LYNN ELEANOR DELISI

Summary

Publications

  1. ncbi request reprint Failure to find progressive temporal lobe volume decreases 10 years subsequent to a first episode of schizophrenia
    Lynn E DeLisi
    Department of Psychiatry, New York University, Center for Advanced Brain Imaging, Nathan S Kline Institute for Psychiatric Research, New York, NY 10016, USA
    Psychiatry Res 138:265-8. 2005
  2. ncbi request reprint A preliminary comparison of the hopes of researchers, clinicians, and families for the future ethical use of genetic findings on schizophrenia
    Lynn E DeLisi
    Department of Psychiatry, New York University, New York, NY 10016, USA
    Am J Med Genet B Neuropsychiatr Genet 141:110-5. 2006
  3. pmc Understanding structural brain changes in schizophrenia
    Lynn E DeLisi
    New York University, The Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, New York, NY 10962, USA
    Dialogues Clin Neurosci 8:71-8. 2006
  4. pmc Searching for the true genetic vulnerability for schizophrenia
    Lynn E DeLisi
    Center for Advanced Brain Imaging, The Nathan S Kline Institute for Psychiatric Research, Old Orangeburg Road, Orangeburg, New York, NY 10962, USA
    Genome Med 1:14. 2009
  5. pmc Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation
    Maureen V Martin
    Department of Psychiatry and Human Behavior, Univ of California, Irvine, CA, USA
    BMC Med Genomics 2:62. 2009
  6. ncbi request reprint Speech disorder in schizophrenia: review of the literature and exploration of its relation to the uniquely human capacity for language
    L E DeLisi
    New York University School of Medicine, Millhauser Laboratories, NY 10016, USA
    Schizophr Bull 27:481-96. 2001
  7. doi request reprint The effect of cannabis on the brain: can it cause brain anomalies that lead to increased risk for schizophrenia?
    Lynn E DeLisi
    New York University, New York, NY 10016, USA
    Curr Opin Psychiatry 21:140-50. 2008
  8. ncbi request reprint Hospitalized psychiatric patients view the World Trade Center disaster
    Lynn E DeLisi
    Department of Psychiatry, New York University, 650 First Avenue, 5th Floor, New York, NY 10016, USA
    Psychiatry Res 129:201-7. 2004
  9. pmc Early detection of schizophrenia by diffusion weighted imaging
    Lynn E DeLisi
    The Nathan S Kline Institute for Psychiatric Research, Department of Medical Physics, Orangeburg, NY 10962, USA
    Psychiatry Res 148:61-6. 2006
  10. ncbi request reprint Schizophrenia today: do we know any more and can we treat it better than a decade ago?
    Lynn E DeLisi
    The Center for Advanced Brain Imaging, The Nathan S Kline Institute, Orangeburg, New York, NY 10016, USA
    Curr Opin Psychiatry 21:131-2. 2008

Detail Information

Publications45

  1. ncbi request reprint Failure to find progressive temporal lobe volume decreases 10 years subsequent to a first episode of schizophrenia
    Lynn E DeLisi
    Department of Psychiatry, New York University, Center for Advanced Brain Imaging, Nathan S Kline Institute for Psychiatric Research, New York, NY 10016, USA
    Psychiatry Res 138:265-8. 2005
    ..No change over time was observed in these structures when patients were compared with controls. These results do not support the notion that progressive temporal lobe deterioration occurs in schizophrenia...
  2. ncbi request reprint A preliminary comparison of the hopes of researchers, clinicians, and families for the future ethical use of genetic findings on schizophrenia
    Lynn E DeLisi
    Department of Psychiatry, New York University, New York, NY 10016, USA
    Am J Med Genet B Neuropsychiatr Genet 141:110-5. 2006
    ..Open public discussion of the ethical and social uses of the information gained from psychiatric genetic research and its limitations is encouraged...
  3. pmc Understanding structural brain changes in schizophrenia
    Lynn E DeLisi
    New York University, The Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, New York, NY 10962, USA
    Dialogues Clin Neurosci 8:71-8. 2006
    ..Current magnetic resonance imaging (MRI) technology can provide a valuable tool for detecting early changes in cortical atrophy and anomalous language processing, which may be predictive of who will develop schizophrenia...
