Thomas Graven-Nielsen

Summary

Affiliation: Aalborg University
Country: Denmark

Publications

  1. ncbi request reprint The peripheral apparatus of muscle pain: evidence from animal and human studies
    T Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Denmark
    Clin J Pain 17:2-10. 2001
  2. ncbi request reprint Induction and assessment of muscle pain, referred pain, and muscular hyperalgesia
    Thomas Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg E, Denmark
    Curr Pain Headache Rep 7:443-51. 2003
  3. ncbi request reprint Painful and non-painful pressure sensations from human skeletal muscle
    Thomas Graven-Nielsen
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7D 3, 9220 Aalborg E, Denmark
    Exp Brain Res 159:273-83. 2004
  4. ncbi request reprint Experimental pain by ischaemic contractions compared with pain by intramuscular infusions of adenosine and hypertonic saline
    Thomas Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg E, Denmark
    Eur J Pain 7:93-102. 2003
  5. ncbi request reprint Inhibition of maximal voluntary contraction force by experimental muscle pain: a centrally mediated mechanism
    Thomas Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg E, Denmark
    Muscle Nerve 26:708-12. 2002
  6. ncbi request reprint Opioid-insensitive hypoalgesia to mechanical stimuli at sites ipsilateral and contralateral to experimental muscle pain in human volunteers
    Thomas Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7D 3, 9220 Aalborg E, Denmark
    Exp Brain Res 146:213-22. 2002
  7. ncbi request reprint Peripheral and central sensitization in musculoskeletal pain disorders: an experimental approach
    Thomas Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg E, Denmark
    Curr Rheumatol Rep 4:313-21. 2002
  8. pmc Thermosensitivity of muscle: high-intensity thermal stimulation of muscle tissue induces muscle pain in humans
    T Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Denmark
    J Physiol 540:647-56. 2002
  9. ncbi request reprint Experimental muscle pain decreases voluntary EMG activity but does not affect the muscle potential evoked by transcutaneous electrical stimulation
    Dario Farina
    Department of Health Science and Technology, Center for Sensory Motor Interaction SMI, Aalborg University, Fredrik Bajers Vej 7 D 3, DK 9220 Aalborg, Denmark
    Clin Neurophysiol 116:1558-65. 2005
  10. ncbi request reprint Experimental muscle pain results in reorganization of coordination among trapezius muscle subdivisions during repetitive shoulder flexion
    Deborah Falla
    Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 3, 9220, Aalborg, Denmark
    Exp Brain Res 178:385-93. 2007

Collaborators

Detail Information

Publications86

  1. ncbi request reprint The peripheral apparatus of muscle pain: evidence from animal and human studies
    T Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Denmark
    Clin J Pain 17:2-10. 2001
    ..The sensitization process by endogenous substances that are likely to be released during trauma or inflammatory injury is probably the best established peripheral mechanism for muscle tenderness and hyperalgesia...
  2. ncbi request reprint Induction and assessment of muscle pain, referred pain, and muscular hyperalgesia
    Thomas Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg E, Denmark
    Curr Pain Headache Rep 7:443-51. 2003
    ..Similarly, the multimodal approach is important in clinical studies to provide evidence for which specific muscle pain modalities and mechanisms are affected and how they are modulated by pharmacologic approaches...
  3. ncbi request reprint Painful and non-painful pressure sensations from human skeletal muscle
    Thomas Graven-Nielsen
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7D 3, 9220 Aalborg E, Denmark
    Exp Brain Res 159:273-83. 2004
    ..Moreover, a pressure sensation can be elicited from deep tissue probably mediated by group III and IV afferents involving low-threshold mechanoreceptors...
  4. ncbi request reprint Experimental pain by ischaemic contractions compared with pain by intramuscular infusions of adenosine and hypertonic saline
    Thomas Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg E, Denmark
    Eur J Pain 7:93-102. 2003
    ....
  5. ncbi request reprint Inhibition of maximal voluntary contraction force by experimental muscle pain: a centrally mediated mechanism
    Thomas Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg E, Denmark
    Muscle Nerve 26:708-12. 2002
    ..This indicates that force inhibition by muscle pain is centrally mediated. This has clinical implications for rehabilitation and training of patients with musculoskeletal pain...
  6. ncbi request reprint Opioid-insensitive hypoalgesia to mechanical stimuli at sites ipsilateral and contralateral to experimental muscle pain in human volunteers
    Thomas Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7D 3, 9220 Aalborg E, Denmark
    Exp Brain Res 146:213-22. 2002
    ..The deep peroneal nerve specifically innervates both the TA muscle and the only site of hyperalgesia indicating spatial summation of afferent activity from these structures...
