Steven T DeKosky

Summary

Publications

  1. ncbi request reprint Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment
    Steven T DeKosky
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Ann Neurol 51:145-55. 2002
  2. pmc Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain 131:1630-45. 2008
  3. pmc Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia
    Beth E Snitz
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
    Neurology 80:1378-84. 2013
  4. ncbi request reprint Apolipoprotein D is a component of compact but not diffuse amyloid-beta plaques in Alzheimer's disease temporal cortex
    Purnima P Desai
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neurobiol Dis 20:574-82. 2005
  5. pmc The relationship of excess cognitive impairment in MCI and early Alzheimer's disease to the subsequent emergence of psychosis
    Elise A Weamer
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, USA
    Int Psychogeriatr 21:78-85. 2009
  6. pmc Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Alzheimer Dis Assoc Disord 22:261-8. 2008
  7. pmc Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer's disease with Pittsburgh Compound B
    Cyrus A Raji
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2593, United States
    J Neurosci Methods 172:277-82. 2008
  8. ncbi request reprint Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 2
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 60:1394-9. 2003
  9. ncbi request reprint Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: implications for clinical outcome
    Eric E Abrahamson
    Department of Neurology, University of Pittsburgh School of Medicine, 3471 Fifth Avenue, Suite 811, 15213, USA
    Exp Neurol 197:437-50. 2006
  10. ncbi request reprint Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease
    Scott K Ziolko
    Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Rm B 938, PA 15213, USA
    Neuroimage 33:94-102. 2006

Detail Information

Publications100

  1. ncbi request reprint Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment
    Steven T DeKosky
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Ann Neurol 51:145-55. 2002
    ..The upregulation in frontal cortex and hippocampal ChAT activity could be an important factor in preventing the transition of MCI subjects to AD...
  2. pmc Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain 131:1630-45. 2008
    ..The strong direct correlation of in vivo PiB retention with region-matched quantitative analyses of Abeta plaques in the same subject supports the validity of PiB-PET imaging as a method for in vivo evaluation of Abeta plaque burden...
  3. pmc Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia
    Beth E Snitz
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
    Neurology 80:1378-84. 2013
    ..To determine whether a high prevalence (55%) of Aβ deposition in a cohort of individuals remaining dementia-free into their 9th and 10th decades is associated with cognitive decline prior to imaging...
  4. ncbi request reprint Apolipoprotein D is a component of compact but not diffuse amyloid-beta plaques in Alzheimer's disease temporal cortex
    Purnima P Desai
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neurobiol Dis 20:574-82. 2005
    ..Elevated apoD in AD brain may influence Abeta aggregation, or facilitate phagocytosis and transport of Abeta fibrils from plaques to cerebral vasculature...
  5. pmc The relationship of excess cognitive impairment in MCI and early Alzheimer's disease to the subsequent emergence of psychosis
    Elise A Weamer
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, USA
    Int Psychogeriatr 21:78-85. 2009
    ..This study seeks to determine whether the degree of cognitive impairment and cognitive decline in early AD predicts subsequent AD + P onset...
  6. pmc Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Alzheimer Dis Assoc Disord 22:261-8. 2008
    ..Our findings are consistent with and supportive of the hypothesis that depression may herald the development of AD in some individuals...
  7. pmc Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer's disease with Pittsburgh Compound B
    Cyrus A Raji
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2593, United States
    J Neurosci Methods 172:277-82. 2008
    ..02, p=0.01) and anterior ventral striatum [t(9)=2.37, p=0.04] in AD. No group differences (AD versus MCI) were detected in laterality [F (1, 15)=0.15, p=0.7] or asymmetry [F (1, 15)=0.7, p=0.42]...
  8. ncbi request reprint Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 2
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 60:1394-9. 2003
    ..To examine the risk factors for mild cognitive impairment (MCI) in a longitudinal population study-the Cardiovascular Health Study Cognition Study...
  9. ncbi request reprint Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: implications for clinical outcome
    Eric E Abrahamson
    Department of Neurology, University of Pittsburgh School of Medicine, 3471 Fifth Avenue, Suite 811, 15213, USA
    Exp Neurol 197:437-50. 2006
    ....
