J M Bruun

Summary

Affiliation: Aarhus University
Country: Denmark

Publications

  1. ncbi request reprint Regulation of interleukin 8 production and gene expression in human adipose tissue in vitro
    J M Bruun
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital and Faculty of Health Sciences, Aarhus University, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 86:1267-73. 2001
  2. ncbi request reprint Estrogen reduces pro-inflammatory cytokines in rodent adipose tissue: studies in vivo and in vitro
    J M Bruun
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Amtssygehus, Aarhus, Denmark
    Horm Metab Res 35:142-6. 2003
  3. ncbi request reprint Association between measures of insulin sensitivity and circulating levels of interleukin-8, interleukin-6 and tumor necrosis factor-alpha. Effect of weight loss in obese men
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital and Faculty of Health Sciences, Aarhus University, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 148:535-42. 2003
  4. ncbi request reprint Opposite regulation of interleukin-8 and tumor necrosis factor-alpha by weight loss
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital and Faculty of Health Sciences, Aarhus University, Denmark
    Obes Res 10:499-506. 2002
  5. ncbi request reprint Effects of pro-inflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital and Faculty of Health Sciences, Aarhus University, Tage Hansensgade 2, Denmark
    Mol Cell Endocrinol 190:91-9. 2002
  6. ncbi request reprint Interleukin-8 production in human adipose tissue. inhibitory effects of anti-diabetic compounds, the thiazolidinedione ciglitazone and the biguanide metformin
    J M Bruun
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital and Faculty of Health Sciences, Aarhus University, Denmark
    Horm Metab Res 32:537-41. 2000
  7. ncbi request reprint Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Denmark
    Am J Physiol Endocrinol Metab 285:E527-33. 2003
  8. ncbi request reprint Differences in plasminogen activator inhibitor 1 in subcutaneous versus omental adipose tissue in non-obese and obese subjects
    G He
    Department of Endocrinology and Metabolism C, Aarhus Kommehospital, Aarhus University Hospital, Aarhus C, Denmark
    Horm Metab Res 35:178-82. 2003
  9. ncbi request reprint Stimulation of PAI-1 and adipokines by glucose in human adipose tissue in vitro
    G He
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Biochem Biophys Res Commun 310:878-83. 2003
  10. ncbi request reprint Regulation of plasminogen activitor inhibitor-1 in human adipose tissue: interaction between cytokines, cortisol and estrogen
    G He
    Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Aarhus University Hospital, Denmark
    Horm Metab Res 32:515-20. 2000