  7. ncbi request reprint Peripheral and central sensitization in musculoskeletal pain disorders: an experimental approach
    Thomas Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg E, Denmark
    Curr Rheumatol Rep 4:313-21. 2002
    ..Central sensitization may play a role in the persistence, amplification, and spread of pain. Interventions should take this aspect into consideration...
  8. pmc Thermosensitivity of muscle: high-intensity thermal stimulation of muscle tissue induces muscle pain in humans
    T Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Denmark
    J Physiol 540:647-56. 2002
    ..Taken together, the data indicate that thermosensation from a given volume of muscle is less potent than nociception...
  9. ncbi request reprint Experimental muscle pain decreases voluntary EMG activity but does not affect the muscle potential evoked by transcutaneous electrical stimulation
    Dario Farina
    Department of Health Science and Technology, Center for Sensory Motor Interaction SMI, Aalborg University, Fredrik Bajers Vej 7 D 3, DK 9220 Aalborg, Denmark
    Clin Neurophysiol 116:1558-65. 2005
    ..The aim of this human study was to investigate if voluntary EMG activity and supra-maximal M-wave are affected by injection of hypertonic saline to experimentally induce muscle pain...
  10. ncbi request reprint Experimental muscle pain results in reorganization of coordination among trapezius muscle subdivisions during repetitive shoulder flexion
    Deborah Falla
    Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 3, 9220, Aalborg, Denmark
    Exp Brain Res 178:385-93. 2007
    ..The results suggest that local elicitation of nociceptive afferents in the upper division of the trapezius induces reorganization in the coordinated activity of the three subdivisions of the trapezius in repetitive dynamic tasks...
  11. doi request reprint Spatial and temporal aspects of muscle hyperalgesia induced by nerve growth factor in humans
    Helle Andersen
    Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory Motor Interaction SMI, Aalborg University, Fredrik Bajers Vej 7 D, 9220 Aalborg E, Denmark
    Exp Brain Res 191:371-82. 2008
    ..In this material there was no gender effect of NGF-induced muscle hyperalgesia. The expansion of muscle hyperalgesia to distant areas indicates that central mechanisms are involved...
  12. doi request reprint Contribution of the local and referred pain from active myofascial trigger points in fibromyalgia syndrome
    Hong You Ge
    Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Pain 147:233-40. 2009
    ..Active MTrPs may serve as one of the sources of noxious input leading to the sensitization of spinal and supraspinal pain pathways in FMS...
  13. doi request reprint Increased trapezius pain sensitivity is not associated with increased tissue hardness
    Helle Andersen
    Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory Motor Interaction SMI, Aalborg University, Aalborg, Denmark
    J Pain 11:491-9. 2010
    ..A heterogeneous distribution of pressure pain sensitivity and muscle hardness was found in the upper trapezius. The short duration of exercise until exhaustion did not change muscle sensitivity or muscle hardness in asymptomatic muscles...
  14. ncbi request reprint Spike-triggered average torque and muscle fiber conduction velocity of low-threshold motor units following submaximal endurance contractions
    Dario Farina
    Center for Sensory Motor Interaction, Dept of Health Science and Technology, Aalborg Univ, Fredrik Bajers Vej 7 D 3, DK 9220 Aalborg, Denmark
    J Appl Physiol (1985) 98:1495-502. 2005
    ..In conclusion, modifications in peak twitch torque of low-threshold motor units with sustained contraction are mainly determined by mechanisms not related to changes in action potential shape and in its propagation velocity...
  15. ncbi request reprint The pain-induced decrease in low-threshold motor unit discharge rate is not associated with the amount of increase in spike-triggered average torque
    Dario Farina
    Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D 3, DK 9220 Aalborg, Denmark
    Clin Neurophysiol 119:43-51. 2008
    ..This study examined whether there is an association between the magnitude of change in motor unit discharge rate and the amount of increase in the spike-triggered average torque during experimental muscle pain...
  16. doi request reprint Experimental muscle pain challenges the postural stability during quiet stance and unexpected posture perturbation
    Rogério Pessoto Hirata
    Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 3, Aalborg, Denmark
    J Pain 12:911-9. 2011
    ..05). These results show that muscle pain impairs postural stability during quiet standing and after unexpected perturbation, which suggest that people suffering from leg muscle pain are more vulnerable to falls...
  17. ncbi request reprint Psychophysical and EEG responses to repeated experimental muscle pain in humans: pain intensity encodes EEG activity
    Peng Fei Chang
    Human Brain Mapping and Cortical Imaging Laboratory, Center for Sensory Motor Interaction, Aalborg University, Aalborg, Denmark
    Brain Res Bull 59:533-43. 2003
    ..These results indicates that pain-related EEG activities were encoded by the pain intensity. The thalamo-cortical system and descending inhibitory neuronal networks may be involved in the regulation of pain intensity...
