S M de la Monte

Summary

Publications

  1. ncbi Mitochondrial dna damage and impaired mitochondrial function contribute to apoptosis of insulin-stimulated ethanol-exposed neuronal cells
    S M de la Monte
    Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    Alcohol Clin Exp Res 25:898-906. 2001
  2. ncbi Oxidative stress and hypoxia-like injury cause Alzheimer-type molecular abnormalities in central nervous system neurons
    S M de la Monte
    Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence 02903, USA
    Cell Mol Life Sci 57:1471-81. 2000
  3. ncbi Ethanol impairs insulin-stimulated mitochondrial function in cerebellar granule neurons
    S M de la Monte
    Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence 02903, USA
    Cell Mol Life Sci 58:1950-60. 2001
  4. ncbi Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease
    S M de la Monte
    Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence 02903, USA
    Lab Invest 80:1323-35. 2000
  5. ncbi Aberrant expression of nitric oxide synthase III in Alzheimer's disease: relevance to cerebral vasculopathy and neurodegeneration
    S M de la Monte
    Rhode Island Hospital, Brown University School of Medicine, 55 Claverick Street, 4th Floor, Providence, RI 02903, USA
    Neurobiol Aging 21:309-19. 2000
  6. ncbi Partial rescue of ethanol-induced neuronal apoptosis by growth factor activation of phosphoinositol-3-kinase
    S M de la Monte
    MGH East Cancer Center and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Alcohol Clin Exp Res 24:716-26. 2000
  7. ncbi Role of aberrant nitric oxide synthase-3 expression in cerebrovascular degeneration and vascular-mediated injury in Alzheimer's disease
    S M de la Monte
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston 02129, USA
    Ann N Y Acad Sci 903:61-71. 2000
  8. ncbi Molecular abnormalities of the brain in Down syndrome: relevance to Alzheimer's neurodegeneration
    S M de la Monte
    Massachusetts General Hospital, Harvard Medical School, Boston, USA
    J Neural Transm Suppl 57:1-19. 1999
  9. ncbi Differential effects of ethanol on insulin-signaling through the insulin receptor substrate-1
    S M de la Monte
    MGH East Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, USA
    Alcohol Clin Exp Res 23:770-7. 1999
  10. ncbi The AD7c-ntp neuronal thread protein biomarker for detecting Alzheimer's disease
    Suzanne M de la Monte
    Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island, USA
    Front Biosci 7:d989-96. 2002

