Maria Delivoria-Papadopoulos

Summary

Publications

  1. ncbi request reprint Effect of post-hypoxic MgSO(4) administration in utero on Ca(2+)-influx and Ca(2+)/calmodulin kinase IV activity in cortical neuronal nuclei
    Dev Maulik
    Department of Obstetrics and Gynecology, Winthrop University Hospital, 259 First Street, Mineola, NY 11501, USA
    Neurosci Lett 386:127-32. 2005
  2. ncbi request reprint Effect of hypoxia on calcium influx and calcium/calmodulin-dependent kinase activity in cortical neuronal nuclei of the guinea pig fetus during development
    Dev Maulik
    Department of Obstetrics and Gynecology, Winthrop University Hospital, Mineola, NY 11501, USA
    Am J Obstet Gynecol 186:658-62. 2002
  3. ncbi request reprint Mechanism of Ca(2+)/calmodulin-dependent protein kinase IV activation and of cyclic AMP response element binding protein phosphorylation during hypoxia in the cerebral cortex of newborn piglets
    Kristie Hornick
    Drexel University College of Medicine Division of Neonatology Department of Pediatrics Mail Stop 1029 245 N, 15th Street Philadelphia, PA 19102, USA
    Brain Res 1150:40-5. 2007
  4. ncbi request reprint Effect of hyperoxia on cortical neuronal nuclear function and programmed cell death mechanisms
    Eddie Chang
    Department of Pediatrics, St Christopher s Neonatal Research, Drexel University College of Medicine, 245 N 15th Street, Mail Stop 1029, New College Building, Room 7402, Philadelphia, PA 19102, USA
    Neurochem Res 32:1142-9. 2007
  5. pmc Mechanisms of expression of apoptotic protease activating factor-1 (Apaf-1) in nuclear, mitochondrial and cytosolic fractions of the cerebral cortex of newborn piglets
    Qazi M Ashraf
    Department of Pediatrics, Division of Neonatology, Drexel University College of Medicine and St Christopher s Hospital for Children, 245 N 15th Street, Philadelphia, PA 19102, USA
    Neurosci Lett 415:253-8. 2007
  6. ncbi request reprint Hypercapnia-induced modifications of neuronal function in the cerebral cortex of newborn piglets
    Karen I Fritz
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s Hospital for Children, Division of Neonatology, Front and Erie Sts, Ste 2212, Philadelphia, PA 19134, USA
    Pediatr Res 57:299-304. 2005
  7. ncbi request reprint Effect of hypoxia on the expression of pro- and anti-apoptotic proteins in neuronal nuclei of the guinea pig fetus during gestation
    Naheed Abedin
    Drexel University College of Medicine, MCP Hospital, Neonatal Research, 3300 Henry Avenue Philadelphia, PA 19133, USA
    Brain Res Dev Brain Res 156:32-7. 2005
  8. ncbi request reprint Increased neuronal nuclear calcium influx in neonatal seizures
    Ignacio Valencia
    Section of Neurology, Department of Pediatrics, St Christopher s Hospital For Children, Drexel University College of Medicine, Erie Avenue at Front Street, Philadelphia, PA 19134, USA
    Neurochem Res 31:1231-7. 2006
  9. ncbi request reprint Mechanism of activation of caspase-9 and caspase-3 during hypoxia in the cerebral cortex of newborn piglets: the role of nuclear Ca2+ -influx
    Maria Delivoria-Papadopoulos
    Department of Pediatrics, Drexel University College of Medicine, Neonatal Research Laboratory, NCB, Mail Stop 1029, 245 N 15th Street, Philadelphia, PA 19102, USA
    Neurochem Res 32:401-5. 2007
  10. pmc Effect of post-hypoxic reoxygenation on DNA fragmentation in cortical neuronal nuclei of newborn piglets
    Jeffrey Parker
    Department of Pediatrics, Drexel University College of Medicine, St Christopher s Hospital For Children, 245 N 15th Street, MS 1029, Philadelphia, PA 19102, USA
    Neurosci Lett 412:273-7. 2007

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Effect of post-hypoxic MgSO(4) administration in utero on Ca(2+)-influx and Ca(2+)/calmodulin kinase IV activity in cortical neuronal nuclei
    Dev Maulik
    Department of Obstetrics and Gynecology, Winthrop University Hospital, 259 First Street, Mineola, NY 11501, USA
    Neurosci Lett 386:127-32. 2005
    ..We conclude that post-hypoxic administration of Mg(2+) prevents hypoxia-induced modification of neuronal nuclear membrane function...