  10. ncbi request reprint Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease
    Scott K Ziolko
    Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Rm B 938, PA 15213, USA
    Neuroimage 33:94-102. 2006
    ..These results indicate that voxel-based methods will be useful for future larger longitudinal studies of amyloid deposition that could improve AD diagnosis and anti-amyloid therapy assessment...
  11. pmc Frequent amyloid deposition without significant cognitive impairment among the elderly
    Howard Jay Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 65:1509-17. 2008
    ....
  12. pmc Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve
    Ann D Cohen
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 29:14770-8. 2009
    ....
  13. pmc Patterns of mild cognitive impairment after treatment of depression in the elderly
    Rishi K Bhalla
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 17:308-16. 2009
    ....
  14. ncbi request reprint Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 25:10598-606. 2005
    ....
  15. pmc Cortical alpha7 nicotinic acetylcholine receptor and beta-amyloid levels in early Alzheimer disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Arch Neurol 66:646-51. 2009
    ..To examine alpha7 nicotinic acetylcholine receptor (nAChR) binding and beta-amyloid (Abeta) peptide load in superior frontal cortex (SFC) across clinical and neuropathological stages of Alzheimer disease (AD)...
  16. ncbi request reprint Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis
    Brian J Lopresti
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Nucl Med 46:1959-72. 2005
    ..This work reports on simplified methods of analysis for human PIB imaging...
  17. ncbi request reprint Psychiatric symptoms vary with the severity of dementia in probable Alzheimer's disease
    Oscar L Lopez
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 15:346-53. 2003
    ..Education and race were independently associated with psychosis. However, while education was associated with psychosis in mild/moderate stages, race was associated with psychosis in moderate/severe stages...
  18. ncbi request reprint Neuropathologic correlates of late-onset major depression
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neuropsychopharmacology 29:2242-50. 2004
    ..These preliminary findings suggest that AD is the predominant neuropathologic condition in LLMD subjects with dementia. Further assessment of the role of comorbid cerebrovascular disease and comorbid DLB is needed...
  19. pmc Genetic variation in the choline acetyltransferase (CHAT) gene may be associated with the risk of Alzheimer's disease
    Ayla Ozturk
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, 624 Parran Hall, Pittsburgh, PA 15261, USA
    Neurobiol Aging 27:1440-4. 2006
    ..0082) effects among non-APOE*4 carriers. The three CHAT SNPs also showed a modest association with MMSE score. Our data suggest that genetic variation in the CHAT gene may be associated with AD risk and quantitative traits related to AD...
  20. pmc Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease
    Clayton A Wiley
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Arch Neurol 66:60-7. 2009
    ..Because postmortem histopathological analyses are limited to single end-stage assessment, the time course and nature of this relationship are not well understood...
  21. ncbi request reprint Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B
    Julie C Price
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Cereb Blood Flow Metab 25:1528-47. 2005
    ..This study also showed that it is feasible to perform quantitative PIB PET imaging studies that are needed to validate simpler methods for routine use across the AD disease spectrum...
  22. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  23. ncbi request reprint Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Exp Neurol 190:192-203. 2004
    ....
  24. ncbi request reprint Cognitive correlates of alterations in acetylcholinesterase in Alzheimer's disease
    Nicolaas I Bohnen
    Department of Neurology, University of Pittsburgh Medical School, Liliane S Kaufmann Building, Suite 811, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Neurosci Lett 380:127-32. 2005
    ..Similar findings were present when the analysis was limited to the temporal cortex. Cortical AChE activity is more robustly associated with functions of attention and working memory compared to performance on primary memory tests in AD...
  25. ncbi request reprint Alzheimer disease with psychosis: excess cognitive impairment is restricted to the misidentification subtype
    Gina Perez-Madriñan
    Dept of Psychiatry, Univ of Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 12:449-56. 2004
    ..We hypothesized that these two groups differed in their patterns of cognitive impairment, compared with AD subjects without psychosis...
  26. pmc Alpha-1-antichymotrypsin (ACT or SERPINA3) polymorphism may affect age-at-onset and disease duration of Alzheimer's disease
    M Ilyas Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neurobiol Aging 27:1435-9. 2006
    ..012). These data suggest that the ACT gene may affect AAO and disease duration of AD...
