Failure to find progressive temporal lobe volume decreases 10 years subsequent to a first episode of schizophreniaLynn E DeLisi
Department of Psychiatry, New York University, Center for Advanced Brain Imaging, Nathan S Kline Institute for Psychiatric Research, New York, NY 10016, USA
Psychiatry Res 138:265-8. 2005
..No change over time was observed in these structures when patients were compared with controls. These results do not support the notion that progressive temporal lobe deterioration occurs in schizophrenia...
- A preliminary comparison of the hopes of researchers, clinicians, and families for the future ethical use of genetic findings on schizophrenia
Lynn E DeLisi
Department of Psychiatry, New York University, New York, NY 10016, USA
Am J Med Genet B Neuropsychiatr Genet 141:110-5. 2006
..Open public discussion of the ethical and social uses of the information gained from psychiatric genetic research and its limitations is encouraged...
- Understanding structural brain changes in schizophrenia
Lynn E DeLisi
New York University, The Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, New York, NY 10962, USA
Dialogues Clin Neurosci 8:71-8. 2006
..Current magnetic resonance imaging (MRI) technology can provide a valuable tool for detecting early changes in cortical atrophy and anomalous language processing, which may be predictive of who will develop schizophrenia...
- Searching for the true genetic vulnerability for schizophrenia
Lynn E DeLisi
Center for Advanced Brain Imaging, The Nathan S Kline Institute for Psychiatric Research, Old Orangeburg Road, Orangeburg, New York, NY 10962, USA
Genome Med 1:14. 2009
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- Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation
Maureen V Martin
Department of Psychiatry and Human Behavior, Univ of California, Irvine, CA, USA
BMC Med Genomics 2:62. 2009
..The purpose of this study was to examine the effects of glucose reduction stress on lymphoblastic cell line (LCL) gene expression in subjects with schizophrenia compared to non-psychotic relatives...
- Speech disorder in schizophrenia: review of the literature and exploration of its relation to the uniquely human capacity for language
L E DeLisi
New York University School of Medicine, Millhauser Laboratories, NY 10016, USA
Schizophr Bull 27:481-96. 2001
..These data are consistent with previous literature and additionally show a familial component to these measures, thus suggesting that deficits in specifically human aspects of language may be related to the genetics of schizophrenia...
- Reviewing the "facts about schizophrenia:: a possible or impossible task?
Lynn E DeLisi
New York University School of Medicine, New York, NY 10968, USA
Schizophr Res 102:19-20. 2008
- Hospitalized psychiatric patients view the World Trade Center disaster
Lynn E DeLisi
Department of Psychiatry, New York University, 650 First Avenue, 5th Floor, New York, NY 10016, USA
Psychiatry Res 129:201-7. 2004
..However, significantly more patients with a schizophrenia spectrum diagnosis showed evidence of worsening in their symptoms than those with affective disorder or other diagnoses in response to the events of September 11...
- The effect of cannabis on the brain: can it cause brain anomalies that lead to increased risk for schizophrenia?
Lynn E DeLisi
New York University, New York, NY 10016, USA
Curr Opin Psychiatry 21:140-50. 2008
..This review explores what is known about the association of cannabis with schizophrenia, its effects on the brain, and whether the brain changes known to be present in schizophrenia could be caused by cannabis and thus lead to a psychosis...
- Klinefelter's syndrome (XXY) as a genetic model for psychotic disorders
Lynn E DeLisi
The Department of Psychiatry New York University, New York, New York 10016, USA
Am J Med Genet B Neuropsychiatr Genet 135:15-23. 2005
..Brain expressed genes that are known to escape inactivation on extra-X chromosomes would be prime candidates...
- Schizophrenia today: do we know any more and can we treat it better than a decade ago?
Lynn E DeLisi
The Center for Advanced Brain Imaging, The Nathan S Kline Institute, Orangeburg, New York, NY 10016, USA
Curr Opin Psychiatry 21:131-2. 2008
- When is a "positive" association truly a "positive" in psychiatric genetics? A commentary based on issues debated at the World Congress of Psychiatric Genetics, Boston, October 12-18, 2005
Lynn E DeLisi
New York University and the Nathan S Kline Institute for Psychiatric Research, New York, USA
Am J Med Genet B Neuropsychiatr Genet 141:319-22. 2006
..This manuscript describes the panel discussion, its implications for the reporting of association studies of psychiatric disorders and suggestions for when to decide that a positive finding is truly positive...
- Early detection of schizophrenia by diffusion weighted imaging
Lynn E DeLisi
The Nathan S Kline Institute for Psychiatric Research, Department of Medical Physics, Orangeburg, NY 10962, USA
Psychiatry Res 148:61-6. 2006
..It is concluded that ADC may be a more sensitive measure than ventricular volume assessments for use in future studies of early prediction of schizophrenia...
- A genome-wide scan for linkage to chromosomal regions in 382 sibling pairs with schizophrenia or schizoaffective disorder
Lynn E DeLisi
Department of Psychiatry, New York University, New York, NY 10016, USA
Am J Psychiatry 159:803-12. 2002
..Since schizophrenia is a complex disorder, a study with sufficient power to detect a locus with a small or moderate gene effect is necessary...