  2. ncbi request reprint Effect of hypoxia on calcium influx and calcium/calmodulin-dependent kinase activity in cortical neuronal nuclei of the guinea pig fetus during development
    Dev Maulik
    Department of Obstetrics and Gynecology, Winthrop University Hospital, Mineola, NY 11501, USA
    Am J Obstet Gynecol 186:658-62. 2002
    ....
  3. ncbi request reprint Mechanism of Ca(2+)/calmodulin-dependent protein kinase IV activation and of cyclic AMP response element binding protein phosphorylation during hypoxia in the cerebral cortex of newborn piglets
    Kristie Hornick
    Drexel University College of Medicine Division of Neonatology Department of Pediatrics Mail Stop 1029 245 N, 15th Street Philadelphia, PA 19102, USA
    Brain Res 1150:40-5. 2007
    ..We speculate that nuclear Ca(2+) influx is a key step that triggers CREB mediated transcription of apoptotic proteins and hypoxic mediated neuronal death...
  4. ncbi request reprint Effect of hyperoxia on cortical neuronal nuclear function and programmed cell death mechanisms
    Eddie Chang
    Department of Pediatrics, St Christopher s Neonatal Research, Drexel University College of Medicine, 245 N 15th Street, Mail Stop 1029, New College Building, Room 7402, Philadelphia, PA 19102, USA
    Neurochem Res 32:1142-9. 2007
    ....
  5. pmc Mechanisms of expression of apoptotic protease activating factor-1 (Apaf-1) in nuclear, mitochondrial and cytosolic fractions of the cerebral cortex of newborn piglets
    Qazi M Ashraf
    Department of Pediatrics, Division of Neonatology, Drexel University College of Medicine and St Christopher s Hospital for Children, 245 N 15th Street, Philadelphia, PA 19102, USA
    Neurosci Lett 415:253-8. 2007
    ..We conclude that cerebral hypoxia-induced increase in Apaf-1 protein will lead to increased activation of procaspase-9 to caspase-9 in the cytosolic compartment leading to a cascade of hypoxic neuronal death...
  6. ncbi request reprint Hypercapnia-induced modifications of neuronal function in the cerebral cortex of newborn piglets
    Karen I Fritz
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s Hospital for Children, Division of Neonatology, Front and Erie Sts, Ste 2212, Philadelphia, PA 19134, USA
    Pediatr Res 57:299-304. 2005
    ....
  7. ncbi request reprint Effect of hypoxia on the expression of pro- and anti-apoptotic proteins in neuronal nuclei of the guinea pig fetus during gestation
    Naheed Abedin
    Drexel University College of Medicine, MCP Hospital, Neonatal Research, 3300 Henry Avenue Philadelphia, PA 19133, USA
    Brain Res Dev Brain Res 156:32-7. 2005
    ..Furthermore, the hypoxia-induced increase in proapoptotic as compared to antiapoptotic proteins at term will accelerate the ongoing active process of programmed cell death at term compared to preterm gestation...
  8. ncbi request reprint Increased neuronal nuclear calcium influx in neonatal seizures
    Ignacio Valencia
    Section of Neurology, Department of Pediatrics, St Christopher s Hospital For Children, Drexel University College of Medicine, Erie Avenue at Front Street, Philadelphia, PA 19134, USA
    Neurochem Res 31:1231-7. 2006
    ....