  27. ncbi request reprint APOE is associated with age-of-onset, but not cognitive functioning, in late-life depression
    Meryl A Butters
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 18:1075-81. 2003
    ..We also predicted that APOE4 allele frequency would be increased among subjects with LLD...
  28. pmc No association of dynamin binding protein (DNMBP) gene SNPs and Alzheimer's disease
    Ryan L Minster
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neurobiol Aging 29:1602-4. 2008
    ..We observed no association of statistical significance in either the total sample or the APOE*4 non-carriers for any of the SNPs...
  29. pmc Prediction of psychosis onset in Alzheimer disease: the role of depression symptom severity and the HTR2A T102C polymorphism
    Patricia A Wilkosz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 144:1054-62. 2007
    ..This did not result from an interaction of HTR2A genotype with antidepressant use. Psychosis onset in AD is strongly associated with severity of depressive symptoms, an association that may be modified by HTR2A genotype...
  30. pmc Trajectories of cognitive decline in Alzheimer's disease
    Patricia A Wilkosz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Int Psychogeriatr 22:281-90. 2010
    ..We therefore used latent class modeling to characterize trajectories of cognitive and behavioral decline in a cohort of AD subjects...
  31. ncbi request reprint Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans
    Steven T DeKosky
    Department of Neurology, University of Pittsburgh, 3471 Fifth Ave, Suite 811, Pittsburgh, PA 15213, USA
    Arch Neurol 64:541-4. 2007
    ..Changes in soluble Abeta levels and their relationship to Abeta plaque formation following TBI are unknown...
  32. ncbi request reprint Investigation of the effect of brain-derived neurotrophic factor (BDNF) polymorphisms on the risk of late-onset Alzheimer's disease (AD) and quantitative measures of AD progression
    Purnima Desai
    Department of Human Genetics, University of Pittsburgh, 624 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Neurosci Lett 379:229-34. 2005
    ..The significant effect of the C270T polymorphism observed on MMSE scores among American Blacks needs to be further explored in a larger cohort...
  33. pmc Amyloid imaging in dementias with atypical presentation
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, USA
    Alzheimers Dement 8:389-98. 2012
    ..We explored the potential value of amyloid imaging in patients with atypical presentations of dementia...
  34. pmc Frequency and correlates of advance planning among cognitively impaired older adults
    Jennifer Hagerty Lingler
    Department of Health and Community Systems, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:643-9. 2008
    ..To examine the prevalence and sociodemographic correlates of written advance planning among patients with or at risk for dementia-imposed decisional incapacity...
  35. pmc Does Ginkgo biloba reduce the risk of cardiovascular events?
    Lewis H Kuller
    Department of Epidemiology, University of Pittsburgh, 130 N Bellefield Ave, Room 550, Pittsburgh, PA 15213, USA
    Circ Cardiovasc Qual Outcomes 3:41-7. 2010
    ..Cardiovascular disease (CVD) was a preplanned secondary outcome of the Ginkgo Evaluation of Memory Study. The trial previously reported that Ginkgo biloba had no effect on the primary outcome, incident dementia...
  36. pmc Marital quality in the context of mild cognitive impairment
    Linda Garand
    University of Pittsburgh, Pittsburgh, PA, USA
    West J Nurs Res 29:976-92. 2007
    ..Results of this study suggest the need for mental health interventions designed to preserve the quality of these marital relationships...
  37. pmc Ginkgo biloba for prevention of dementia: a randomized controlled trial
    Steven T DeKosky
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    JAMA 300:2253-62. 2008
    ..Ginkgo biloba is widely used for its potential effects on memory and cognition. To date, adequately powered clinical trials testing the effect of G. biloba on dementia incidence are lacking...
  38. ncbi request reprint Plasma and cerebrospinal fluid alpha1-antichymotrypsin levels in Alzheimer's disease: correlation with cognitive impairment
    Steven T DeKosky
    Department of Neurology and the Alzheimer s Disease Research Center, University of Pittsburgh, PA, USA
    Ann Neurol 53:81-90. 2003
    ....
  39. ncbi request reprint Prediction of psychosis onset in Alzheimer disease: The role of cognitive impairment, depressive symptoms, and further evidence for psychosis subtypes
    Patricia A Wilkosz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 14:352-60. 2006
    ..Most prior studies of the clinical correlates of AD+P have been limited, however, by the inclusion of prevalent cases...
