Research Topics
| Kjeld HermansenSummaryAffiliation: Aarhus University Hospital Country: Denmark Publications
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Detail Information
Publications
Effects of one single bout of low-intensity exercise on postprandial lipaemia in type 2 diabetic menMarian Dalgaard
Department of Endocrinology and Metabolism, Aarhus University Hospital, Denmark
Br J Nutr 92:469-76. 2004..One protocol was without any exercise. No significant effect of low-intensity exercise on postprandial lipaemia following a fat-rich meal with alcohol was seen in the middle-aged type 2 diabetic men...- Diet, blood pressure and hypertensionK Hermansen
Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Aarhus University Hospital, Denmark
Br J Nutr 83:S113-9. 2000..Further high-quality research on the influence of macronutrients and food will yield data for updated recommendations, enabling better prevention and control of the blood pressure problem... - [Insulin pump treatment in Denmark]Kjeld Hermansen
Arhus Universitetshospital, Arhus Sygehus, Medicinsk Endokrinologisk Afdeling C
Ugeskr Laeger 166:3685-9. 2004 - Intensive therapy with inhaled insulin via the AERx insulin diabetes management system: a 12-week proof-of-concept trial in patients with type 2 diabetesKjeld Hermansen
Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
Diabetes Care 27:162-7. 2004..To compare the glycemic control of inhaled insulin via the AERx insulin diabetes management system (iDMS) with that of subcutaneous (SC) insulin, both combined with NPH insulin at bedtime, in patients with type 2 diabetes... - Waiting to inhale: noninjectable insulin, are we there yet?Kjeld Hermansen
Aarhus University Hospital, Department of Endocrinology and Metabolism, Tage Hansens Gade 2, Aarhus DK 8000, Denmark
Curr Diab Rep 4:335-41. 2004..It appears that years of research into noninvasive methods of insulin administration are close to fruition and this review outlines the most recent findings in this area... - Improved postprandial glycemic control with biphasic insulin aspart relative to biphasic insulin lispro and biphasic human insulin in patients with type 2 diabetesKjeld Hermansen
University Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Aarhus, Denmark
Diabetes Care 25:883-8. 2002.... - Ethanol with a mixed meal decreases the incretin levels early postprandially and increases postprandial lipemia in type 2 diabetic patientsMarian Dalgaard
Aarhus Amtssygehus, Aarhus University Hospital, Denmark
Metabolism 53:77-83. 2004..Whether this reflects an alcohol-induced suppression of the incretin response, which adds to the alcohol-induced impairment of triacylglycerol clearance in type 2 diabetic patients, remains to be elucidated... - Antihyperglycemic effects of stevioside in type 2 diabetic subjectsSøren Gregersen
Department of Endocrinology and Metabolism C, Aarhus University Hospital, Denmark
Metabolism 53:73-6. 2004..In conclusion, stevioside reduces postprandial blood glucose levels in type 2 diabetic patients, indicating beneficial effects on the glucose metabolism. Stevioside may be advantageous in the treatment of type 2 diabetes... - Energy restriction prevents the development of type 2 diabetes in Zucker diabetic fatty rats: coordinated patterns of gene expression for energy metabolism in insulin-sensitive tissues and pancreatic islets determined by oligonucleotide microarray analysiMichele Colombo
Department of Endocrinology and Metabolism C, Aarhus Sygehus THG, Tage Hansens Gade 2, 8000 Aarhus C, Denmark
Metabolism 55:43-52. 2006.... 
Differential effects of protein quality on postprandial lipemia in response to a fat-rich meal in type 2 diabetes: comparison of whey, casein, gluten, and cod proteinLene S Mortensen
Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus, Denmark
Am J Clin Nutr 90:41-8. 2009..Dietary fat and carbohydrates profoundly influence postprandial hypertriglyceridemia, whereas little information exists on the effect of proteins...- Stevioside does not cause increased basal insulin secretion or beta-cell desensitization as does the sulphonylurea, glibenclamide: studies in vitroJianguo Chen
Department of Endocrinology and Metabolism, Aarhus Sygehus THG, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
Life Sci 78:1748-53. 2006..Our study suggests that SVS pretreatment does not cause a stimulation of BIS and does not desensitize beta-cells, i.e. SVS seems to have advantageous characteristics to GB as a potential treatment of type 2 diabetes... - Preventive effects of a soy-based diet supplemented with stevioside on the development of the metabolic syndrome and type 2 diabetes in Zucker diabetic fatty ratsStig Eric Underbjerg Dyrskog
Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus THG, 8000 Aarhus C, Denmark
Metabolism 54:1181-8. 2005..A long-term human study of the concept in type 2 diabetic subjects is needed to verify these promising results in animal diabetes... - Stevioside improves pancreatic beta-cell function during glucotoxicity via regulation of acetyl-CoA carboxylaseJianguo Chen
Department of Endocrinology and Metabolism, C Aarhus Sygehus THG, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
Am J Physiol Endocrinol Metab 292:E1906-16. 2007..SVS possesses the potential to alleviate negative effects of glucotoxicity in beta-cells via a unique mechanism of action... 