Detail Information

Publications33

  1. ncbi request reprint Regulation of interleukin 8 production and gene expression in human adipose tissue in vitro
    J M Bruun
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital and Faculty of Health Sciences, Aarhus University, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 86:1267-73. 2001
    ....
  2. ncbi request reprint Estrogen reduces pro-inflammatory cytokines in rodent adipose tissue: studies in vivo and in vitro
    J M Bruun
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Amtssygehus, Aarhus, Denmark
    Horm Metab Res 35:142-6. 2003
    ..Since estrogen is suggested to be anti-atherosclerotic, this effect might be caused by a reduction in cytokine production from the adipose tissue...
  3. ncbi request reprint Association between measures of insulin sensitivity and circulating levels of interleukin-8, interleukin-6 and tumor necrosis factor-alpha. Effect of weight loss in obese men
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital and Faculty of Health Sciences, Aarhus University, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 148:535-42. 2003
    ....
  4. ncbi request reprint Opposite regulation of interleukin-8 and tumor necrosis factor-alpha by weight loss
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital and Faculty of Health Sciences, Aarhus University, Denmark
    Obes Res 10:499-506. 2002
    ..Tumor necrosis factor-alpha (TNF-alpha) was used for comparison and determined in parallel with IL-8...
  5. ncbi request reprint Effects of pro-inflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital and Faculty of Health Sciences, Aarhus University, Tage Hansensgade 2, Denmark
    Mol Cell Endocrinol 190:91-9. 2002
    ....
  6. ncbi request reprint Interleukin-8 production in human adipose tissue. inhibitory effects of anti-diabetic compounds, the thiazolidinedione ciglitazone and the biguanide metformin
    J M Bruun
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital and Faculty of Health Sciences, Aarhus University, Denmark
    Horm Metab Res 32:537-41. 2000
    ..These findings open the possibility that the beneficial effects on cardiovascular risk-factors of these anti-diabetic compounds might involve a reduction in the interleukin-8 produced in human adipose tissue...
  7. ncbi request reprint Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Denmark
    Am J Physiol Endocrinol Metab 285:E527-33. 2003
    ..This could be of importance for the association between cytokines (e.g., IL-6) and insulin resistance and atherosclerosis...
  8. ncbi request reprint Differences in plasminogen activator inhibitor 1 in subcutaneous versus omental adipose tissue in non-obese and obese subjects
    G He
    Department of Endocrinology and Metabolism C, Aarhus Kommehospital, Aarhus University Hospital, Aarhus C, Denmark
    Horm Metab Res 35:178-82. 2003
    ..Finally, PAI-1 production in adipose tissue from obese women was higher in non-obese women after incubation for 72 h...
  9. ncbi request reprint Stimulation of PAI-1 and adipokines by glucose in human adipose tissue in vitro
    G He
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Biochem Biophys Res Commun 310:878-83. 2003
    ....
  10. ncbi request reprint Regulation of plasminogen activitor inhibitor-1 in human adipose tissue: interaction between cytokines, cortisol and estrogen
    G He
    Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Aarhus University Hospital, Denmark
    Horm Metab Res 32:515-20. 2000
    ..The interplay between these hormones may be of importance for the levels of PAI-1 observed in obesity and associated states...
  11. ncbi request reprint Regulation of UCP1, UCP2, and UCP3 mRNA expression in brown adipose tissue, white adipose tissue, and skeletal muscle in rats by estrogen
    S B Pedersen
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Biochem Biophys Res Commun 288:191-7. 2001
    ....
  12. doi request reprint Effect of weight loss and exercise on angiogenic factors in the circulation and in adipose tissue in obese subjects
    K B Cullberg
    Medical Department of Endocrinology and Internal Medicine MEA, Tage Hansens Gade 2, Aarhus University Hospital, Aarhus, Denmark
    Obesity (Silver Spring) 21:454-60. 2013
    ..Some AT cytokines and hormones have effects on vascular development, like vascular endothelial growth factor (VEGF-A), angiopoietin (ANG-1), ANG-2 and angiopoietin-like protein-4 (ANGPTL-4)...
  13. ncbi request reprint Metformin, but not thiazolidinediones, inhibits plasminogen activator inhibitor-1 production in human adipose tissue in vitro
    G He
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    Horm Metab Res 35:18-23. 2003
    ..Our findings indicate no direct effects of TZDs on PAI-1 secretion, whereas metformin was able to directly inhibit PAI-1 production in human adipose tissue...
  14. pmc The effect of weight loss on serum mannose-binding lectin levels
    P H Høyem
    Department of Endocrinology and Internal Medicine MEA, Aarhus University Hospital, Denmark
    Clin Dev Immunol 2012:354894. 2012
    ..In this study we examine the effects of weight loss on MBL levels, and in continuation of this if MBL is synthesized in human adipose tissue...
  15. ncbi request reprint Demonstration of estrogen receptor subtypes alpha and beta in human adipose tissue: influences of adipose cell differentiation and fat depot localization
    S B Pedersen
    Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Mol Cell Endocrinol 182:27-37. 2001
    ..These findings may indicate that estrogens could have differentiation and depot specific effects in human adipose tissue...
  16. ncbi request reprint Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects
    T Christiansen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    Int J Obes (Lond) 29:146-50. 2005
    ..The human adipose tissue produce several adipokines including monocyte chemoattractant protein (MCP)-1, associated with cardiovascular disease and found to be involved in the pathogenesis of atherosclerosis in vitro...
  17. ncbi request reprint Effects of as-cast and wrought Cobalt-Chrome-Molybdenum and Titanium-Aluminium-Vanadium alloys on cytokine gene expression and protein secretion in J774A.1 macrophages
    Stig S Jakobsen
    Department of Orthopaedics, Aarhus University Hospital, Aarhus, Denmark
    Eur Cell Mater 14:45-54; discussion 54-5. 2007
    ..The results suggest that as-cast CoCrMo alloy is more inert than wrought CoCrMo and wrought TiAlV alloys and could prove to be a superior implant material generating less inflammation which might result in less osteolysis...
  18. ncbi request reprint Higher production of IL-8 in visceral vs. subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissue
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital and Faculty of Health Sciences, Aarhus University, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Am J Physiol Endocrinol Metab 286:E8-13. 2004
    ..The high levels of IL-8 release from human adipose tissue and accumulation of this tissue in obese subjects may account for some of the increase in circulating IL-8 observed in obesity...
  19. doi request reprint Upregulation of adipose 11-beta-hydroxysteroid dehydrogenase type 1 expression in ovariectomized rats is due to obesity rather than lack of estrogen
    Søren K Paulsen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade, Aarhus C, Denmark
    Obesity (Silver Spring) 16:731-5. 2008
    ..Estrogen suppresses hepatic and renal 11beta-HSD1 in rats; hence we investigated the in vitro effect of estrogen on human and rat AT, and the in vivo effects on rat AT 11beta-HSD1 expression...
  20. ncbi request reprint Interleukin-18 in plasma and adipose tissue: effects of obesity, insulin resistance, and weight loss
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 157:465-71. 2007
    ....
  21. ncbi request reprint Sulfatide increases adiponectin and decreases TNF-alpha, IL-6, and IL-8 in human adipose tissue in vitro
    Jens M Bruun
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Mol Cell Endocrinol 263:142-8. 2007
    ..Accordingly, the reported low serum levels of sulfatide in patients with type 2 diabetes might be of importance in relation to the chronic low-grade inflammatory state found in this disease...
  22. ncbi request reprint Adiponectin receptors in human adipose tissue: effects of obesity, weight loss, and fat depots
    Maria S Rasmussen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Obesity (Silver Spring) 14:28-35. 2006
    ..To investigate the presence and regulatory properties of the adiponectin receptors, AdipoR1 and AdipoR2, in human adipose tissue (AT) and in isolated human adipocytes...
  23. ncbi request reprint Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects
    Jens M Bruun
    Dept of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Sygehus, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Am J Physiol Endocrinol Metab 290:E961-7. 2006
    ..Markers of inflammation were particularly reduced in AT, whereas SM does not contribute to this attenuation of whole body inflammation...
  24. ncbi request reprint Lower expression of adiponectin mRNA in visceral adipose tissue in lean and obese subjects
    Aina S Lihn
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Mol Cell Endocrinol 219:9-15. 2004
    ..In conclusion, adiponectin gene expression is lower in visceral AT than in subcutaneous abdominal AT, suggesting subcutaneous AT to be more important for circulating adiponectin levels...
  25. ncbi request reprint Novel associations between bioavailable estradiol and adipokines in elderly women with different phenotypes of obesity: implications for atherogenesis
    Laszlo B Tanko
    Prospective Epidemiological Risk Factor PERF study group, Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Ballerup, Denmark
    Circulation 110:2246-52. 2004
    ..Peripheral adiposity confers protection against diabetes and atherosclerosis in elderly women. The underlying mechanisms, however, remain to be elucidated...
  26. ncbi request reprint Serum adiponectin levels in adults with Prader-Willi syndrome are independent of anthropometrical parameters and do not change with GH treatment
    Charlotte Hoybye
    Department of Endocrinology and Diabetology, Karolinska University Hospital, Sweden
    Eur J Endocrinol 151:457-61. 2004
    ..Low adiponectin values are associated with obesity and the metabolic syndrome. We therefore found it of interest to measure adiponectin levels in PWS...
  27. ncbi request reprint Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT
    Jens M Bruun
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Sygehus, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 90:2282-9. 2005
    ..Human adipose tissue (AT) produces several adipokines including monocyte chemoattractant protein (MCP)-1, involved in the pathogenesis of atherosclerosis...
  28. ncbi request reprint Cobalt-chromium-molybdenum alloy causes metal accumulation and metallothionein up-regulation in rat liver and kidney
    Stig S Jakobsen
    Department of Neurobiology, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
    Basic Clin Pharmacol Toxicol 101:441-6. 2007
    ..That the liberated metal ions affect the tissues is supported by an up-regulation of the detoxifying/pacifying metalloprotein I/II in the liver...
  29. doi request reprint Weight loss larger than 10% is needed for general improvement of levels of circulating adiponectin and markers of inflammation in obese subjects: a 3-year weight loss study
    Erik L Madsen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 158:179-87. 2008
    ..Moreover, to evaluate the effect of the lipase inhibitor, orlistat, on these parameters...
  30. ncbi request reprint Weight loss maintenance in severely obese adults after an intensive lifestyle intervention: 2- to 4-year follow-up
    Tore Christiansen
    Department of Medicine and Endocrinology C, Aarhus Sygehus, Aarhus University Hospital, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Obesity (Silver Spring) 15:413-20. 2007
    ..To evaluate the long-term weight loss maintenance after 2 to 4 years in severely obese subjects after a lifestyle intervention at a weight loss camp in Denmark...
  31. ncbi request reprint An oil mixture with trans-10, cis-12 conjugated linoleic acid increases markers of inflammation and in vivo lipid peroxidation compared with cis-9, trans-11 conjugated linoleic acid in postmenopausal women
    Tine Tholstrup
    Department of Human Nutrition, Faculty of Life Science, University of Copenhagen, 1958 Frederiksberg, Denmark
    J Nutr 138:1445-51. 2008
    ....
  32. ncbi request reprint Reduced bone mineral density and increased bone turnover in Prader-Willi syndrome compared with controls matched for sex and body mass index--a cross-sectional study
    Peter Vestergaard
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital and Faculty of Health Sciences, Aarhus University, Aarhus, Denmark
    J Pediatr 144:614-9. 2004
    ..To study bone mineral status, body composition, and biochemical markers of bone turnover in Prader-Willi syndrome (PWS)...
  33. ncbi request reprint Acute exercise increases adipose tissue interstitial adiponectin concentration in healthy overweight and lean subjects
    Lise Højbjerre
    Department of Biomedical Sciences, The Panum Institute, The Copenhagen Muscle Research Centre, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Eur J Endocrinol 157:613-23. 2007
    ..We studied how an acute bout of exercise influences expression and concentration of adiponectin and regulators of adiponectin in adipose tissue and plasma...