  18. ncbi request reprint Temporal summation of pain evoked by mechanical stimulation in deep and superficial tissue
    Hongling Nie
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Aalborg, Denmark
    J Pain 6:348-55. 2005
    ..01) and (2) faster in deep tissue compared with skin (P < .01). No gender difference was observed. The temporal summation might be related to both central and peripheral mechanisms...
  19. ncbi request reprint Delayed onset muscle soreness at tendon-bone junction and muscle tissue is associated with facilitated referred pain
    William Gibson
    Department of Health Science and Technology, Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7D 3, 9220, Aalborg, Denmark
    Exp Brain Res 174:351-60. 2006
    ..The results indicate that muscle belly and TBJ sites are sensitised while tendon tissue per se is unaffected by DOMS. Central sensitivity changes caused by DOMS may explain the increase in referred pain frequency and enlarged pain areas...
  20. ncbi request reprint Experimental muscle pain changes motor control strategies in dynamic contractions
    Ulysses F Ervilha
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 3, 9220, Aalborg, Denmark
    Exp Brain Res 164:215-24. 2005
    ..Such a changed motor strategy may be highly relevant in models of occupational musculoskeletal pain conditions...
  21. ncbi request reprint Enhanced temporal summation of pressure pain in the trapezius muscle after delayed onset muscle soreness
    Hongling Nie
    Laboratory for Experimental Pain Research, Department of Health Science and Technology, Center for Sensory Motor Interaction SMI, Aalborg University, Fredrik Bajers Vej 7D 3, 9220, Aalborg, Denmark
    Exp Brain Res 170:182-90. 2006
    ..These data indicate that muscle soreness might facilitate the central components of temporal summation to mechanical stimulation...
  22. ncbi request reprint Experimental muscle pain reduces initial motor unit discharge rates during sustained submaximal contractions
    Dario Farina
    Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D 3, DK 9220 Aalborg, Denmark
    J Appl Physiol (1985) 98:999-1005. 2005
    ....
  23. ncbi request reprint Localized muscle pain causes prolonged recovery after fatiguing isometric contractions
    Andrei Ciubotariu
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction SMI, Aalborg University, Fredrik Bajers Vej 7D 3, 9220, Aalborg E, Denmark
    Exp Brain Res 181:147-58. 2007
    ..These effects can modify the normal patterns of synergistic activation and can also generate overload problems in muscle pain patients if compensatory motor control strategies are applied...
  24. ncbi request reprint Effect of temperature on spike-triggered average torque and electrophysiological properties of low-threshold motor units
    Dario Farina
    Center for Sensory Motor Interaction, Dept of Health Science and Technology, Aalborg Univ, Fredrik Bajers Vej 7 D 3, DK 9220 Aalborg, Denmark
    J Appl Physiol (1985) 99:197-203. 2005
    ..43), and with the decrease in action potential amplitude (r2 = 0.50). In conclusion, temperature-induced modifications in fiber membrane conduction properties may have a direct effect on contractile motor unit properties...
  25. doi request reprint Increased pain from muscle fascia following eccentric exercise: animal and human findings
    William Gibson
    Laboratory for Experimental Pain Research, Department of Health Science and Technology, Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7D 3, 9220, Aalborg, Denmark
    Exp Brain Res 194:299-308. 2009
    ..Response to deep muscle stimulation was not different between sides. This suggests that fascia rather than muscle tissue is important in DOMS associated sensitisation...
  26. doi request reprint The predetermined sites of examination for tender points in fibromyalgia syndrome are frequently associated with myofascial trigger points
    Hong You Ge
    Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    J Pain 11:644-51. 2010
    ..Overall spontaneous pain intensity and pain pattern were recorded before manual identification of MTrPs. Local and referred pain pattern from active MTrPs were drawn following manual palpation at TP sites...
  27. doi request reprint Latent myofascial trigger points are associated with an increased antagonistic muscle activity during agonist muscle contraction
    José Miota Ibarra
    Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    J Pain 12:1282-8. 2011
    ..05). The current study provides the first evidence that increased motor unit excitability is associated with reduced antagonist reciprocal inhibition...
  28. pmc Reproduction of overall spontaneous pain pattern by manual stimulation of active myofascial trigger points in fibromyalgia patients
    Hong You Ge
    Department of Health Science and Technology, Aalborg University, Fredrik Bajersvej 7, Aalborg, DK 9220, Denmark
    Arthritis Res Ther 13:R48. 2011
    ..The current study investigated whether the overall spontaneous FM pain pattern can be reproduced by local and referred pain from active MTPs located in different muscles...