  40. pmc Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, 200 Lothrop Street BST S521, Pittsburgh, PA 15213 USA
    Acta Neuropathol 123:433-47. 2012
    ..Studies in greater numbers of [C-11]PiB PET autopsy cases are needed to define the Aβ concentration and [H-3]PiB binding levels required to produce a positive [C-11]PiB PET signal...
  41. pmc Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial
    Beth E Snitz
    Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    JAMA 302:2663-70. 2009
    ..The herbal product Ginkgo biloba is taken frequently with the intention of improving cognitive health in aging. However, evidence from adequately powered clinical trials is lacking regarding its effect on long-term cognitive functioning...
  42. ncbi request reprint Superior frontal cortex cholinergic axon density in mild cognitive impairment and early Alzheimer disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, 341 Fifth Ave, Ste 811, Pittsburgh, PA 15213, USA
    Arch Neurol 64:1312-7. 2007
    ....
  43. doi request reprint Oxidative lipidomics of apoptosis: quantitative assessment of phospholipid hydroperoxides in cells and tissues
    Vladimir A Tyurin
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA
    Methods Mol Biol 610:353-74. 2010
    ..This has important implications for evaluation of apoptosis in vivo. The anionic phospholipids, cardiolipin (CL) and phosphatidylserine (PS), are the preferred peroxidation substrates...
  44. ncbi request reprint Gender-specific association of ATP-binding cassette transporter 1 (ABCA1) polymorphisms with the risk of late-onset Alzheimer's disease
    Purnima Desai Sundar
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neurobiol Aging 28:856-62. 2007
    ..Our data suggest a gender-specific and APOE and UBQLN1 independent association between the ABCA1/R219K polymorphism and LOAD...
  45. ncbi request reprint Association of tagSNPs in the urokinase-plasminogen activator (PLAU) gene with Alzheimer's disease and associated quantitative traits
    Ayla Ozturk
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Med Genet B Neuropsychiatr Genet 144:79-82. 2007
    ..01) and disease duration (P = 0.006). Our data on a large number of AD cases and controls suggest that genetic variation in PLAU may affect the risk and AAO of AD...
  46. ncbi request reprint Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report
    Brian J Bacskai
    MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Charlestown, MA 02129, USA
    Arch Neurol 64:431-4. 2007
    ..Imaging revealed marked region specific binding of PiB and abnormal fluorodeoxyglucose uptake. Intervention Autopsy was performed 3 months after the PiB scan...
  47. pmc Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 27:6174-84. 2007
    ..The early, focal striatal amyloid deposition observed in these PS1 mutation carriers is often is not associated with clinical symptoms...
  48. ncbi request reprint Mild cognitive impairment, amnestic type: an epidemiologic study
    Mary Ganguli
    Division of Geriatrics and Neuropsychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neurology 63:115-21. 2004
    ..To estimate the prevalence and examine the course of mild cognitive impairment (MCI), amnestic type, using current criteria, within a representative community sample...
  49. ncbi request reprint Alzheimer disease and mortality: a 15-year epidemiological study
    Mary Ganguli
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15213 2593, USA
    Arch Neurol 62:779-84. 2005
    ..Alzheimer disease (AD) is considered a leading cause of death, but few studies have examined the contribution of AD to mortality based on follow-up of representative US cohorts...
  50. pmc No association between CALHM1 variation and risk of Alzheimer disease
    Ryan L Minster
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hum Mutat 30:E566-9. 2009
    ..368 for genotypes; p=0.796 for alleles) was observed in our sample. However, a potential modest association of minor allele homozygosity (TT) with an earlier age-at-onset was seen (p=0.034)...
  51. ncbi request reprint Alteration of a clinically meaningful outcome in the natural history of Alzheimer's disease by cholinesterase inhibition
    Oscar L Lopez
    Alzheimer s Disease Research Center and Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 53:83-7. 2005
    ..To describe the effect of cholinesterase inhibitors (CEIs) on the natural course of Alzheimer's disease (AD) using clinically meaningful outcomes...