  9. ncbi request reprint Mechanism of activation of caspase-9 and caspase-3 during hypoxia in the cerebral cortex of newborn piglets: the role of nuclear Ca2+ -influx
    Maria Delivoria-Papadopoulos
    Department of Pediatrics, Drexel University College of Medicine, Neonatal Research Laboratory, NCB, Mail Stop 1029, 245 N 15th Street, Philadelphia, PA 19102, USA
    Neurochem Res 32:401-5. 2007
    ..We conclude that the high afinity Ca2+ -ATPase-dependent increased nuclear Ca2+ during hypoxia results in increased caspase-9 and caspase-3 activity...
  10. pmc Effect of post-hypoxic reoxygenation on DNA fragmentation in cortical neuronal nuclei of newborn piglets
    Jeffrey Parker
    Department of Pediatrics, Drexel University College of Medicine, St Christopher s Hospital For Children, 245 N 15th Street, MS 1029, Philadelphia, PA 19102, USA
    Neurosci Lett 412:273-7. 2007
    ..We propose that the biphasic pattern of DNA fragmentation during reoxygenation occurs by an initial oxidative DNA injury followed by an enzymatic cleavage of DNA by endonucleases activation...
  11. ncbi request reprint Effects of magnesium sulfate administration during hypoxia on CaM kinase IV and protein tyrosine kinase activities in the cerebral cortex of newborn piglets
    Ahmed G Mami
    Department of Pediatric Surgery, Drexel University College of Medicine and St Christopher s Hospital for Children, Philadelphia, PA 19129, USA
    Neurochem Res 31:57-62. 2006
    ..As a result, phosphorylation of CREB and Bcl-2 family of proteins is prevented leading to prevention of programmed cell death...
  12. ncbi request reprint Effects of magnesium sulfate administration during hypoxia on Ca(2+) influx and IP(3) receptor modification in cerebral cortical neuronal nuclei of newborn piglets
    Ahmed G Mami
    Department of Pediatric Surgery, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Neurochem Res 31:63-70. 2006
    ....
  13. ncbi request reprint Nuclear Ca(++)-influx, Ca (++)/calmodulin-dependent protein kinase IV activity and CREB protein phosphorylation during post-hypoxic reoxygenation in neuronal nuclei of newborn piglets: the role of nitric oxide
    Om Prakash Mishra
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s Hospital for Children, New College Building, Philadelphia, PA 19102, USA
    Neurochem Res 31:1463-71. 2006
    ..We propose that hypoxia-induced increase in CaM Kinase IV activity leads to increased phosphorylation of CREB protein and transcription of proapoptotic genes during post-Hx reox resulting in Hx neuronal death...
  14. ncbi request reprint Nuclear mechanisms of hypoxic cerebral injury in the newborn
    Maria Delivoria-Papadopoulos
    Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Clin Perinatol 31:91-105. 2004
    ....
  15. ncbi request reprint The effect of moderate hypocapnic ventilation on nuclear Ca2+-ATPase activity, nuclear Ca2+ flux, and Ca2+/calmodulin kinase IV activity in the cerebral cortex of newborn piglets
    Karen I Fritz
    Department of Pediatrics, Drexel University College of Medicine, St Christopher s Hospital For Children, Neonatology Research Laboratories, Philadelphia, Pennsylvania 19134, USA
    Neurochem Res 29:791-6. 2004
    ..We conclude that hypocapnia alters nuclear membrane Ca++ flux mechanisms and may alter neuronal phosphorylation mechanisms in the cerebral cortex of piglets...
  16. ncbi request reprint Inositol tetrakisphosphate (IP4)- and inositol triphosphate (IP3)-dependent Ca2+ influx in cortical neuronal nuclei of newborn piglets following graded hypoxia
    Om Prakash Mishra
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s Hospital for Children, Philadelphia, Pennsylvania 19129, USA
    Neurochem Res 29:391-6. 2004
    ....
