T Graven-Nielsen

Summary

Affiliation: Aalborg University
Country: Denmark

Publications

  1. ncbi Quantification of deep and superficial sensibility in saline-induced muscle pain--a psychophysical study
    T Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Denmark
    Somatosens Mot Res 15:46-53. 1998
  2. ncbi Quantification of local and referred muscle pain in humans after sequential i.m. injections of hypertonic saline
    T Graven-Nielsen
    Center for Sensory Motor Interaction, Aalborg University, Denmark
    Pain 69:111-7. 1997
  3. ncbi In vivo model of muscle pain: quantification of intramuscular chemical, electrical, and pressure changes associated with saline-induced muscle pain in humans
    T Graven-Nielsen
    Center for Sensory Motor Interaction, Aalborg University, Denmark
    Pain 69:137-43. 1997
  4. ncbi Effects of experimental muscle pain on muscle activity and co-ordination during static and dynamic motor function
    T Graven-Nielsen
    Center for Sensory Motor Interaction, Aalborg University, Denmark
    Electroencephalogr Clin Neurophysiol 105:156-64. 1997
  5. ncbi Quantitative analysis of reflex inhibition in single motor units in human masseter muscle: effects of stimulus intensity
    T Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg E, Denmark
    Muscle Nerve 23:259-66. 2000
  6. ncbi Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients
    T Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220, Aalborg, Denmark
    Pain 85:483-91. 2000
  7. ncbi Experimental human muscle pain and muscular hyperalgesia induced by combinations of serotonin and bradykinin
    V Babenko
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Aalborg E, Denmark
    Pain 82:1-8. 1999
  8. ncbi The effect of compression and regional anaesthetic block on referred pain intensity in humans
    R J Laursen
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Denmark
    Pain 80:257-63. 1999
  9. ncbi Different EEG topographic effects of painful and non-painful intramuscular stimulation in man
    P F Chang
    Human Brain Mapping and Cortical Imaging Laboratory, Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7 D 3, 9220 Aalborg, Denmark
    Exp Brain Res 141:195-203. 2001
  10. ncbi Experimental jaw-muscle pain does not change heteronymous H-reflexes in the human temporalis muscle
    P Svensson
    Center for Sensory Motor Interaction, Orofacial Pain Laboratory, Aalborg University, Denmark
    Exp Brain Res 121:311-8. 1998

