M I Dawson

Summary

Publications

  1. ncbi request reprint The importance of vitamin A in nutrition
    M I Dawson
    Department of Medicinal Chemistry, Molecular Medicine Research Institute, 325 East Middlefield Rd, Mountain View, CA 94943, USA
    Curr Pharm Des 6:311-25. 2000
  2. ncbi request reprint sp2-bridged diaryl retinoids: effects of bridge-region substitution on retinoid X receptor (RXR) selectivity
    M I Dawson
    Medicinal Chemistry Department, Molecular Medicine Research Institute, Mountain View, CA 94043, USA
    Bioorg Med Chem Lett 10:1307-10. 2000
  3. ncbi request reprint 4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists
    M I Dawson
    Medicinal Chemistry Department, Molecular Medicine Research Institute, Mountain View, CA 94043, USA
    Bioorg Med Chem Lett 10:1311-3. 2000
  4. ncbi request reprint Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA-induced ZBP-89 in ODC inhibition
    M I Dawson
    Molecular Medicine Research Institute, Mountain View, CA 94043, USA
    Int J Cancer 91:8-21. 2001
  5. ncbi request reprint Discovery and design of retinoic acid receptor and retinoid X receptor class- and subtype-selective synthetic analogs of all-trans-retinoic acid and 9-cis-retinoic acid
    Marcia I Dawson
    Department of Medicinal Chemistry, Molecular Medicine Research Institute, Mountain View, La Jolla, CA 94043, USA
    Curr Med Chem 9:623-37. 2002
  6. ncbi request reprint Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity
    M I Dawson
    Department of Medicinal Chemistry, Molecular Medicine Research Institute, Mountain View, California 94043, USA
    Cancer Res 61:4723-30. 2001
  7. ncbi request reprint Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt
    Y H Han
    Burnham Institute for Medical Research, Cancer Center, La Jolla, CA 92037, USA
    Oncogene 25:2974-86. 2006
  8. ncbi request reprint Synthetic retinoids and their nuclear receptors
    M I Dawson
    Cancer Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Med Chem Anticancer Agents 4:199-230. 2004
  9. ncbi request reprint Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3
    H Li
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 289:1159-64. 2000
  10. ncbi request reprint Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest
    Marcia I Dawson
    The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Med Chem 47:3518-36. 2004