  29. ncbi request reprint Pressure pain sensitivity and hardness along human normal and sensitized muscle
    Helle Andersen
    Laboratory for Experimental Pain Research, Aalborg University, Center for Sensory Motor Interaction SMI, and The Parker Institute, Frederiksberg Hospital, Denmark
    Somatosens Mot Res 23:97-109. 2006
    ..In DOMS, specific muscle belly sites were more sensitive to pressure stimulation. Muscle-tendon sites were harder compared to muscle belly sites...
  30. doi request reprint Effects of adipose thickness and muscle hardness on pressure pain sensitivity
    Sara Finocchietti
    Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 3, Aalborg, Denmark
    Clin J Pain 27:414-24. 2011
    ..Pressure algometry is used for assessment of pain sensitivity. In this study the relation between tissue characteristics and pressure pain thresholds was investigated...
  31. doi request reprint Assessment of mechanisms in localized and widespread musculoskeletal pain
    Thomas Graven-Nielsen
    Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, DK 9220 Aalborg E, Denmark
    Nat Rev Rheumatol 6:599-606. 2010
    ..This sensitization for the chronification of pain should be assessed by adequate pain biomarkers. Furthermore, pain prevention should target early intervention strategies and new anti-hyperalgesic compounds should be developed...
  32. doi request reprint Temporal summation of pressure pain during muscle hyperalgesia evoked by nerve growth factor and eccentric contractions
    Hongling Nie
    Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg, Denmark
    Eur J Pain 13:704-10. 2009
    ..Intramuscular administration of NGF intensified the DOMS responses, evoking facilitated temporal summation. Central as well as peripheral sensitization mechanisms may play a role in the facilitation...
  33. doi request reprint Pressure-induced muscle pain and tissue biomechanics: a computational and experimental study
    Sara Finocchietti
    Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 3, Aalborg, Denmark
    Eur J Pain 15:36-44. 2011
    ..The relatively low stress in the deep tissue suggests that the mechanosensitivity of nociceptors in the deep tissue is lower compared with nociceptors in the superficial tissue...
  34. doi request reprint Glutamate and capsaicin-induced pain, hyperalgesia and modulatory interactions in human tendon tissue
    William Gibson
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 3, 9220, Aalborg, Denmark
    Exp Brain Res 194:173-82. 2009
    ..PPTs were only reliably reduced by capsaicin injection. These results emphasize the possible importance of peripheral glutamate receptor antagonists in pain management in musculoskeletal conditions...
  35. ncbi request reprint Effect of load level and muscle pain intensity on the motor control of elbow-flexion movements
    Ulysses Fernandes Ervilha
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7D 3, 9220 Aalborg, Denmark
    Eur J Appl Physiol 92:168-75. 2004
    ..Perturbations of motor planning lead to changes on movement strategies, which might be a potential cause of musculoskeletal problems...
  36. ncbi request reprint Nociceptive withdrawal reflexes evoked by uniform-temperature laser heat stimulation of large skin areas in humans
    Carsten Dahl Mørch
    Center for Sensory Motor Interaction SMI, Aalborg University, Fredrik Bajers Vej 7 D 3, DK 9220 Aalborg, Denmark
    J Neurosci Methods 160:85-92. 2007
    ..The paper presents a new method to evoke NWRs by uniform-temperature laser heat stimulation of large skin areas in humans. These heat evoked reflexes had a stimulus-response relationship...
  37. ncbi request reprint Effects of a manual therapy technique in experimental lateral epicondylalgia
    Helen Slater
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Aalborg, Denmark
    Man Ther 11:107-17. 2006
    ..These data suggest that the lateral glide-MWM does not activate mechanisms associated with analgesia or force augmentation in subjects with experimentally induced features simulating lateral epicondylalgia...
  38. doi request reprint Current pain and fear of pain contribute to reduced maximum voluntary contraction of neck muscles in patients with chronic neck pain
    René Lindstroem
    Center for Sensory Motor Interaction, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark
    Arch Phys Med Rehabil 93:2042-8. 2012
    ..To assess a range of physical and psychological factors and determine which factors contribute the most to reduced strength in patients with neck pain...
  39. doi request reprint Homotopic and heterotopic variation in skin blood flow and temperature following experimental muscle pain in humans
    Jing Lei
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg, Denmark
    Brain Res 1232:85-93. 2008
    ..This suggested that both homotopic and heterotopic vascular reactions triggered by hypertonic saline stimulation of thin muscle afferent fibers were a neurogenically associated reaction...
