Jacques de Keyser

Summary

Publications

  1. ncbi request reprint Aminergic receptors in astrogliotic plaques from patients with multiple sclerosis
    Esther Zeinstra
    Department of Neurology, University Hospital Groningen, Hanzeplein 1, 9700RB, The, Groningen, Netherlands
    Neurosci Lett 331:87-90. 2002
  2. ncbi request reprint Serum uric acid levels and leukocyte nitric oxide production in multiple sclerosis patients outside relapses
    Jop P Mostert
    Department of Neurology, Academisch Ziekenhuis Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Neurol Sci 231:41-4. 2005
  3. ncbi request reprint The insulin-like growth factor system in multiple sclerosis
    Daniel Chesik
    Department of Neurology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Int Rev Neurobiol 79:203-26. 2007
  4. doi request reprint Hypoperfusion of the cerebral white matter in multiple sclerosis: possible mechanisms and pathophysiological significance
    Jacques de Keyser
    Department of Neurology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    J Cereb Blood Flow Metab 28:1645-51. 2008
  5. pmc Cerebral hypoperfusion in multiple sclerosis is reversible and mediated by endothelin-1
    Miguel D'haeseleer
    Department of Neurology, Universitair Ziekenhuis Brussel, 1090 Brussels, Belgium
    Proc Natl Acad Sci U S A 110:5654-8. 2013
  6. pmc White-matter astrocytes, axonal energy metabolism, and axonal degeneration in multiple sclerosis
    Melissa Cambron
    Department of Neurology, Center for Neurosciences, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussel, Belgium
    J Cereb Blood Flow Metab 32:413-24. 2012
  7. doi request reprint Vascular aspects of multiple sclerosis
    Miguel D'haeseleer
    Department of Neurology, Universitair Ziekenhuis Brussel, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium
    Lancet Neurol 10:657-66. 2011
  8. doi request reprint Astrocytes as potential targets to suppress inflammatory demyelinating lesions in multiple sclerosis
    Jacques de Keyser
    Department of Neurology, University Hospital Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Neurochem Int 57:446-50. 2010
  9. ncbi request reprint Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes
    Marcus W Koch
    Neurology 68:1163; author reply 1163-4. 2007
  10. ncbi request reprint Janus faces of microglia in multiple sclerosis
    Patricia Sanders
    Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Brain Res Rev 54:274-85. 2007

Collaborators

  • Daniel Chesik
  • Miguel D'haeseleer
  • Roel Beelen
  • Marcus W Koch
  • P E Sijens
  • Klaske Wynia
  • Nadine Wilczak
  • Jop P Mostert
  • Esther Zeinstra
  • Melissa Cambron
  • Geeta S M Ramsaransing
  • Patricia Sanders
  • Barth Oeseburg
  • Maartje Boon
  • Felix Geeraedts
  • Anneke Zorgdrager
  • Ralph Clinckers
  • Jan Debruyne
  • Guy Laureys
  • Dick Hoekstra
  • Matthijs Oudkerk
  • Marco Heerings
  • Dorothea J Heersema
  • Albert Teelken
  • Gerard J Te Meerman
  • Ilja M Nolte
  • Charles H C M Buys
  • Rob van Binnendijk
  • Alexander V Arutjunyan
  • Daniëlle Jansen
  • Paula Te Riele
  • Xavier Langlois
  • Josée Leysen