Differential effects of dietary protein sources on postprandial low-grade inflammation after a single high fat meal in obese non-diabetic subjectsJens Holmer-Jensen
Department of Endocrinology and Metabolism MEA, Aarhus University Hospital, Aarhus, Denmark
Nutr J 10:115. 2011..In this study we investigated the acute effect of dietary protein sources on postprandial low-grade inflammatory markers after a high-fat meal in obese non-diabetic subjects...- Isosteviol has beneficial effects on palmitate-induced α-cell dysfunction and gene expressionXiaoping Chen
The Department of Endocrinology and Metabolism MEA, Aarhus University Hospital, Aarhus, Denmark
PLoS ONE 7:e34361. 2012..The aim of this study was to explore if the antihyperglycemic agent, Isosteviol (ISV), is able to counteract palmitate-induced α-cell dysfunction and to influence α-cell gene expression... - Stevioside counteracts the glyburide-induced desensitization of the pancreatic beta-cell function in mice: studies in vitroJianguo Chen
Department of Endocrinology and Metabolism C, Aarhus Sygehus THG, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
Metabolism 55:1674-80. 2006..SVS is able to counteract the desensitizing effects of GB and may be a putative new drug candidate for the treatment of type 2 diabetes mellitus... - Chronic exposure to leucine in vitro induces β-cell dysfunction in INS-1E cells and mouse isletsZhenping Liu
Department of Medicine and Endocrinology, Aarhus University Hospital, Aarhus Sygehus THG, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
J Endocrinol 215:79-88. 2012..Our findings indicate that chronic exposure to elevated levels of leucine may have detrimental effects on both β-cell function and insulin sensitivity. Aminoacidotoxicity may play a pathogenic role in the development of type 2 diabetes... - Prevention of hyperglycemia in Zucker diabetic fatty rats by exercise training: effects on gene expression in insulin-sensitive tissues determined by high-density oligonucleotide microarray analysisMichele Colombo
Department of Endocrinology and Metabolism C, Aarhus Sygehus THG, Aarhus University Hospital, Tage Hansens Gade 2, Aarhus, Denmark
Metabolism 54:1571-81. 2005.... - A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-naive people with type 2 diabetesKjeld Hermansen
Department of Endocrinology and Metabolism, Aarhus Sygehus THG, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
Diabetes Care 29:1269-74. 2006..To assess efficacy and tolerability of insulin detemir or NPH insulin added to oral therapy for type 2 diabetes in a treat-to-target titration protocol... - Postprandial glycemic control with biphasic insulin aspart in patients with type 1 diabetesKjeld Hermansen
University Department of Endocrinology and Metabolism, Arhus Amtssygehus, Arhus, Denmark
Metabolism 51:896-900. 2002..We conclude that postprandial glycemic control was more effective with BIAsp 30 than with BHI 30, irrespective of timing of BHI 30 injection... - Differential effects of saturated and monounsaturated fats on postprandial lipemia and glucagon-like peptide 1 responses in patients with type 2 diabetesClaus Thomsen
University Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
Am J Clin Nutr 77:605-11. 2003.... - Effects of ghrelin and other neuropeptides (CART, MCH, orexin A and B, and GLP-1) on the release of insulin from isolated rat isletsMichele Colombo
Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus University, Denmark
Pancreas 27:161-6. 2003..The aim of this study is to clarify the dose and glucose-dependency of ghrelin on the insulin secretion and to compare its effect with that of other neuropeptides-GLP-1, CART (55-102), CART (55-76), CART (62-76), MCH, orexin A, and B... - The short-term effect of fatty acids on glucagon secretion is influenced by their chain length, spatial configuration, and degree of unsaturation: studies in vitroJing Hong
Department of Endocrinology and Metabolism, Aarhus Sygehus THG, Aarhus University Hospital, 8000 Aarhus C, Denmark
Metabolism 54:1329-36. 2005..Fatty acids immediately stimulate glucagon secretion from isolated mouse islets pancreatic alpha cells. The chain length, spatial configuration, and degree of unsaturation of fatty acids influence the glucagonotropic effect... - Comparison of a high saturated fat diet with a high carbohydrate diet during pregnancy and lactation: effects on insulin sensitivity in offspring of ratsSøren Gregersen
Department of Endocrinology and Metabolism, Tage Hansensgade 2, Aarhus University Hospital, 8000 Aarhus C, Denmark