  17. ncbi request reprint Nitric oxide-mediated Ca++-influx in neuronal nuclei and cortical synaptosomes of normoxic and hypoxic newborn piglets
    Om Prakash Mishra
    Department of Pediatrics, MCP Hahnemann School of Medicine and St Chrtistopher s, Hospital for Children, Philadelphia, PA, USA
    Neurosci Lett 318:93-7. 2002
    ....
  18. doi request reprint Activation of p38 mitogen-activated protein kinase (p38 MAPK), extracellular signal-regulated kinase (ERK) and c-jun N-terminal kinase (JNK) during hypoxia in cerebral cortical nuclei of guinea pig fetus at term: role of nitric oxide
    Dev Maulik
    Department of Obstetrics and Gynecology, University of Missouri, Kansas City, Hospital Hill Building, Truman Medical Center, 2301 Holmes Street, Kansas City, MO 64108, United States
    Neurosci Lett 439:94-9. 2008
    ..We speculate that NO-mediated modification of cysteine residue leading to inhibition of MAP kinase phosphatases results in increased activation of p38, ERK and JNK in the guinea pig fetus at term...
  19. doi request reprint Effect of hypoxia on the expression of procaspase-9 and procaspase-3 in neuronal nuclear, mitochondrial and cytosolic fractions of the cerebral cortex of newborn piglets
    Maria Delivoria-Papadopoulos
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s Hospital for Children, Philadelphia, PA 19102, USA
    Neurosci Lett 438:38-41. 2008
    ....
  20. doi request reprint Effect of hypoxia on expression of apoptotic proteins in nuclear, mitochondrial and cytosolic fractions of the cerebral cortex of newborn piglets: the role of nuclear Ca++ -influx
    Maria Delivoria-Papadopoulos
    Division of Neonatology, Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Neurochem Res 33:1196-204. 2008
    ....
  21. pmc Mechanism of Ca2+-influx and Ca2+/calmodulin-dependent protein kinase IV activity during in utero hypoxia in cerebral cortical neuronal nuclei of the guinea pig fetus at term
    Yanick M Vibert
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s Hospital for Children, Philadelphia, PA 19102, United States
    Neurosci Lett 440:227-31. 2008
    ..We speculate that hypoxia-induced alteration of high-affinity Ca(2+)-ATPase is a key step that triggers nuclear Ca(2+)-influx, leading to CREB protein-mediated increased expression of apoptotic proteins and hypoxic neuronal death...
  22. doi request reprint Mechanism of DNA fragmentation during hypoxia in the cerebral cortex of newborn piglets
    Ming Chou Chiang
    Department of Pediatrics, St Christopher s Hospital For Children, Drexel University College of Medicine, 245 N 15th Street, Room 7410, 7th Floor New College Building, Philadelphia, PA 19102, USA
    Neurochem Res 33:1232-7. 2008
    ....
  23. ncbi request reprint Hypoxia-induced Ca2+-influx in cerebral cortical neuronal nuclei of newborn piglets
    Maria Delivoria-Papadopoulos
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s Hospital for Children, Philadelphia, PA, USA
    Neurosci Lett 342:119-23. 2003
    ....
  24. ncbi request reprint Hypoxia-induced modification of the inositol triphosphate receptor in neuronal nuclei of newborn piglets: role of nitric oxide
    Om Prakash Mishra
    Department of Pediatrics, Drexel University College of Medicine, and St Christopher s Hospital for Children, Philadelphia, Pennsylvania, USA
    J Neurosci Res 74:333-8. 2003
    ....
