Research Topics
| Thomas Graven-NielsenSummaryAffiliation: Aalborg University Country: Denmark Publications
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Detail Information
Publications
The peripheral apparatus of muscle pain: evidence from animal and human studiesT Graven-Nielsen
Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Denmark
Clin J Pain 17:2-10. 2001..The sensitization process by endogenous substances that are likely to be released during trauma or inflammatory injury is probably the best established peripheral mechanism for muscle tenderness and hyperalgesia...- Induction and assessment of muscle pain, referred pain, and muscular hyperalgesiaThomas Graven-Nielsen
Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg E, Denmark
Curr Pain Headache Rep 7:443-51. 2003..Similarly, the multimodal approach is important in clinical studies to provide evidence for which specific muscle pain modalities and mechanisms are affected and how they are modulated by pharmacologic approaches... - Experimental pain by ischaemic contractions compared with pain by intramuscular infusions of adenosine and hypertonic salineThomas Graven-Nielsen
Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg E, Denmark
Eur J Pain 7:93-102. 2003.... - Painful and non-painful pressure sensations from human skeletal muscleThomas Graven-Nielsen
Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7D 3, 9220 Aalborg E, Denmark
Exp Brain Res 159:273-83. 2004..Moreover, a pressure sensation can be elicited from deep tissue probably mediated by group III and IV afferents involving low-threshold mechanoreceptors... - Inhibition of maximal voluntary contraction force by experimental muscle pain: a centrally mediated mechanismThomas Graven-Nielsen
Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg E, Denmark
Muscle Nerve 26:708-12. 2002..This indicates that force inhibition by muscle pain is centrally mediated. This has clinical implications for rehabilitation and training of patients with musculoskeletal pain... - Opioid-insensitive hypoalgesia to mechanical stimuli at sites ipsilateral and contralateral to experimental muscle pain in human volunteersThomas Graven-Nielsen
Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7D 3, 9220 Aalborg E, Denmark
Exp Brain Res 146:213-22. 2002..The deep peroneal nerve specifically innervates both the TA muscle and the only site of hyperalgesia indicating spatial summation of afferent activity from these structures... - Peripheral and central sensitization in musculoskeletal pain disorders: an experimental approachThomas Graven-Nielsen
Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg E, Denmark
Curr Rheumatol Rep 4:313-21. 2002..Central sensitization may play a role in the persistence, amplification, and spread of pain. Interventions should take this aspect into consideration... 
Thermosensitivity of muscle: high-intensity thermal stimulation of muscle tissue induces muscle pain in humansT Graven-Nielsen
Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Denmark
J Physiol 540:647-56. 2002..Taken together, the data indicate that thermosensation from a given volume of muscle is less potent than nociception...- Experimental muscle pain decreases voluntary EMG activity but does not affect the muscle potential evoked by transcutaneous electrical stimulationDario Farina
Department of Health Science and Technology, Center for Sensory Motor Interaction SMI, Aalborg University, Fredrik Bajers Vej 7 D 3, DK 9220 Aalborg, Denmark
Clin Neurophysiol 116:1558-65. 2005..The aim of this human study was to investigate if voluntary EMG activity and supra-maximal M-wave are affected by injection of hypertonic saline to experimentally induce muscle pain... - Experimental muscle pain results in reorganization of coordination among trapezius muscle subdivisions during repetitive shoulder flexionDeborah Falla
Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 3, 9220, Aalborg, Denmark
Exp Brain Res 178:385-93. 2007..The results suggest that local elicitation of nociceptive afferents in the upper division of the trapezius induces reorganization in the coordinated activity of the three subdivisions of the trapezius in repetitive dynamic tasks... 