Collaborators

Detail Information

Publications34

  1. ncbi Quantification of deep and superficial sensibility in saline-induced muscle pain--a psychophysical study
    T Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Denmark
    Somatosens Mot Res 15:46-53. 1998
    ..The present placebo-controlled experiments failed to show muscular or subcutaneous hyperalgesia after saline-induced muscle pain per se...
  2. ncbi Quantification of local and referred muscle pain in humans after sequential i.m. injections of hypertonic saline
    T Graven-Nielsen
    Center for Sensory Motor Interaction, Aalborg University, Denmark
    Pain 69:111-7. 1997
    ..64, P < 0.0001, n = 231) and referred (R = 0.47, P < 0.0001, n = 231) pain areas. Based on the above results it can be concluded that experimental muscle pain is influenced by temporal and spatial summation...
  3. ncbi In vivo model of muscle pain: quantification of intramuscular chemical, electrical, and pressure changes associated with saline-induced muscle pain in humans
    T Graven-Nielsen
    Center for Sensory Motor Interaction, Aalborg University, Denmark
    Pain 69:137-43. 1997
    ..m. infusion of hypertonic saline produced a saline-pool, causing the i.m. pressure to increase. Possibly, pain activation and cessation are related to increased intramuscular sodium and potassium content respectively...
  4. ncbi Effects of experimental muscle pain on muscle activity and co-ordination during static and dynamic motor function
    T Graven-Nielsen
    Center for Sensory Motor Interaction, Aalborg University, Denmark
    Electroencephalogr Clin Neurophysiol 105:156-64. 1997
    ..Progress in Fibromyalgia and Myofascial Pain. Elsevier, Amsterdam, 1993, pp. 311-327.) which predicts increased activity of antagonistic muscle and decreased activity of agonistic muscle during experimental and clinical muscle pain...
  5. ncbi Quantitative analysis of reflex inhibition in single motor units in human masseter muscle: effects of stimulus intensity
    T Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg E, Denmark
    Muscle Nerve 23:259-66. 2000
    ..The methods used in the present study provide a useful means of quantifying the effects of motoneuron excitability in detail...
  6. ncbi Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients
    T Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220, Aalborg, Denmark
    Pain 85:483-91. 2000
    ..Whether this is specific for FMS patients or a general phenomena in painful musculoskeletal disorders is not known...
  7. ncbi Experimental human muscle pain and muscular hyperalgesia induced by combinations of serotonin and bradykinin
    V Babenko
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Aalborg E, Denmark
    Pain 82:1-8. 1999
    ..Pre-treatment with serotonin may enhance the effect of bradykinin in the generation of muscle pain and muscular hyperalgesia in humans...
  8. ncbi The effect of compression and regional anaesthetic block on referred pain intensity in humans
    R J Laursen
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Denmark
    Pain 80:257-63. 1999
    ..The present findings suggest that both peripheral and central mechanisms play a role in referred pain and that the myelinated fibres mediate the peripheral component...
  9. ncbi Different EEG topographic effects of painful and non-painful intramuscular stimulation in man
    P F Chang
    Human Brain Mapping and Cortical Imaging Laboratory, Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7 D 3, 9220 Aalborg, Denmark
    Exp Brain Res 141:195-203. 2001
    ....
  10. ncbi Experimental jaw-muscle pain does not change heteronymous H-reflexes in the human temporalis muscle
    P Svensson
    Center for Sensory Motor Interaction, Orofacial Pain Laboratory, Aalborg University, Denmark
    Exp Brain Res 121:311-8. 1998
    ..2 ms). These reflex responses did not show a systematic change during the pain conditions. In conclusion, acute contralateral jaw-muscle pain does not seem to modulate the motoneuron excitability as measured by the heteronymous H-reflex...
  11. ncbi Duration and distribution of experimental muscle hyperalgesia in humans following combined infusions of serotonin and bradykinin
    V Babenko
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220, Aalborg, Denmark
    Brain Res 853:275-81. 2000
    ..No widespread hyperalgesia to the ankle and other leg (tested at 10 cm below the patella and ankle) was observed suggesting a predominant peripheral origin of the experimentally induced hyperalgesic stage...
  12. ncbi Muscle pain induces task-dependent changes in cervical agonist/antagonist activity
    D Falla
    Center for Sensory Motor Interaction SMI, Dept of Health Science, and Technology, Aalborg Univ, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg, Denmark