Collaborators

Detail Information

Publications26

  1. ncbi Mitochondrial dna damage and impaired mitochondrial function contribute to apoptosis of insulin-stimulated ethanol-exposed neuronal cells
    S M de la Monte
    Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    Alcohol Clin Exp Res 25:898-906. 2001
    ..An important consequence of ethanol inhibition of insulin signaling is increased apoptosis due to reduced levels of insulin-stimulated phosphoinositol-3-kinase activity...
  2. ncbi Oxidative stress and hypoxia-like injury cause Alzheimer-type molecular abnormalities in central nervous system neurons
    S M de la Monte
    Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence 02903, USA
    Cell Mol Life Sci 57:1471-81. 2000
    ..Since similar abnormalities occur in AD, both oxidative stress and hypoxic injury can contribute to AD neurodegeneration...
  3. ncbi Ethanol impairs insulin-stimulated mitochondrial function in cerebellar granule neurons
    S M de la Monte
    Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence 02903, USA
    Cell Mol Life Sci 58:1950-60. 2001
    ....
  4. ncbi Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease
    S M de la Monte
    Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence 02903, USA
    Lab Invest 80:1323-35. 2000
    ..Impaired mitochondrial function caused by MtDNA damage may render brain cells in AD more susceptible to oxidative injury and thereby provide a mechanism by which systemic or environmental factors could influence the course of disease...
  5. ncbi Aberrant expression of nitric oxide synthase III in Alzheimer's disease: relevance to cerebral vasculopathy and neurodegeneration
    S M de la Monte
    Rhode Island Hospital, Brown University School of Medicine, 55 Claverick Street, 4th Floor, Providence, RI 02903, USA
    Neurobiol Aging 21:309-19. 2000
    ..The aggregate findings suggest that cell loss and neurodegeneration may be mediated by somewhat distinct but overlapping mechanisms in AD and AD+CVD...
  6. ncbi Partial rescue of ethanol-induced neuronal apoptosis by growth factor activation of phosphoinositol-3-kinase
    S M de la Monte
    MGH East Cancer Center and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Alcohol Clin Exp Res 24:716-26. 2000
    ..We now provide evidence that the growth-inhibitory effect of ethanol in insulin-stimulated PNET2 cells is partly due to apoptosis...
  7. ncbi Role of aberrant nitric oxide synthase-3 expression in cerebrovascular degeneration and vascular-mediated injury in Alzheimer's disease
    S M de la Monte
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston 02129, USA
    Ann N Y Acad Sci 903:61-71. 2000
    ..The role for phosphodiesterases as modulators of NOS activity is discussed, as these molecules represent potential therapeutic targets given their cell type and cyclic nucleotide specificities of action...
  8. ncbi Molecular abnormalities of the brain in Down syndrome: relevance to Alzheimer's neurodegeneration
    S M de la Monte
    Massachusetts General Hospital, Harvard Medical School, Boston, USA
    J Neural Transm Suppl 57:1-19. 1999
    ..This article reviews the functional importance of abnormal gene expression in relation to Alzheimer-type neurodegeneration in brains of individuals with Down syndrome...
  9. ncbi Differential effects of ethanol on insulin-signaling through the insulin receptor substrate-1
    S M de la Monte
    MGH East Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, USA
    Alcohol Clin Exp Res 23:770-7. 1999
    ..In addition, ethanol exposure may preferentially inhibit downstream signaling that requires interaction between Syp and PY-IRS-1...
  10. ncbi The AD7c-ntp neuronal thread protein biomarker for detecting Alzheimer's disease
    Suzanne M de la Monte
    Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island, USA
    Front Biosci 7:d989-96. 2002
    ..The aggregate results from a number of studies suggest that AD7c-NTP is an excellent biomarker that could be helpful in the routine clinical evaluation of elderly patients at risk for AD...
  11. ncbi Chronic gestational exposure to ethanol impairs insulin-stimulated survival and mitochondrial function in cerebellar neurons
    S M de la Monte
    Department of Medicine, Rhode Island Hospital, Providence 02903, USA
    Cell Mol Life Sci 59:882-93. 2002
    ....
  12. ncbi ATP luminescence-based motility-invasion assay
    Suzanne M de la Monte
    Brown Medical School and Rhode Island Hospital, Providence, USA
    Biotechniques 33:98-100, 102, 104 passim. 2002
    ..In conclusion, the ALMI assay provides a reliable and flexible method to quantify cell motility and invasiveness using a luminescence microplate reader...
  13. ncbi Neurodegeneration changes in primary central nervous system neurons transfected with the Alzheimer-associated neuronal thread protein gene
    S M de la Monte
    Rhode Island Hospital, Brown University Medical School, Providence 02903, USA
    Cell Mol Life Sci 58:844-9. 2001
    ..In addition, we demonstrate that primary post-mitotic neurons can be efficiently transfected with conventional recombinant plasmid DNA to evaluate the effects of gene over-expression in relevant in vitro models...
  14. ncbi Chronic gestational exposure to ethanol causes insulin and IGF resistance and impairs acetylcholine homeostasis in the brain