  25. doi request reprint Effect of hypoxia on protein tyrosine phosphatase activity and expression of protein tyrosine phosphatases PTP-1B, PTP-SH1 and PTP-SH2 in the cerebral cortex of guinea pig fetus
    Dev Maulik
    Department of Pediatrics, Drexel University College of Medicine, St Christopher s Hospital For Children, Philadelphia, PA, USA
    Neurosci Lett 432:174-8. 2008
    ..We conclude that the decrease in PTP activity during hypoxia is not due to protein modification of PTP and due to alteration in PTP expression...
  26. ncbi request reprint Effects of severe hypocapnia on expression of bax and bcl-2 proteins, DNA fragmentation, and membrane peroxidation products in cerebral cortical mitochondria of newborn piglets
    Anayansi Lasso Pirot
    Division of Pulmonology, Department of Pediatrics, University of Maryland, Baltimore, MD 21201, USA
    Neonatology 91:20-7. 2007
    ..Since mitochondria regulate apoptosis, these alterations may initiate a cascade of reactions that lead to apoptotic cell death...
  27. ncbi request reprint Differential expression of apoptotic proteins following hypoxia-induced CREB phosphorylation in the cerebral cortex of newborn piglets
    Maria Delivoria-Papadopoulos
    Department of Pediatrics, Drexel University College of Medicine, New College Building, 7th Floor, Room 7410, 245N 15th Street, Philadelphia, PA 19102, USA
    Neurochem Res 32:1256-63. 2007
    ..We propose that the increased expression of proapoptotic vs antiapoptotic genes will lead to an increased potential for apoptotic programmed cell death in the Hx newborn brain...
  28. ncbi request reprint Effect of hypoxia on caspase-3, -8, and -9 activity and expression in the cerebral cortex of newborn piglets
    Poonam Khurana
    Neurochem Res 27:931-8. 2002
    ..We conclude that hypoxia results in stimulation of both the pathways of caspase-3 activation...
  29. ncbi request reprint Mechanism of caspase-3 activation during hypoxia in the cerebral cortex of newborn piglets
    Ming Chou Chiang
    Department of Pediatrics, Chang Gung University College of Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Neurosci Lett 421:67-71. 2007
    ..We conclude that the hypoxia-induced activation of caspase-3 during hypoxia in the cerebral cortex of newborn piglets is mediated by caspase-9...
  30. pmc ATP and cytochrome c-dependent activation of caspase-9 during hypoxia in the cerebral cortex of newborn piglets
    Maria Delivoria-Papadopoulos
    Department of Pediatrics, Drexel University College of Medicine, St Christopher s Hospital For Children, Philadelphia, PA 19102, United States
    Neurosci Lett 429:115-9. 2007
    ..We propose that the ATP and cytochrome c sites of apoptotic protease activating factor I that mediate caspase-9 activation are modified during hypoxia...
  31. ncbi request reprint Effect of 7-nitroindazole sodium on the cellular distribution of neuronal nitric oxide synthase in the cerebral cortex of hypoxic newborn piglets
    Christos D Katsetos
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s Hospital for Children, Philadelphia, PA, USA
    Neurochem Res 31:899-906. 2006
    ..We conclude that nNOS expression in cortical neurons of hypoxic newborn piglets is NO-mediated. We speculate that nNOS inhibition by 7-NINA will protect against hypoxia-induced NO-mediated neuronal death...
  32. ncbi request reprint Effect of nitric oxide synthase inhibition during post-hypoxic reoxygenation on Bax and Bcl-2 protein expression and DNA fragmentation in neuronal nuclei of newborn piglets
    Om Prakash Mishra
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s Hospital for Children, Room 701, 7th Floor Heritage Building, 3300 Henry Avenue, Philadelphia, PA 19129, USA
    Brain Res 1101:20-8. 2006
    ..We propose that in addition to NO-mediated nuclear DNA damage, the hypoxia-induced increased ratio of Bax/Bcl-2 protein will lead to caspase-activated cascade of hypoxic neuronal death during post-hypoxic reoxygenation...