  40. doi request reprint Spatial and temporal summation of pain evoked by mechanical pressure stimulation
    Hongling Nie
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Eur J Pain 13:592-9. 2009
    ..The combination of temporal and spatial integration of nociceptive input facilitates the pain intensity, suggesting that temporal summation is clinically relevant in conditions with widespread pain...
  41. ncbi request reprint Referred pain and hyperalgesia in human tendon and muscle belly tissue
    William Gibson
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Denmark
    Pain 120:113-23. 2006
    ..Furthermore, there may be site specific central changes reflected by the differences in the results regarding sensitivity and summation over time...
  42. ncbi request reprint Effects of gabapentin on experimental somatic pain and temporal summation
    Lars Arendt-Nielsen
    Center for Sensory Motor Interactions, Department of Health Science and Technology, Aalborg University, Denmark
    Reg Anesth Pain Med 32:382-8. 2007
    ..The aim of this double-blind, placebo-controlled experimental pain study, conducted on 20 healthy volunteers, was to examine the effect of a single dose of 1200 mg gabapentin on multi-modal experimental cutaneous and muscle pain models...
  43. ncbi request reprint Modality-specific facilitation and adaptation to painful tonic stimulation in humans
    Romanas Polianskis
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction SMI, Aalborg University, Frederik Bajers Vej 7, D 3, DK 9220 Aalborg, Denmark
    Eur J Pain 6:475-84. 2002
    ..The results of the study suggest that tolerance of tonic painful pressure and cold stimulations is specific to stimulus modality and may represent separate nociceptive mechanisms...
  44. ncbi request reprint Comparative EEG activation to skin pain and muscle pain induced by capsaicin injection
    Peng Fei Chang
    Human Brain Mapping and Cortical Imaging Laboratory, Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7 D 3, DK 9220, Aalborg, Denmark
    Int J Psychophysiol 51:117-26. 2004
    ..No difference was found between the vehicle-induced non-painful sensations in skin and muscle. These results implicate that the nociceptive inputs from muscle and skin are processed differently in the similar neural matrix of the brain...
  45. doi request reprint Variability of three-dimensional forces increase during experimental knee pain
    Sauro E Salomoni
    Laboratory for Musculoskeletal Pain and Motor Control, Department of Health Science and Technology, Faculty of Medicine, Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7D 3, 9220 Aalborg E, Denmark
    Eur J Appl Physiol 113:567-75. 2013
    ..These findings indicate a less efficient motor strategy during knee joint pain, suggesting that pain relief may enhance training for the control of smooth forces by knee pain patients...
  46. doi request reprint Experimental calf muscle pain attenuates the postural stability during quiet stance and perturbation
    Rogério Pessoto Hirata
    Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Clin Biomech (Bristol, Avon) 25:931-7. 2010
    ..The purpose of this study was to evaluate how acute pain changes the postural control and stability during quiet standing and after unexpected perturbations...
  47. ncbi request reprint Effect of innervation-zone distribution on estimates of average muscle-fiber conduction velocity
    Mogens Nielsen
    Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D3, 9220 Aalborg, Denmark
    Muscle Nerve 37:68-78. 2008
    ..The effect of innervation-zone distribution on MFCV estimates is thus substantial and may be a significant confounding factor in experimental and clinical studies on muscles with diffuse innervation zones...
  48. ncbi request reprint Sensory and motor effects of experimental muscle pain in patients with lateral epicondylalgia and controls with delayed onset muscle soreness
    Helen Slater
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7D, 9220 Aalborg E, Denmark
    Pain 114:118-30. 2005
    ..0001), at all Day 1 times compared with the control arms. In patients, the bilateral increase in deep tissue sensitivity and enlarged referred pain areas during saline-induced pain might suggest involvement of central sensitisation...
  49. ncbi request reprint Impact of clinical and experimental pain on muscle strength and activity
    Thomas Graven-Nielsen
    Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg E, Denmark
    Curr Rheumatol Rep 10:475-81. 2008
    ..The motor control assessment procedures provide complementary clinical information and give further support for optimizing treatment regimens and prevention procedures for musculoskeletal pain...
  50. doi request reprint Increased H-reflex response induced by intramuscular electrical stimulation of latent myofascial trigger points
    Hong You Ge
    Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D 3, Aalborg, Denmark
    Acupunct Med 27:150-4. 2009
    ..The purpose of this current study was to explore whether an H-reflex response could be elicited from intramuscular electrical stimulation. If so, to assess the possibility of increased reflex response at MTrPs...
  51. doi request reprint Sensitization in patients with painful knee osteoarthritis
    Lars Arendt-Nielsen
    Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Pain 149:573-81. 2010
    ..This study highlights the importance of central sensitization as an important manifestation in knee OA...
