P Garred

Summary

Affiliation: Aarhus University Hospital
Country: Denmark

Publications

  1. doi request reprint Mannose-binding lectin genetics: from A to Z
    Peter Garred
    Department of Clinical Immunology, Section 7631, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Biochem Soc Trans 36:1461-6. 2008
  2. pmc Gene frequency and partial protein characterization of an allelic variant of mannan binding protein associated with low serum concentrations
    P Garred
    Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark
    Clin Exp Immunol 90:517-21. 1992
  3. ncbi request reprint Mannose-binding lectin genotype as a risk factor for invasive pneumococcal infection
    Gitte Kronborg
    Lancet 360:1176. 2002
  4. ncbi request reprint The influence of mannose binding lectin polymorphisms on disease outcome in early polyarthritis. TIRA Group
    S Jacobsen
    Department of Rheumatology, Hvidovre Hospital, Copenhagen University Hospital, Denmark
    J Rheumatol 28:935-42. 2001
  5. pmc Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis
    P Garred
    Tissue Typing Laboratory, Department of Clinical Immunology, Danish Cystic Fibrosis Center, The National University Hospital Rigshospitalet, DK 2200 Copenhagen, Denmark
    J Clin Invest 104:431-7. 1999
  6. pmc Functional analysis of Ficolin-3 mediated complement activation
    Estrid Hein
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 5:e15443. 2010
  7. pmc Allelic lineages of the ficolin genes (FCNs) are passed from ancestral to descendant primates
    Tina Hummelshøj
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 6:e28187. 2011
  8. pmc The interaction pattern of murine serum ficolin-A with microorganisms
    Tina Hummelshøj
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 7:e38196. 2012
  9. pmc Association of ficolin-3 with severity and outcome of chronic heart failure
    Zoltan Prohaszka
    IIIrd Department of Internal Medicine, Semmelweis University, and Research Group of Inflammation Biology and Immunogenomics, Hungarian Academy of Sciences, Budapest, Hungary
    PLoS ONE 8:e60976. 2013
  10. pmc Pentraxin-3 serum levels are associated with disease severity and mortality in patients with systemic inflammatory response syndrome
    Simone Bastrup-Birk
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 8:e73119. 2013

Detail Information

Publications83

  1. doi request reprint Mannose-binding lectin genetics: from A to Z
    Peter Garred
    Department of Clinical Immunology, Section 7631, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Biochem Soc Trans 36:1461-6. 2008
    ..The fact that these genetic variations are very frequent, indicates a dual role of MBL. This overview summarizes the current molecular understanding of human MBL2 genetics...
  2. pmc Gene frequency and partial protein characterization of an allelic variant of mannan binding protein associated with low serum concentrations
    P Garred
    Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark
    Clin Exp Immunol 90:517-21. 1992
    ..Accordingly, it can be concluded that the GAC allele is able to produce a functional MBP protein which may be detected in serum at low concentrations...
  3. ncbi request reprint Mannose-binding lectin genotype as a risk factor for invasive pneumococcal infection
    Gitte Kronborg
    Lancet 360:1176. 2002
  4. ncbi request reprint The influence of mannose binding lectin polymorphisms on disease outcome in early polyarthritis. TIRA Group
    S Jacobsen
    Department of Rheumatology, Hvidovre Hospital, Copenhagen University Hospital, Denmark
    J Rheumatol 28:935-42. 2001
    ....
  5. pmc Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis
    P Garred
    Tissue Typing Laboratory, Department of Clinical Immunology, Danish Cystic Fibrosis Center, The National University Hospital Rigshospitalet, DK 2200 Copenhagen, Denmark
    J Clin Invest 104:431-7. 1999
    ..Presence of MBL variant alleles is therefore associated with poor prognosis and early death in patients with CF...
  6. pmc Functional analysis of Ficolin-3 mediated complement activation
    Estrid Hein
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 5:e15443. 2010
    ..The assay provides the possibility to diagnose functional and genetic defects of Ficolin-3 and down stream components in the lectin complement pathway...
  7. pmc Allelic lineages of the ficolin genes (FCNs) are passed from ancestral to descendant primates
    Tina Hummelshøj
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 6:e28187. 2011
    ..Taken together all the FCN genes show the same characteristics in lower and higher primates. The existence of trans-species polymorphisms suggests that different FCN allelic lineages may be passed from ancestral to descendant species...
