Hans E Johnsen

Summary

Affiliation: Aarhus University Hospital
Country: Denmark

Publications

  1. doi request reprint Validation and implementation of a method for microarray gene expression profiling of minor B-cell subpopulations in man
    Kim Steve Bergkvist
    Department of Haematology, Aalborg University Hospital Science and Innovation Center, Sdr Skovvej 15, DK 9000 Aalborg, Denmark
    BMC Immunol 15:3. 2014
  2. pmc A model system for assessing and comparing the ability of exon microarray and tag sequencing to detect genes specific for malignant B-cells
    Maria Bro Kloster
    Department of Haematology, Aalborg Hospital, Aarhus University Hospital, Sdr Skovvej 15, 9000 Aalborg, Denmark
    BMC Genomics 13:596. 2012
  3. ncbi request reprint [The haematological biobank--an infrastructure for quality assurance, development and research]
    Hans E Johnsen
    Hæmatologisk Afdeling, Medicinsk Center, Aarhus Universitetshospital, Aalborg Sygehus, Denmark
    Ugeskr Laeger 173:1489-93. 2011
  4. doi request reprint Improved survival for multiple myeloma in denmark based on autologous stem cell transplantation and novel drug therapy in collaborative trials: analysis of accrual, prognostic variables, selection bias, and clinical behavior on survival in more than 1200
    Hans E Johnsen
    Department of Haematology, Herlev Hospital, Copenhagen University, Denmark
    Clin Lymphoma Myeloma Leuk 10:290-6. 2010
  5. doi request reprint Priming with r-metHuSCF and filgrastim or chemotherapy and filgrastim in patients with malignant lymphomas: a randomized phase II pilot study of mobilization and engraftment
    H E Johnsen
    Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    Bone Marrow Transplant 46:44-51. 2011
  6. ncbi request reprint [The clinical research unit]
    Hans E Johnsen
    Arhus Universitetshospital, Aalborg Sygehus, Haematologisk Afdeling, Medicinsk Center, Denmark
    Ugeskr Laeger 172:1380-3. 2010
  7. doi request reprint Multiparametric flow cytometry profiling of neoplastic plasma cells in multiple myeloma
    Hans E Johnsen
    Department of Haematology, Medical Center and Aalborg Hospital Science and Innovation Center AHSIC, Aarhus University Hospital, Aalborg, Denmark
    Cytometry B Clin Cytom 78:338-47. 2010
  8. pmc Generation of a predictive melphalan resistance index by drug screen of B-cell cancer cell lines
    Martin Boegsted
    Department of Haematology, Aalborg Hospital Science and Innovation Center, Aarhus University Hospital, Aalborg, Denmark
    PLoS ONE 6:e19322. 2011
  9. ncbi request reprint [Use of translational database at clinical department]
    Anne Dirks Højfeldt
    Arhus Universitetshospital, Aalborg Sygehus, Haematologisk Afdeling, Medicinsk Center
    Ugeskr Laeger 172:2062-4. 2010
  10. ncbi request reprint Serum YKL-40 concentrations in newly diagnosed multiple myeloma patients and YKL-40 expression in malignant plasma cells
    Anne K Mylin
    Department of Haematology, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    Eur J Haematol 77:416-24. 2006

