- P-glycoprotein interaction with risperidone and 9-OH-risperidone studied in vitro, in knock-out mice and in drug-drug interaction experimentsThomas B Ejsing
The Centre for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, Denmark
Hum Psychopharmacol 20:493-500. 2005..Drug-drug interaction effects in relation to P-gp, however, appear to be more limited...
- Influence of P-glycoprotein inhibition on the distribution of the tricyclic antidepressant nortriptyline over the blood-brain barrierThomas B Ejsing
Centre for Basic Psychiatric Research, Aarhus Psychiatric University Hospital, Skovagervej 2, DK-8240 Risskov, Denmark
Hum Psychopharmacol 20:149-53. 2005..In conclusion, the results show that drug-drug interaction at P-gp may influence the intracerebral NT concentration, but apparently, a major inhibition of P-gp is necessary to attain a measurable effect...