  8. pmc The interaction pattern of murine serum ficolin-A with microorganisms
    Tina Hummelshøj
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 7:e38196. 2012
    ..In contrast, ficolin-3 did not bind to any of the investigated microorganisms and the anti-microbial role of ficolin-3 still remains elusive...
  9. pmc Association of ficolin-3 with severity and outcome of chronic heart failure
    Zoltan Prohaszka
    IIIrd Department of Internal Medicine, Semmelweis University, and Research Group of Inflammation Biology and Immunogenomics, Hungarian Academy of Sciences, Budapest, Hungary
    PLoS ONE 8:e60976. 2013
    ..We hypothesized that the main initiator molecules of the lectin complement pathway mannose-binding lectin (MBL), ficolin-2 and ficolin-3 were related to disease severity and outcome in chronic heart failure...
  10. pmc Pentraxin-3 serum levels are associated with disease severity and mortality in patients with systemic inflammatory response syndrome
    Simone Bastrup-Birk
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 8:e73119. 2013
    ..0, p = 0.0009). In conclusion, we have established a highly sensitive and robust assay for measurement of PTX3 and found that its serum concentrations correlated with disease severity and mortality in patients with SIRS and sepsis...
  11. pmc Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke
    George Fust
    3rd Department of Internal Medicine, Semmelwies University, Budapest, Hungary
    J Neuroinflammation 8:185. 2011
    ..Although several papers demonstrated the significance of MBL in ischemic stroke, the role of ficolins has not been examined...
  12. pmc Influence of Factor V Leiden on susceptibility to and outcome from critical illness: a genetic association study
    Thomas Benfield
    Department of Infectious Diseases and Clinical Research Centre, Hvidovre University Hospital, Kettegaard Alle 30, Hvidovre, Denmark
    Crit Care 14:R28. 2010
    ..The objective of this study is to determine whether the Factor V Leiden (FVL) mutation is associated with susceptibility to or death from critical illness...
  13. pmc Association of HMGB1 polymorphisms with outcome in patients with systemic inflammatory response syndrome
    Brian Kornblit
    Department of Clinical Immunology 7631, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen O, Denmark
    Crit Care 12:R83. 2008
    ..Whether genetic variation in the human HMGB1 gene is associated with disease susceptibility is unknown...
  14. pmc Genetic and other factors determining mannose-binding lectin levels in American Indians: the Strong Heart Study
    Lyle G Best
    Missouri Breaks Industries Research Inc, Timber Lake, SD, USA
    BMC Med Genet 10:5. 2009
    ..The genetic control of MBL2 expression is complex and genetic background effects in specific populations are largely unknown...
  15. doi request reprint MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement
    Peter Garred
    Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Denmark
    Mol Immunol 46:2737-44. 2009
    ..This overview will summarize the current molecular knowledge of the human MBL2, FCN1, FCN2 and FCN3 genes...
  16. ncbi request reprint CC chemokine receptor 5 polymorphism in rheumatoid arthritis
    P Garred
    Department of Clinical Immunology, The National University Hospital Rigshospitalet, Copenhagen, Denmark
    J Rheumatol 25:1462-5. 1998
    ..Chemokines are suggested to be critical for establishment of inflammatory processes in autoimmune diseases such as rheumatoid arthritis (RA). We hypothesized that the defective allele may modulate the inflammatory process in RA...
  17. ncbi request reprint Association of mannose-binding lectin polymorphisms with sepsis and fatal outcome, in patients with systemic inflammatory response syndrome
    Peter Garred
    Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    J Infect Dis 188:1394-403. 2003
    ..These data show that MBL insufficiency plays an important role in the susceptibility of critically ill patients to the development and progression of sepsis and confers a substantial risk of fatal outcome...
  18. pmc Mannose-binding lectin is a disease modifier in clinical malaria and may function as opsonin for Plasmodium falciparum-infected erythrocytes
    Peter Garred
    Tissue Typing Laboratory 7631, Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark
    Infect Immun 71:5245-53. 2003
    ..falciparum and may thus be involved in sequestration of the parasite, which in turn may explain the association between homozygosity for MBL variant alleles and high parasite counts...