  52. ncbi request reprint Cholinergic plasticity in hippocampus of individuals with mild cognitive impairment: correlation with Alzheimer's neuropathology
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, PA 15213, USA
    J Alzheimers Dis 5:39-48. 2003
    ..Moreover, the present findings suggest that the short-term memory loss observed in MCI is not caused by cholinergic deficits; it more likely relates to disrupted entorhinal-hippocampal connectivity...
  53. pmc Temporoparietal hypometabolism in frontotemporal lobar degeneration and associated imaging diagnostic errors
    Kyle B Womack
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9129, USA
    Arch Neurol 68:329-37. 2011
    ....
  54. ncbi request reprint Effects of post-injury hypothermia and nerve growth factor infusion on antioxidant enzyme activity in the rat: implications for clinical therapies
    Steven T DeKosky
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 90:998-1004. 2004
    ..These results have implications for clinical treatment of TBI, demonstrating that moderate hypothermia suppresses NGF and the antioxidant response after TBI; the latter cannot be countered by exogenous NGF administration...
  55. ncbi request reprint Alzheimer disease subjects with psychosis have increased schizotypal symptoms before dementia onset
    Elise A Eror
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 58:325-30. 2005
    ..One prediction of this model would be that AD+P subjects would have evidence of increased degrees of subsyndromal psychosis before AD onset...
  56. pmc In vivo assessment of amyloid-β deposition in nondemented very elderly subjects
    Chester A Mathis
    Department of Radiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Ann Neurol 73:751-61. 2013
    ....
  57. pmc A medial temporal lobe division of labor: insights from memory in aging and early Alzheimer disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Hippocampus 21:461-6. 2011
    ..These results are consistent with a division of labor in the MTL and the dual process model...
  58. ncbi request reprint Incidence of dementia in mild cognitive impairment in the cardiovascular health study cognition study
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh School of Medicine, 3501 Forbes Ave, Suite 830, Oxford Bldg, Pittsburgh, PA 15213 3323, USA
    Arch Neurol 64:416-20. 2007
    ..To examine the incidence of dementia in subjects with mild cognitive impairment (MCI) in the Cardiovascular Health Study Cognition Study...
  59. ncbi request reprint Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 60:1385-9. 2003
    ..To examine the prevalence of mild cognitive impairment (MCI) and its diagnostic classification in the Cardiovascular Health Study (CHS) Cognition Study...
  60. ncbi request reprint The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component
    William E Klunk
    Laboratory of Molecular Neuropharmacology, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 23:2086-92. 2003
    ..Finally, BTA-1 did not appear to bind significantly to common neuroreceptors or transporter sites. These data suggest that the binding of BTA-1 to AD brain is dominated by a specific interaction with Abeta amyloid deposits...
  61. doi request reprint Simvastatin therapy prevents brain trauma-induced increases in beta-amyloid peptide levels
    Eric E Abrahamson
    Department of Neurology, Brain Trauma Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Ann Neurol 66:407-14. 2009
    ..The ability of statins to reduce post-injury A beta load and ameliorate pathological sequelae of brain injury makes them potentially effective in reducing the risk of developing Alzheimer's disease in TBI patients...
  62. ncbi request reprint Detection and management of cognitive impairment in primary care: The Steel Valley Seniors Survey
    Mary Ganguli
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 52:1668-75. 2004
    ..To identify characteristics of older primary care patients who were cognitively impaired and who underwent mental status testing by their physicians...
  63. ncbi request reprint Reduction of choline acetyltransferase activity in primary visual cortex in mild to moderate Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology and the Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 25213, USA
    Arch Neurol 62:425-30. 2005
    ..Cholinergic deficits in the primary visual cortex (PVC) may underlie some of the abnormalities in visual processing and global cognitive performance in Alzheimer's disease (AD)...
  64. ncbi request reprint Investigation of oxidized LDL-receptor 1 (OLR1) as the candidate gene for Alzheimer's disease on chromosome 12
    Erin Luedecking-Zimmer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Hum Genet 111:443-51. 2002
    ..Our data suggest that genetic variation in the OLR1 gene may modify the risk of AD in an APOE*4-dependent fashion...
  65. pmc Association studies of 22 candidate SNPs with late-onset Alzheimer's disease
    Jessica A Figgins
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Med Genet B Neuropsychiatr Genet 150:520-6. 2009
    ..Our data suggest that the association of the studied variants with LOAD risk, if it exists, is not statistically significant in our sample...
