Lise Lotte Christensen
Affiliation: Aarhus University Hospital
Christensen L, Tobiasen H, Holm A, Schepeler T, Ostenfeld M, Thorsen K, et al
. MiRNA-362-3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer. Int J Cancer. 2013;133:67-78 pubmed publisher
..We conclude that miR-362-3p may be a novel prognostic marker in CRC, and hypothesize that the positive effects of augmented miR-362-3p expression may in part be mediated through the targets E2F1, USF2 and PTPN1. ..
Christensen L, Madsen B, Wikman F, Wiuf C, Koed K, Tjønneland A, et al
. The association between genetic variants in hMLH1 and hMSH2 and the development of sporadic colorectal cancer in the Danish population. BMC Med Genet. 2008;9:52 pubmed publisher
..Nevertheless, some of the rare unclassified variants in hMLH1 and hMSH2 might be involved in the development of colorectal cancer in the families where they were originally identified. ..
Christensen L, Kariola R, Korhonen M, Wikman F, Sunde L, Gerdes A, et al
. Functional characterization of rare missense mutations in MLH1 and MSH2 identified in Danish colorectal cancer patients. Fam Cancer. 2009;8:489-500 pubmed publisher
..Met688Val mutation, which caused reduced protein expression. Although, no deficiencies have been identified in the proteins harbouring the other missense mutations, pathogenicity of these variants cannot be unambiguously excluded. ..