- Genome-wide scan for linkage to schizophrenia in a Spanish-origin cohort from Costa Rica
Lynn E DeLisi
Department of Psychiatry, New York University, Millhauser Laboratories, New York, New York 10016, USA
Am J Med Genet 114:497-508. 2002
..The latter casts some doubt on this population being an isolate, although there was evidence of inbreeding among the offspring...
- The concept of progressive brain change in schizophrenia: implications for understanding schizophrenia
Lynn E DeLisi
New York University School of Medicine, 650 First Avenue, New York, NY 1006, USA
Schizophr Bull 34:312-21. 2008
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- Neuropsychological performance as endophenotypes in extended schizophrenia families from the Central Valley of Costa Rica
Hilary Bertisch
Department of Psychiatry, New York University School of Medicine, New York 10016, USA
Psychiatr Genet 19:45-52. 2009
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- A survey of New Yorkers after the Sept. 11, 2001, terrorist attacks
Lynn E DeLisi
Department of Psychiatry, New York University, USA
Am J Psychiatry 160:780-3. 2003
..This study examined the prevalence of psychiatric symptoms among residents/workers in Manhattan 3-6 months after the Sept. 11, 2001, terrorist attacks...
- Language pathway abnormalities in schizophrenia: a review of fMRI and other imaging studies
Xiaobo Li
Center for Advanced Brain Imaging, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
Curr Opin Psychiatry 22:131-9. 2009
..This review discusses recent neuroimaging studies reporting on impairment in brain functioning relevant to language processing in individuals with schizophrenia and those who are at a genetic risk for its development...
- Cerebral ventricular change over the first 10 years after the onset of schizophrenia
Lynn E DeLisi
Department of Psychiatry, New York University and the Nathan S Kline Institute for Psychiatric Research, Building 35, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Psychiatry Res 130:57-70. 2004
..Despite these differences among patients, the present study fails to detect any relationship of ventricular enlargement to poorer outcome as has been reported by other investigators...
- A rare polymorphism affects a mitogen-activated protein kinase site in synapsin III: possible relationship to schizophrenia
Barbara Porton
Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
Biol Psychiatry 55:118-25. 2004
..To determine if synapsin III plays a role in this disease, we searched for polymorphisms in this gene in patients with schizophrenia and controls...
- Summary of the 1st Schizophrenia International Research Society Conference oral sessions, Venice, Italy, June 21-25, 2008: the rapporteur reports
Roohi Abubaker
Morehouse School of Medicine, Department of Psychiatry, 720 Westview Drive, Atlanta, GA 30310, United States
Schizophr Res 105:289-383. 2008
..The abstracts of all presentations, as submitted by the authors a few months prior, were previously published as supplement 2 to volume 102/1-3, June 2008...
- Ten year longitudinal study of neuropsychological functioning subsequent to a first episode of schizophrenia
Anne L Hoff
Department of Psychiatry, 650 First Avenue, 5th Floor, New York University, New York, NY10016, USA
Schizophr Res 78:27-34. 2005
..Most cognitive change takes place early in this illness, prior to the first hospitalization, but its exact timing still remains unknown...
- A DTI study of white matter microstructure in individuals at high genetic risk for schizophrenia
Matthew J Hoptman
Division of Clinical Research, The Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Bldg 35, Orangeburg, NY 10962, United States
Schizophr Res 106:115-24. 2008
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- Telomerase levels in schizophrenia: a preliminary study
Barbara Porton
Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Schizophr Res 106:242-7. 2008
..Further studies are needed to investigate the role of telomerase in schizophrenia...
- Heritability estimates for cognitive factors and brain white matter integrity as markers of schizophrenia
Hilary Bertisch
Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
Am J Med Genet B Neuropsychiatr Genet 153:885-94. 2010
..In addition, other cognitive and neuroimaging variables that were not studied here may be candidates for schizophrenia endophenotypes...
- fMRI study of language activation in schizophrenia, schizoaffective disorder and in individuals genetically at high risk
Xiaobo Li
Center for Advanced Brain Imaging, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Schizophr Res 96:14-24. 2007
..We now extend this finding to specifically examine functional activity in three language related cortical regions using a larger cohort of individuals...
- Dysregulation of X-linked gene expression in Klinefelter's syndrome and association with verbal cognition
Marquis P Vawter
Department of Psychiatry, University of California, Irvine, California, USA
Am J Med Genet B Neuropsychiatr Genet 144:728-34. 2007
..A screen of candidate genes may serve as biomarkers of KS for early diagnosis...
- Confirmatory evidence for linkage of relative hand skill to 2p12-q11
Clyde Francks
Am J Hum Genet 72:499-502. 2003
- Evaluation of linkage disequilibrium between chromosome 22q11 single nucleotide polymorphisms in a large outbred population
Sarah H Shaw
Axys Pharmaceuticals Inc, La Jolla, California, USA
Am J Med Genet 114:205-13. 2002
..30. Finally, we observed a 60 kb region with non-significant LD, which could reflect increased recombination in this region...