    J Appl Physiol (1985) 102:601-9. 2007
    ..Experimentally induced neck muscle pain resulted in task-dependent changes in cervical agonist/antagonist activity without modifications in muscle fiber CV...
  13. ncbi Interaction between cutaneous and muscle afferent activity in polysynaptic reflex pathways: a human experimental study
    O K Andersen
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajersvej 7, Bldg D3, DK 9220, Aalborg, Denmark
    Pain 84:29-36. 2000
    ..The findings indicate an interaction of input from thin muscle afferents and cutaneous group A-fibre afferents in polysynaptic segmental reflex pathways, which seems to depend on the location of the muscle pain...
  14. ncbi Modulation of an inhibitory reflex in single motor units in human masseter by tonic painful stimulation
    P Svensson
    Center for Sensory Motor Interaction, Orofacial Pain Laboratory, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220, Aalborg, Denmark
    Pain 83:441-6. 1999
    ..In conclusion, this study indicates that tonic masseter pain has a net excitatory effect on the inhibitory jaw-reflexes, which could be mediated by presynaptic mechanisms on the involved motoneurons...
  15. ncbi The effect of differential and complete nerve block on experimental muscle pain in humans
    R J Laursen
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7 D 3, DK 9220 Aalborg O, Denmark
    Muscle Nerve 22:1564-70. 1999
    ..Based on the present psychophysical experiments, it is suggested that: (1) myelinated afferents mediated mainly electrically induced muscle pain, and (2) unmyelinated afferents mediated mainly saline-induced muscle pain...
  16. ncbi Experimentally induced muscle pain induces hypoalgesia in heterotopic deep tissues, but not in homotopic deep tissues
    T Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Aalborg, Denmark
    Brain Res 787:203-10. 1998
    ..Thus, a pathologically disturbed inhibitory mechanism may result in widespread deep hyperalgesia in muscle pain patients...
  17. ncbi Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study
    P Bajaj
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7, D3, 9220 Aalborg East, Aalborg, Denmark
    Pain 93:107-14. 2001
    ..05). It is concluded that muscle hyperalgesia and extended pain areas might be due to central sensitization caused by painful osteoarthritis...
  18. ncbi Mechanical hyperesthesia of human facial skin induced by tonic painful stimulation of jaw muscles
    P Svensson
    Center for Sensory Motor Interaction, Aalborg University, Denmark
    Pain 74:93-100. 1998
    ..Similar hyperexcitability changes may be part of the pathophysiological mechanisms involved in painful temporomandibular disorders...
  19. ncbi Effect of clenching levels on heteronymous H-reflex in human temporalis muscle
    P Svensson
    Orofacial Pain Laboratory, Center for Sensory Motor Interaction, Aalborg University, Aalborg S, Denmark
    Exp Brain Res 126:467-72. 1999
    ..008). These data indicate that the heteronymous H-reflex can be reliably elicited by means of an automatic system for stimulus delivery and that the amplitude of the H-reflex is dependent on the preceding activity of the motoneuron pool...
  20. ncbi Modulation of stretch-evoked reflexes in single motor units in human masseter muscle by experimental pain
    P Svensson
    Center for Sensory Motor Interaction, Orofacial Pain Laboratory, Aalborg University, Denmark
    Exp Brain Res 132:65-71. 2000
    ..It is concluded that the most likely explanation for the reduced reflex response of low-threshold masseter motor units during experimental pain is a tonic reduction in the fusimotor drive to the masseter spindles...
  21. doi Pain evoked by pressure stimulation on the tibia bone - influence of probe diameter on tissue stress and strain
    S Finocchietti
    Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Denmark
    Eur J Pain 16:534-42. 2012
    ..Mechanosensitive nociceptors innervating the periosteum are ideally placed to mediate pain evoked by pressure stimulation on the tibia bone and small diameter probes may be optimal for assessing bone associated pain sensitivity...
  22. ncbi Effects of experimental muscle pain on mechanical properties of single motor units in human masseter
    M K Sohn
    Center for Sensory Motor Interaction, Aalborg University, DK 9220 Aalborg, Denmark
    Clin Neurophysiol 115:76-84. 2004
    ..Therefore, the objective of the present study was to measure the mechanical properties of SMU in the masseter to clarify the mechanism which underlies the decrease in SMU firing rate during jaw-muscle pain...
  23. pmc Thermosensitivity of muscle: high-intensity thermal stimulation of muscle tissue induces muscle pain in humans
