Aminergic receptors in astrogliotic plaques from patients with multiple sclerosisEsther Zeinstra
Department of Neurology, University Hospital Groningen, Hanzeplein 1, 9700RB, The, Groningen, Netherlands
Neurosci Lett 331:87-90. 2002
..Radiotracers for these aminergic receptors might be useful for studying astrogliosis in patients with MS, and compounds acting at some of these receptors may have potential to modulate astroglial function in MS...
- Serum uric acid levels and leukocyte nitric oxide production in multiple sclerosis patients outside relapses
Jop P Mostert
Department of Neurology, Academisch Ziekenhuis Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
J Neurol Sci 231:41-4. 2005
..CONCLUSIONS: Our findings suggest that in MS patients there is no primary deficit in serum uric acid. NO production by peripheral blood leukocytes is increased, but there is no association with serum uric acid levels...
- The insulin-like growth factor system in multiple sclerosis
Daniel Chesik
Department of Neurology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
Int Rev Neurobiol 79:203-26. 2007
..This chapter provides an overview of the role of the IGF system in the pathophysiology of MS, relevant findings in preclinical models, and discusses the possible use of IGF-1 as a therapeutic agent for MS...
Hypoperfusion of the cerebral white matter in multiple sclerosis: possible mechanisms and pathophysiological significanceJacques de Keyser
Department of Neurology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
J Cereb Blood Flow Metab 28:1645-51. 2008
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White-matter astrocytes, axonal energy metabolism, and axonal degeneration in multiple sclerosisMelissa Cambron
Department of Neurology, Center for Neurosciences, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussel, Belgium
J Cereb Blood Flow Metab 32:413-24. 2012
..White-matter astrocytes may be considered as a potential target for neuroprotective MS therapies...
- Vascular aspects of multiple sclerosis
Miguel D'haeseleer
Department of Neurology, Universitair Ziekenhuis Brussel, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium
Lancet Neurol 10:657-66. 2011
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- Astrocytes as potential targets to suppress inflammatory demyelinating lesions in multiple sclerosis
Jacques de Keyser
Department of Neurology, University Hospital Brussel, Vrije Universiteit Brussel, Brussels, Belgium
Neurochem Int 57:446-50. 2010
..If confirmed and extended by additional studies, suppressing the antigen presenting capacity of astrocytes could be a novel therapeutic option for the treatment of MS...
- Tremor in multiple sclerosis
Marcus Koch
Department of Neurology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
J Neurol 254:133-45. 2007
..Physiotherapy, tremor reducing orthoses, and limb cooling can achieve some functional improvement. Tremor in MS remains a significant challenge and unmet need, requiring further basic and clinical research...
- Progression in multiple sclerosis: further evidence of an age dependent process
Marcus Koch
Department of Neurology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
J Neurol Sci 255:35-41. 2007
..Time to progression was significantly shorter in SPMS patients with higher age at disease onset. Our data give further support to the notion that progression in MS is an age dependent process independent of relapses...
- Janus faces of microglia in multiple sclerosis
Patricia Sanders
Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
Brain Res Rev 54:274-85. 2007
..This review provides an overview of the functions of the most important microglia-associated molecules in MS, being CD40, B7-1 and B7-2, interferon-gamma, tumor necrosis factor-alpha, chemokines, prostanoids, and nitric oxide...
- Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes
Marcus W Koch
Neurology 68:1163; author reply 1163-4. 2007
- Insulin-like growth factor binding protein-2 as a regulator of IGF actions in CNS: implications in multiple sclerosis
Daniel Chesik
Department of Neurology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
Cytokine Growth Factor Rev 18:267-78. 2007
..This review discusses our current understanding of biological functions of IGFBP-2 in the CNS and its implications in the demyelinating disease MS...
- The Multiple Sclerosis impact Profile (MSIP). Development and testing psychometric properties of an ICF-based health measure
Klaske Wynia
Department of Health Sciences, University Medical Center Groningen, University of Groningen, The Netherlands
Disabil Rehabil 30:261-74. 2008
..The aim of this study was to develop and test the structure of the Multiple Sclerosis Impact Profile (MSIP), and to evaluate its reliability and validity within a large group of MS patients...
- Cigarette smoking and progression in multiple sclerosis
Marcus Koch
Department of Neurology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
Neurology 69:1515-20. 2007
..To investigate the influence of cigarette smoking on progression and disability accumulation in multiple sclerosis (MS)...
- Peripheral blood leukocyte NO production and oxidative stress in multiple sclerosis
Marcus Koch
Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Mult Scler 14:159-65. 2008
..The reason for increased peripheral blood leukocyte (PBL) nitric oxide (NO) production in patients with multiple sclerosis (MS) is unknown...
- Seizures in multiple sclerosis
Marcus Koch
Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Epilepsia 49:948-53. 2008
..In this article we present an overview of the current literature on the epidemiology, clinical presentation, pathology, imaging, prognosis and treatment of epileptic seizures in MS...
- IGF binding protein alterations on periplaque oligodendrocytes in multiple sclerosis: implications for remyelination
Nadine Wilczak
Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
Neurochem Int 52:1431-5. 2008
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- Plasma S100beta and NSE levels and progression in multiple sclerosis
Marcus Koch
Department of Neurology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
J Neurol Sci 252:154-8. 2007
..33 and -0.38, p=0.027 and 0.003). There were no significant differences between patient groups in plasma S100beta levels. Plasma NSE levels appear inversely related to disease progression in MS...