- Allele sharing for schizophrenia and schizo-affective disorder within a region of Homo sapiens specific XY homology
Timothy R J Nicholson
University Department of Biological Anthropology, Banbury Road, Oxford, United Kingdom
Am J Med Genet 114:637-40. 2002
..With respect to the latter possibility we draw attention to the recent evolutionary history of the Xq21.3/Yp region. Genes within the region are in transition to protection from X inactivation and therefore may be epigenetically labile...
- Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia
Cathryn M Lewis
Division of Genetics and Development, Guy's, King's and St Thomas' School of Medicine, London, UK
Am J Hum Genet 73:34-48. 2003
..There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations...
- Sex-dependent effects of schizophrenia: an MRI study of gyral folding, and cortical and white matter volume
J Robin Highley
The Schizophrenia Research Group, Department of Clinical Neurology (Neuropathology, Radcliffe Infirmary, OX2 6HE, Oxford, UK
Psychiatry Res 124:11-23. 2003
..It is concluded that the changes in connectivity underlying the pathogenesis of schizophrenia are sex-specific and expressed in occipito-parietal white matter...
- Application of a new image analysis technique to study brain asymmetry in schizophrenia
Clare E Mackay
Prince of Wales International Centre for SANE Research POWIC, Department of Psychiatry, University of Oxford, Warneford Hospital, Headington, Oxford OX3 7JX, UK
Psychiatry Res 124:25-35. 2003
..Future studies with larger sample sizes should consider sexual dimorphism and specific symptoms in relation to asymmetry...
- Parent-of-origin effects on handedness and schizophrenia susceptibility on chromosome 2p12-q11
Clyde Francks
Wellcome Trust Centre for Human Genetics, University of Oxford, UK
Hum Mol Genet 12:3225-30. 2003
..The linkages may be due to a single maternally imprinted influence on lateralized brain development that contains common functional polymorphisms...
- Correlates of cognitive deficits in first episode schizophrenia
Gitry Heydebrand
Washington University School of Medicine, St Louis, MO, USA
Schizophr Res 68:1-9. 2004
..If present, such relationships should be most clearly observable in patients with first episode schizophrenia; that is, before the effects of chronic illness, institutionalization, or treatment might confound them...
- ProtocadherinX/Y, a candidate gene-pair for schizophrenia and schizoaffective disorder: a DHPLC investigation of genomic sequence
Maria Giouzeli
Department of Psychiatry, POWIC SANE Research Centre, University of Oxford, Warneford Hospital, Oxford, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 129:1-9. 2004
..However, we note the unusual status of this region with respect to X-inactivation. Further investigation of the epigenetic control of PCDHX/Y in relation to psychosis is warranted...
- CAA insertion polymorphism in the 3'UTR of Nogo gene on 2p14 is not associated with schizophrenia
Lan Xiong
Department of Psychiatry, Douglas Hospital Research Centre, 6875 Boulevard LaSalle, FBC Pavillion, Verdun, Quebec, Canada H4H1R3
Brain Res Mol Brain Res 133:153-6. 2005
..0% vs. 15.0%, chi2=0.985, p>0.1). Furthermore, neither CAAins/TATCdel individually, nor the haplotype carrying both CAAins and TATCdel is preferentially transmitted to affected offspring...
- Schizophrenia research in the era of the genome, 2007
Lynn E DeLisi
Curr Opin Psychiatry 20:109-10. 2007
..Going beyond genetic linkage and association studies to pathways, mechanisms and what changes gene expression will be the key...
- Methylation of two Homo sapiens-specific X-Y homologous genes in Klinefelter's syndrome (XXY)
Norman L J Ross
SANE POWIC, University of Oxford, Warneford Hospital, Oxford, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 141:544-8. 2006
..The origin of the parental alleles or their preferential X inactivation was not associated with psychotic symptoms...
- Celebrating twenty years of schizophrenia research
Lynn E DeLisi
Schizophr Res 100:1-3. 2008
- Quantitation of X-Y homologous genes in patients with schizophrenia by multiplex polymerase chain reaction
Norman L J Ross
University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford, UK
Psychiatr Genet 13:115-9. 2003
..This study determined whether dosage imbalances of X-Y homologous regions in general are associated with schizophrenia...
- Familial cognitive deficits in schizophrenia
Anne L Hoff
Napa State Hospital, Napa, California and Department of Psychiatry, UC Davis, USA
Am J Med Genet B Neuropsychiatr Genet 133:43-9. 2005
..These latter correlations suggest that some cognitive measures may be genetically related to the illness...
- An fMRI study of language processing in people at high genetic risk for schizophrenia
Xiaobo Li
The Center for Advanced Brain Imaging at The Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, United States
Schizophr Res 91:62-72. 2007
..If language pathway abnormalities can be detected early in people at high-risk for schizophrenia prior to the onset of symptoms, early treatment can ensue...