  19. ncbi request reprint Mannose-binding lectin and its genetic variants
    P Garred
    Tissue Typing Laboratory 7631, Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark
    Genes Immun 7:85-94. 2006
    ..The fact that these genetic variations are very frequent indicates a dual role for MBL in host defence. In this survey, we summarize the current molecular understanding of human MBL genetics...
  20. ncbi request reprint Association of mannose-binding lectin gene variation with disease severity and infections in a population-based cohort of systemic lupus erythematosus patients
    P Garred
    Tissue Typing Laboratory 7631, Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark
    Genes Immun 2:442-50. 2001
    ..MBL variant alleles were also associated with increased risk of disease activity and of complicating infections indicating that the MBL gene is an SLE disease modifier locus...
  21. ncbi request reprint Two edged role of mannose binding lectin in rheumatoid arthritis: a cross sectional study
    P Garred
    Tissue Typing Laboratory, Department of Clinical Immunology, The National University Hospital Rigshospitalet, Copenhagen, Denmark
    J Rheumatol 27:26-34. 2000
    ....
  22. ncbi request reprint Mannose-binding lectin deficiency--revisited
    Peter Garred
    Department of Clinical Immunology, Tissue Typing Laboratory 7631, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Mol Immunol 40:73-84. 2003
    ..However, the variant MBL has lower molecular weight and is dysfunctional compared to normal MBL. The physiological relevance of variant MBL remains to be established...
  23. ncbi request reprint A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein
    H O Madsen
    Department of Clinical Immunology, Righospitalet, Copenhagen N, Denmark
    Immunogenetics 40:37-44. 1994
    ..05) in both Africans and Caucasians, but was absent in Eskimos. Hardy-Weinberg equilibrium is now seen in the investigated ethnic groups. All cases of MBP deficiency may be explained by these three variants...
  24. ncbi request reprint Different molecular events result in low protein levels of mannan-binding lectin in populations from southeast Africa and South America
    H O Madsen
    Department of Clinical Immunology, National University Hospital, Copenhagen, Denmark
    J Immunol 161:3169-75. 1998
    ..Taken together, the results of this study show that different molecular mechanisms are the basis for low MBL levels on the two continents...
  25. pmc Depressed activation of the lectin pathway of complement in hereditary angioedema
    L Varga
    3rd Department of Internal Medicine, Semmelweis University, Hungarian Academy of Sciences, Budapest, Hungary
    Clin Exp Immunol 153:68-74. 2008
    ..0001) in healthy controls, but there was no significant correlation in the HAE patients. We conclude that the activation of LP might also occur in subjects with C1INH deficiency, which is reflected by the low MASP-2 and C4 levels...
  26. ncbi request reprint The impact of FCN2 polymorphisms and haplotypes on the Ficolin-2 serum levels
    L Munthe-Fog
    Tissue Typing Laboratory, Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Scand J Immunol 65:383-92. 2007
    ..Our results show that inter-individual variation of Ficolin-2 concentration is associated with polymorphisms in the promoter and the structural part of the FCN2 gene...
  27. ncbi request reprint Association between early onset and organ manifestations of systemic lupus erythematosus (SLE) and a down-regulating promoter polymorphism in the MBL2 gene
    L Jakab
    3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
    Clin Immunol 125:230-6. 2007
    ..003) and pleuritis/pericarditis (p=0.013) as compared with the rest of the patients. These data indicate that MBL may act as a disease modifier in SLE patients through a mechanism to be identified...
  28. ncbi request reprint Chemokine receptor CCR5 in interferon-treated multiple sclerosis
    F Sellebjerg
    The MS Clinic, Department of Neurology, Glostrup Hospital, University of Copenhagen, 57 Nordre Ringvej, DK 2600 Glostrup, Denmark
    Acta Neurol Scand 115:413-8. 2007
    ..To study the relationship between CC chemokine receptor CCR5 expression and disease activity in multiple sclerosis (MS) patients treated with beta-interferon (IFN-beta)...
  29. ncbi request reprint CCR5 delta32, matrix metalloproteinase-9 and disease activity in multiple sclerosis
    F Sellebjerg
    Department of Neurology, University of Copenhagen, Glostrup Hospital, Denmark
    J Neuroimmunol 102:98-106. 2000
    ..These results directly link intrathecal inflammation to disease activity in patients with MS, suggesting that treatments targeting CCR5 or treatment with MMP inhibitors may attenuate disease activity in MS...