Spatial and temporal aspects of muscle hyperalgesia induced by nerve growth factor in humansHelle Andersen
Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory Motor Interaction SMI, Aalborg University, Fredrik Bajers Vej 7 D, 9220 Aalborg E, Denmark
Exp Brain Res 191:371-82. 2008..In this material there was no gender effect of NGF-induced muscle hyperalgesia. The expansion of muscle hyperalgesia to distant areas indicates that central mechanisms are involved...- Contribution of the local and referred pain from active myofascial trigger points in fibromyalgia syndromeHong You Ge
Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
Pain 147:233-40. 2009..Active MTrPs may serve as one of the sources of noxious input leading to the sensitization of spinal and supraspinal pain pathways in FMS... - The pain-induced decrease in low-threshold motor unit discharge rate is not associated with the amount of increase in spike-triggered average torqueDario Farina
Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D 3, DK 9220 Aalborg, Denmark
Clin Neurophysiol 119:43-51. 2008..This study examined whether there is an association between the magnitude of change in motor unit discharge rate and the amount of increase in the spike-triggered average torque during experimental muscle pain... - Increased trapezius pain sensitivity is not associated with increased tissue hardnessHelle Andersen
Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory Motor Interaction SMI, Aalborg University, Aalborg, Denmark
J Pain 11:491-9. 2010..Developments of new techniques that objectively can identify tender points are important, but thus far, manual palpation is best clinical practice... - Spike-triggered average torque and muscle fiber conduction velocity of low-threshold motor units following submaximal endurance contractionsDario Farina
Center for Sensory Motor Interaction, Dept of Health Science and Technology, Aalborg Univ, Fredrik Bajers Vej 7 D 3, DK 9220 Aalborg, Denmark
J Appl Physiol 98:1495-502. 2005..In conclusion, modifications in peak twitch torque of low-threshold motor units with sustained contraction are mainly determined by mechanisms not related to changes in action potential shape and in its propagation velocity... - Experimental muscle pain challenges the postural stability during quiet stance and unexpected posture perturbationRogério Pessoto Hirata
Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 3, Aalborg, Denmark
J Pain 12:911-9. 2011..This measure could potentially help clinicians who seek to assess how pain responses may contribute to patient's postural control and stability during quiet standing and after recovering from unexpected perturbations... - Temporal summation of pain evoked by mechanical stimulation in deep and superficial tissueHongling Nie
Laboratory for Experimental Pain Research, Center for Sensory-Motor Interaction, Aalborg University, Aalborg, Denmark
J Pain 6:348-55. 2005..PERSPECTIVE: Pain originating in deep tissue influences central pain processing systems more than superficial tissue. This might be of importance in patients with musculoskeletal pain... - Psychophysical and EEG responses to repeated experimental muscle pain in humans: pain intensity encodes EEG activityPeng Fei Chang
Human Brain Mapping and Cortical Imaging Laboratory, Center for Sensory Motor Interaction, Aalborg University, Aalborg, Denmark
Brain Res Bull 59:533-43. 2003..These results indicates that pain-related EEG activities were encoded by the pain intensity. The thalamo-cortical system and descending inhibitory neuronal networks may be involved in the regulation of pain intensity... - Delayed onset muscle soreness at tendon-bone junction and muscle tissue is associated with facilitated referred painWilliam Gibson
Department of Health Science and Technology, Laboratory for Experimental Pain Research, Center for Sensory-Motor Interaction, Aalborg University, Fredrik Bajers Vej 7D-3, 9220, Aalborg, Denmark
Exp Brain Res 174:351-60. 2006..The results indicate that muscle belly and TBJ sites are sensitised while tendon tissue per se is unaffected by DOMS. Central sensitivity changes caused by DOMS may explain the increase in referred pain frequency and enlarged pain areas... - Experimental muscle pain reduces initial motor unit discharge rates during sustained submaximal contractionsDario Farina
Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D 3, DK 9220 Aalborg, Denmark
J Appl Physiol 98:999-1005. 2005.... - Experimental muscle pain changes motor control strategies in dynamic contractionsUlysses F Ervilha
Laboratory for Experimental Pain Research, Center for Sensory-Motor Interaction (SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D-3, 9220, Aalborg, Denmark
Exp Brain Res 164:215-24. 2005..Such a changed motor strategy may be highly relevant in models of occupational musculoskeletal pain conditions... - Enhanced temporal summation of pressure pain in the trapezius muscle after delayed onset muscle sorenessHongling Nie