Metabolism 54:1316-22. 2005..A diet high in SAFA given to mothers during gestation and/or the weaning period does not seem to have deleterious effects on the insulin sensitivity in the offspring... - Incremental area under response curve more accurately describes the triglyceride response to an oral fat load in both healthy and type 2 diabetic subjectsMarius Carstensen
Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
Metabolism 52:1034-7. 2003..The 3-point test seems less suitable for the determination of postprandial response in both healthy and type 2 diabetic subjects... - Amino acid-induced gene expression profiling in clonal β-cell line INS-1E cellsZhenping Liu
Department of Endocrinology and Metabolism MEA, Aarhus University Hospital, Aarhus Sygehus THG, Tage Hansens Gade 2, Aarhus C, Denmark
Diabetes Metab Res Rev 27:120-76. 2011..We aimed to investigate global alterations in β-cell gene expression after long-term exposure of clonal INS-1E cells to elevated level of specific AA in vitro... - Effects of dietary saturated, monounsaturated, and n-3 fatty acids on blood pressure in healthy subjectsBirthe M Rasmussen
Department of Clinical Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus, Denmark
Am J Clin Nutr 83:221-6. 2006..Interestingly, the beneficial effect on BP induced by fat quality was negated by the consumption of a high total fat intake. The addition of n-3 fatty acids to the diet had no significant effect on BP... - Bodyweight changes associated with antihyperglycaemic agents in type 2 diabetes mellitusKjeld Hermansen
Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus, Denmark
Drug Saf 30:1127-42. 2007..This is already possible with careful selection of available therapies, while several emerging therapies promise to further extend the options available... - Comparison of insulin responses in experiments using pooled mice islets versus islets from individual animals in the study of diabetesStig Eric Dyrskog
Department of Endocrinology and Metabolism C, Aarhus Sygehus THG, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
Metabolism 56:304-7. 2007..This will in turn produce too small P values when using statistical tests to compare mean responses to different stimuli... - Fatty acid-induced effect on glucagon secretion is mediated via fatty acid oxidationJing Hong
Department of Endocrinology and Metabolism, Aarhus Sygehus THG, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark
Diabetes Metab Res Rev 23:202-10. 2007..This study evaluates the long-term impact of fatty acids on alpha cell function and proliferation as well as fatty acid oxidation... - Rebaudioside A potently stimulates insulin secretion from isolated mouse islets: studies on the dose-, glucose-, and calcium-dependencyReziwanggu Abudula
Department of Endocrinology and Metabolism, Aarhus University Hospital, Denmark
Metabolism 53:1378-81. 2004..In conclusion, rebaudioside A possesses insulinotropic effects and may serve a potential role as treatment in type 2 diabetes mellitus... - Acute differential effects of dietary protein quality on postprandial lipemia in obese non-diabetic subjectsJens Holmer-Jensen
Department of Endocrinology and Metabolism, MEA, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark Electronic address
Nutr Res 33:34-40. 2013..As postprandial lipemia is closely correlated to cardiovascular disease, long-term dietary supplementation with whey protein may prove beneficial in preventing cardiovascular disease in obese non-diabetic subjects... - Patient-reported outcomes in patients with type 2 diabetes treated with liraglutide or glimepiride, both as add-on to metforminKjeld Hermansen
Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus, Denmark
Prim Care Diabetes 4:113-7. 2010..Patients perceived lower frequency of hypoglycaemia than glimepiride+metformin and lower frequency of hyperglycaemia than metformin. Impact of weight on quality of life did not differ... - Acute effects of dietary fat on inflammatory markers and gene expression in first-degree relatives of type 2 diabetes patientsAnna Pietraszek
Department of Medicine and Endocrinology, Aarhus University Hospital, Aarhus, Denmark
Rev Diabet Stud 8:477-89. 2011..Low-grade inflammation, an independent risk factor for CVD, is modifiable by diet. Subjects with T2D show elevated postprandial inflammatory responses to fat-rich meals, while information on postprandial inflammation in REL is sparse... - Effects of different protein sources on plasminogen inhibitor-1 and factor VII coagulant activity added to a fat-rich meal in type 2 diabetesLene S Mortensen
