Timothy L Lash

Summary

Affiliation: Aarhus University Hospital
Country: Denmark

Publications

  1. doi request reprint Comorbidity and survival of Danish cirrhosis patients: a nationwide population-based cohort study
    Peter Jepsen
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    Hepatology 48:214-20. 2008
  2. pmc Family history of later-onset breast cancer, breast healthy behavior and invasive breast cancer among postmenopausal women: a cohort study
    Robert Gramling
    Department of Family Medicine, University of Rochester, NY 14620, USA
    Breast Cancer Res 12:R82. 2010
  3. doi request reprint Methods to apply probabilistic bias analysis to summary estimates of association
    Timothy L Lash
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    Pharmacoepidemiol Drug Saf 19:638-44. 2010
  4. pmc CYP2D6 inhibition and breast cancer recurrence in a population-based study in Denmark
    Timothy L Lash
    Department of Clinical Epidemiology, Aarhus University Hospital, Denmark
    J Natl Cancer Inst 103:489-500. 2011
  5. pmc Breast cancer recurrence risk related to concurrent use of SSRI antidepressants and tamoxifen
    Timothy L Lash
    Department of Clinical Epidemiology, Aarhus University Hospital, Denmark
    Acta Oncol 49:305-12. 2010
  6. doi request reprint Hospitalization rates and survival associated with COPD: a nationwide Danish cohort study
    Timothy L Lash
    Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Alle 43 45, 8200 Aarhus, Denmark
    Lung 189:27-35. 2011
  7. pmc Hospital recorded morbidity and breast cancer incidence: a nationwide population-based case-control study
    Anne Gulbech Ording
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    PLoS ONE 7:e47329. 2012
  8. doi request reprint Five-year mortality in colorectal cancer patients with ulcerative colitis or Crohn's disease: a nationwide population-based cohort study
    Anne G Ording
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    Inflamm Bowel Dis 19:800-5. 2013
  9. doi request reprint Nonsteroidal antiinflammatory drug use and cardiovascular risks after coronary stent implantation
    Morten Schmidt
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    Pharmacotherapy 31:458-68. 2011
  10. pmc Use of β-blockers, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and risk of breast cancer recurrence: a Danish nationwide prospective cohort study
    Gitte Vrelits Sørensen
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    J Clin Oncol 31:2265-72. 2013

Collaborators

Detail Information

Publications45

  1. doi request reprint Comorbidity and survival of Danish cirrhosis patients: a nationwide population-based cohort study
    Peter Jepsen
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    Hepatology 48:214-20. 2008
    ..15). In the first year of follow-up, but not later, comorbidity increased the risk of cirrhosis-related death, and this was consistent with an apparent synergy between the cirrhosis and comorbidity effects on mortality in the same period...
  2. pmc Family history of later-onset breast cancer, breast healthy behavior and invasive breast cancer among postmenopausal women: a cohort study
    Robert Gramling
    Department of Family Medicine, University of Rochester, NY 14620, USA
    Breast Cancer Res 12:R82. 2010
    ....
  3. doi request reprint Methods to apply probabilistic bias analysis to summary estimates of association
    Timothy L Lash
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    Pharmacoepidemiol Drug Saf 19:638-44. 2010
    ..We have developed probabilistic methods to evaluate bias from disease misclassification or an unmeasured confounder that can be applied to adjusted estimates of association...
  4. pmc CYP2D6 inhibition and breast cancer recurrence in a population-based study in Denmark
    Timothy L Lash
    Department of Clinical Epidemiology, Aarhus University Hospital, Denmark
    J Natl Cancer Inst 103:489-500. 2011
    ..Cytochrome P450 2D6 (CYP2D6) inhibition reduces the concentration of 4-hydroxylated tamoxifen metabolites, but the clinical relevance remains uncertain...