    T Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Denmark
    J Physiol 540:647-56. 2002
    ..Taken together, the data indicate that thermosensation from a given volume of muscle is less potent than nociception...
  24. ncbi The influence of low back pain on muscle activity and coordination during gait: a clinical and experimental study
    L Arendt-Nielsen
    Laboratory for Experimental Pain Research, Aalborg University, Denmark
    Pain 64:231-40. 1996
    ..New possibilities to monitor and investigate altered motor performance may help to develop more rational therapies for CLBP patients...
  25. doi Descending pain modulation and its interaction with peripheral sensitization following sustained isometric muscle contraction in fibromyalgia
    H Y Ge
    Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, DK 9220, Aalborg, Denmark
    Eur J Pain 16:196-203. 2012
    ..We hypothesized that fatiguing contraction may shift descending pain modulation from inhibition towards facilitation and that the effect of descending pain modulation be dependent on peripheral muscle pain sensitivity...
  26. ncbi Non-painful and painful surface and intramuscular electrical stimulation at the thenar and hypothenar sites: differential cerebral dynamics of early to late latency SEPs
    D M Niddam
    Human Brain Mapping and Cortical Imaging Laboratory, Center for Sensory-Motor Interaction, Aalborg University, Denmark
    Brain Topogr 13:283-92. 2001
    ..These results indicate differences in the early and late processing of sensory input from skin and muscle...
  27. ncbi Topographic effects of tonic cutaneous nociceptive stimulation on human electroencephalograph
    P F Chang
    Human Brain Mapping and Cortical Imaging Laboratory, Center for Sensory-Motor Interaction, Aalborg University, Fredrik Bajers Vej 7 D-3 DK-9220, Aalborg, Denmark
    Neurosci Lett 305:49-52. 2001
    ..This implicates that the observed topographic EEG activation is not specific for pain but probably related to the cutaneous stimulation...
  28. ncbi Craniofacial muscle pain: review of mechanisms and clinical manifestations
    P Svensson
    Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg E, Denmark
    J Orofac Pain 15:117-45. 2001
    ..Changes in somatosensory and motor function may therefore be viewed as consequences of pain and not factors leading to pain. Implications for the diagnosis and management of persistent muscle pain are discussed from this perspective...
  29. ncbi Inhibition of motor system excitability at cortical and spinal level by tonic muscle pain
    D Le Pera
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Aalborg, Denmark
    Clin Neurophysiol 112:1633-41. 2001
    ..To assess whether the motor system excitability can be modified by experimental tonic pain induced either in muscles or in subcutis...
  30. ncbi The peripheral apparatus of muscle pain: evidence from animal and human studies
    T Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Denmark
    Clin J Pain 17:2-10. 2001
    ..The sensitization process by endogenous substances that are likely to be released during trauma or inflammatory injury is probably the best established peripheral mechanism for muscle tenderness and hyperalgesia...
  31. ncbi Computer-controlled pneumatic pressure algometry--a new technique for quantitative sensory testing
    R Polianskis
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction SMI, Aalborg University, Frederik Bajers Vej 7, D 3, DK 9220 Aalborg, Denmark
    Eur J Pain 5:267-77. 2001
    ..The cuff algometry technique is appropriate for pressure-pain stimulus-response studies. Cuff algometry allowed quantification of psychophysical response to the change of stimulus configuration...
  32. doi Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement
    T Graven-Nielsen
    Aalborg University, Aalborg, Denmark
    Arthritis Rheum 64:2907-16. 2012
    ..This study evaluated the importance of ongoing tissue pathology in the maintenance of enhanced central pain processing...
  33. ncbi Spatial dependency of trapezius muscle activity during repetitive shoulder flexion
    D Falla
    Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg, Denmark
    J Electromyogr Kinesiol 17:299-306. 2007
    ..This suggests non-uniform muscle fiber distribution and/or recruitment. The results also highlight the importance of multiple recording sites when investigating trapezius muscle function in dynamic tasks...
  34. ncbi Post-exercise muscle soreness after eccentric exercise: psychophysical effects and implications on mean arterial pressure
    P Bajaj
    Laboratory for Experimental Pain Research, Center for Sensory-Motor Interaction, University of Aalborg, Aalborg, Denmark
    Scand J Med Sci Sports 11:266-73. 2001
    ....