Department of Endocrinology and Metabolism MEA, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark
Rev Diabet Stud 7:233-40. 2010..Both elevated plasminogen inhibitor 1 (PAI-1) and increased factor VII coagulant activity (FVIIc) are potential important contributors to the increased risk of cardiovascular disease in type 2 diabetes... - Observational, open-label study of type 1 and type 2 diabetes patients switching from human insulin to insulin analogue basal-bolus regimens: insights from the PREDICTIVE studyKjeld Hermansen
Department of Endocrinology and Metabolism, Aarhus University Hospital, Tage Hansens Gade 2, Aarhus C, Denmark
Curr Med Res Opin 25:2601-8. 2009..Evaluation of the safety and efficacy of insulin detemir (IDet) in the observational and non-interventional PREDICTIVE study... - Dose- and Glucose-Dependent Effects of Amino Acids on Insulin Secretion from Isolated Mouse Islets and Clonal INS-1E Beta-CellsZhenping Liu
Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus THG, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
Rev Diabet Stud 5:232-44. 2008..The influence of glucose and fatty acids on beta-cell function is well established whereas little is known about the role of amino acids (AAs)... - Impact of dietary FA and energy restriction on plasma leptin and ob gene expression in miceSøren Gregersen
Department of Endocrinology and Metabolism, Aarhus University Hospital, 8000 Aarhus C, Denmark
Lipids 38:513-7. 2003..This indicates that saturated fat may alter protein handling by adipose tissue or the whole body clearance of leptin... - Expression Analysis of cPLA2 Alpha Interacting TIP60 in Diabetic KKAy and Non-Diabetic C57BL Wild-Type Mice: No Impact of Transient and Stable TIP60 Overexpression on Glucose-Stimulated Insulin Secretion in Pancreatic Beta-CellsIver Nordentoft
Department of Endocrinology and Metabolism C, Aarhus Sygehus THG, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
Rev Diabet Stud 4:147-58. 2007..The aim was to test our hypothesis that TIP60 plays a regulatory role in glucose-stimulated insulin secretion from pancreatic beta-cells... - [Diet in the prevention of common diseases]Bjørn Richelsen
Arhus Universitetshospital, Arhus Sygehus, Medicinskendokrinologisk Afdeling C
Ugeskr Laeger 166:1557-60. 2004 - Glucose desensitization in INS-1 cells: evidence of impaired function caused by glucose metabolite(s) rather than by the glucose molecule per seBirgitte Brock
Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus, Denmark
Metabolism 51:671-7. 2002..It would therefore seem that at least one glucose metabolite is involved in the glucose desensitization in INS-1 cells, which opens the prospect of regulatory factor(s), which possess(es) negative, as well as positive, actions... - Differential impact of acute and chronic lipotoxicity on gene expression in INS-1 cellsJianzhong Xiao
Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus University, Aarhus, Denmark
Metabolism 51:155-62. 2002..In conclusion, insulin secretion and gene expression in INS-1 cells depends on palminate exposure time and concentration... - The G-250A polymorphism in the hepatic lipase gene promoter is associated with changes in hepatic lipase activity and LDL cholesterol: The KANWU StudyVirpi Lindi
University of Kuopio, Department of Clinical Nutrition, P O Box 1627, FIN 70211 Kuopio, Finland
Nutr Metab Cardiovasc Dis 18:88-95. 2008..A common G-250A polymorphism in the promoter of the hepatic lipase gene (LIPC) has been described. The aim was to study the effects of the G-250A polymorphism on HL activity, serum lipid profile and insulin sensitivity... - Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trialsNish Chaturvedi
International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College Healthcare NHS Trust, London, UK
Lancet 372:1394-402. 2008..We therefore designed the DIabetic REtinopathy Candesartan Trials (DIRECT) Programme to assess whether candesartan could reduce the incidence and progression of retinopathy in type 1 diabetes... - Repeated prolonged whole-body low-intensity exercise: effects on insulin sensitivity and limb muscle adaptationsJoern W Helge
Copenhagen Muscle Research Centre, State Hospital, 2200 Copenhagen, Denmark
Metabolism 55:217-23. 2006.... - Combining insulins with oral antidiabetic agents: effect on hyperglycemic control, markers of cardiovascular risk and diseaseKjeld Hermansen