  5. pmc Breast cancer recurrence risk related to concurrent use of SSRI antidepressants and tamoxifen
    Timothy L Lash
    Department of Clinical Epidemiology, Aarhus University Hospital, Denmark
    Acta Oncol 49:305-12. 2010
    ..The SSRI citalopram has limited potency to inhibit CYP2D6 activity, so has been recommended for breast cancer patients taking tamoxifen. This study provides epidemiologic evidence to support this recommendation...
  6. doi request reprint Hospitalization rates and survival associated with COPD: a nationwide Danish cohort study
    Timothy L Lash
    Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Alle 43 45, 8200 Aarhus, Denmark
    Lung 189:27-35. 2011
    ..COPD continues to be a major public health problem causing substantial mortality in the 5 years after hospitalization, particularly in the first 180 days and in patients with comorbid diseases...
  7. pmc Hospital recorded morbidity and breast cancer incidence: a nationwide population-based case-control study
    Anne Gulbech Ording
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    PLoS ONE 7:e47329. 2012
    ..Chronic diseases and their complications may increase breast cancer risk through known or still unknown mechanisms, or by shared causes. The association between morbidities and breast cancer risk has not been studied in depth...
  8. doi request reprint Five-year mortality in colorectal cancer patients with ulcerative colitis or Crohn's disease: a nationwide population-based cohort study
    Anne G Ording
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    Inflamm Bowel Dis 19:800-5. 2013
    ..We studied the overall mortality in CRC patients with a history of ulcerative colitis (UC) or Crohn's disease (CD) compared with non-IBD-CRC patients...
  9. doi request reprint Nonsteroidal antiinflammatory drug use and cardiovascular risks after coronary stent implantation
    Morten Schmidt
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    Pharmacotherapy 31:458-68. 2011
    ..To determine whether use of nonselective nonsteroidal antiinflammatory drugs (NSAIDs) or cyclooxygenase-2 (COX-2)-selective inhibitors in patients with coronary stents increased the 3-year rate of major adverse cardiovascular events (MACE)...
  10. pmc Use of β-blockers, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and risk of breast cancer recurrence: a Danish nationwide prospective cohort study
    Gitte Vrelits Sørensen
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    J Clin Oncol 31:2265-72. 2013
    ..To estimate associations between use of β-blockers, angiotensin-converting enzyme (ACE) inhibitors, or angiotensin receptor blockers (ARBs) and breast cancer recurrence in a large Danish cohort...
  11. pmc Factors associated with concordant estrogen receptor expression at diagnosis and centralized re-assay in a Danish population-based breast cancer study
    Deirdre P Cronin-Fenton
    Department of Clinical Epidemiology, Aarhus University Hospital, Denmark
    Acta Oncol 51:254-61. 2012
    ..We examined clinical factors associated with concordance between ER expression at diagnosis and centralized re-assay, and the association of concordance with breast cancer recurrence...
  12. pmc Comorbid diseases interact with breast cancer to affect mortality in the first year after diagnosis--a Danish nationwide matched cohort study
    Anne Gulbech Ording
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    PLoS ONE 8:e76013. 2013
    ..Survival of breast cancer patients with comorbidity, compared to those without comorbidity, has been well characterized. The interaction between comorbid diseases and breast cancer, however, has not been well-studied...
  13. pmc Manganese superoxide dismutase and breast cancer recurrence: a Danish clinical registry-based case-control study, and a meta-analysis
    Deirdre P Cronin-Fenton
    Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark
    PLoS ONE 9:e87450. 2014
    ..We examined the association of SOD2 genotype and breast cancer recurrence (BCR) among patients treated with cyclophosphamide-based chemotherapy (Cyclo). We compared our findings with published studies using meta-analyses...
  14. doi request reprint Superficial and deep venous thrombosis, pulmonary embolism and subsequent risk of cancer
    Henrik Toft Sørensen
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark
    Eur J Cancer 48:586-93. 2012
    ..In contrast to deep venous thrombosis and pulmonary embolism, superficial venous thrombosis has not been considered to be a marker of occult cancer. However, actual data regarding the association are very limited...