Detail Information

Publications34

  1. ncbi request reprint Aminergic receptors in astrogliotic plaques from patients with multiple sclerosis
    Esther Zeinstra
    Department of Neurology, University Hospital Groningen, Hanzeplein 1, 9700RB, The, Groningen, Netherlands
    Neurosci Lett 331:87-90. 2002
    ..Radiotracers for these aminergic receptors might be useful for studying astrogliosis in patients with MS, and compounds acting at some of these receptors may have potential to modulate astroglial function in MS...
  2. ncbi request reprint Serum uric acid levels and leukocyte nitric oxide production in multiple sclerosis patients outside relapses
    Jop P Mostert
    Department of Neurology, Academisch Ziekenhuis Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Neurol Sci 231:41-4. 2005
    ..Because peripheral blood leukocyte NO production and NO metabolites in serum are raised in MS patients, associations might be expected between serum uric acid levels and peripheral NO production...
  3. ncbi request reprint The insulin-like growth factor system in multiple sclerosis
    Daniel Chesik
    Department of Neurology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Int Rev Neurobiol 79:203-26. 2007
    ..This chapter provides an overview of the role of the IGF system in the pathophysiology of MS, relevant findings in preclinical models, and discusses the possible use of IGF-1 as a therapeutic agent for MS...
  4. doi request reprint Hypoperfusion of the cerebral white matter in multiple sclerosis: possible mechanisms and pathophysiological significance
    Jacques de Keyser
    Department of Neurology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    J Cereb Blood Flow Metab 28:1645-51. 2008
    ....
  5. pmc Cerebral hypoperfusion in multiple sclerosis is reversible and mediated by endothelin-1
    Miguel D'haeseleer
    Department of Neurology, Universitair Ziekenhuis Brussel, 1090 Brussels, Belgium
    Proc Natl Acad Sci U S A 110:5654-8. 2013
    ..Restoring CBF by interfering with the ET-1 system warrants further investigation as a potential new therapeutic target for MS...
  6. pmc White-matter astrocytes, axonal energy metabolism, and axonal degeneration in multiple sclerosis
    Melissa Cambron
    Department of Neurology, Center for Neurosciences, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussel, Belgium
    J Cereb Blood Flow Metab 32:413-24. 2012
    ..White-matter astrocytes may be considered as a potential target for neuroprotective MS therapies...
  7. doi request reprint Vascular aspects of multiple sclerosis
    Miguel D'haeseleer
    Department of Neurology, Universitair Ziekenhuis Brussel, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium
    Lancet Neurol 10:657-66. 2011
    ....
  8. doi request reprint Astrocytes as potential targets to suppress inflammatory demyelinating lesions in multiple sclerosis
    Jacques de Keyser
    Department of Neurology, University Hospital Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Neurochem Int 57:446-50. 2010
    ..If confirmed and extended by additional studies, suppressing the antigen presenting capacity of astrocytes could be a novel therapeutic option for the treatment of MS...
  9. ncbi request reprint Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes
    Marcus W Koch
    Neurology 68:1163; author reply 1163-4. 2007
  10. ncbi request reprint Janus faces of microglia in multiple sclerosis
    Patricia Sanders
    Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Brain Res Rev 54:274-85. 2007
    ..This review provides an overview of the functions of the most important microglia-associated molecules in MS, being CD40, B7-1 and B7-2, interferon-gamma, tumor necrosis factor-alpha, chemokines, prostanoids, and nitric oxide...
  11. ncbi request reprint Progression in multiple sclerosis: further evidence of an age dependent process
    Marcus Koch
    Department of Neurology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Neurol Sci 255:35-41. 2007
    ..Time to progression was significantly shorter in SPMS patients with higher age at disease onset. Our data give further support to the notion that progression in MS is an age dependent process independent of relapses...
  12. pmc Tremor in multiple sclerosis
    Marcus Koch
    Department of Neurology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Neurol 254:133-45. 2007
    ..Physiotherapy, tremor reducing orthoses, and limb cooling can achieve some functional improvement. Tremor in MS remains a significant challenge and unmet need, requiring further basic and clinical research...
  13. ncbi request reprint Insulin-like growth factor binding protein-2 as a regulator of IGF actions in CNS: implications in multiple sclerosis