  30. ncbi request reprint Three new alleles of IGHG2 and their prevalence in Danish Caucasians, Mozambican Blacks and Japanese
    L Hougs
    Department of Clinical Immunology, Sect 7631, The National University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen N, Denmark
    Tissue Antigens 61:231-9. 2003
    ..5%), but was not found in Japanese or Mozambicans. The two other new alleles (IGHG2*03 and IGHG2*05) both encode the G2m(n-) allotype. The IGHG2*03 allele encodes most of the IgG2 of the G2m(n-) allotype in Danish Caucasians...
  31. doi request reprint Variation in FCN1 affects biosynthesis of ficolin-1 and is associated with outcome of systemic inflammation
    L Munthe-Fog
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
    Genes Immun 13:515-22. 2012
    ..Functional polymorphic sites in the promoter region of FCN1 regulate both the expression and synthesis of ficolin-1 and are associated with outcome in severe inflammation...
  32. pmc The CCR5 receptor acts as an alloantigen in CCR5Delta32 homozygous individuals: identification of chemokineand HIV-1-blocking human antibodies
    H J Ditzel
    Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, DK 2200 Copenhagen, Denmark
    Proc Natl Acad Sci U S A 95:5241-5. 1998
    ..The identified human antibodies to CCR5 define an alloantigen that may cause allograft rejection in a mismatch situation even in individuals with no history of blood transfusions or i.v. drug abuse...
  33. doi request reprint Molecular basis of hereditary C1q deficiency--revisited: identification of several novel disease-causing mutations
    L Schejbel
    Department of Clinical Immunology, Laboratory of Molecular Medicine, Rigshospitalet, Copenhagen, Denmark
    Genes Immun 12:626-34. 2011
    ..With the results presented here, confirmed C1q deficiency is reported in 64 patients from at least 38 families...
  34. ncbi request reprint A novel mannose-binding lectin-associated serine protease 1/3 gene variant
    G Weiss
    Tissue Typing Laboratory 7631, Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Scand J Immunol 65:430-4. 2007
    ..07), which was not observed in the other groups. In conclusion, the MASP1/3 gene harbours a low-frequent polymorphic site resulting in an amino acid substitution, which may influence the function of the gene product...
  35. pmc Autoantibodies against interleukin 1alpha in rheumatoid arthritis: association with long term radiographic outcome
    N A Graudal
    Institute for Inflammation Research, Copenhagen University Hospital, Denmark
    Ann Rheum Dis 61:598-602. 2002
    ..To investigate the possible association of interleukin 1alpha autoantibodies (IL1alpha aAb) with the long term course of joint erosion in patients with rheumatoid arthritis (RA)...
  36. ncbi request reprint Cerebrospinal fluid levels of nitric oxide metabolites predict response to methylprednisolone treatment in multiple sclerosis and optic neuritis
    F Sellebjerg
    Department of Neurology, University of Copenhagen, Glostrup Hospital, Nordre Ringvej 57, DK 2600 Glostrup Copenhagen, Denmark
    J Neuroimmunol 125:198-203. 2002
    ..These findings suggest an association of high CSF levels of NO(x) with more severe disease activity in relapsing-remitting MS...
  37. doi request reprint Complement factor H deficiency and endocapillary glomerulonephritis due to paternal isodisomy and a novel factor H mutation
    L Schejbel
    Department of Clinical Immunology, Laboratory of Molecular Medicine, Rigshospitalet, Copenhagen, Denmark
    Genes Immun 12:90-9. 2011
    ....
  38. ncbi request reprint Ascites fluid and plasma calprotectin concentrations in liver disease
    C Homann
    Dept of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    Scand J Gastroenterol 38:415-20. 2003
    ..The aims were to study concentrations of calprotectin in patients with various liver diseases, and to further investigate the prognostic value of calprotectin in cirrhosis...
  39. ncbi request reprint Complement activation and its prognostic role in post-cardiac arrest patients
    Z M Jenei
    3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
    Scand J Immunol 79:404-9. 2014
    ..Complement activation occurs in post-cardiac arrest patients, and its extent correlates with 30-day survival. The C3a/C3 ratio might prove useful for estimating the prognosis of comatose post-cardiac arrest patients...