    S J Soscia
    Department of Pathology, Pierre Galletti Research Building, Rhode Island Hospital, Brown Medical School, Providence, RI 02903, USA
    Cell Mol Life Sci 63:2039-56. 2006
    ..In conclusion, cerebellar hypoplasia in FAS is mediated by insulin/IGF resistance with attendant impairments in energy production and ACh homeostasis...
  15. pmc Impaired placentation in fetal alcohol syndrome
    F Gundogan
    Department of Pathology and Medicine, Women and Infants Hospital, Providence, RI 02903, USA
    Placenta 29:148-57. 2008
    ..Ethanol-impaired placentation is associated with inhibition of AAH expression in trophoblasts. This effect of chronic gestational exposure to ethanol may contribute to IUGR in FAS...
  16. ncbi Ethanol inhibits insulin expression and actions in the developing brain
    S M de la Monte
    Department of Pathology and Medicine, Pierre Galletti Research Building, Rhode Island Hospital, Providence, USA
    Cell Mol Life Sci 62:1131-45. 2005
    ..The results demonstrate that ethanol inhibits insulin-mediated actions in the developing brain by reducing local insulin production and insulin RTK activation, leading to inhibition of glucose transport and ATP production...
  17. pmc Precision-cut slice culture method for rat placenta
    J Gilligan
    Department of Medicine, Liver Research Center, Rhode Island Hospital, Providence, RI, USA
    Placenta 33:67-72. 2012
    ..Herein, we demonstrate the utility of the precision-cut placental slice culture model for studying trophoblastic diseases...
  18. ncbi Alzheimer-associated neuronal thread protein-induced apoptosis and impaired mitochondrial function in human central nervous system-derived neuronal cells
    S M de la Monte
    Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence 02903, USA
    J Neuropathol Exp Neurol 60:195-207. 2001
    ....
  19. ncbi Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease
    S M de la Monte
    Alzheimer s Disease Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston 02129, USA
    J Neurol Sci 152:73-83. 1997
    ..Finally, apoptosis of glial cells (A2B5+) required to maintain the functional integrity of axons and dendrites may represent an important pathogenic mechanism of axonal loss and synaptic disconnection in AD...
  20. ncbi Neuronal thread protein regulation and interaction with microtubule-associated proteins in SH-Sy5y neuronal cells
    S M de la Monte
    Department of Medicine, Rhode Island Hospital and Brown Medical School, 55 Claverick Street, Providence, Rhode Island 02903, USA
    Cell Mol Life Sci 60:2679-91. 2003
    ..The results suggest a functional role for NTP in relation to the turnover or processing of neuronal cytoskeletal proteins, attributes that may be modulated by insulin/IGF-1-mediated signaling...
  21. doi Incidence, risk factors and clinical consequences of neutropenia following kidney transplantation: a retrospective study
    L Zafrani
    Service de transplantation et unité de soins intensifs, Hopital Necker, Paris, France
    Am J Transplant 9:1816-25. 2009
    ..02). G-CSF accelerates recovery of neutropenia and may be a good therapeutic alternative for severely neutropenic patients...
  22. ncbi Metabolic derangements mediate cognitive impairment and Alzheimer's disease: role of peripheral insulin-resistance diseases
    S M de la Monte
    Department of Neuropathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA
    Panminerva Med 54:171-8. 2012
    ..The data suggest that a mal-signaling network mediated by toxic ceramides, ER stress, and insulin-resistance should be targeted to disrupt positive feedback loops that drive the AD neurodegeneration cascade...
  23. pmc Structural and functional heterogeneity of nuclear bodies
    D B Bloch
    Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts
    Mol Cell Biol 19:4423-30. 1999
    ..Taken together, these observations suggest that the nuclear bodies within a cell may be heterogeneous with respect to both composition and function...
  24. ncbi CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression
    K Maemura
    Cardiovascular and the Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 275:36847-51. 2000
    ..These results suggest that CLIF regulates the circadian oscillation of PAI-1 gene expression in endothelial cells. In addition, the results potentially provide a molecular basis for the morning onset of myocardial infarction...
  25. ncbi Identification and characterization of a leukocyte-specific component of the nuclear body
    D B Bloch
    Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Biol Chem 271:29198-204. 1996
    ..The location of Sp140 in the NB, and expression of this gene in cells involved in host defense, suggest that Sp140 may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection...
  26. ncbi Regional and maturation-associated expression of endothelin 2 in rat gastrointestinal tract
    S M de la Monte
    Department of Pathology, Harvard Medical School, Boston, Massachusetts
    J Histochem Cytochem 43:203-9. 1995
    ..Increased ET2 gene expression at the villous tip is associated with more mature overlying epithelial cells, suggesting a possible role for this vasoactive peptide in intestinal epithelial differentiation or secretory activity...