Collaborators

Detail Information

Publications20

  1. doi request reprint Validation and implementation of a method for microarray gene expression profiling of minor B-cell subpopulations in man
    Kim Steve Bergkvist
    Department of Haematology, Aalborg University Hospital Science and Innovation Center, Sdr Skovvej 15, DK 9000 Aalborg, Denmark
    BMC Immunol 15:3. 2014
    ..However, some of the differentiating compartments involve a low number of cells and therefore it is important to optimize and validate each step in the procedure...
  2. pmc A model system for assessing and comparing the ability of exon microarray and tag sequencing to detect genes specific for malignant B-cells
    Maria Bro Kloster
    Department of Haematology, Aalborg Hospital, Aarhus University Hospital, Sdr Skovvej 15, 9000 Aalborg, Denmark
    BMC Genomics 13:596. 2012
    ..A model system was established by eight serial dilutions of the malignant B-cell lymphoma cell line, OCI-Ly8, into the embryonic kidney cell line, HEK293, prior to parallel analysis by exon microarrays and tag-seq...
  3. ncbi request reprint [The haematological biobank--an infrastructure for quality assurance, development and research]
    Hans E Johnsen
    Hæmatologisk Afdeling, Medicinsk Center, Aarhus Universitetshospital, Aalborg Sygehus, Denmark
    Ugeskr Laeger 173:1489-93. 2011
    ..Together, these form the basis for retrospective validation of clinical progress and prognostic evaluation of new diagnostic methods, which can therefore be more quickly implemented in the clinic...
  4. doi request reprint Improved survival for multiple myeloma in denmark based on autologous stem cell transplantation and novel drug therapy in collaborative trials: analysis of accrual, prognostic variables, selection bias, and clinical behavior on survival in more than 1200
    Hans E Johnsen
    Department of Haematology, Herlev Hospital, Copenhagen University, Denmark
    Clin Lymphoma Myeloma Leuk 10:290-6. 2010
    ..It was hypothesized that a detailed analysis of potential explanations would reveal important information for future designs of clinical trials for multiple myeloma (MM) patients in Denmark...
  5. doi request reprint Priming with r-metHuSCF and filgrastim or chemotherapy and filgrastim in patients with malignant lymphomas: a randomized phase II pilot study of mobilization and engraftment
    H E Johnsen
    Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    Bone Marrow Transplant 46:44-51. 2011
    ....
  6. ncbi request reprint [The clinical research unit]
    Hans E Johnsen
    Arhus Universitetshospital, Aalborg Sygehus, Haematologisk Afdeling, Medicinsk Center, Denmark
    Ugeskr Laeger 172:1380-3. 2010
    ..Understanding these mechanisms is fundamental for the quality of care in the Danish health care system and needs a national supportive strategy...
  7. doi request reprint Multiparametric flow cytometry profiling of neoplastic plasma cells in multiple myeloma
    Hans E Johnsen
    Department of Haematology, Medical Center and Aalborg Hospital Science and Innovation Center AHSIC, Aarhus University Hospital, Aalborg, Denmark
    Cytometry B Clin Cytom 78:338-47. 2010
    ..The primary aim of this study was to perform global analysis of CD expression on the PC compartment and subsequently to evaluate the prognostic impact. Secondary aims were to study the diagnostic and predictive impact...
  8. pmc Generation of a predictive melphalan resistance index by drug screen of B-cell cancer cell lines
    Martin Boegsted
    Department of Haematology, Aalborg Hospital Science and Innovation Center, Aarhus University Hospital, Aalborg, Denmark
    PLoS ONE 6:e19322. 2011
    ..The hypothesis is that melphalan screens and GEPs of B-cell cancer cell lines combined with multivariate statistics may provide predictive clinical information...
  9. ncbi request reprint [Use of translational database at clinical department]
    Anne Dirks Højfeldt
    Arhus Universitetshospital, Aalborg Sygehus, Haematologisk Afdeling, Medicinsk Center
    Ugeskr Laeger 172:2062-4. 2010
    ..It is expected that along with automated prediction and prognosis tools, such a database system may have the potential to assist the development of new machine-based diagnostic decision-making processes...
  10. ncbi request reprint Serum YKL-40 concentrations in newly diagnosed multiple myeloma patients and YKL-40 expression in malignant plasma cells
    Anne K Mylin