- Insulin-like growth factor binding proteins: regulation in chronic active plaques in multiple sclerosis and functional analysis of glial cells
Daniel Chesik
Department of Neurology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
Eur J Neurosci 24:1645-52. 2006
..Our results suggest that the up-regulation of IGFBP-2 in reactive astrocytes in MS lesions may primarily serve to enhance the IGF-1-mediated mitogenic stimulus for astrocytes rather than supporting oligodendrocyte survival...
- Uric acid in multiple sclerosis
Marcus Koch
Department of Neurology, University Medical Centre Groningen, University of Groningen, The Netherlands
Neurol Res 28:316-9. 2006
..Serum uric acid levels could be used as a biomarker for monitoring disease activity in MS. Therapeutic strategies aimed at raising serum uric acid levels may have a glial/neuroprotective effect on MS patients...
- The premenstrual period and exacerbations in multiple sclerosis
Anneke Zorgdrager
Department of Neurology, University Hospital Groningen, The Netherlands
Eur Neurol 48:204-6. 2002
..There was no relationship with the premenstrual syndrome, and there was no protective effect of oral contraceptives. Our results suggest that the premenstrual period triggers exacerbations in a subgroup of females with MS...
- Are astrocytes central players in the pathophysiology of multiple sclerosis?
Jacques de Keyser
Department of Neurology, Academisch Ziekenhuis Groningen, The Netherlands
Arch Neurol 60:132-6. 2003
..If this hypothesis is correct, pharmacologic suppression of the antigen-presenting capacities of astrocytes may be a potential therapy for MS...
- Reactive astrocytes in chronic active lesions of multiple sclerosis express co-stimulatory molecules B7-1 and B7-2
Esther Zeinstra
Department of Neurology, University Hospital Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
J Neuroimmunol 135:166-71. 2003
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- Peripheral blood leukocyte NO production in MS patients with a benign vs progressive course
Geeta S M Ramsaransing
Department of Neurology, Academisch Ziekenhuis Groningen, The Netherlands
Neurology 62:239-42. 2004
..There was a correlation between nitrite concentrations and serum levels of IL-12 (p = 0.04), but not of TNFalpha. CONCLUSION: Increased NO production by PBL in patients with MS is independent of the disease course...
- Astrocytic beta2-adrenergic receptors and multiple sclerosis
Jacques de Keyser
Department of Neurology, University Hospital Groningen, Groningen, The Netherlands
Neurobiol Dis 15:331-9. 2004
..Fourth, it may impair astrocytic glycogenolysis, which supplies energy to axons, and this may represent a mechanism underlying axonal degeneration that is hold responsible for the progressive chronic disability...
- Beta 2-adrenoceptor involvement in inflammatory demyelination and axonal degeneration in multiple sclerosis
Jacques de Keyser
Department of Neurology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
Trends Pharmacol Sci 25:67-71. 2004
..If this hypothesis is correct, therapies designed to elevate cAMP levels in astrocytes should reduce or prevent both relapses and progression of MS...
- Search for morbillivirus proteins in multiple sclerosis brain tissue
Felix Geeraedts
Department of Neurology, Academisch Ziekenhuis Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
Neuroreport 15:27-32. 2004
..The F3-5 epitope may represent a protein that is upregulated during inflammation or point to a yet unrecognised morbillivirus in the human central nervous system that might be implicated in MS pathogenesis...
- Inheritance mode of multiple sclerosis: the effect of HLA class II alleles is stronger than additive
Maartje Boon
Department of Neurology, University Hospital Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
Hum Genet 115:280-4. 2004
..31-164.74). This susceptibility locus for MS seems to follow an intermediate mode of inheritance. Fitting additive, multiplicative and third power risk models to the data, the effect appears to be significantly stronger than additive...
- Reducing discrepancies between MS patients' needs and use of healthcare services by applying a transmural care model
Barth Oeseburg
Groningen University Medical Center, Department of Health Sciences, Department of Nursing Affairs, Groningen, Netherlands
J Neurosci Nurs 36:214-9, 230. 2004
..There were no significant changes over time in EDSS, ISS, ESS, and RAND-36. Overall, the TCMMS was applicable to practice and decreased the discrepancies between needs and services...
- (1)H MR spectroscopy of the brain in multiple sclerosis subtypes with analysis of the metabolite concentrations in gray and white matter: initial findings
Paul E Sijens
Department of Radiology, University Medical Center Groningen, Hanzeplein 1, 9713, GZ Groningen, The Netherlands
Eur Radiol 16:489-95. 2006
..In conclusion, the concentrations of Cho, Cr and NAA are reduced in PPMS/SPMS patients, especially in GM and in WML. Despite contrary observations in previous studies, increases in the concentrations of Cr and/or Cho were not observed...
- Oxidative stress in serum and peripheral blood leukocytes in patients with different disease courses of multiple sclerosis
Marcus Koch
Department of Neurology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
J Neurol 253:483-7. 2006
..The role of oxidative stress in patients with multiple sclerosis (MS) is poorly understood...
- Relationships between brain water content and diffusion tensor imaging parameters (apparent diffusion coefficient and fractional anisotropy) in multiple sclerosis
Paul E Sijens
Department of Radiology, University Medical Center Groningen and University of Groningen, The Netherlands
Eur Radiol 16:898-904. 2006
..88; P<0.00001) than in GM (r=-0.69, P<0.01). The demonstrated relationship between DTI parameters and water content in multiple sclerosis patients suggests a potential for therapy monitoring in normal-appearing brain tissue...
- Fluoxetine increases cerebral white matter NAA/Cr ratio in patients with multiple sclerosis
Jop P Mostert
Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands
Neurosci Lett 402:22-4. 2006
..84 at the end of the second week (p=0.007). These findings show evidence for a reversible axonal dysfunction in patients with MS and provide a rationale for investigating whether fluoxetine has neuroprotective effects in MS...