  40. ncbi request reprint The genetic variation of the human HMGB1 gene
    B Kornblit
    Tissue Typing Laboratory 7631, Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Tissue Antigens 70:151-6. 2007
    ..This study has characterized genetic variations in the HMGB1 gene locus, which may have a regulating role in the expression of HMGB1, providing the basis for molecular investigations of the HMGB1 gene in different disease settings...
  41. doi request reprint Rapid bead-based immunoassay for measurement of mannose-binding lectin
    J T Bay
    Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Scand J Immunol 69:570-5. 2009
    ..These results show that MBL can be measured readily using a bead-based platform, which may form an efficient basis for a multiplex approach to measure different antigens in the same sample...
  42. ncbi request reprint Early rise in serum VEGF and PDGF levels predisposes patients with a normal MBL2 genotype to restenosis after eversion endarterectomy
    Attila Szabo
    Department of Vascular and Cardiac Surgery, Semmelweis University, Budapest, Hungary
    Stroke 38:2247-53. 2007
    ....
  43. ncbi request reprint Heterozygosity of mannose-binding lectin (MBL2) genotypes predicts advantage (heterosis) in relation to fatal outcome in intensive care patients
    Dorthe Hellemann
    Department of Anaesthesiology and Intensive Care, Herlev, Copenhagen University Hospital, Rigshospitalet, Denmark
    Hum Mol Genet 16:3071-80. 2007
    ..01). Heterozygosity for MBL2 alleles confers a protective effect whereas homozygosity is associated with the worst outcome soon after discharge from ICU. This may be an example of heterosis...
  44. ncbi request reprint Low c1-inhibitor levels predict early restenosis after eversion carotid endarterectomy
    Gábor Széplaki
    3rd Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Kutvolgyi ut 4, H 1125, Hungary
    Arterioscler Thromb Vasc Biol 27:2756-62. 2007
    ..Activation of the lectin pathway is regulated by C1-inhibitor (C1-INH). The objective of the present study was to determine the predictive value of C1-INH in restenosis after CEA...
  45. doi request reprint Characterization of a polymorphism in the coding sequence of FCN3 resulting in a Ficolin-3 (Hakata antigen) deficiency state
    Lea Munthe-Fog
    Department of Clinical Immunology, University of Copenhagen, 2100 Copenhagen, Denmark
    Mol Immunol 45:2660-6. 2008
    ..Characterization of recombinant variant Ficolin-3 shows that homozygosity for the FCN3+1637delC deletion may lead to Ficolin-3 deficiency and may thus be the basis for a novel complement deficiency state...
  46. ncbi request reprint N965S is a common ABCA4 variant in Stargardt-related retinopathies in the Danish population
    Thomas Rosenberg
    Gordon Norrie Center for Genetic Eye Diseases, National Eye Clinic for the Visually Impaired, Kennedy Center, Hellerup, Denmark
    Mol Vis 13:1962-9. 2007
    ..The study was conducted to resolve the spectrum of ABCA4 mutations in a cohort of unrelated Danish residents with early-onset macular dystrophy...
  47. ncbi request reprint Mannose-binding lectin (MBL) therapy in an MBL-deficient patient with severe cystic fibrosis lung disease
    Peter Garred
    Tissue Typing Laboratory, Department of Clinical Immunology, National University Hospital Rigshospitalet, Copenhagen, Denmark
    Pediatr Pulmonol 33:201-7. 2002
    ..Moreover, purified mannose-binding lectin can safely be administered to chronically ill patients, and may be a potential treatment in CF and other diseases in which mannose-binding lectin deficiency plays a pathophysiological role...
  48. doi request reprint Functional SNPs in the human ficolin (FCN) genes reveal distinct geographical patterns
    Tina Hummelshøj
    Department of Clinical Immunology, University of Copenhagen, Denmark
    Mol Immunol 45:2508-20. 2008
    ....
  49. doi request reprint Early complement activation follows eversion carotid endarterectomy and correlates with the time of clamping of the carotid artery
    Gábor Széplaki
    3rd Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Kutvolgyi ut 4, H 1125Budapest, Hungary
    Mol Immunol 45:3289-94. 2008
    ..Complement activation plays an important role in ischemia/reperfusion (I/R) injury. The objective of the present study was to detect the presence and mechanism of complement activation in patients who underwent carotid endarterectomy (CEA)...