    Daniel Chesik
    Department of Neurology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Cytokine Growth Factor Rev 18:267-78. 2007
    ..This review discusses our current understanding of biological functions of IGFBP-2 in the CNS and its implications in the demyelinating disease MS...
  14. ncbi request reprint The Multiple Sclerosis impact Profile (MSIP). Development and testing psychometric properties of an ICF-based health measure
    Klaske Wynia
    Department of Health Sciences, University Medical Center Groningen, University of Groningen, The Netherlands
    Disabil Rehabil 30:261-74. 2008
    ..The aim of this study was to develop and test the structure of the Multiple Sclerosis Impact Profile (MSIP), and to evaluate its reliability and validity within a large group of MS patients...
  15. ncbi request reprint Cigarette smoking and progression in multiple sclerosis
    Marcus Koch
    Department of Neurology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Neurology 69:1515-20. 2007
    ..To investigate the influence of cigarette smoking on progression and disability accumulation in multiple sclerosis (MS)...
  16. ncbi request reprint Peripheral blood leukocyte NO production and oxidative stress in multiple sclerosis
    Marcus Koch
    Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Mult Scler 14:159-65. 2008
    ..The reason for increased peripheral blood leukocyte (PBL) nitric oxide (NO) production in patients with multiple sclerosis (MS) is unknown...
  17. doi request reprint Seizures in multiple sclerosis
    Marcus Koch
    Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Epilepsia 49:948-53. 2008
    ..In this article we present an overview of the current literature on the epidemiology, clinical presentation, pathology, imaging, prognosis and treatment of epileptic seizures in MS...
  18. doi request reprint IGF binding protein alterations on periplaque oligodendrocytes in multiple sclerosis: implications for remyelination
    Nadine Wilczak
    Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Neurochem Int 52:1431-5. 2008
    ....
  19. ncbi request reprint Plasma S100beta and NSE levels and progression in multiple sclerosis
    Marcus Koch
    Department of Neurology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Neurol Sci 252:154-8. 2007
    ..33 and -0.38, p=0.027 and 0.003). There were no significant differences between patient groups in plasma S100beta levels. Plasma NSE levels appear inversely related to disease progression in MS...
  20. ncbi request reprint Insulin-like growth factor binding proteins: regulation in chronic active plaques in multiple sclerosis and functional analysis of glial cells
    Daniel Chesik
    Department of Neurology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Eur J Neurosci 24:1645-52. 2006
    ..Our results suggest that the up-regulation of IGFBP-2 in reactive astrocytes in MS lesions may primarily serve to enhance the IGF-1-mediated mitogenic stimulus for astrocytes rather than supporting oligodendrocyte survival...
  21. ncbi request reprint The premenstrual period and exacerbations in multiple sclerosis
    Anneke Zorgdrager
    Department of Neurology, University Hospital Groningen, The Netherlands
    Eur Neurol 48:204-6. 2002
    ..There was no relationship with the premenstrual syndrome, and there was no protective effect of oral contraceptives. Our results suggest that the premenstrual period triggers exacerbations in a subgroup of females with MS...
  22. ncbi request reprint Are astrocytes central players in the pathophysiology of multiple sclerosis?
    Jacques de Keyser
    Department of Neurology, Academisch Ziekenhuis Groningen, The Netherlands
    Arch Neurol 60:132-6. 2003
    ..If this hypothesis is correct, pharmacologic suppression of the antigen-presenting capacities of astrocytes may be a potential therapy for MS...
  23. ncbi request reprint Reactive astrocytes in chronic active lesions of multiple sclerosis express co-stimulatory molecules B7-1 and B7-2
    Esther Zeinstra
    Department of Neurology, University Hospital Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    J Neuroimmunol 135:166-71. 2003
    ....
  24. ncbi request reprint Peripheral blood leukocyte NO production in MS patients with a benign vs progressive course
    Geeta S M Ramsaransing
    Department of Neurology, Academisch Ziekenhuis Groningen, The Netherlands
    Neurology 62:239-42. 2004
    ..Nitric oxide (NO) may play a role in tissue destruction and axonal degeneration in multiple sclerosis (MS)...
  25. ncbi request reprint Astrocytic beta2-adrenergic receptors and multiple sclerosis