  52. ncbi request reprint Spatial and temporal changes of upper trapezius muscle fiber conduction velocity are not predicted by surface EMG spectral analysis during a dynamic upper limb task
    Deborah Falla
    Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, DK 9220 Aalborg, Denmark
    J Neurosci Methods 156:236-41. 2006
    ..This finding suggests that spectral analysis cannot be used to infer changes in the spatial and temporal behavior of muscle fiber CV during dynamic tasks...
  53. doi request reprint Deformation and pressure propagation in deep tissue during mechanical painful pressure stimulation
    Sara Finocchietti
    Department of Health Science and Technology, Faculty of Medicine, Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory Motor Interaction, Aalborg University, Aalborg, Denmark
    Med Biol Eng Comput 51:113-22. 2013
    ..This new approach is relevant as the clinical routine assesses all muscles equally. This results in a different exposure to pressure in relation to the muscle evaluated which may affect the outcome of the examination...
  54. doi request reprint Experimental knee pain impairs postural stability during quiet stance but not after perturbations
    Rogério Pessoto Hirata
    Laboratory for Musculoskeletal Pain and Motor Control, Department of Health Science and Technology, Center for Sensory Motor Interaction SMI, Aalborg University, Fredrik Bajers Vej 7D 3, 9220, Aalborg, Denmark
    Eur J Appl Physiol 112:2511-21. 2012
    ..This measure could potentially help clinicians who seek to assess how pain responses may contribute to patient's postural control and stability during quiet standing...
  55. doi request reprint Translational musculoskeletal pain research
    Lars Arendt-Nielsen
    Center for Sensory Motor Interaction SMI, Department of Health Sciences and Technology, Faculty of Medicine, Aalborg University, Fredrik Bajers Vej 7, Aalborg, Denmark
    Best Pract Res Clin Rheumatol 25:209-26. 2011
    ..New safe and efficient compounds are highly needed in the area of musculoskeletal pain management...
  56. ncbi request reprint Spatial and temporal aspects of deep tissue pain assessed by cuff algometry
    Romanas Polianskis
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Frederik Bajers Vej 7, D 3, DK 9220, Aalborg, Denmark
    Pain 100:19-26. 2002
    ..The presented models are useful additions to a researcher's armamentarium for further pharmacological and clinical studies on deep tissue pain and related mechanisms...
  57. doi request reprint Muscle pain: sensory implications and interaction with motor control
    Lars Arendt-Nielsen
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Denmark
    Clin J Pain 24:291-8. 2008
    ..In recent years, it has become evident that muscle pain can interfere with motor control strategies and different patters of interaction are seen during rest, static contractions, and dynamic conditions...
  58. doi request reprint Moving coil pressure algometer produces consistent force gradient and repeated stimulation
    Djordje Adnadjevic
    Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 9220 Aalborg, Denmark
    Conf Proc IEEE Eng Med Biol Soc 2012:6591-4. 2012
    ..Through fast switching between different modes of operation of the actuator, force overshoot was reduced from as much as 300 to 20% for the same force magnitude, at the expense of a slight delay in repeated pulse delivery scheme...
  59. doi request reprint Muscle fatigue increases the amplitude of fluctuations of tangential forces during isometric contractions
    Sauro E Salomoni
    Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Denmark
    Hum Mov Sci 31:758-71. 2012
    ..Moreover, alternation of activity between multiple synergist muscles is associated with increased fluctuations of tangential forces, especially during fatigue...
  60. doi request reprint Experimental muscle pain increases normalized variability of multidirectional forces during isometric contractions
    Sauro E Salomoni
    Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D3, 9220 Aalborg, Denmark
    Eur J Appl Physiol 112:3607-17. 2012
    ..Although pain adaptations are believed to aim at the protection of the painful site, the current results show that they result in impairments in steadiness of force...
  61. doi request reprint Tissue characteristics during temporal summation of pressure-evoked pain
    Sara Finocchietti
    Laboratory for Musculoskeletal Pain and Motor Control, Department of Health Science and Technology, Faculty of Medicine, Center for Sensory Motor Interaction SMI, Aalborg University, Fredrik Bajers Vej 7D 3, 9220 Aalborg E, Denmark
    Exp Brain Res 219:255-65. 2012
    ....
  62. ncbi request reprint Pain-induced changes in cervical muscle activation do not affect muscle fatigability during sustained isometric contraction
    Deborah Falla
    Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7, D 3, DK 9220 Aalborg, Denmark
    J Electromyogr Kinesiol 18:938-46. 2008
    ..This finding has implications for interpreting the mechanisms underlying greater cervical muscle fatigue in people with neck pain disorders...
  63. ncbi request reprint The effect of muscle pain on elbow flexion and coactivation tasks
    Ulysses F Ervilha
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7D 3, 9220 Aalborg, Denmark
    Exp Brain Res 156:174-82. 2004
    ....