  15. pmc 25 year trends in first time hospitalisation for acute myocardial infarction, subsequent short and long term mortality, and the prognostic impact of sex and comorbidity: a Danish nationwide cohort study
    Morten Schmidt
    Department of Clinical Epidemiology, Aarhus University Hospital, Denmark
    BMJ 344:e356. 2012
    ..To examine 25 year trends in first time hospitalisation for acute myocardial infarction in Denmark, subsequent short and long term mortality, and the prognostic impact of sex and comorbidity...
  16. doi request reprint Null association between tamoxifen use and dementia in Danish breast cancer patients
    Anne Gulbech Ording
    Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Alle 43 45, 8200 Aarhus N, Denmark
    Cancer Epidemiol Biomarkers Prev 22:993-6. 2013
    ..We examined whether tamoxifen or other endocrine therapy was associated with dementia risk in a large population of patients with breast cancer...
  17. doi request reprint Cognitive test scores in young men and subsequent risk of type 2 diabetes, cardiovascular morbidity, and death
    Morten Schmidt
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    Epidemiology 24:632-6. 2013
    ..The association between cognitive scores in young adulthood and long-term cardiometabolic risks remains unclear...
  18. doi request reprint Clopidogrel use and short-term mortality after peptic ulcer bleeding: a population-based cohort study
    Morten Schmidt
    Department of Clinical Epidemiology, Aarhus University Hospital, DK 8200, Aarhus N, Denmark
    Am J Ther 20:13-20. 2013
    ..Although the use of clopidogrel increases the risk of PUB, former use and current use of clopidogrel were not associated with increased short-term mortality after admission for this condition...
  19. pmc Mortality in cancer patients with a history of cutaneous squamous cell carcinoma--a nationwide population-based cohort study
    Sigrun Alba Johannesdottir
    Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Alle 43 45, 8200 Aarhus N, Denmark
    BMC Cancer 12:126. 2012
    ....
  20. pmc Prescriptions for selective cyclooxygenase-2 inhibitors, non-selective non-steroidal anti-inflammatory drugs, and risk of breast cancer in a population-based case-control study
    Deirdre P Cronin-Fenton
    Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Alle 43 45, Aarhus N, Denmark
    Breast Cancer Res 12:R15. 2010
    ....
  21. doi request reprint Relative mortality rates from incident chronic diseases among breast cancer survivors - A 14year follow-up of five-year survivors diagnosed in Denmark between 1994 and 2007
    Anne Gulbech Ording
    Department of Clinical Epidemiology, Aarhus University Hospital, Denmark Electronic address
    Eur J Cancer 51:767-75. 2015
    ..It remains unknown whether incident chronic diseases are more often fatal among breast cancer survivors than among women free of breast cancer...
  22. doi request reprint Development and validation of a comorbidity scoring system for patients with cirrhosis
    Peter Jepsen
    Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark Electronic address
    Gastroenterology 146:147-56; quiz e15-6. 2014
    ..We developed a cirrhosis-specific comorbidity scoring system (CirCom) to help determine how these comorbidities affect mortality and compared it with the generic Charlson Comorbidity Index...
  23. doi request reprint Hospitalization with acute exacerbation of chronic obstructive pulmonary disease and associated health resource utilization: a population-based Danish cohort study
    Sigrun A Johannesdottir
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark
    J Med Econ 16:897-906. 2013
    ..Therefore, a population-based cohort study was conducted to characterize patients hospitalized with AECOPD with regard to HRU, mortality, recurrence, and predictors of readmission with AECOPD...
  24. pmc Use of glucocorticoids and risk of breast cancer: a Danish population-based case-control study
    Gitte Vrelits Sørensen
    Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Alle 43 45, 8200 Aarhus N, Denmark
    Breast Cancer Res 14:R21. 2012
    ..It belongs to the same steroid superfamily as estrogens, which are known to play a role in breast cancer. However, the effect of glucocorticoid use on the risk of breast cancer is not clear...