  4. pmc Searching for the true genetic vulnerability for schizophrenia
    Lynn E DeLisi
    Center for Advanced Brain Imaging, The Nathan S Kline Institute for Psychiatric Research, Old Orangeburg Road, Orangeburg, New York, NY 10962, USA
    Genome Med 1:14. 2009
    ....
  5. pmc Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation
    Maureen V Martin
    Department of Psychiatry and Human Behavior, Univ of California, Irvine, CA, USA
    BMC Med Genomics 2:62. 2009
    ..The purpose of this study was to examine the effects of glucose reduction stress on lymphoblastic cell line (LCL) gene expression in subjects with schizophrenia compared to non-psychotic relatives...
  6. ncbi request reprint Speech disorder in schizophrenia: review of the literature and exploration of its relation to the uniquely human capacity for language
    L E DeLisi
    New York University School of Medicine, Millhauser Laboratories, NY 10016, USA
    Schizophr Bull 27:481-96. 2001
    ..These data are consistent with previous literature and additionally show a familial component to these measures, thus suggesting that deficits in specifically human aspects of language may be related to the genetics of schizophrenia...
  7. doi request reprint The effect of cannabis on the brain: can it cause brain anomalies that lead to increased risk for schizophrenia?
    Lynn E DeLisi
    New York University, New York, NY 10016, USA
    Curr Opin Psychiatry 21:140-50. 2008
    ..This review explores what is known about the association of cannabis with schizophrenia, its effects on the brain, and whether the brain changes known to be present in schizophrenia could be caused by cannabis and thus lead to a psychosis...
  8. ncbi request reprint Hospitalized psychiatric patients view the World Trade Center disaster
    Lynn E DeLisi
    Department of Psychiatry, New York University, 650 First Avenue, 5th Floor, New York, NY 10016, USA
    Psychiatry Res 129:201-7. 2004
    ..However, significantly more patients with a schizophrenia spectrum diagnosis showed evidence of worsening in their symptoms than those with affective disorder or other diagnoses in response to the events of September 11...
  9. pmc Early detection of schizophrenia by diffusion weighted imaging
    Lynn E DeLisi
    The Nathan S Kline Institute for Psychiatric Research, Department of Medical Physics, Orangeburg, NY 10962, USA
    Psychiatry Res 148:61-6. 2006
    ..It is concluded that ADC may be a more sensitive measure than ventricular volume assessments for use in future studies of early prediction of schizophrenia...
  10. ncbi request reprint Schizophrenia today: do we know any more and can we treat it better than a decade ago?
    Lynn E DeLisi
    The Center for Advanced Brain Imaging, The Nathan S Kline Institute, Orangeburg, New York, NY 10016, USA
    Curr Opin Psychiatry 21:131-2. 2008
  11. ncbi request reprint Klinefelter's syndrome (XXY) as a genetic model for psychotic disorders
    Lynn E DeLisi
    The Department of Psychiatry New York University, New York, New York 10016, USA
    Am J Med Genet B Neuropsychiatr Genet 135:15-23. 2005
    ..Brain expressed genes that are known to escape inactivation on extra-X chromosomes would be prime candidates...
  12. pmc The concept of progressive brain change in schizophrenia: implications for understanding schizophrenia
    Lynn E DeLisi
    New York University School of Medicine, 650 First Avenue, New York, NY 1006, USA
    Schizophr Bull 34:312-21. 2008
    ....
  13. ncbi request reprint Reviewing the "facts about schizophrenia:: a possible or impossible task?
    Lynn E DeLisi
    New York University School of Medicine, New York, NY 10968, USA
    Schizophr Res 102:19-20. 2008
  14. ncbi request reprint When is a "positive" association truly a "positive" in psychiatric genetics? A commentary based on issues debated at the World Congress of Psychiatric Genetics, Boston, October 12-18, 2005
    Lynn E DeLisi
    New York University and the Nathan S Kline Institute for Psychiatric Research, New York, USA
    Am J Med Genet B Neuropsychiatr Genet 141:319-22. 2006
    ..This manuscript describes the panel discussion, its implications for the reporting of association studies of psychiatric disorders and suggestions for when to decide that a positive finding is truly positive...