  50. ncbi request reprint Variant mannose-binding lectin genotypes and outcome in early versus late rheumatoid arthritis: comment on the article by Ip et al
    Niels A Graudal
    Gentofte University Hospital, Denmark
    Arthritis Rheum 46:555-6. 2002
  51. ncbi request reprint High rate of early restenosis after carotid eversion endarterectomy in homozygous carriers of the normal mannose-binding lectin genotype
    Szabolcs Rugonfalvi-Kiss
    Third Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Stroke 36:944-8. 2005
    ..Thus, we investigated the role of MBL in restenosis after eversion endarterectomy in patients with severe carotid atherosclerosis...
  52. ncbi request reprint A common polymorphism in the SFTPD gene influences assembly, function, and concentration of surfactant protein D
    Rikke Leth-Larsen
    Medical Biotechnology Center, Institute for Medical Biology, University of Southern Denmark, Odense, Denmark
    J Immunol 174:1532-8. 2005
    ..Our data strongly suggest that polymorphic variation in the N-terminal domain of the SP-D molecule influences oligomerization, function, and the concentration of the molecule in serum...
  53. ncbi request reprint Mannose-binding lectin variant alleles and the risk of arterial thrombosis in systemic lupus erythematosus
    Tommy Øhlenschlaeger
    Department of Rheumatology, Bispebjerg Hospital, Copenhagen, Denmark
    N Engl J Med 351:260-7. 2004
    ..We determined whether mannose-binding lectin variant alleles were associated with an increased risk of arterial thrombosis among patients with SLE...
  54. ncbi request reprint Mannose-binding lectin polymorphisms in clinical tuberculosis
    Christian Søborg
    Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark
    J Infect Dis 188:777-82. 2003
    ..The same tendency also was observed in patients of other ethnic origin. It may be hypothesized that heterozygosity for MBL variant alleles, which encodes low serum MBL levels, is associated with protection against clinical tuberculosis...
  55. ncbi request reprint [Acute respiratory tract infections and mannose-binding lectin insufficiency in small children]
    Anders Koch
    Afdeling for Epidemiologisk Forskning, Statens Serum Institut, Artillerivej 5, DK 2300 København S
    Ugeskr Laeger 164:5635-40. 2002
    ..To investigate the effect of MBL insufficiency on the risk of acute respiratory infections (ARI) in unselected children, we performed a prospective population-based study of ARI in young children in Sisimiut, Greenland...
  56. ncbi request reprint Increased frequency of mannose-binding lectin insufficiency among children with acute lymphoblastic leukemia
    Kjeld Schmiegelow
    Pediatric Clinic II, Juliane Marie Centre, Department of Clinical Immunology, The University Hospital, Rigshospitalet, Copenhagen, Denmark
    Blood 100:3757-60. 2002
    ..9 vs 5.2 years; P =.04). The study shows that the presence of low-level MBL genotypes is associated with an increased risk of childhood ALL, particularly with early age at onset...
  57. ncbi request reprint Mannose-binding lectin variant alleles and HLA-DR4 alleles are associated with giant cell arteritis
    Soren Jacobsen
    Department of Rheumatology, Hvidovre Hospital, Copenhagen, Denmark
    J Rheumatol 29:2148-53. 2002
    ....
  58. ncbi request reprint Association of Chlamydia pneumoniae with coronary artery disease and its progression is dependent on the modifying effect of mannose-binding lectin
    Szabolcs Rugonfalvi-Kiss
    3rd Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Circulation 106:1071-6. 2002
    ....
  59. ncbi request reprint Natural resistance-associated macrophage protein 1 polymorphisms are associated with microscopy-positive tuberculosis
    Christian Søborg
    Department of Clinical Immunology, Tissue Typing Laboratory, Rigshospitalet, Denmark
    J Infect Dis 186:517-21. 2002
    ..These results indicate that variant alleles in the Nramp1 gene are associated with increased mycobacterial replication rather than susceptibility for tuberculosis and may thus confer increased risk of severe disease...