  25. doi request reprint Heart disease may be a risk factor for pulmonary embolism without peripheral deep venous thrombosis
    Henrik T Sørensen
    Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Alle 43 45, DK 8200 Aarhus N, Denmark
    Circulation 124:1435-41. 2011
    ..Heart diseases increase the risk of arterial embolism; whether they increase the risk of pulmonary embolism without peripheral venous thrombosis is less certain...
  26. ncbi request reprint Survival in Danish patients with breast cancer and inflammatory bowel disease: a nationwide cohort study
    Kirstine Kobberøe Søgaard
    Department of Clinical Epidemiology, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Inflamm Bowel Dis 14:519-25. 2008
    ..The influence of IBD on breast cancer prognosis, however, is unknown. We therefore examined the impact of IBD on treatment receipt and survival in breast cancer patients...
  27. pmc Use of selective serotonin reuptake inhibitors and risk of re-operation due to post-surgical bleeding in breast cancer patients: a Danish population-based cohort study
    Rune Gärtner
    Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Alle 43 45, Aarhus N 8200, Denmark
    BMC Surg 10:3. 2010
    ..Selective serotonin reuptake inhibitors (SSRI) decrease platelet-function, which suggests that SSRI use may increase the risk of post-surgical bleeding. Few studies have investigated this potential association...
  28. pmc The impact of exacerbation frequency on mortality following acute exacerbations of COPD: a registry-based cohort study
    Sigrún Alba Jóhannesdóttir Schmidt
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark
    BMJ Open 4:e006720. 2014
    ..To examine the association between exacerbation frequency and mortality following an acute exacerbation of chronic obstructive pulmonary disease (AECOPD)...
  29. doi request reprint Statin use and risk of amyotrophic lateral sclerosis and other motor neuron disorders
    Henrik Toft Sørensen
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    Circ Cardiovasc Qual Outcomes 3:413-7. 2010
    ..We assessed whether statin use is associated with the occurrence of amyotrophic lateral sclerosis and other motor neuron disorders...
  30. pmc Impact of comorbidity on risk of venous thromboembolism in patients with breast cancer: a Danish population-based cohort study
    Anne Gulbech Ording
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    BMJ Open 4:e005082. 2014
    ..To assess the interaction between comorbidity and breast cancer (BC) on the rate of venous thromboembolism (VTE) beyond what can be explained by the independent effects of BC and comorbidity...
  31. pmc Clinical epidemiology and pharmacology of CYP2D6 inhibition related to breast cancer outcomes
    Deirdre P Cronin-Fenton
    Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Alle 43 45, 8200 Aarhus C, Denmark
    Expert Rev Clin Pharmacol 4:363-77. 2011
    ....
  32. doi request reprint Use of penicillin and other antibiotics and risk of multiple sclerosis: a population-based case-control study
    Mette Nørgaard
    Department of Clinical Epidemiology, Institute of Clinical Medicine, Aarhus University Hospital, Denmark
    Am J Epidemiol 174:945-8. 2011
    ..08 and 1.83. Thus, this study found that penicillin use and use of other antibiotics were similarly associated with increased risk of MS, suggesting that the underlying infections may be causally associated with MS...
  33. ncbi request reprint Birth outcome in Danish women with cutaneous malignant melanoma
    Vivian Langagergaard
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    Melanoma Res 17:31-6. 2007
    ..7; 12). This estimate was, however, based on only five stillbirths in the exposed group and was an unexpected finding. With this exception, our data suggest no substantially increased risk of adverse birth outcome for women with melanoma...
  34. pmc Digoxin treatment is associated with an increased incidence of breast cancer: a population-based case-control study
    Thomas P Ahern
    Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Alle 43 45, 8200 Aarhus N, Denmark
    Breast Cancer Res 10:R102. 2008
    ..We explored the association between digoxin treatment and invasive breast cancer incidence among postmenopausal Danish women...
  35. pmc The predictive value of ICD-10 diagnostic coding used to assess Charlson comorbidity index conditions in the population-based Danish National Registry of Patients
    Sandra K Thygesen
    Department of Clinical Epidemiology, The Institute of Clinical Medicine, Aarhus University Hospital, Denmark
    BMC Med Res Methodol 11:83. 2011
    ..We examined the positive predictive value (PPV) of the ICD-10 diagnostic coding in the Danish National Registry of Patients (NRP) for the 19 Charlson conditions...
