- Xenopus importin beta validates human importin beta as a cell cycle negative regulator
Valerie A Delmar
Section of Cell and Developmental Biology, Division of Biological Sciences 0347, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0347, USA
BMC Cell Biol 9:14. 2008
..If human importin beta acts instead as a dominant negative mutant inhibitor, we should then see no inhibitory effect when we added the Xenopus homologue...
- Transportin regulates major mitotic assembly events: from spindle to nuclear pore assembly
Corine K Lau
Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0347, USA
Mol Biol Cell 20:4043-58. 2009
..We conclude that the interplay of the two negative regulators, transportin and importin beta, along with the positive regulator RanGTP, allows precise choreography of multiple cell cycle assembly events...
- Topology of yeast Ndc1p: predictions for the human NDC1/NET3 homologue
Corine K Lau
Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, 92093, USA
Anat Rec A Discov Mol Cell Evol Biol 288:681-94. 2006
..Lastly, we bring together data from another study to demonstrate that the human homologue of NDC1 is the known inner nuclear membrane protein, NET3...
- The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase
Christopher T Eggers
Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94143 92280, USA
Biochem J 379:107-18. 2004
..This suggests that an important part of the antimicrobial mechanism of neutrophil elastase may be a periplasmic bacteriostatic effect of protease that has translocated across the damaged outer membrane...
- Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes
Christopher R Brown
Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
Genes Dev 22:627-39. 2008
..Our studies show that inhibiting HDACs leads to significant changes in genomic organization, recruiting regions of transcriptional regulation to mammalian nuclear pore complexes...