  60. ncbi request reprint Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients
    Gitte Kronborg
    Department of Infectious Diseases, Rigshospitalet, 2100 Copenhagen, Denmark
    J Infect Dis 185:1517-20. 2002
    ..Thus, in a random adult population with invasive pneumococcal infection, MBL does not seem to play a role in the pathophysiology, in contrast to earlier observations in patients with other concomitant immune abnormalities...
  61. ncbi request reprint Extra-hepatic transcription of the human mannose-binding lectin gene (mbl2) and the MBL-associated serine protease 1-3 genes
    Jeanette Seyfarth
    Tissue Typing Laboratory 7631, Department of Clinical Immunology, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Mol Immunol 43:962-71. 2006
    ....
  62. ncbi request reprint Genetically determined high serum levels of mannose-binding lectin and agalactosyl IgG are associated with ischemic heart disease in rheumatoid arthritis
    Lone N Troelsen
    Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Arthritis Rheum 56:21-9. 2007
    ..MBL also enhances inflammation-mediated tissue injury during postischemic reperfusion. This study was undertaken to examine whether these factors are associated with increased risk of ischemic heart disease in RA...
  63. ncbi request reprint Influence of candidate susceptibility genes on tuberculosis in a high endemic region
    Christian Søborg
    Tissue Typing Laboratory of the Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark
    Mol Immunol 44:2213-20. 2007
    ..The observed association was seen only in HIV negative patients suggesting that this genetic susceptibility for tuberculosis may be surpassed by co-infections...
  64. ncbi request reprint Association between combined properdin and mannose-binding lectin deficiency and infection with Neisseria meningitidis
    Lise Bathum
    Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark
    Mol Immunol 43:473-9. 2006
    ..In this study we report our findings in a Danish family with a remarkably high incidence of meningococcal meningitis-in total four cases, one of them fatal...
  65. ncbi request reprint Strong combined gene-environment effects in anti-cyclic citrullinated peptide-positive rheumatoid arthritis: a nationwide case-control study in Denmark
    Merete Pedersen
    Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark
    Arthritis Rheum 56:1446-53. 2007
    ....
  66. ncbi request reprint Elevated complement C3 is associated with early restenosis after eversion carotid endarterectomy
    Gábor Széplaki
    3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
    Thromb Haemost 96:529-34. 2006
    ..On the other hand, our results indicate that the regulation of C3 differs from non-complement APRs...
  67. ncbi request reprint Infections during induction therapy of childhood acute lymphoblastic leukemia--no association to mannose-binding lectin deficiency
    Birgitte Lausen
    Pediatric Clinic II, Juliane Marie Centre, H S Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Eur J Haematol 76:481-7. 2006
    ..Thus, these patients have been proposed to be candidates for MBL replacement therapy...
  68. ncbi request reprint Comparative study of the human ficolins reveals unique features of Ficolin-3 (Hakata antigen)
    Tina Hummelshoj
    Department of Clinical Immunology, Section 7631, Rigshospitalet, Copenhagen University, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Mol Immunol 45:1623-32. 2008
    ..Moreover, Ficolin-3 has a high complement activating potential and is the only collagenase proteolytic resistant molecule among the lectin complement pathway initiators...
  69. ncbi request reprint Ficolin-2 recognizes DNA and participates in the clearance of dying host cells
    Maria Lund Jensen
    Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen O, Denmark
    Mol Immunol 44:856-65. 2007
    ..Ficolin-2 may therefore be a scavenger molecule participating in the removal of host cells and maintenance of tissue homeostasis...
  70. ncbi request reprint C1q deficiency in an Inuit family: identification of a new class of C1q disease-causing mutations
    Hanne Vibeke Marquart
    Dept of Clinical Immunology sect 7631, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Denmark
    Clin Immunol 124:33-40. 2007
    ..None of 100 healthy controls carried the mutation. Our findings define a third class of molecular mechanisms behind C1q deficiency, where missense mutations cause a lack of detectable C1q-antigen in serum...
  71. ncbi request reprint The innate immune component ficolin 3 (Hakata antigen) mediates the clearance of late apoptotic cells
    Christian Honore
    Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Arthritis Rheum 56:1598-607. 2007
    ..Dysfunction in this mechanism is regarded as an important contributor to the pathophysiology of SLE. Thus, we sought to determine whether ficolin 3 participates in the clearance of apoptotic cells...