  66. ncbi request reprint Patterns of change in the treatment of psychiatric symptoms in patients with probable Alzheimer's disease from 1983 to 2000
    Oscar L Lopez
    Alzheimer s Disease Research Center, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 15:67-73. 2003
    ..g., aggression, agitation) and sleep disorders in AD. Although the use of SHA has a proven deleterious effect on patients with AD, their use has increased over the past two decades...
  67. ncbi request reprint Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans
    Anne M Fagan
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 59:512-9. 2006
    ..This decrease may reflect plaques acting as an Abeta(42) "sink," hindering transport of soluble Abeta(42) between brain and CSF. We investigated this hypothesis...
  68. ncbi request reprint Development of a short form of the Severe Impairment Battery
    Judith Saxton
    Univ of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 13:999-1005. 2005
    ..The authors sought to develop a short form of the Severe Impairment Battery (SIB)...
  69. pmc Recollection and familiarity in amnestic mild cognitive impairment: a global decline in recognition memory
    David A Wolk
    Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 15213 2582, USA
    Neuropsychologia 46:1965-78. 2008
    ..As familiarity is thought to be spared in normal aging, its measurement may provide a relatively specific marker for the early pathological changes of Alzheimer's disease...
  70. pmc Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, BSTWR S 521, Pittsburgh, PA 15261, USA
    J Histochem Cytochem 56:1065-73. 2008
    ..The relationship between elevated intracellular 5-LOX and hallmark AD pathological lesions provides further evidence that neuroinflammatory pathways contribute to the pathogenesis of AD...
  71. ncbi request reprint Psychosis in Alzheimer disease: postmortem magnetic resonance spectroscopy evidence of excess neuronal and membrane phospholipid pathology
    Robert A Sweet
    Department of Psychiatry, Division of Geriatrics, Neuropsychiatry, University of Pittsburgh School of Medicine, PA, USA
    Neurobiol Aging 23:547-53. 2002
    ..Although AD+P has been inconsistently associated with more severe neuropathology, no prior studies have examined measures of neuronal and synaptic integrity...
  72. ncbi request reprint Cognitive and behavioral correlates of low vitamin B12 levels in elderly patients with progressive dementia
    Ellen M Whyte
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 10:321-7. 2002
    ..In AD, the prevalence of low vitamin B12 serum levels is consistent with that found in community-dwelling elderly persons in general but is associated with greater overall cognitive impairment...
  73. ncbi request reprint Differential cortical atrophy in subgroups of mild cognitive impairment
    Sandra Bell-McGinty
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Neurol 62:1393-7. 2005
    ..To compare gray matter brain volumes in patients diagnosed with subtypes of mild cognitive impairment (MCI) (those with a focal amnestic disorder and those with more diffuse cognitive dysfunction) with those of elderly controls...
  74. ncbi request reprint Looking backward to move forward: early detection of neurodegenerative disorders
    Steven T DeKosky
    Department of Neurology and Alzheimer Disease Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Science 302:830-4. 2003
    ..Early detection of these slowly progressive diseases offers the promise of presymptomatic diagnosis and, ultimately, of disease-modifying medications for use early in disease and during the presymptomatic period...
  75. ncbi request reprint Blood pressure and cognitive impairment in India and the United States: a cross-national epidemiological study
    Rajesh Pandav
    Division of Geriatrics and Neuropsychiatry, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Arch Neurol 60:1123-8. 2003
    ..To evaluate the relationship between blood pressure (BP) and cognitive impairment in elderly populations in India and the United States in a cross-national epidemiological study...
  76. ncbi request reprint Research evaluation and prospective diagnosis of dementia with Lewy bodies
    Oscar L Lopez
    Alzheimer s Disease Research Center, University of Pittsburgh, PA, USA
    Arch Neurol 59:43-6. 2002
    ..To evaluate the relative merits of recently developed criteria for dementia with Lewy bodies (DLBs) in a longitudinal study of dementia...
  77. pmc Caregiving burden and psychiatric morbidity in spouses of persons with mild cognitive impairment
    Linda Garand
    The University of Pittsburgh School of Nursing, Health and Community Systems Department, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 20:512-22. 2005
    ..We characterized the nature and level of caregiver burden and psychiatric morbidity in spouses of persons diagnosed with MCI...