  15. ncbi request reprint A genome-wide scan for linkage to chromosomal regions in 382 sibling pairs with schizophrenia or schizoaffective disorder
    Lynn E DeLisi
    Department of Psychiatry, New York University, New York, NY 10016, USA
    Am J Psychiatry 159:803-12. 2002
    ..Since schizophrenia is a complex disorder, a study with sufficient power to detect a locus with a small or moderate gene effect is necessary...
  16. ncbi request reprint Genome-wide scan for linkage to schizophrenia in a Spanish-origin cohort from Costa Rica
    Lynn E DeLisi
    Department of Psychiatry, New York University, Millhauser Laboratories, New York, New York 10016, USA
    Am J Med Genet 114:497-508. 2002
    ..The latter casts some doubt on this population being an isolate, although there was evidence of inbreeding among the offspring...
  17. doi request reprint Neuropsychological performance as endophenotypes in extended schizophrenia families from the Central Valley of Costa Rica
    Hilary Bertisch
    Department of Psychiatry, New York University School of Medicine, New York 10016, USA
    Psychiatr Genet 19:45-52. 2009
    ....
  18. ncbi request reprint Cerebral ventricular change over the first 10 years after the onset of schizophrenia
    Lynn E DeLisi
    Department of Psychiatry, New York University and the Nathan S Kline Institute for Psychiatric Research, Building 35, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Psychiatry Res 130:57-70. 2004
    ..Despite these differences among patients, the present study fails to detect any relationship of ventricular enlargement to poorer outcome as has been reported by other investigators...
  19. ncbi request reprint A survey of New Yorkers after the Sept. 11, 2001, terrorist attacks
    Lynn E DeLisi
    Department of Psychiatry, New York University, USA
    Am J Psychiatry 160:780-3. 2003
    ..This study examined the prevalence of psychiatric symptoms among residents/workers in Manhattan 3-6 months after the Sept. 11, 2001, terrorist attacks...
  20. doi request reprint Language pathway abnormalities in schizophrenia: a review of fMRI and other imaging studies
    Xiaobo Li
    Center for Advanced Brain Imaging, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Curr Opin Psychiatry 22:131-9. 2009
    ..This review discusses recent neuroimaging studies reporting on impairment in brain functioning relevant to language processing in individuals with schizophrenia and those who are at a genetic risk for its development...
  21. doi request reprint Summary of the 1st Schizophrenia International Research Society Conference oral sessions, Venice, Italy, June 21-25, 2008: the rapporteur reports
    Roohi Abubaker
    Morehouse School of Medicine, Department of Psychiatry, 720 Westview Drive, Atlanta, GA 30310, United States
    Schizophr Res 105:289-383. 2008
    ..The abstracts of all presentations, as submitted by the authors a few months prior, were previously published as supplement 2 to volume 102/1-3, June 2008...
  22. ncbi request reprint A rare polymorphism affects a mitogen-activated protein kinase site in synapsin III: possible relationship to schizophrenia
    Barbara Porton
    Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Biol Psychiatry 55:118-25. 2004
    ..To determine if synapsin III plays a role in this disease, we searched for polymorphisms in this gene in patients with schizophrenia and controls...
  23. doi request reprint A DTI study of white matter microstructure in individuals at high genetic risk for schizophrenia
    Matthew J Hoptman
    Division of Clinical Research, The Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Bldg 35, Orangeburg, NY 10962, United States
    Schizophr Res 106:115-24. 2008
    ....
  24. pmc Heritability estimates for cognitive factors and brain white matter integrity as markers of schizophrenia
    Hilary Bertisch
    Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    Am J Med Genet B Neuropsychiatr Genet 153:885-94. 2010
    ..In addition, other cognitive and neuroimaging variables that were not studied here may be candidates for schizophrenia endophenotypes...
  25. pmc Telomerase levels in schizophrenia: a preliminary study
    Barbara Porton
    Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Schizophr Res 106:242-7. 2008
    ..Further studies are needed to investigate the role of telomerase in schizophrenia...
  26. ncbi request reprint Ten year longitudinal study of neuropsychological functioning subsequent to a first episode of schizophrenia
    Anne L Hoff
    Department of Psychiatry, 650 First Avenue, 5th Floor, New York University, New York, NY10016, USA
    Schizophr Res 78:27-34. 2005
    ..Most cognitive change takes place early in this illness, prior to the first hospitalization, but its exact timing still remains unknown...