  33. ncbi request reprint Nitration of Bax and Bcl-2 proteins during hypoxia in cerebral cortex of newborn piglets and the effect of nitric oxide synthase inhibition
    Qazi M Ashraf
    Department of Pediatrics, MCP Hahnemann University, Room 701, 3300 Henry Ave, Philadelphia, PA 19129, USA
    Biol Neonate 81:65-72. 2002
    ..We speculate that, during hypoxia, nitration of Bax and Bcl-2 proteins may regulate heterodimer formation and activation of programmed cell death mechanisms...
  34. ncbi request reprint NMDA receptor modification during graded hypoxia in the cerebral cortex of newborn piglets
    Karen I Fritz
    Department of Pediatrics, St Christopher s Hospital for Children and MCP Hahnemann University, Philadelphia, PA 19129 1191, USA
    Biol Neonate 82:46-52. 2002
    ..Alterations in receptor phosphorylation may gradually modify the NMDA receptor and may be initiated by subtle decreases in tissue oxygenation in the newborn brain...
  35. ncbi request reprint Nitric oxide-mediated expression of Bax protein and DNA fragmentation during hypoxia in neuronal nuclei from newborn piglets
    Alan B Zubrow
    Department of Pediatrics, MCP Hahnemann University and St Christopher s Hospital for Children, Front Street at Erie Ave, Philadelphia, PA 19134, USA
    Brain Res 954:60-7. 2002
    ..The data show that NNLA-pretreatment prevents the hypoxia-induced increase in Bax expression and DNA fragmentation demonstrating that the hypoxia-induced Bax gene expression and the DNA fragmentation are NO-mediated...
  36. ncbi request reprint Nitric oxide-mediated Ca2+/calmodulin-dependent protein kinase IV activity during hypoxia in neuronal nuclei from newborn piglets
    Alan B Zubrow
    Department of Pediatrics, College of Medicine, Drexel University, Philadelphia, PA, USA
    Neurosci Lett 335:5-8. 2002
    ..Nx, P<0.05 vs. Hx) animals. The results demonstrate that the cerebral tissue hypoxia results in an increase in neuronal nuclear CaM kinase IV activity, and the hypoxia-induced increase in CaM kinase IV activity is NO-mediated...
  37. ncbi request reprint Effects of Ca2+ sensing receptor activation in the growth plate
    Shufang Wu
    Section of Endocrinology and Diabetes, Drexel University College of Medicine, St Christopher s Hospital For Children, Philadelphia, Pennsylvania 19134, USA
    FASEB J 18:143-5. 2004
    ..In conclusion, our findings suggest that the activation of CaR in the growth plate accelerates longitudinal bone growth by stimulating growth plate chondrogenesis...
  38. ncbi request reprint The effect of hypocapnia (PaCO2 27 mmHg) on CaM kinase IV activity, Bax/Bcl-2 protein expression and DNA fragmentation in the cerebral cortex of newborn piglets
    Karen I Fritz
    Department of Pediatrics, Drexel University College of Medicine, St Christopher s Hospital For Children, Neonatology Research Laboratories, Medical College of Pennsylvania, Philadelphia, PA 19129, USA
    Neurosci Lett 352:211-5. 2003
    ..We conclude that hypocapnia (PaCO(2) 27 mmHg) results in increased expression of pro-apoptotic proteins and fragmentation of nuclear DNA in newborn piglets...
  39. ncbi request reprint Expression of phosphorylation of N-methyl-D-aspartate receptor subunits during graded hypoxia in the cerebral cortex of newborn piglets
    Karen I Fritz
    Department of Pediatrics, St Christopher s Neonatology Research Laboratory, Drexel University College of Medicine, Neonatology Research Laboratories, Medical College of Pennsylvania, Philadelphia, PA 19129, USA
    Biol Neonate 85:128-37. 2004
    ..We speculate that an alteration in the ratio of phosphorylated/dephosphorylated residues of the NMDA receptor may regulate receptor activation during hypoxia...
