
    Department of Clinical Biochemistry, Aarhus Sygehus, Aarhus University Hospital, Nørrebrogade 44, DK 8000 Aarhus C, Denmark
    Immunobiology 216:882-90. 2011
  10. doi Macrophage markers in serum and tumor have prognostic impact in American Joint Committee on Cancer stage I/II melanoma
    Trine O Jensen
    Department of Oncology, Aarhus University Hospital, Denmark
    J Clin Oncol 27:3330-7. 2009

Collaborators

Detail Information

Publications14

  1. pmc High mobility group box-1 protein in patients with suspected community-acquired infections and sepsis: a prospective study
    Shahin Gaïni
    Department of Infectious Diseases, Odense University Hospital, Søndre Boulevard 29, DK 5000 Odense C, Denmark
    Crit Care 11:R32. 2007
    ..Its role as a pro-inflammatory cytokine in sepsis and rheumatoid arthritis has been described recently. The aim of our study was to evaluate HMGB1 as a molecular marker in patients with community-acquired infections...
  2. pmc A comparison of high-mobility group-box 1 protein, lipopolysaccharide-binding protein and procalcitonin in severe community-acquired infections and bacteraemia: a prospective study
    Shahin Gaïni
    Department of Infectious Diseases, Odense University Hospital, Søndre Boulevard 29, DK 5000 Odense C, Denmark
    Crit Care 11:R76. 2007
    ..The study plan included analysis of the levels of the inflammatory markers in relation to the severity of infection, to the prognosis and to the ability to identify patients with bacteraemia...
  3. pmc Soluble CD163 from activated macrophages predicts mortality in acute liver failure
    Holger Jon Møller
    Department of Clinical Biochemistry AS, Aarhus University Hospital, Aarhus, Denmark
    J Hepatol 47:671-6. 2007
    ..Soluble CD163 (sCD163) is a scavenger receptor shed in serum during inflammatory activation of macrophages. We investigated if sCD163 was increased and predicted outcome in acute liver failure (ALF)...
  4. doi Soluble macrophage-derived CD163: a homogenous ectodomain protein with a dissociable haptoglobin-hemoglobin binding
    Holger Jon Møller
    Department of Clinical Biochemistry, Aarhus University Hospital, Nørrebrogade 44, 8000 Arhus Sygehus, Denmark
    Immunobiology 215:406-12. 2010
    ..Here, we have characterized molecular forms in serum and investigated a role of sCD163 as a binder of Hp-Hb complexes...
  5. doi Efficient intracellular drug-targeting of macrophages using stealth liposomes directed to the hemoglobin scavenger receptor CD163
    Anders Etzerodt
    Department of Biomedicine, Aarhus University, Ole Worms Alle 2, Aarhus, Denmark
    J Control Release 160:72-80. 2012
    ..In conclusion, the use of stealth liposomes modified to recognize CD163 is a potential way to target drugs to macrophages that support inflammatory and malignant processes...
  6. doi Tumor-promoting macrophages induce the expression of the macrophage-specific receptor CD163 in malignant cells
    Maciej Bogdan Maniecki
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    Int J Cancer 131:2320-31. 2012
    ..CD163 expressing tumor cells may constitute a subpopulation of tumor cells with a phenotypic shift associated with epithelial-to-mesenchymal transition (EMT) and increased metastatic activity induced by TAMs...
  7. ncbi Soluble CD163 and interleukin-6 are increased in aqueous humour from patients with endothelial rejection of corneal grafts
    Mikkel Funding
    Department of Ophthalmology, Aarhus University Hospital, Aarhus, Denmark
    Acta Ophthalmol Scand 83:234-9. 2005
    ....
  8. ncbi CD163 positive subsets of blood dendritic cells: the scavenging macrophage receptors CD163 and CD91 are coexpressed on human dendritic cells and monocytes
    Maciej Bogdan Maniecki
    Department of Clinical Biochemistry, Aarhus University Hospital, Norrebrogade 44, DK 8000 Aarhus C, Denmark
    Immunobiology 211:407-17. 2006
    ..The CD163 expression pattern suggests that if antigens are targeted to CD163 they may induce an immunostimulatory response like that of CD91-targeted antigens...
  9. doi Comparative assessment of the recognition of domain-specific CD163 monoclonal antibodies in human monocytes explains wide discrepancy in reported levels of cellular surface CD163 expression
    Maciej Bogdan Maniecki
    Department of Clinical Biochemistry, Aarhus Sygehus, Aarhus University Hospital, Nørrebrogade 44, DK 8000 Aarhus C, Denmark
    Immunobiology 216:882-90. 2011
    ..In this study we sought to clarify this inconsistency in reported levels of CD163 surface expression by a detailed analysis of a panel of CD163 antibodies used in previous studies...
  10. doi Macrophage markers in serum and tumor have prognostic impact in American Joint Committee on Cancer stage I/II melanoma
    Trine O Jensen
    Department of Oncology, Aarhus University Hospital, Denmark
    J Clin Oncol 27:3330-7. 2009
    ..The scavenger receptor CD163 is associated with anti-inflammatory macrophages, and it is shed from their surface...
  11. doi Hemoglobin and heme scavenger receptors
    Marianne Jensby Nielsen
    Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
    Antioxid Redox Signal 12:261-73. 2010
    ....
  12. doi Impaired CD163-mediated hemoglobin-scavenging and severe toxic symptoms in patients treated with gemtuzumab ozogamicin
    Maciej Bogdan Maniecki
    Department of Clinical Biochemistry, Arhus Sygehus, Aarhus University Hospital, Aarhus, Denmark
    Blood 112:1510-4. 2008
    ..Furthermore, the cases provide further circumstantial evidence of a key role of (CD163-expressing) monocytes/macrophages in plasma hemoglobin clearance in vivo...
  13. ncbi Plasma level of the macrophage-derived soluble CD163 is increased and positively correlates with severity in Gaucher's disease
    Holger Jon Møller
    Department of Clinical Biochemistry, AKH Aarhus University Hospital, Aarhus, Denmark
    Eur J Haematol 72:135-9. 2004
    ..43, P < 0.0061) and chitotriosidase activity (rho = 0.71, P > 0.0001). This study further establishes that sCD163 may be a valuable laboratory parameter in monitoring disease with increased macrophage activity...
  14. doi Kupffer cells are activated in cirrhotic portal hypertension and not normalised by TIPS
    Peter Holland-Fischer
    Department of Medicine V Hepato and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark
    Gut 60:1389-93. 2011
    ....