    Department of Haematology, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    Eur J Haematol 77:416-24. 2006
    ..The purpose of this study was to evaluate the clinical value of serum YKL-40 (sYKL-40) in multiple myeloma (MM) and to examine YKL-40 expression in malignant plasma cells (MM PCs)...
  11. doi request reprint Multiparametric flow cytometry for identification and fluorescence activated cell sorting of five distinct B-cell subpopulations in normal tonsil tissue
    Malene Krag Kjeldsen
    Department of Haematology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    Am J Clin Pathol 136:960-9. 2011
    ..This study has established a detailed and fast procedure for simultaneous sorting of up to 5 distinct maturation-associated B-cell subpopulations from human tonsils...
  12. pmc Identification of translocation products but not K-RAS mutations in memory B cells from patients with multiple myeloma
    Thomas Rasmussen
    1Department of Hematology, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    Haematologica 95:1730-7. 2010
    ..Several laboratories have shown that cells with a memory B-cell phenotype can have the same clonotype as multiple myeloma tumor cells...
  13. ncbi request reprint [Cancer stem cells in the haematopoietic system]
    Thomas Urup
    Arhus Universitetshospital, Aalborg Sygehus, Haematologisk Afdeling, Denmark
    Ugeskr Laeger 172:2597-600. 2010
    ..In this article, we focus on normal haematopoietic stem cells and cancer stem cells in leukaemia and multiple myeloma...
  14. pmc Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects
    Kaspar R Nielsen
    Department of Clinical Immunology, Aalborg Hospital, Aarhus University Hospital, Reberbansgade, Pobox 561, 9000, Aalborg, Denmark
    Arthritis Res Ther 13:R109. 2011
    ..YKL-40 concentrations are elevated in the serum of patients with RA compared to healthy subjects, and YKL-40 has been suggested to be an auto-antigen and may play a role in development of RA and in inflammation...
  15. ncbi request reprint [Designer drugs and their rational use in clinical hematology]
    Anne Bukh
    Arhus Universitetshospital, Aalborg Sygehus, Haematologisk Afdeling
    Ugeskr Laeger 167:2180-3. 2005
  16. ncbi request reprint Expression of HOXA genes in patients with multiple myeloma
    Heidi Rye Hudlebusch
    Department of Hematology L, Herlev Hospital, University of Copenhagen, 2730 Herlev, Denmark
    Leuk Lymphoma 45:1215-7. 2004
    ..We found that 9.4% (3/32) of the MM patients expressed the tested HOX genes in their PCs suggesting that HOXA genes are frequently dysregulated and might have an oncogenic potential in MM...
  17. pmc Proof of the concept to use a malignant B cell line drug screen strategy for identification and weight of melphalan resistance genes in multiple myeloma
    Martin Bøgsted
    Department of Haematology, Aalborg Hospital Science and Innovation Center AHSIC, Aalborg University Hospital, Aalborg, Denmark Department of Mathematical Sciences, Aalborg University, Aalborg, Denmark
    PLoS ONE 8:e83252. 2013
    ..This study provides clinical proof of concept to use in vitro drug screen for identification of melphalan resistance gene signatures for future functional analysis. ..
  18. ncbi request reprint Molecular and clinical follow-up after treatment of multiple myeloma
    Thomas Rasmussen
    Department of Hematology L 54P4, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    Acta Haematol 112:105-10. 2004
    ..However, for the MRD evaluation of autotransplants, where few patients achieve molecular remission, flow cytometry monitoring seems to be sufficient...
  19. ncbi request reprint Possible roles for activating RAS mutations in the MGUS to MM transition and in the intramedullary to extramedullary transition in some plasma cell tumors
    Thomas Rasmussen
    Department of Hematology L 54P4, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    Blood 105:317-23. 2005
    ....
  20. ncbi request reprint Acute and late toxicity following adjuvant high-dose chemotherapy for high-risk primary operable breast cancer--a quality assessment study
    Inge M Svane
    Department of Oncology, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    Acta Oncol 41:675-83. 2002
    ..Until now, high-dose chemotherapy has not proven superior to conventional-dose adjuvant chemotherapy, therefore it is necessary in the future to focus on well-designed randomized studies...