  64. ncbi request reprint Central sensitization in fibromyalgia and other musculoskeletal disorders
    Lars Arendt-Nielsen
    Laboratory for Human Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7, Building D3, DK 9220 Aalborg, Denmark
    Curr Pain Headache Rep 7:355-61. 2003
    ....
  65. ncbi request reprint The influence of muscle pain and fatigue on the activity of synergistic muscles of the leg
    Andrei Ciubotariu
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7D 3, 9220 Aalborg E, Denmark
    Eur J Appl Physiol 91:604-14. 2004
    ..These findings may have implications for the understanding of manifestations seen in relation to painful musculoskeletal disorders...
  66. pmc Basic aspects of musculoskeletal pain: from acute to chronic pain
    Lars Arendt-Nielsen
    Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, School of Medicine, Aalborg University, Aalborg E, Denmark
    J Man Manip Ther 19:186-93. 2011
    ..From a management perspective, it is therefore highly important to reduce pain intensity and try to minimize the duration of pain...
  67. ncbi request reprint Assessment of single motor unit conduction velocity during sustained contractions of the tibialis anterior muscle with advanced spike triggered averaging
    Dario Farina
    Department of Electronics, Centro di Bioingegneria, Politecnico di Torino, Italy
    J Neurosci Methods 115:1-12. 2002
    ..1 m/s with less than 2 s data epochs. The method allows reliable assessment of firing rate and conduction properties of single MUs with applications for the investigation of central and peripheral fatigue mechanisms...
  68. ncbi request reprint Glutamate-evoked pain and mechanical allodynia in the human masseter muscle
    Peter Svensson
    Department of Clinical Oral Physiology, Dental School, Aarhus University, DK 8000 Aarhus C, Denmark
    Pain 101:221-7. 2003
    ..The present results suggest that injection of 1.0M glutamate into the masseter muscle may provide a useful experimental method to test sensitization and efficacy of peripheral EAA receptor antagonists in human subjects...
  69. ncbi request reprint Computerized cuff pressure algometry: A new method to assess deep-tissue hypersensitivity in fibromyalgia
    Anders Jespersen
    The Parker Institute, Frederiksberg Hospital, Nordre Fasanvej 57, DK 2000 Frederiksberg, Denmark
    Pain 131:57-62. 2007
    ..CPA was associated with knee muscle strength but not with measures thought to be influenced by psychological distress and mood...
  70. ncbi request reprint Standardising surface electromyogram recordings for assessment of activity and fatigue in the human upper trapezius muscle
    Dario Farina
    Centro di Bioingegneria, Dept of Electronics, Politecnico di Torino, Corso Duca degli Abruzzi 24, Turin 10129, Italy
    Eur J Appl Physiol 86:469-78. 2002
    ..Data on the myoelectric manifestations of muscle fatigue of the upper trapezius muscle are provided for the optimal electrode location...
  71. ncbi request reprint Selectivity of spatial filters for surface EMG detection from the tibialis anterior muscle
    Dario Farina
    Centro di Bioingegneria, Dipartimento di Elettronica, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy
    IEEE Trans Biomed Eng 50:354-64. 2003
    ..The 2-D filters investigated (including C1) showed very similar performance and were, thus, considered equivalent from the point of view of spatial selectivity...
  72. ncbi request reprint Experimental deep tissue pain in wrist extensors--a model of lateral epicondylalgia
    Helen Slater
    School of Physiotherapy, Curtin University of Technology, Perth, Australia
    Eur J Pain 7:277-88. 2003
    ....
  73. ncbi request reprint Increased muscle pain sensitivity in patients with tension-type headache
    Peter T Schmidt-Hansen
    Department of Neurology, Viborg Hospital, Denmark
    Pain 129:113-21. 2007
    ..Gender differences in deep pain sensitivity seem to be a consistent finding both in healthy controls and patients with tension-type headache...
  74. ncbi request reprint Two-dimensional spatial distribution of surface mechanomyographical response to single motor unit activity
    Corrado Cescon
    Laboratory for Engineering of the Neuromuscular System, Department of Electronics, Politecnico di Torino, Torino, Italy
    J Neurosci Methods 159:19-25. 2007
    ..The maps of acceleration showed spatial dependency in single motor unit MMG activities. The technique provides a new insight into motor unit contractile properties...
  75. ncbi request reprint Managing chronic whiplash associated pain with a combination of low-dose opioid (remifentanil) and NMDA-antagonist (ketamine)
    Dag Lemming
    Pain and Rehabilitation Centre, University Hospital, Linkoping, Sweden
    Eur J Pain 11:719-32. 2007
    ..Experimental pain was attenuated by both combinations containing the opioid, however, KET seemed to enhance the effect of REMI on electrical pain thresholds when a low REMI target concentration was used...