Laboratory for Experimental Pain Research, Department of Health Science and Technology, Center for Sensory-Motor Interaction (SMI, Aalborg University, Fredrik Bajers Vej 7D-3, 9220, Aalborg, Denmark
Exp Brain Res 170:182-90. 2006..These data indicate that muscle soreness might facilitate the central components of temporal summation to mechanical stimulation... - Effect of temperature on spike-triggered average torque and electrophysiological properties of low-threshold motor unitsDario Farina
Center for Sensory Motor Interaction, Dept of Health Science and Technology, Aalborg Univ, Fredrik Bajers Vej 7 D 3, DK 9220 Aalborg, Denmark
J Appl Physiol 99:197-203. 2005..43), and with the decrease in action potential amplitude (r2 = 0.50). In conclusion, temperature-induced modifications in fiber membrane conduction properties may have a direct effect on contractile motor unit properties... - Localized muscle pain causes prolonged recovery after fatiguing isometric contractionsAndrei Ciubotariu
Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction SMI, Aalborg University, Fredrik Bajers Vej 7D 3, 9220, Aalborg E, Denmark
Exp Brain Res 181:147-58. 2007..These effects can modify the normal patterns of synergistic activation and can also generate overload problems in muscle pain patients if compensatory motor control strategies are applied... - Increased pain from muscle fascia following eccentric exercise: animal and human findingsWilliam Gibson
Laboratory for Experimental Pain Research, Department of Health Science and Technology, Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7D 3, 9220, Aalborg, Denmark
Exp Brain Res 194:299-308. 2009..Response to deep muscle stimulation was not different between sides. This suggests that fascia rather than muscle tissue is important in DOMS associated sensitisation... - The predetermined sites of examination for tender points in fibromyalgia syndrome are frequently associated with myofascial trigger pointsHong You Ge
Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
J Pain 11:644-51. 2010..Most of the TP sites in FMS are MTrPs. Active MTrPs may serve as a peripheral generator of fibromyalgia pain and inactivation of active MTrPs may thus be an alternative for the treatment of FMS... - Latent myofascial trigger points are associated with an increased antagonistic muscle activity during agonist muscle contractionJosé Miota Ibarra
Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
J Pain 12:1282-8. 2011..Elimination of latent MTPs and/or prevention of latent MTPs from becoming active may improve motor functions... - Reproduction of overall spontaneous pain pattern by manual stimulation of active myofascial trigger points in fibromyalgia patientsHong You Ge
Department of Health Science and Technology, Aalborg University, Fredrik Bajersvej 7, Aalborg, DK 9220, Denmark
Arthritis Res Ther 13:R48. 2011..The current study investigated whether the overall spontaneous FM pain pattern can be reproduced by local and referred pain from active MTPs located in different muscles... - Pressure pain sensitivity and hardness along human normal and sensitized muscleHelle Andersen
Laboratory for Experimental Pain Research, Aalborg University, Center for Sensory-Motor Interaction (SMI, and The Parker Institute, Frederiksberg Hospital, Denmark
Somatosens Mot Res 23:97-109. 2006..In DOMS, specific muscle belly sites were more sensitive to pressure stimulation. Muscle-tendon sites were harder compared to muscle belly sites... - Pressure-induced muscle pain and tissue biomechanics: a computational and experimental studySara Finocchietti
Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 3, Aalborg, Denmark
Eur J Pain 15:36-44. 2011..The relatively low stress in the deep tissue suggests that the mechanosensitivity of nociceptors in the deep tissue is lower compared with nociceptors in the superficial tissue... - Effects of adipose thickness and muscle hardness on pressure pain sensitivitySara Finocchietti
Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 3, Aalborg, Denmark
Clin J Pain 27:414-24. 2011..Pressure algometry is used for assessment of pain sensitivity. In this study the relation between tissue characteristics and pressure pain thresholds was investigated... - Temporal summation of pressure pain during muscle hyperalgesia evoked by nerve growth factor and eccentric contractionsHongling Nie
Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg, Denmark
Eur J Pain 13:704-10. 2009..Intramuscular administration of NGF intensified the DOMS responses, evoking facilitated temporal summation. Central as well as peripheral sensitization mechanisms may play a role in the facilitation... - Effect of load level and muscle pain intensity on the motor control of elbow-flexion movementsUlysses Fernandes Ervilha