Department of Endocrinology and Metabolism C, Aarhus University Hospital DK 8000 Aarhus, Denmark
Vasc Health Risk Manag 4:561-74. 2008..These factors may possibly have a positive influence on CVD risk. Future studies will hopefully elucidate the benefits of this approach... - [Health economic consequences of insulin analogues in the treatment of type 1 diabetes in Denmark]Andrew J Palmer
CORE Center for Outcomes Research, Allschwill, Schweiz Novo Nordisk Scandinavia AB, København S
Ugeskr Laeger 170:1250-4. 2008..Diabetes is a major challenge to the Danish health care system, and complications account for the majority of total treatment costs... - Effects of dietary saturated, monounsaturated and n-3 fatty acids on fasting lipoproteins, LDL size and post-prandial lipid metabolism in healthy subjectsAngela A Rivellese
Department of Clinical and Experimental Medicine, School of Medicine, Federico II University, Via S Pansini 5, 80131 Naples, Italy
Atherosclerosis 167:149-58. 2003..The influence of the quality of dietary fat on some aspects of lipid metabolism-i.e. lipoprotein concentrations, post-prandial lipids and LDL size-is not completely understood, especially in healthy individuals... - [The impact of sugar on health]Chistian Mølgaard
Danmarks Tekniske Universitet, BioCentrum, Københavns Universitet, Institut for Medicinsk Biokemi og Genetik, Arhus Amtssygehus, Medicinsk Endokrinologisk Afdeling C, Tandlaegeskolen i Arhus
Ugeskr Laeger 165:4207-10. 2003 - Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trialAnne Katrin Sjølie
Department of Ophthalmology, Odense University Hospital, Odense, Denmark
Lancet 372:1385-93. 2008..Diabetic retinopathy remains a leading cause of visual loss in people of working age. We examined whether candesartan treatment could slow the progression and, secondly, induce regression of retinopathy in people with type 2 diabetes... - Equivalence of indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients with type 2 diabetes: the NESTOR StudyMichel Marre
Hopital Bichat, Service de Diabétologie et d Endocrinologie, Paris, France
J Hypertens 22:1613-22. 2004.... - Comparison of the effects on insulin resistance and glucose tolerance of 6-mo high-monounsaturated-fat, low-fat, and control dietsAnette Due
Department of Human Nutrition, Centre for Advanced Food Studies, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark
Am J Clin Nutr 87:855-62. 2008..The effect of dietary fat and carbohydrate on glucose metabolism has been debated for decades... - Comparative evaluation of simple indices of insulin resistanceOlga Vaccaro
Department of Clinical and Experimental Medicine, Federico II University of Naples, Italy
Metabolism 53:1522-6. 2004..The novel indices QUICKI and R-QUICKI do not perform better than HOMA and fasting insulin as surrogate measures of insulin resistance or means for the identification of people with MS in the general population... - [Alcohol and lifestyle diseases]Kjeld Hermansen
Motions og Ernaeringsrådet, Søborg
Ugeskr Laeger 169:3404-6. 2007..No clear association is found between alcohol and obesity. In contrast, alcohol intake is associated with increased risk of various cancers, e.g. a linear increased risk of breast cancer with every unit of alcohol is present... - [A scientific evaluation of the "alternative" food pyramid]Bjørn Richelsen
Ernaeringsrådet, Søborg
Ugeskr Laeger 167:927-31. 2005 - Efficacy of indapamide SR compared with enalapril in elderly hypertensive patients with type 2 diabetesJuan Garcia Puig
Servicio de Medicina Interna, Hospital La Paz, Paseo de la Castellana 261, 28046 Madrid, Spain
Am J Hypertens 20:90-7. 2007.... - Fish oil, insulin sensitivity, insulin secretion and glucose tolerance in healthy people: is there any effect of fish oil supplementation in relation to the type of background diet and habitual dietary intake of n-6 and n-3 fatty acids?Rosalba Giacco
Institute of Food Science, Italian National Research Council, Avellino, Italy
Nutr Metab Cardiovasc Dis 17:572-80. 2007.... - Dietary (n-3) fatty acids reduce plasma F2-isoprostanes but not prostaglandin F2alpha in healthy humansCecilia Nälsén
The KANWU Study Group at Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Sweden
J Nutr 136:1222-8. 2006..We conclude that supplementation with (n-3) fatty acids decreases nonenzymatic free radical-catalyzed isoprostane formation, but does not affect cyclooxygenase-mediated prostaglandin formation...