  78. ncbi request reprint Functional analysis of plasma alpha(2)-macroglobulin from Alzheimer's disease patients with the A2M intronic deletion
    Caroline Hope
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neurobiol Dis 14:504-12. 2003
    ..These observations suggest a possible functional basis by which the A2M deletion may influence multifactorial AD pathogenesis...
  79. ncbi request reprint Functional transitions and active life expectancy associated with Alzheimer disease
    Hiroko H Dodge
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    Arch Neurol 60:253-9. 2003
    ....
  80. ncbi request reprint Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study
    Nicolaas I Bohnen
    Departments of Neurology and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Neurol 60:1745-8. 2003
    ..We hypothesized that patients with PDem would have cholinergic deficits that were similar to or greater than those of patients with AD...
  81. ncbi request reprint Genetic variation in alpha(1)-antichymotrypsin and its association with Alzheimer's disease
    Xiaoyan Wang
    Department of Human Genetics, Graduate School of Public Health, 130 DeSoto Street, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hum Genet 110:356-65. 2002
    ....
  82. pmc Lack of association of two chromosome 10q24 SNPs with Alzheimer's disease
    Ryan L Minster
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neurosci Lett 408:170-2. 2006
    ..We examined the association of these two SNPs with LOAD risk in a large Caucasian American cohort comprising about 2000 cases and controls. Neither SNP revealed significant association with LOAD risk or age-at-onset...
  83. ncbi request reprint Caregivers as subjects of clinical drug trials: a review of human subjects protection practices in published studies of Alzheimer's disease pharmacotherapies
    Jennifer Hagerty Lingler
    Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    IRB 28:11-8. 2006
  84. ncbi request reprint Genetic variation in apolipoprotein D affects the risk of Alzheimer disease in African-Americans
    Purnima P Desai
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Med Genet B Neuropsychiatr Genet 116:98-101. 2003
    ..14; P = 0.13). Our data suggest that the risk of AD among African-Americans may be modified by genetic variation in APOD. Larger population-based or case-control studies are needed to confirm the role of APOD genetic variation in AD...
  85. ncbi request reprint Dementia and Alzheimer's disease incidence in relationship to cardiovascular disease in the Cardiovascular Health Study cohort
    Anne B Newman
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Geriatr Soc 53:1101-7. 2005
    ..To determine whether coronary artery disease, peripheral arterial disease (PAD), or noninvasive markers of cardiovascular disease (CVD) predict the onset of dementia and Alzheimer's disease (AD)...
  86. pmc Cholinergic forebrain degeneration in the APPswe/PS1DeltaE9 transgenic mouse
    Sylvia E Perez
    Department of Neurological Sciences, Alla V and Solomon Jesmer Chair in Aging, Rush University Medical Center, 1735 W Harrison Street, Suite 300, Chicago, IL 60612, USA
    Neurobiol Dis 28:3-15. 2007
    ....
  87. ncbi request reprint Preservation of brain nerve growth factor in mild cognitive impairment and Alzheimer disease
    Elliott J Mufson
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, 2242 W Harrison Street, Chicago, IL 60612, USA
    Arch Neurol 60:1143-8. 2003
    ..The status of nerve growth factor (NGF) levels during the prodromal phase of Alzheimer disease (AD), characterized by mild cognitive impairment (MCI), remains unknown...
  88. ncbi request reprint Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial
    Michael Grundman
    Department of Neurosciences, University of California, San Diego, La Jolla, USA
    J Mol Neurosci 19:23-7. 2002
    ..In summary, these data suggest that MRI hippocampal volume may be a useful correlate of disease severity in MCI subjects and a prognostic indicator of subsequent AD...
  89. ncbi request reprint Hippocampal volume is associated with memory but not monmemory cognitive performance in patients with mild cognitive impairment
    Michael Grundman
    Department of Neurosciences, University of California, San Diego, La Jolla 92093 0949, USA
    J Mol Neurosci 20:241-8. 2003
    ..We conclude that the relationship between hippocampal volume and risk of AD is likely tied to reduced memory performance and not associated with impairment in nonmemory cognitive domains...