Laboratory for Experimental Pain Research, Center for Sensory-Motor Interaction, Aalborg University, Fredrik Bajers Vej 7D-3, 9220 Aalborg, Denmark
Eur J Appl Physiol 92:168-75. 2004..Perturbations of motor planning lead to changes on movement strategies, which might be a potential cause of musculoskeletal problems... - Glutamate and capsaicin-induced pain, hyperalgesia and modulatory interactions in human tendon tissueWilliam Gibson
Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 3, 9220, Aalborg, Denmark
Exp Brain Res 194:173-82. 2009..PPTs were only reliably reduced by capsaicin injection. These results emphasize the possible importance of peripheral glutamate receptor antagonists in pain management in musculoskeletal conditions... - Assessment of mechanisms in localized and widespread musculoskeletal painThomas Graven-Nielsen
Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, DK 9220 Aalborg E, Denmark
Nat Rev Rheumatol 6:599-606. 2010..This sensitization for the chronification of pain should be assessed by adequate pain biomarkers. Furthermore, pain prevention should target early intervention strategies and new anti-hyperalgesic compounds should be developed... - Effects of a manual therapy technique in experimental lateral epicondylalgiaHelen Slater
Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Aalborg, Denmark
Man Ther 11:107-17. 2006..These data suggest that the lateral glide-MWM does not activate mechanisms associated with analgesia or force augmentation in subjects with experimentally induced features simulating lateral epicondylalgia... - Nociceptive withdrawal reflexes evoked by uniform-temperature laser heat stimulation of large skin areas in humansCarsten Dahl Mørch
Center for Sensory Motor Interaction SMI, Aalborg University, Fredrik Bajers Vej 7 D 3, DK 9220 Aalborg, Denmark
J Neurosci Methods 160:85-92. 2007..The paper presents a new method to evoke NWRs by uniform-temperature laser heat stimulation of large skin areas in humans. These heat evoked reflexes had a stimulus-response relationship... - Current pain and fear of pain contribute to reduced maximum voluntary contraction of neck muscles in patients with chronic neck painRené Lindstroem
Center for Sensory Motor Interaction, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark
Arch Phys Med Rehabil 93:2042-8. 2012..To assess a range of physical and psychological factors and determine which factors contribute the most to reduced strength in patients with neck pain... - Homotopic and heterotopic variation in skin blood flow and temperature following experimental muscle pain in humansJing Lei
Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg, Denmark
Brain Res 1232:85-93. 2008..This suggested that both homotopic and heterotopic vascular reactions triggered by hypertonic saline stimulation of thin muscle afferent fibers were a neurogenically associated reaction... - Effects of gabapentin on experimental somatic pain and temporal summationLars Arendt-Nielsen
Center for Sensory Motor Interactions, Department of Health Science and Technology, Aalborg University, Denmark
Reg Anesth Pain Med 32:382-8. 2007..The aim of this double-blind, placebo-controlled experimental pain study, conducted on 20 healthy volunteers, was to examine the effect of a single dose of 1200 mg gabapentin on multi-modal experimental cutaneous and muscle pain models... - Spatial and temporal summation of pain evoked by mechanical pressure stimulationHongling Nie
Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
Eur J Pain 13:592-9. 2009..The combination of temporal and spatial integration of nociceptive input facilitates the pain intensity, suggesting that temporal summation is clinically relevant in conditions with widespread pain... - Referred pain and hyperalgesia in human tendon and muscle belly tissueWilliam Gibson
Laboratory for Experimental Pain Research, Center for Sensory-Motor Interaction (SMI, Department of Health Science and Technology, Aalborg University, Denmark
Pain 120:113-23. 2006..Furthermore, there may be site specific central changes reflected by the differences in the results regarding sensitivity and summation over time... - Comparative EEG activation to skin pain and muscle pain induced by capsaicin injectionPeng Fei Chang
Human Brain Mapping and Cortical Imaging Laboratory, Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7 D 3, DK 9220, Aalborg, Denmark
Int J Psychophysiol 51:117-26. 2004..No difference was found between the vehicle-induced non-painful sensations in skin and muscle. These results implicate that the nociceptive inputs from muscle and skin are processed differently in the similar neural matrix of the brain... - Modality-specific facilitation and adaptation to painful tonic stimulation in humansRomanas Polianskis
Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction SMI, Aalborg University, Frederik Bajers Vej 7, D 3, DK 9220 Aalborg, Denmark