  76. ncbi request reprint Muscle temperature has a different effect on force fluctuations in young and older women
    Susan Dewhurst
    Department of Applied Physiology, University of Strathclyde, Glasgow, UK
    Clin Neurophysiol 118:762-9. 2007
    ..To investigate the effect of muscle temperature on force fluctuations during isometric contractions in young and older females...
  77. ncbi request reprint Generalized deep-tissue hyperalgesia in patients with chronic low-back pain
    Søren O'Neill
    Human Locomotion Science, University of Southern Denmark, Odense, Denmark
    Eur J Pain 11:415-20. 2007
    ....
  78. ncbi request reprint Experimental quadriceps muscle pain impairs knee joint control during walking
    Marius Henriksen
    Clinical Motor Function Laboratory, Parker Institute, Frederiksberg Hospital, Ndr Fasanvej 57, DK 2000 Frederiksberg, Denmark
    J Appl Physiol (1985) 103:132-9. 2007
    ....
  79. ncbi request reprint [Gender differences in response to pain]
    Thomas Graven-Nielsen
    Aalborg Universitet, Institut for Sundhedsvidenskab og Teknologi, Center for Sanse Motorisk Interaktion
    Ugeskr Laeger 169:2425-7. 2007
    ..The gender difference in pain sensitivity might partly be linked to the female sex hormones but is also dependent on a complex interaction between psychosocial and physiological factors...
  80. ncbi request reprint Increased joint loads during walking--a consequence of pain relief in knee osteoarthritis
    Marius Henriksen
    The Parker Institute, Frederiksberg Hospital, Ndr Fasanvej 57, DK 2000 Frederiksberg, Denmark
    Knee 13:445-50. 2006
    ..Although the patients walked with less compressive knee joint forces compared to the reference group, the effects of pain relief may accelerate the degenerative changes...
  81. ncbi request reprint Pivotal involvement of neurogenic mechanism in subcutaneous bee venom-induced inflammation and allodynia in unanesthetized conscious rats
    Hui Sheng Chen
    Department of Neurology, General Hospital of Shen Yang Military Region, Shen Yang 110016, PR China
    Exp Neurol 200:386-91. 2006
    ..In addition, the capsaicin-sensitive primary afferents may play differential roles in the development of the BV-induced static and dynamic mechanical allodynia...
  82. ncbi request reprint Reduction of human experimental muscle pain by alfentanil and morphine
    Helène Schulte
    Department for Clinical Science, Intervention and Technology, Division of Anesthesiology, Karolinska Institute at Karolinska University Hospital Huddinge SE 141 86, Stockholm, Sweden
    Eur J Pain 10:733-41. 2006
    ..Both alfentanil and morphine reduced experimental muscle pain. There were no indications of any true pharmacodynamic differences between the two drugs...
  83. ncbi request reprint Effect of experimental muscle pain on motor unit firing rate and conduction velocity
    Dario Farina
    Centro di Bioingegneria, Dipartimento di Elettronica, Politecnico di Torino, 10129 Turin, Italy
    J Neurophysiol 91:1250-9. 2004
    ..This decrease is not associated with a change in MU membrane properties, indirectly assessed by CV. This study demonstrates a central inhibitory motor control mechanism with an efficacy correlated to the nociceptive activity...
  84. ncbi request reprint The responses to pharmacological challenges and experimental pain in patients with chronic whiplash-associated pain
    Dag Lemming
    Pain and Rehabilitation Centre, University Hospital, Linkoping, Sweden
    Clin J Pain 21:412-21. 2005
    ..In addition, experimental muscle pain sensitivity and its correlation to pain duration and pharmacological responses were assessed...
  85. ncbi request reprint Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle
    Brian E Cairns
    Department of Anesthesia, Harvard Medical School Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurophysiol 90:2098-105. 2003
    ..It is conceivable that activation of peripheral NMDA receptors may contribute to masticatory muscle pain and that peripherally acting NMDA receptor antagonists could prove to be effective analgesics for this type of pain...
  86. ncbi request reprint Impulse-forces during walking are not increased in patients with knee osteoarthritis
    Marius Henriksen
    The Parker Institute, Frederiksberg Hospital Frederiksberg, DK 2000 Denmark
    Acta Orthop 77:650-6. 2006
    ..We thus evaluated the impulsive sagittal ground reaction forces (iGRF), shock waves and lower extremity joint kinematics at heel strike during walking in knee osteoarthritis (OA) patients and compared them to those in healthy subjects...