  40. ncbi request reprint Proteomic approach to the identification of voltage-dependent anion channel protein isoforms in guinea pig brain synaptosomes
    Sabrina Liberatori
    Department of Molecular Biology, University of Siena, Italy
    Proteomics 4:1335-40. 2004
    ....
  41. ncbi request reprint Nitric oxide-mediated alterations of protein tyrosine phosphatase activity and expression during hypoxia in the cerebral cortex of newborn piglets
    Qazi M Ashraf
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s Hospital for Children, Philadelphia, PA 19129, USA
    Neurosci Lett 362:108-12. 2004
    ..nNOS inhibition also prevented the hypoxia-induced increase in PTP activity and expression in cytosol, and therefore we conclude that modification of PTP during hypoxia is NO-mediated...
  42. ncbi request reprint ATP and cytochrome c-dependent inhibition of caspase-9 activity in the cerebral cortex of newborn piglets
    Om P Mishra
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s Hospital for Children, Philadelphia, PA 19129, USA
    Neurosci Lett 364:119-23. 2004
    ..To our knowledge, this is a completely new concept and a new mechanism of regulation of caspase-9 activity that may lead to hypoxia-induced programmed cell death...
  43. ncbi request reprint Effect of hypoxia on protein tyrosine kinase activity in cortical membranes of newborn piglets--the role of nitric oxide
    Om Prakash Mishra
    Department of Pediatrics, Neonatal Research Laboratory, Drexel University College of Medicine, MCP, Room 701, 7th Floor Heritage Building, 3300 Henry Avenue, Philadelphia, PA 19129, USA
    Neurosci Lett 372:114-8. 2004
    ..We propose that the hypoxia-induced increase in protein tyrosine kinase activity leading to increased phosphorylation of Bcl-2 is a critical link to hypoxic neuronal injury pathway...
  44. ncbi request reprint Cyclooxygenase-mediated generation of free radicals during hypoxia in the cerebral cortex of newborn piglets
    Leonardo Torres
    Neonatal Research Laboratory, MCP Hospital, Philadelphia, PA 19129, USA
    Neurochem Res 29:1825-30. 2004
    ..These data provide direct evidence of the presence of free radicals during hypoxia and the contribution of cyclooxygenase metabolism to their formation...
  45. ncbi request reprint Effect of nitration on protein tyrosine phosphatase and protein phosphatase activity in neuronal cell membranes of newborn piglets
    Carlos J Lopez
    Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA, USA
    Neurosci Lett 386:78-81. 2005
    ....
  46. ncbi request reprint Effect of allopurinol on brain adenosine levels during hypoxia in newborn piglets
    Peter J Marro
    Department of Pediatrics, Division of Neonatology, Barbara Bush Children s Hospital at Maine Medical Center, 22 Bramhall Street, Portland, ME 04102 3134, USA
    Brain Res 1073:444-50. 2006
    ..The increased accumulation of CNS adenosine during hypoxia which is seen in the allopurinol-treated animals may potentiate adenosine's intrinsic neuroprotective mechanisms...
  47. ncbi request reprint Effect of neuronal nitric oxide synthase inhibition on caspase-9 activity during hypoxia in the cerebral cortex of newborn piglets
    Om P Mishra
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s Hospital for Children, Philadelphia, PA 19129, USA
    Neurosci Lett 401:81-5. 2006
    ..We propose that the NO generated during hypoxia leads to activation of caspase-9 and results in initiation of caspase-cascade-dependent hypoxic neuronal death...
  48. ncbi request reprint Nitration of N-methyl-D-aspartate receptor subunits following in vitro dephosphorylation of cerebral cortical membranes of newborn piglets
    Om Prakash Mishra
    Department of Pediatrics, MCP Hahnemann University Hospital, 3300 Henry Avenue, Philadelphia, PA 19129, USA
    Neurosci Lett 317:115-8. 2002
    ....