Claus Graff

Summary

Affiliation: Aalborg University
Country: Denmark

Publications

  1. doi request reprint Identifying drug-induced repolarization abnormalities from distinct ECG patterns in congenital long QT syndrome: a study of sotalol effects on T-wave morphology
    Claus Graff
    Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Drug Saf 32:599-611. 2009
  2. doi request reprint Effects of bilastine on T-wave morphology and the QTc interval: a randomized, double-blind, placebo-controlled, thorough QTc study
    Claus Graff
    Medical Informatics Group, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Clin Drug Investig 32:339-51. 2012
  3. doi request reprint Quantitative analysis of T-wave morphology increases confidence in drug-induced cardiac repolarization abnormalities: evidence from the investigational IKr inhibitor Lu 35-138
    Claus Graff
    Department of Health Science and Technology, Center for Sensory Motor Interaction, Aalborg University, Aalborg, Denmark
    J Clin Pharmacol 49:1331-42. 2009
  4. doi request reprint Covariate analysis of QTc and T-wave morphology: new possibilities in the evaluation of drugs that affect cardiac repolarization
    C Graff
    Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Clin Pharmacol Ther 88:88-94. 2010
  5. doi request reprint New descriptors of T-wave morphology are independent of heart rate
    Mads P Andersen
    Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    J Electrocardiol 41:557-61. 2008
  6. doi request reprint Assessing common classification methods for the identification of abnormal repolarization using indicators of T-wave morphology and QT interval
    Saeed Shakibfar
    Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Comput Biol Med 42:485-91. 2012
  7. doi request reprint Assessing QT interval prolongation and its associated risks with antipsychotics
    Jimmi Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Aalborg, Denmark
    CNS Drugs 25:473-90. 2011

Detail Information

Publications7

  1. doi request reprint Identifying drug-induced repolarization abnormalities from distinct ECG patterns in congenital long QT syndrome: a study of sotalol effects on T-wave morphology
    Claus Graff
    Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Drug Saf 32:599-611. 2009
    ..This current is also inhibited in the congenital type 2 form of the long QT syndrome (LQT2). It is therefore possible that electrocardiographic LQT2 patterns might be used to identify abnormal repolarization patterns induced by drugs...
  2. doi request reprint Effects of bilastine on T-wave morphology and the QTc interval: a randomized, double-blind, placebo-controlled, thorough QTc study
    Claus Graff
    Medical Informatics Group, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Clin Drug Investig 32:339-51. 2012
    ....
  3. doi request reprint Quantitative analysis of T-wave morphology increases confidence in drug-induced cardiac repolarization abnormalities: evidence from the investigational IKr inhibitor Lu 35-138
    Claus Graff
    Department of Health Science and Technology, Center for Sensory Motor Interaction, Aalborg University, Aalborg, Denmark
    J Clin Pharmacol 49:1331-42. 2009
    ..As a covariate to the assessment of QT interval liability, MCS offered important additive information to the effect of Lu 35-138 on cardiac repolarization...
  4. doi request reprint Covariate analysis of QTc and T-wave morphology: new possibilities in the evaluation of drugs that affect cardiac repolarization
    C Graff
    Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Clin Pharmacol Ther 88:88-94. 2010
    ..one associated with a high risk and describes the added benefits of a T-wave MCS as a covariate to the assessment of the QTc interval...
  5. doi request reprint New descriptors of T-wave morphology are independent of heart rate
    Mads P Andersen
    Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    J Electrocardiol 41:557-61. 2008
    ..42). Both the advanced T-wave descriptors (asymmetry, flatness, and others), ToTe intervals and TpTe intervals, were practically independent of heart rate (R(2) = 0-0.08), making heart rate correction unnecessary for these parameters...
  6. doi request reprint Assessing common classification methods for the identification of abnormal repolarization using indicators of T-wave morphology and QT interval
    Saeed Shakibfar
    Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Comput Biol Med 42:485-91. 2012
    ..Whether this is true in general with other ECG markers and other data sets is uncertain because the approach has not been tested in this setting...
  7. doi request reprint Assessing QT interval prolongation and its associated risks with antipsychotics
    Jimmi Nielsen
    Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Aalborg, Denmark
    CNS Drugs 25:473-90. 2011
    ....