Collaborators

Detail Information

Publications26

  1. ncbi request reprint The importance of vitamin A in nutrition
    M I Dawson
    Department of Medicinal Chemistry, Molecular Medicine Research Institute, 325 East Middlefield Rd, Mountain View, CA 94943, USA
    Curr Pharm Des 6:311-25. 2000
    ..In addition to serving as a metabolic source of retinol, beta-carotene, along with other dietary carotenoids, function as antioxidants that can prevent carcinogenesis by decreasing the levels of the free-radicals that cause DNA damage...
  2. ncbi request reprint sp2-bridged diaryl retinoids: effects of bridge-region substitution on retinoid X receptor (RXR) selectivity
    M I Dawson
    Medicinal Chemistry Department, Molecular Medicine Research Institute, Mountain View, CA 94043, USA
    Bioorg Med Chem Lett 10:1307-10. 2000
    ....
  3. ncbi request reprint 4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists
    M I Dawson
    Medicinal Chemistry Department, Molecular Medicine Research Institute, Mountain View, CA 94043, USA
    Bioorg Med Chem Lett 10:1311-3. 2000
    ..Both classes of these ligand-inducible transcription factors are involved in mediating the inhibitory effects of retinoids on cancer cell growth...
  4. ncbi request reprint Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA-induced ZBP-89 in ODC inhibition
    M I Dawson
    Molecular Medicine Research Institute, Mountain View, CA 94043, USA
    Int J Cancer 91:8-21. 2001
    ..The natural retinoid all-trans-RA induced expression of transcription factor ZBP-89, which represses activation of the GC box in the ODC promoter by the transcription factor Sp1...
  5. ncbi request reprint Discovery and design of retinoic acid receptor and retinoid X receptor class- and subtype-selective synthetic analogs of all-trans-retinoic acid and 9-cis-retinoic acid
    Marcia I Dawson
    Department of Medicinal Chemistry, Molecular Medicine Research Institute, Mountain View, La Jolla, CA 94043, USA
    Curr Med Chem 9:623-37. 2002
    ....
  6. ncbi request reprint Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity
    M I Dawson
    Department of Medicinal Chemistry, Molecular Medicine Research Institute, Mountain View, California 94043, USA
    Cancer Res 61:4723-30. 2001
    ..These studies strongly suggest that AHPN exerts its cell cycle arrest and apoptotic activity by a signaling pathway independent of retinoid receptor activation...
  7. ncbi request reprint Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt
    Y H Han
    Burnham Institute for Medical Research, Cancer Center, La Jolla, CA 92037, USA
    Oncogene 25:2974-86. 2006
    ..Together, our results demonstrate that both activation of JNK and inhibition of Akt play a role in translocation of Nur77 from the nucleus to the cytoplasm...
  8. ncbi request reprint Synthetic retinoids and their nuclear receptors
    M I Dawson
    Cancer Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Med Chem Anticancer Agents 4:199-230. 2004
    ..Emphasis is placed on the retinoid X receptors and their ligands...
  9. ncbi request reprint Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3
    H Li
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 289:1159-64. 2000
    ..Our results reveal a mechanism by which a nuclear transcription factor translocates to mitochondria to initiate apoptosis...
  10. ncbi request reprint Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest
    Marcia I Dawson
    The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Med Chem 47:3518-36. 2004
    ..As a result, the position of RARgamma helix H12 in forming the coactivator-binding site was impacted in a manner consistent with the experimental effect of each analogue on RARgamma transcriptional activation...
  11. ncbi request reprint Nicotine modulates the effects of retinoids on growth inhibition and RAR beta expression in lung cancer cells
    Guo quan Chen
    The Burnham Institute, Cancer Center, La Jolla, CA 92037, USA
    Int J Cancer 99:171-8. 2002
    ....
  12. ncbi request reprint Determinants of retinoid X receptor transcriptional antagonism
    Claudio N Cavasotto
    Cancer Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    J Med Chem 47:4360-72. 2004
    ..The antagonist also blocked activation of RAR subtypes alpha and beta by 9-cis-RA but not that of RARgamma...
  13. pmc Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene
    Marcia I Dawson
    Cancer Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA
    ChemMedChem 4:1106-19. 2009
    ....
  14. ncbi request reprint The peptidomimetic, 1-adamantyl-substituted, and flex-het classes of retinoid-derived molecules: structure-activity relationships and retinoid receptor-independent anticancer activities
    Marcia I Dawson
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mini Rev Med Chem 10:455-91. 2010
    ..Structure-activity relationships and potential for clinical translation as anticancer therapeutics are presented...
  15. ncbi request reprint Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells
    Sharon Y James
    Cancer Center, The Burnham Institute, La Jolla, California 92037, USA
    Cancer Res 63:3531-8. 2003
    ....
  16. ncbi request reprint Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3
    Bingzhen Lin
    The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 116:527-40. 2004
    ....
  17. doi request reprint Studies of cannabinoid-1 receptor antagonists for the treatment of obesity: hologram QSAR model for biarylpyrazolyl oxadiazole ligands
    Mao Ye
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Bioorg Med Chem Lett 19:3310-5. 2009
    ..Both the HQSAR model and analysis from the contribution map should be useful for the further design of novel structurally related CB(1) antagonists...
  18. pmc Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting
    Xihua Cao
    The Burnham Institute, Cancer Center, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Mol Cell Biol 24:9705-25. 2004
    ..Together, our results reveal a novel nongenotropic function of RXRalpha and its involvement in the regulation of the Nur77-dependent apoptotic pathway [corrected]..
  19. pmc An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and
    Marcia I Dawson
    Cancer Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Med Chem 50:2622-39. 2007
    ..3-Cl-AHPC at 1.0 microM induced human microvascular endothelial cell apoptosis but did not inhibit cell migration or tube formation...
  20. doi request reprint 3D-QSAR and QSSR studies of 3,8-diazabicyclo[4.2.0]octane derivatives as neuronal nicotinic acetylcholine receptors by comparative molecular field analysis (CoMFA)
    Mao Ye
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Bioorg Med Chem Lett 19:127-31. 2009
    ..924, 0.935 and 0.875 for conventional r(2). Analyses indicated that both the steric and electrostatic factors should be considered in the rational design of more active and selective nAChR agonists...
  21. doi request reprint Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and
    Marcia I Dawson
    Cancer Center and Inflammatory and Infectious Disease Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Med Chem 51:5650-62. 2008
    ..Inhibitory activity against Src homology 2 domain-containing protein tyrosine phosphatase 2 (Shp-2) was also assessed. The most active Shp-2 inhibitor was found to be the 3'-(3,3-dimethylbutynyl) analogue of 3-Cl-AHPC...
  22. pmc Mass-spectrometric analysis of agonist-induced retinoic acid receptor gamma conformational change
    Valerie J Peterson
    Laboratory of Molecular Pharmacology, Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, U S A
    Biochem J 362:173-81. 2002
    ..This technique should be generally applicable to other members of the nuclear receptor superfamily that undergo an induced structural alteration upon agonist or antagonist binding, DNA binding and/or protein-protein interaction...
  23. pmc Retinoic acid (RA) regulates 17beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolism
    You Hong Cheng
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, 303 E Superior Street, Chicago, IL 60611, USA
    J Clin Endocrinol Metab 93:1915-23. 2008
    ..Retinoic acid (RA) induces HSD17B2 expression, but the underlying mechanism is not known...
  24. ncbi request reprint Induction of apoptosis of human B-CLL and ALL cells by a novel retinoid and its nonretinoidal analog
    Yuxiang Zhang
    Department of Medicine, Karmanos Cancer Institute, Wayne State University, and the John D Dingell VA Medical Center, Detroit, MI 48201, USA
    Blood 100:2917-25. 2002
    ..These results suggest that CD437 and MM002 analogs may have a potential role in the treatment of B-CLL and ALL...
  25. ncbi request reprint Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437
    Arun K Rishi
    Veterans Affairs Medical Center, Department of Internal Medicine and Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 278:33422-35. 2003
    ..Identification of CARP-1 as a key mediator of signaling by CD437 or adriamycin allows for delineation of pathways that, in turn, may prove beneficial for design and targeting of novel antitumor agents...
  26. ncbi request reprint Induction of apoptosis in retinoid-refractory acute myelogenous leukemia by a novel AHPN analog
    Yuxiang Zhang
    John D Dingell VA Medical Center, and Department of Medicine, Wayne State University, Detroit, MI 48201, USA
    Blood 102:3743-52. 2003
    ..3-log kill in the leukemic blasts. While 3-Cl-AHPC does not activate retinoic nuclear receptors, it is a potent inducer of apoptosis in AML cells and may represent a novel therapy in the treatment of this disease...