  27. pmc fMRI study of language activation in schizophrenia, schizoaffective disorder and in individuals genetically at high risk
    Xiaobo Li
    Center for Advanced Brain Imaging, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Schizophr Res 96:14-24. 2007
    ..We now extend this finding to specifically examine functional activity in three language related cortical regions using a larger cohort of individuals...
  28. pmc Dysregulation of X-linked gene expression in Klinefelter's syndrome and association with verbal cognition
    Marquis P Vawter
    Department of Psychiatry, University of California, Irvine, California, USA
    Am J Med Genet B Neuropsychiatr Genet 144:728-34. 2007
    ..A screen of candidate genes may serve as biomarkers of KS for early diagnosis...
  29. pmc Confirmatory evidence for linkage of relative hand skill to 2p12-q11
    Clyde Francks
    Am J Hum Genet 72:499-502. 2003
  30. ncbi request reprint Sex-dependent effects of schizophrenia: an MRI study of gyral folding, and cortical and white matter volume
    J Robin Highley
    The Schizophrenia Research Group, Department of Clinical Neurology Neuropathology, Radcliffe Infirmary, OX2 6HE, Oxford, UK
    Psychiatry Res 124:11-23. 2003
    ..It is concluded that the changes in connectivity underlying the pathogenesis of schizophrenia are sex-specific and expressed in occipito-parietal white matter...
  31. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia
    Cathryn M Lewis
    Division of Genetics and Development, Guy s, King s and St Thomas School of Medicine, London, UK
    Am J Hum Genet 73:34-48. 2003
    ..There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations...
  32. ncbi request reprint Allele sharing for schizophrenia and schizo-affective disorder within a region of Homo sapiens specific XY homology
    Timothy R J Nicholson
    University Department of Biological Anthropology, Banbury Road, Oxford, United Kingdom
    Am J Med Genet 114:637-40. 2002
    ..With respect to the latter possibility we draw attention to the recent evolutionary history of the Xq21.3/Yp region. Genes within the region are in transition to protection from X inactivation and therefore may be epigenetically labile...
  33. ncbi request reprint Application of a new image analysis technique to study brain asymmetry in schizophrenia
    Clare E Mackay
    Prince of Wales International Centre for SANE Research POWIC, Department of Psychiatry, University of Oxford, Warneford Hospital, Headington, Oxford OX3 7JX, UK
    Psychiatry Res 124:25-35. 2003
    ..Future studies with larger sample sizes should consider sexual dimorphism and specific symptoms in relation to asymmetry...
  34. ncbi request reprint Parent-of-origin effects on handedness and schizophrenia susceptibility on chromosome 2p12-q11
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Hum Mol Genet 12:3225-30. 2003
    ..The linkages may be due to a single maternally imprinted influence on lateralized brain development that contains common functional polymorphisms...
  35. ncbi request reprint Correlates of cognitive deficits in first episode schizophrenia
    Gitry Heydebrand
    Washington University School of Medicine, St Louis, MO, USA
    Schizophr Res 68:1-9. 2004
    ..If present, such relationships should be most clearly observable in patients with first episode schizophrenia; that is, before the effects of chronic illness, institutionalization, or treatment might confound them...
  36. ncbi request reprint ProtocadherinX/Y, a candidate gene-pair for schizophrenia and schizoaffective disorder: a DHPLC investigation of genomic sequence
    Maria Giouzeli
    Department of Psychiatry, POWIC SANE Research Centre, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 129:1-9. 2004
    ..However, we note the unusual status of this region with respect to X-inactivation. Further investigation of the epigenetic control of PCDHX/Y in relation to psychosis is warranted...
  37. ncbi request reprint CAA insertion polymorphism in the 3'UTR of Nogo gene on 2p14 is not associated with schizophrenia
    Lan Xiong
    Department of Psychiatry, Douglas Hospital Research Centre, 6875 Boulevard LaSalle, FBC Pavillion, Verdun, Quebec, Canada H4H1R3
    Brain Res Mol Brain Res 133:153-6. 2005
    ..0% vs. 15.0%, chi2=0.985, p>0.1). Furthermore, neither CAAins/TATCdel individually, nor the haplotype carrying both CAAins and TATCdel is preferentially transmitted to affected offspring...