  90. ncbi request reprint Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease
    Scott E Counts
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Neurol 64:1771-6. 2007
    ..Although alterations in these AChRs occur in the AD cortex, there is little information detailing whether defects in nAChR and mAChR gene expression occur in cholinergic NB neurons during disease progression...
  91. ncbi request reprint Immunohistochemical study of the hnRNP A2 and B1 in the hippocampal formations of brains with Alzheimer's disease
    Katsuyoshi Mizukami
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Neurosci Lett 386:111-5. 2005
    ..Our study suggests that hnRNP A2 and B1 display different responses in the AD hippocampus, and further suggests that the post-transcriptional regulation is disturbed in neurons of the AD hippocampus...
  92. ncbi request reprint Human cholinergic basal forebrain: chemoanatomy and neurologic dysfunction
    Elliott J Mufson
    Department of Neurological Sciences and Alzheimer s Disease Center, Rush Presbyterian St Luke s Medical Center, Tech 2000, 2242 West Harrison St, Suite 200, Chicago, IL 60612, USA
    J Chem Neuroanat 26:233-42. 2003
    ..These observations indicate the complexity of the chemoanatomy of the human CBF and suggest that multiple factors play different roles in its dysfunction in aging and AD...
  93. ncbi request reprint Sex, apolipoprotein E epsilon 4 status, and hippocampal volume in mild cognitive impairment
    Adam Fleisher
    Department of Neurosciences, University of California San Diego, La Jolla, Calif, USA
    Arch Neurol 62:953-7. 2005
    ..The presence of the apolipoprotein E epsilon4 (APOE*E4) allele has been associated with greater hippocampal atrophy in women than in men with Alzheimer disease. This relationship has not been demonstrated in MCI...
  94. ncbi request reprint Changes in hippocampal GABABR1 subunit expression in Alzheimer's patients: association with Braak staging
    Masahiko Iwakiri
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, 305 8575, Tsukuba City, Ibaraki, Japan
    Acta Neuropathol 109:467-74. 2005
    ..Thus, changes in hippocampal GBR1 may reflect alterations in the balance between excitatory and inhibitory neurotransmitter systems, which likely contributes to dysfunction of hippocampal circuitry in AD...
  95. ncbi request reprint Galanin fiber hypertrophy within the cholinergic nucleus basalis during the progression of Alzheimer's disease
    Scott E Counts
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Dement Geriatr Cogn Disord 21:205-14. 2006
    ..These observations indicate that GAL hypertrophy within the anterior NB subfield is a late-stage AD response, which may play a role in regulating the cholinergic tone of remaining basocortical projection neurons...
  96. pmc High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial
    Paul S Aisen
    Department of Neurosciences, University of California, San Diego, 9500 Gilman Dr, M C 0949, La Jolla, CA 92093, USA
    JAMA 300:1774-83. 2008
    ..Prior studies of B vitamins to reduce homocysteine in AD have not had sufficient size or duration to assess their effect on cognitive decline...
  97. ncbi request reprint Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease
    Ayla Ozturk
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Neurobiol Aging 26:1161-5. 2005
    ..However, haplotype analysis revealed a modest association of one haplotype with AD risk (p = 0.04). Additional markers in these genes need to be screened to explore their role in the etiology of AD...
  98. ncbi request reprint Redox-reactive autoantibodies in Alzheimer's patients' cerebrospinal fluids: preliminary studies
    John A McIntyre
    HLA Vascular Biology Laboratory, St Francis Hospital and Health Care Centers, Beech Grove, IN 46107, USA
    Autoimmunity 40:390-6. 2007
    ..These novel autoantibody observations may stimulate thoughts about additional therapeutic approaches and warrant similar studies for other neurodegenerative diseases...
  99. ncbi request reprint Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
    Keith A Johnson
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Neurol 62:229-34. 2007
    ....
  100. ncbi request reprint Immunohistochemical study of hnRNP B1 in the postmortem temporal cortices of patients with Alzheimer's disease
    Masanori Ishikawa
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Neurosci Res 50:481-4. 2004
    ..Our study suggests that hnRNP B1-associated post-transcriptional regulations are preserved in the inferior temporal cortex of Alzheimer's disease...