Research Topics

Hans De Winter

Summary

Publications

  1. Van Rompaey D, Verstraete K, Peelman F, Savvides S, Augustyns K, Van der Veken P, et al. Author Correction: Virtual screening for inhibitors of the human TSLP:TSLPR interaction. Sci Rep. 2018;8:6673 pubmed publisher
    ..A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ..
  2. Gladysz R, Dos Santos F, Langenaeker W, Thijs G, Augustyns K, De Winter H. Spectrophores as one-dimensional descriptors calculated from three-dimensional atomic properties: applications ranging from scaffold hopping to multi-target virtual screening. J Cheminform. 2018;10:9 pubmed publisher
    ..In our present report we demonstrate the applicability of our novel methodology for scaffold hopping as well as virtual screening. ..
  3. Rea D, Van Elzen R, De Winter H, Van Goethem S, Landuyt B, Luyten W, et al. Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling. Eur J Med Chem. 2017;139:482-491 pubmed publisher
    ..The functional similarity between human and bacterial DPP4 was confirmed using 124 potential peptide substrates. ..
  4. Van Rompaey D, Verstraete K, Peelman F, Savvides S, Augustyns K, Van der Veken P, et al. Virtual screening for inhibitors of the human TSLP:TSLPR interaction. Sci Rep. 2017;7:17211 pubmed publisher
    ..This work provides a proof-of-principle for use of fragments in the inhibition of TSLP:TSLPR complexation. ..
  5. Ryabtsova O, Joossens J, Van der Veken P, Vanden Berghe W, Augustyns K, De Winter H. Novel selective glucocorticoid receptor agonists (SEGRAs) with a covalent warhead for long-lasting inhibition. Bioorg Med Chem Lett. 2016;26:5032-5038 pubmed publisher
    ..The synthesis and in vitro properties of six analogues of the selective glucocorticoid receptor (GR) agonist GSK866, bearing a warhead for covalent linkage to the glucocorticoid receptor, is described. ..