Eur J Pain 6:475-84. 2002..The results of the study suggest that tolerance of tonic painful pressure and cold stimulations is specific to stimulus modality and may represent separate nociceptive mechanisms... - Effect of innervation-zone distribution on estimates of average muscle-fiber conduction velocityMogens Nielsen
Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D3, 9220 Aalborg, Denmark
Muscle Nerve 37:68-78. 2008..The effect of innervation-zone distribution on MFCV estimates is thus substantial and may be a significant confounding factor in experimental and clinical studies on muscles with diffuse innervation zones... - Sensory and motor effects of experimental muscle pain in patients with lateral epicondylalgia and controls with delayed onset muscle sorenessHelen Slater
Laboratory for Experimental Pain Research, Center for Sensory-Motor Interaction, Aalborg University, Fredrik Bajers Vej 7D, 9220 Aalborg E, Denmark
Pain 114:118-30. 2005..0001), at all Day 1 times compared with the control arms. In patients, the bilateral increase in deep tissue sensitivity and enlarged referred pain areas during saline-induced pain might suggest involvement of central sensitisation... - Spatial and temporal changes of upper trapezius muscle fiber conduction velocity are not predicted by surface EMG spectral analysis during a dynamic upper limb taskDeborah Falla
Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, DK 9220 Aalborg, Denmark
J Neurosci Methods 156:236-41. 2006..This finding suggests that spectral analysis cannot be used to infer changes in the spatial and temporal behavior of muscle fiber CV during dynamic tasks... - Increased H-reflex response induced by intramuscular electrical stimulation of latent myofascial trigger pointsHong You Ge
Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D 3, Aalborg, Denmark
Acupunct Med 27:150-4. 2009..The purpose of this current study was to explore whether an H-reflex response could be elicited from intramuscular electrical stimulation. If so, to assess the possibility of increased reflex response at MTrPs... - Sensitization in patients with painful knee osteoarthritisLars Arendt-Nielsen
Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
Pain 149:573-81. 2010..This study highlights the importance of central sensitization as an important manifestation in knee OA... - Experimental calf muscle pain attenuates the postural stability during quiet stance and perturbationRogério Pessoto Hirata
Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
Clin Biomech (Bristol, Avon) 25:931-7. 2010..The purpose of this study was to evaluate how acute pain changes the postural control and stability during quiet standing and after unexpected perturbations... - Impact of clinical and experimental pain on muscle strength and activityThomas Graven-Nielsen
Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg E, Denmark
Curr Rheumatol Rep 10:475-81. 2008..The motor control assessment procedures provide complementary clinical information and give further support for optimizing treatment regimens and prevention procedures for musculoskeletal pain... - Experimental knee pain impairs postural stability during quiet stance but not after perturbationsRogério Pessoto Hirata
Laboratory for Musculoskeletal Pain and Motor Control, Department of Health Science and Technology, Center for Sensory Motor Interaction SMI, Aalborg University, Fredrik Bajers Vej 7D 3, 9220, Aalborg, Denmark
Eur J Appl Physiol 112:2511-21. 2012..This measure could potentially help clinicians who seek to assess how pain responses may contribute to patient's postural control and stability during quiet standing... - Translational musculoskeletal pain researchLars Arendt-Nielsen
Center for Sensory Motor Interaction SMI, Department of Health Sciences and Technology, Faculty of Medicine, Aalborg University, Fredrik Bajers Vej 7, Aalborg, Denmark
Best Pract Res Clin Rheumatol 25:209-26. 2011..New safe and efficient compounds are highly needed in the area of musculoskeletal pain management... - Spatial and temporal aspects of deep tissue pain assessed by cuff algometryRomanas Polianskis
Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Frederik Bajers Vej 7, D 3, DK 9220, Aalborg, Denmark
Pain 100:19-26. 2002..The presented models are useful additions to a researcher's armamentarium for further pharmacological and clinical studies on deep tissue pain and related mechanisms... - Muscle pain: sensory implications and interaction with motor controlLars Arendt-Nielsen
Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Denmark
Clin J Pain 24:291-8. 2008..In recent years, it has become evident that muscle pain can interfere with motor control strategies and different patters of interaction are seen during rest, static contractions, and dynamic conditions... - Pain-induced changes in cervical muscle activation do not affect muscle fatigability during sustained isometric contractionDeborah Falla
Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7, D 3, DK 9220 Aalborg, Denmark
J Electromyogr Kinesiol 18:938-46. 2008..This finding has implications for interpreting the mechanisms underlying greater cervical muscle fatigue in people with neck pain disorders... - Central sensitization in fibromyalgia and other musculoskeletal disordersLars Arendt-Nielsen
Laboratory for Human Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7, Building D3, DK 9220 Aalborg, Denmark
Curr Pain Headache Rep 7:355-61. 2003.... - The effect of muscle pain on elbow flexion and coactivation tasksUlysses F Ervilha
Laboratory for Experimental Pain Research, Center for Sensory-Motor Interaction, Aalborg University, Fredrik Bajers Vej 7D-3, 9220 Aalborg, Denmark
Exp Brain Res 156:174-82. 2004.... - The influence of muscle pain and fatigue on the activity of synergistic muscles of the legAndrei Ciubotariu
Laboratory for Experimental Pain Research, Center for Sensory-Motor Interaction, Aalborg University, Fredrik Bajers Vej 7D-3, 9220 Aalborg E, Denmark
Eur J Appl Physiol 91:604-14. 2004..These findings may have implications for the understanding of manifestations seen in relation to painful musculoskeletal disorders... - Basic aspects of musculoskeletal pain: from acute to chronic painLars Arendt-Nielsen
Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, School of Medicine, Aalborg University, Aalborg E, Denmark
J Man Manip Ther 19:186-93. 2011..From a management perspective, it is therefore highly important to reduce pain intensity and try to minimize the duration of pain... - Tissue characteristics during temporal summation of pressure-evoked painSara Finocchietti
Laboratory for Musculoskeletal Pain and Motor Control, Department of Health Science and Technology, Faculty of Medicine, Center for Sensory Motor Interaction SMI, Aalborg University, Fredrik Bajers Vej 7D 3, 9220 Aalborg E, Denmark
Exp Brain Res 219:255-65. 2012.... - Two-dimensional spatial distribution of surface mechanomyographical response to single motor unit activityCorrado Cescon
Laboratory for Engineering of the Neuromuscular System, Department of Electronics, Politecnico di Torino, Torino, Italy
J Neurosci Methods 159:19-25. 2007..The maps of acceleration showed spatial dependency in single motor unit MMG activities. The technique provides a new insight into motor unit contractile properties... - Glutamate-evoked pain and mechanical allodynia in the human masseter musclePeter Svensson
Department of Clinical Oral Physiology, Dental School, Aarhus University, DK 8000 Aarhus C, Denmark
Pain 101:221-7. 2003..The present results suggest that injection of 1.0M glutamate into the masseter muscle may provide a useful experimental method to test sensitization and efficacy of peripheral EAA receptor antagonists in human subjects... - Pivotal involvement of neurogenic mechanism in subcutaneous bee venom-induced inflammation and allodynia in unanesthetized conscious ratsHui Sheng Chen
Department of Neurology, General Hospital of Shen Yang Military Region, Shen Yang 110016, PR China
Exp Neurol 200:386-91. 2006..In addition, the capsaicin-sensitive primary afferents may play differential roles in the development of the BV-induced static and dynamic mechanical allodynia... - Increased muscle pain sensitivity in patients with tension-type headachePeter T Schmidt-Hansen
Department of Neurology, Viborg Hospital, Denmark
Pain 129:113-21. 2007..Gender differences in deep pain sensitivity seem to be a consistent finding both in healthy controls and patients with tension-type headache... - Generalized deep-tissue hyperalgesia in patients with chronic low-back painClaus Manniche
Human Locomotion Science, University of Southern Denmark, Odense, Denmark
Eur J Pain 11:415-20. 2007.... - Standardising surface electromyogram recordings for assessment of activity and fatigue in the human upper trapezius muscleDario Farina
Centro di Bioingegneria, Dept of Electronics, Politecnico di Torino, Corso Duca degli Abruzzi 24, Turin 10129, Italy
Eur J Appl Physiol 86:469-78. 2002..Data on the myoelectric manifestations of muscle fatigue of the upper trapezius muscle are provided for the optimal electrode location... - Increased joint loads during walking--a consequence of pain relief in knee osteoarthritisMarius Henriksen
The Parker Institute, Frederiksberg Hospital, Ndr Fasanvej 57, DK 2000 Frederiksberg, Denmark
Knee 13:445-50. 2006..Although the patients walked with less compressive knee joint forces compared to the reference group, the effects of pain relief may accelerate the degenerative changes... - Assessment of single motor unit conduction velocity during sustained contractions of the tibialis anterior muscle with advanced spike triggered averagingDario Farina