    Jacques de Keyser
    Department of Neurology, University Hospital Groningen, Groningen, The Netherlands
    Neurobiol Dis 15:331-9. 2004
    ..Fourth, it may impair astrocytic glycogenolysis, which supplies energy to axons, and this may represent a mechanism underlying axonal degeneration that is hold responsible for the progressive chronic disability...
  26. ncbi request reprint Beta 2-adrenoceptor involvement in inflammatory demyelination and axonal degeneration in multiple sclerosis
    Jacques de Keyser
    Department of Neurology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Trends Pharmacol Sci 25:67-71. 2004
    ..If this hypothesis is correct, therapies designed to elevate cAMP levels in astrocytes should reduce or prevent both relapses and progression of MS...
  27. ncbi request reprint Search for morbillivirus proteins in multiple sclerosis brain tissue
    Felix Geeraedts
    Department of Neurology, Academisch Ziekenhuis Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Neuroreport 15:27-32. 2004
    ..The F3-5 epitope may represent a protein that is upregulated during inflammation or point to a yet unrecognised morbillivirus in the human central nervous system that might be implicated in MS pathogenesis...
  28. ncbi request reprint Inheritance mode of multiple sclerosis: the effect of HLA class II alleles is stronger than additive
    Maartje Boon
    Department of Neurology, University Hospital Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Hum Genet 115:280-4. 2004
    ..31-164.74). This susceptibility locus for MS seems to follow an intermediate mode of inheritance. Fitting additive, multiplicative and third power risk models to the data, the effect appears to be significantly stronger than additive...
  29. ncbi request reprint Reducing discrepancies between MS patients' needs and use of healthcare services by applying a transmural care model
    Barth Oeseburg
    Groningen University Medical Center, Department of Health Sciences, Department of Nursing Affairs, Groningen, Netherlands
    J Neurosci Nurs 36:214-9, 230. 2004
    ..There were no significant changes over time in EDSS, ISS, ESS, and RAND-36. Overall, the TCMMS was applicable to practice and decreased the discrepancies between needs and services...
  30. ncbi request reprint (1)H MR spectroscopy of the brain in multiple sclerosis subtypes with analysis of the metabolite concentrations in gray and white matter: initial findings
    Paul E Sijens
    Department of Radiology, University Medical Center Groningen, Hanzeplein 1, 9713, GZ Groningen, The Netherlands
    Eur Radiol 16:489-95. 2006
    ..In conclusion, the concentrations of Cho, Cr and NAA are reduced in PPMS/SPMS patients, especially in GM and in WML. Despite contrary observations in previous studies, increases in the concentrations of Cr and/or Cho were not observed...
  31. ncbi request reprint Oxidative stress in serum and peripheral blood leukocytes in patients with different disease courses of multiple sclerosis
    Marcus Koch
    Department of Neurology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    J Neurol 253:483-7. 2006
    ..The role of oxidative stress in patients with multiple sclerosis (MS) is poorly understood...
  32. ncbi request reprint Relationships between brain water content and diffusion tensor imaging parameters (apparent diffusion coefficient and fractional anisotropy) in multiple sclerosis
    Paul E Sijens
    Department of Radiology, University Medical Center Groningen and University of Groningen, The Netherlands
    Eur Radiol 16:898-904. 2006
    ..88; P<0.00001) than in GM (r=-0.69, P<0.01). The demonstrated relationship between DTI parameters and water content in multiple sclerosis patients suggests a potential for therapy monitoring in normal-appearing brain tissue...
  33. ncbi request reprint Fluoxetine increases cerebral white matter NAA/Cr ratio in patients with multiple sclerosis
    Jop P Mostert
    Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands
    Neurosci Lett 402:22-4. 2006
    ..84 at the end of the second week (p=0.007). These findings show evidence for a reversible axonal dysfunction in patients with MS and provide a rationale for investigating whether fluoxetine has neuroprotective effects in MS...
  34. ncbi request reprint Uric acid in multiple sclerosis
    Marcus Koch
    Department of Neurology, University Medical Centre Groningen, University of Groningen, The Netherlands
    Neurol Res 28:316-9. 2006
    ..Serum uric acid levels could be used as a biomarker for monitoring disease activity in MS. Therapeutic strategies aimed at raising serum uric acid levels may have a glial/neuroprotective effect on MS patients...