  38. ncbi request reprint Schizophrenia research in the era of the genome, 2007
    Lynn E DeLisi
    Curr Opin Psychiatry 20:109-10. 2007
    ....
  39. ncbi request reprint Methylation of two Homo sapiens-specific X-Y homologous genes in Klinefelter's syndrome (XXY)
    Norman L J Ross
    SANE POWIC, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 141:544-8. 2006
    ..The origin of the parental alleles or their preferential X inactivation was not associated with psychotic symptoms...
  40. ncbi request reprint Evaluation of linkage disequilibrium between chromosome 22q11 single nucleotide polymorphisms in a large outbred population
    Sarah H Shaw
    Axys Pharmaceuticals Inc, La Jolla, California, USA
    Am J Med Genet 114:205-13. 2002
    ..30. Finally, we observed a 60 kb region with non-significant LD, which could reflect increased recombination in this region...
  41. doi request reprint Celebrating twenty years of schizophrenia research
    Lynn E DeLisi
    Schizophr Res 100:1-3. 2008
  42. pmc An fMRI study of language processing in people at high genetic risk for schizophrenia
    Xiaobo Li
    The Center for Advanced Brain Imaging at The Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, United States
    Schizophr Res 91:62-72. 2007
    ..If language pathway abnormalities can be detected early in people at high-risk for schizophrenia prior to the onset of symptoms, early treatment can ensue...
  43. ncbi request reprint Familial cognitive deficits in schizophrenia
    Anne L Hoff
    Napa State Hospital, Napa, California and Department of Psychiatry, UC Davis, USA
    Am J Med Genet B Neuropsychiatr Genet 133:43-9. 2005
    ..These latter correlations suggest that some cognitive measures may be genetically related to the illness...
  44. ncbi request reprint Quantitation of X-Y homologous genes in patients with schizophrenia by multiplex polymerase chain reaction
    Norman L J Ross
    University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford, UK
    Psychiatr Genet 13:115-9. 2003
    ..This study determined whether dosage imbalances of X-Y homologous regions in general are associated with schizophrenia...

Research Grants17

  1. Biological Prediction of Psychosis Susceptibility among Adolescent Cannabis Users
    LYNN ELEANOR DELISI; Fiscal Year: 2010
    ..abstract_text> ..
  2. Biological Prediction of Psychosis Susceptibility among Adolescent Cannabis Users
    Lynn DeLisi; Fiscal Year: 2007
    ..Another implication of this study would be that people who have a family history of schizophrenia should be strongly cautioned from using cannabis and if they do as adolescents, be observed closely for adverse psychotic symptoms. ..
  3. World Congress of Psychiatric Genetics with Emphasis on Genes for Drug Abuse
    Lynn DeLisi; Fiscal Year: 2007
    ....
  4. World Congress of Psychiatric Genetics
    Lynn DeLisi; Fiscal Year: 2007
    ..All ISPG board members oversee each annual congress. Its founder and secretary/treasurer (LE DeLisi) is a full-time professor at New York University (NYU). Thus, NYU is sponsoring this proposal. ..
  5. White Matter Integrity in Familial Schizophrenia
    Lynn DeLisi; Fiscal Year: 2006
    ..Since this hypothesis has not been tested specifically in this way and is speculative, but if correct, may have a great impact on future research, we are using the R21 exploratory mechanism. ..
  6. BRAIN MORPHOLOGY AT ONSET OF SCHIZOPHRENIA
    Lynn DeLisi; Fiscal Year: 2001
    ..A new cohort of first episode patients continues to be formed, based on referrals from the Stony Brook Psychiatric Emergency Room (CPEP). ..
  7. DETECTION OF MAJOR GENE LOCI FOR SCHIZOPHRENIA
    Lynn DeLisi; Fiscal Year: 1999
    ..Are we willing to provide the complete approved protocol to the NIH to be abstracted for inclusion in various publicly available databases (e.g; PDQ, Rare Disease, Clinical Trials Research)? No ..