  36. doi request reprint A validated algorithm to ascertain colorectal cancer recurrence using registry resources in Denmark
    Timothy L Lash
    Department of Epidemiology, Rollins School of Public Health, Atlanta, GA Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    Int J Cancer 136:2210-5. 2015
    ..It can be used in the Danish registries and adapted to similar registries elsewhere. ..
  37. doi request reprint Hospitalized prenatal and childhood infections and obesity in Danish male conscripts
    Noelle M Cocoros
    Bureau of Infectious Disease, Massachusetts Department of Public Health, Jamaica Plain, Massachusetts, USA
    Ann Epidemiol 23:307-13. 2013
    ..We examined the relation between early life infections and adult obesity...
  38. ncbi request reprint NO excess risk of breast cancer among female users of systemic glucocorticoids
    Henrik Toft Sørensen
    Department of Clinical Epidemiology, Aarhus University Hospital, Ole Worms Allé 150, 8000 Aarhus C, Denmark
    Cancer Epidemiol Biomarkers Prev 14:1022-3. 2005
  39. doi request reprint Long-term statin use and the risk of gallstone disease: A population-based case-control study
    Rune Erichsen
    Department of Clinical Epidemiology, Aarhus University Hospital, Denmark
    Am J Epidemiol 173:162-70. 2011
    ..In former users, the corresponding adjusted odds ratios were 1.24 (95% CI: 1.11, 1.39), 0.97 (95% CI: 0.86, 1.10), and 0.79 (95% CI: 0.64, 0.97), respectively. The use of other lipid-lowering drugs showed no similar association...
  40. doi request reprint Autoimmune diseases and breast cancer recurrence: a Danish nationwide cohort study
    Lone Winther Lietzen
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    Breast Cancer Res Treat 149:497-504. 2015
    ..56 (95 % CI 0.40, 0.78). Among women with BC, a history of at least one AD diagnosis was not associated with BC recurrence, with the possible exception of ADs of the central nervous/neuromuscular system...
  41. doi request reprint Persistent geographical disparities in the use of primary percutaneous coronary intervention in 120 European regions: exploring the variation
    Kristina G Laut
    Department of Cardiology, Aarhus University Hospital, Skejby, Denmark
    EuroIntervention 9:469-76. 2013
    ....
  42. pmc Prognosis of ovarian cancer subsequent to venous thromboembolism: a nationwide Danish cohort study
    Mette S Tetsche
    Department of Clinical Epidemiology, Aarhus University Hospital, 8000 Aarhus, Denmark
    BMC Cancer 6:189. 2006
    ..Our aims were to examine the extent of disease at the time of the diagnosis of ovarian cancer and to estimate the impact of VTE on survival of ovarian cancer...
  43. ncbi request reprint Beyond randomized controlled trials: a critical comparison of trials with nonrandomized studies
    Henrik Toft Sørensen
    Department of Clinical Epidemiology, Aarhus University Hospital, 8000 Aarhus C, Denmark
    Hepatology 44:1075-82. 2006
    ..Observational studies cannot replace trials, nor do trials make observational studies unnecessary. Both designs are susceptible to particular bias, so neither provides perfect information...
  44. pmc Metabolism and transport of tamoxifen in relation to its effectiveness: new perspectives on an ongoing controversy
    Deirdre P Cronin-Fenton
    Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark
    Future Oncol 10:107-22. 2014
    ....
  45. pmc Correspondence between general practitionerreported medication use and timing of prescription dispensation
    Sigrun Alba Johannesdottir
    Department of Clinical Epidemiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
    Clin Epidemiol 4:13-8. 2012
    ..55 for ACE-inhibitors to 1.00 for oral glucose-lowering agents. The correspondence was greater when analyzed within therapeutic groups than when analyzed for exact medications within these groups...