Department of Electronics, Centro di Bioingegneria, Politecnico di Torino, Italy
J Neurosci Methods 115:1-12. 2002..1 m/s with less than 2 s data epochs. The method allows reliable assessment of firing rate and conduction properties of single MUs with applications for the investigation of central and peripheral fatigue mechanisms... - Managing chronic whiplash associated pain with a combination of low-dose opioid (remifentanil) and NMDA-antagonist (ketamine)Dag Lemming
Pain and Rehabilitation Centre, University Hospital, Linkoping, Sweden
Eur J Pain 11:719-32. 2007..Experimental pain was attenuated by both combinations containing the opioid, however, KET seemed to enhance the effect of REMI on electrical pain thresholds when a low REMI target concentration was used... - Experimental quadriceps muscle pain impairs knee joint control during walkingMarius Henriksen
Clinical Motor Function Laboratory, Parker Institute, Frederiksberg Hospital, Ndr Fasanvej 57, DK 2000 Frederiksberg, Denmark
J Appl Physiol 103:132-9. 2007.... - Selectivity of spatial filters for surface EMG detection from the tibialis anterior muscleDario Farina
Centro di Bioingegneria, Dipartimento di Elettronica, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy
IEEE Trans Biomed Eng 50:354-64. 2003..The 2-D filters investigated (including C1) showed very similar performance and were, thus, considered equivalent from the point of view of spatial selectivity... - Computerized cuff pressure algometry: A new method to assess deep-tissue hypersensitivity in fibromyalgiaAnders Jespersen
The Parker Institute, Frederiksberg Hospital, Nordre Fasanvej 57, DK 2000 Frederiksberg, Denmark
Pain 131:57-62. 2007..CPA was associated with knee muscle strength but not with measures thought to be influenced by psychological distress and mood... - Experimental deep tissue pain in wrist extensors--a model of lateral epicondylalgiaHelen Slater
School of Physiotherapy, Curtin University of Technology, Perth, Australia
Eur J Pain 7:277-88. 2003.... - Muscle temperature has a different effect on force fluctuations in young and older womenSusan Dewhurst
Department of Applied Physiology, University of Strathclyde, Glasgow, UK
Clin Neurophysiol 118:762-9. 2007..To investigate the effect of muscle temperature on force fluctuations during isometric contractions in young and older females... - Reduction of human experimental muscle pain by alfentanil and morphineHelène Schulte
Department for Clinical Science, Intervention and Technology, Division of Anesthesiology, Karolinska Institute at Karolinska University Hospital Huddinge SE 141 86, Stockholm, Sweden
Eur J Pain 10:733-41. 2006..Both alfentanil and morphine reduced experimental muscle pain. There were no indications of any true pharmacodynamic differences between the two drugs... - [Gender differences in response to pain]Thomas Graven-Nielsen
Aalborg Universitet, Institut for Sundhedsvidenskab og Teknologi, Center for Sanse Motorisk Interaktion
Ugeskr Laeger 169:2425-7. 2007..The gender difference in pain sensitivity might partly be linked to the female sex hormones but is also dependent on a complex interaction between psychosocial and physiological factors... - Effect of experimental muscle pain on motor unit firing rate and conduction velocityDario Farina
Centro di Bioingegneria, Dipartimento di Elettronica, Politecnico di Torino, 10129 Turin, Italy
J Neurophysiol 91:1250-9. 2004..This decrease is not associated with a change in MU membrane properties, indirectly assessed by CV. This study demonstrates a central inhibitory motor control mechanism with an efficacy correlated to the nociceptive activity... - Impulse-forces during walking are not increased in patients with knee osteoarthritisMarius Henriksen
The Parker Institute, Frederiksberg Hospital Frederiksberg, DK 2000 Denmark
Acta Orthop 77:650-6. 2006..We thus evaluated the impulsive sagittal ground reaction forces (iGRF), shock waves and lower extremity joint kinematics at heel strike during walking in knee osteoarthritis (OA) patients and compared them to those in healthy subjects... - Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscleBrian E Cairns
Department of Anesthesia, Harvard Medical School Children s Hospital, Boston, Massachusetts 02115, USA
J Neurophysiol 90:2098-105. 2003..It is conceivable that activation of peripheral NMDA receptors may contribute to masticatory muscle pain and that peripherally acting NMDA receptor antagonists could prove to be effective analgesics for this type of pain... - The responses to pharmacological challenges and experimental pain in patients with chronic whiplash-associated painDag Lemming
Pain and Rehabilitation Centre, University Hospital, , Sweden
Clin J Pain 21:412-21. 2005..However, the pattern of responses to the pharmacological challenges did not show any clear relationships with pain duration or the experimental pain tests...