  72. ncbi request reprint Early rise of anti-pseudomonas antibodies and a mucoid phenotype of pseudomonas aeruginosa are risk factors for development of chronic lung infection--a case control study
    Tacjana Pressler
    Copenhagen Cystic Fibrosis Center, Department of Paediatrics, Copenhagen University Hospital, Rigshospitalet, Copenhagen corrected Denmark
    J Cyst Fibros 5:9-15. 2006
    ..9, 7.7 and 7.4, respectively (p<0.005), and growth of mucoid P. aeruginosa strains with OR of 7.4, p=0.006). Occurrence of Aspergillus was also a risk factor for developing chronic P. aeruginosa infection with the OR of 4.7 (p=0.008)...
  73. ncbi request reprint [Genetic epidemiology]
    Arne Svejgaard
    Klinisk Immunologisk Afdeling 7631, Rigshospitalet, Blegdamsvej 9, DK 2100 København Ø
    Ugeskr Laeger 165:927-9. 2003
    ....
  74. ncbi request reprint Molecular organization of human Ficolin-2
    Tina Hummelshoj
    Tissue Typing Laboratory, Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark
    Mol Immunol 44:401-11. 2007
    ..Based on our findings we propose a model in which disulfide bridges located in the N-terminal region of the polypeptides explain the oligomerization pattern of human Ficolin-2...
  75. ncbi request reprint Mannose-binding lectin engagement with late apoptotic and necrotic cells
    Alma J Nauta
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Eur J Immunol 33:2853-63. 2003
    ..These results demonstrate that MBL interacts with structures exposed on cells rendered late apoptotic or necrotic and facilitates uptake by macrophages. Thus, MBL may promote non-inflammatory sequestration of dying host cells...
  76. ncbi request reprint Mannose-binding lectin in respiratory syncytial virus infection
    Kim Kristensen
    J Pediatr 143:544. 2003
  77. ncbi request reprint Disease-associated mutations in human mannose-binding lectin compromise oligomerization and activity of the final protein
    Flemming Larsen
    Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    J Biol Chem 279:21302-11. 2004
    ..Mutations in the collagenous region of human MBL compromise assembly of higher order oligomers, resulting in reduced ligand binding capacity and thus reduced capability to activate complement...
  78. ncbi request reprint Antibody-mediated activation of the classical pathway of complement may compensate for mannose-binding lectin deficiency
    Anja Roos
    Leiden University Medical Center, Department of Nephrology, Leiden, The Netherlands
    Eur J Immunol 34:2589-98. 2004
    ....
  79. ncbi request reprint Deficiency of somatic hypermutation of the antibody light chain is associated with increased frequency of severe respiratory tract infection in common variable immunodeficiency
    Pernille Andersen
    Department of Clinical Immunology, Blood Bank, University Hospital, Copenhagen, Copenhagen, Denmark
    Blood 105:511-7. 2005
    ..01). This suggests that most patients with CVID fail to recruit affinity-maturated B cells, adding a qualitative deficiency to the quantitative deficiency characterizing these patients...
  80. doi request reprint The innate pattern recognition molecule Ficolin-1 is secreted by monocytes/macrophages and is circulating in human plasma
    Christian Honore
    Department of Clinical Immunology, Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark
    Mol Immunol 45:2782-9. 2008
    ..Importantly, these results demonstrate that Ficolin-1 exists in human plasma and serum under normal conditions, hereby revising the general assumption that Ficolin-1 is solely a cellular associated protein...
  81. ncbi request reprint Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2
    Tina Hummelshoj
    Department of Clinical Immunology, Tissue Typing Laboratory 7631, Rigshospitalet, 2100 Copenhagen, Denmark
    Hum Mol Genet 14:1651-8. 2005
    ....
  82. ncbi request reprint The 'involution' of mannose-binding lectin
    Jeanette Seyfarth
    Tissue Typing Laboratory 7631, Department of Clinical Immunology, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Hum Mol Genet 14:2859-69. 2005
    ..Our results indicate that the MBL1P1 gene has been selectively turned off during evolution through the same molecular mechanisms causing the MBL2 variant alleles in man, suggesting an evolutionary selection for low-producing MBL genes...
  83. ncbi request reprint Primary immunodeficiency: complex genetic disorders?
    Lone Schejbel
    Clin Chem 53:159-60. 2007