Behavioral interventions in children and adolescents with autism spectrum disorder: a review of recent findingsGeraldine Dawson
Autism Speaks and Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Curr Opin Pediatr 23:616-20. 2011
..The study provides an overview of recent studies on behavioral interventions for children and adolescents with autism spectrum disorder (ASD)...
Early behavioral intervention is associated with normalized brain activity in young children with autismGeraldine Dawson
University of North Carolina at Chapel Hill, the University of Washington UW, and Autism Speaks
J Am Acad Child Adolesc Psychiatry 51:1150-9. 2012
..This report describes a secondary outcome measurement from this trial, EEG activity...
- Social attention: a possible early indicator of efficacy in autism clinical trials
Geraldine Dawson
Autism Speaks, New York, NY, USA
J Neurodev Disord 4:11. 2012
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- Autism risk assessment in siblings of affected children using sex-specific genetic scores
Jerome Carayol
IntegraGen SA, Evry, France
Mol Autism 2:17. 2011
..abstract:..
- Assessing the impact of a combined analysis of four common low-risk genetic variants on autism risk
Jerome Carayol
IntegraGen SA, Evry, France
Mol Autism 1:4. 2010
..Genetic scores are designed to test for association of genetic markers with disease...
- Randomized, controlled trial of an intervention for toddlers with autism: the Early Start Denver Model
Geraldine Dawson
Autism Speaks, Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA
Pediatrics 125:e17-23. 2010
....
- Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder
Geraldine Dawson
Autism Speaks, Hillsborough, NC 27278, USA
Dev Psychopathol 20:775-803. 2008
..This article describes a developmental model of risk, risk processes, symptom emergence, and adaptation in ASD that offers a framework for understanding early brain plasticity in ASD and its role in prevention of the disorder...
Heterogeneous association between engrailed-2 and autism in the CPEA networkCamille W Brune
Department of Psychiatry, Institute for Juvenile Research, University of Illinois Chicago, Chicago, Illinois, USA
Am J Med Genet B Neuropsychiatr Genet 147:187-93. 2008
..Future studies investigating EN2 should consider how the association of variants in this gene with autism could be influenced by differences in phenotype and possible interactions with genotypes at other autism candidate genes...
- Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network
Bernie Devlin
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Med Genet B Neuropsychiatr Genet 126:46-50. 2004
..Neither is significantly associated with Reelin alleles. Our results are not consistent with a major role for Reelin alleles in liability to autism...
- Cerebral cortical gray matter overgrowth and functional variation of the serotonin transporter gene in autism
Thomas H Wassink
Department of Psychiatry, The University of Iowa, USA
Arch Gen Psychiatry 64:709-17. 2007
..Autism is a heritable neurodevelopmental disorder characterized biologically by enlargement of the head and brain and abnormalities of serotonin neurotransmission...
- Head circumference and height in autism: a study by the Collaborative Program of Excellence in Autism
Janet E Lainhart
Department of Psychiatry, The Brain Institute at the University of Utah, Salt Lake City, Utah 84108, USA
Am J Med Genet A 140:2257-74. 2006
..The wide distribution of head circumference in autism has major implications for genetic, neuroimaging, and other neurobiological research...
- Performance on Cambridge Neuropsychological Test Automated Battery subtests sensitive to frontal lobe function in people with autistic disorder: evidence from the Collaborative Programs of Excellence in Autism network
Sally Ozonoff
Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA
J Autism Dev Disord 34:139-50. 2004
....
- Mortality in individuals with autism, with and without epilepsy
Jane Pickett
Autism Tissue Program, Autism Speaks, San Diego, California 92124, USA
J Child Neurol 26:932-9. 2011
..Various national health care and state developmental disability agency initiatives to reduce risk of mortality are described...
- Differences in white matter fiber tract development present from 6 to 24 months in infants with autism
Jason J Wolff
Carolina Institute for Developmental Disabilities and the Department of Psychiatry, University of North Carolina, Chapel Hill, USA
Am J Psychiatry 169:589-600. 2012
..The authors prospectively examined white matter fiber tract organization from 6 to 24 months in high-risk infants who developed autism spectrum disorders (ASDs) by 24 months...
- A global public health strategy for autism spectrum disorders
Simon Wallace
Autism Speaks, 1 East 33rd Street, New York, NY 10016, USA
Autism Res 5:211-7. 2012
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- No evidence for linkage of liability to autism to HOXA1 in a sample from the CPEA network
Bernie Devlin
Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
Am J Med Genet 114:667-72. 2002
..Therefore, although we cannot exclude the possibility that the samples in the two studies are intrinsically different, our data from our sample argue against a major role for HOXA1 (His)73(Arg) in liability to autism...
- Head circumference as an early predictor of autism symptoms in younger siblings of children with autism spectrum disorder
Lauren M Elder
Department of Psychology, Autism Center, University of Washington, Box 357920, Seattle, WA, USA
J Autism Dev Disord 38:1104-11. 2008
..Among infant siblings of children with autism, atypical HC growth might alert pediatricians to provide screening and/or referral for further evaluation...
- Trajectories of maternal depression over 7 years: relations with child psychophysiology and behavior and role of contextual risks
Sharon B Ashman
University of Washington, USA
Dev Psychopathol 20:55-77. 2008
..Contextual risk factors were found to mediate the relation between maternal depression and child behavioral outcomes...
- Age-related differences in neural correlates of face recognition during the toddler and preschool years
Leslie J Carver
Psychology Department, University of California, San Diego, La Jolla, CA 92093 0109, USA
Dev Psychobiol 42:148-59. 2003
..We propose that these changes are based on age-related differences in the perceived salience of the face of the primary caregiver versus strangers...
- Characteristics associated with presence of depressive symptoms in adults with autism spectrum disorder
Lindsey Sterling
UW Autism Center, Department of Psychology, University of Washington, Seattle, WA, USA
J Autism Dev Disord 38:1011-8. 2008
..These characteristics may be vulnerability factors for the development of depression, and should be considered when screening and treating adults with ASD...
- Level of intellectual functioning predicts patterns of associated symptoms in school-age children with autism spectrum disorder
Annette Mercer Estes
Autism Center, University of Washington, Seattle 98195, USA
Am J Ment Retard 112:439-49. 2007
..Results suggest that level of intellectual functioning may be a risk factor for different patterns of associated symptoms by later childhood...
- Preschool outcomes of children of depressed mothers: role of maternal behavior, contextual risk, and children's brain activity
Geraldine Dawson
Department of Psychology, Center on Human Development and Disability, University of Washington, Seattle, WA 98195, USA
Child Dev 74:1158-75. 2003
..g., marital discord and stress) and their children had more behavior problems. Children's frontal brain activation and contextual risk level mediated the relation between maternal depression and child behavior problems...
- Rate of head circumference growth as a function of autism diagnosis and history of autistic regression
Sara Jane Webb
Department of Psychiatry and Behavioral Sciences, University of Washington Autism Center, University of Washington, Seattle, WA 98195, USA
J Child Neurol 22:1182-90. 2007
..Findings from this study suggest that the aberrant growth is present in the first year of life and precedes the onset and diagnosis in children with autism spectrum disorder with and without a history of autistic regression...
- Early intervention and brain plasticity in autism
Geraldine Dawson
Autism Center, University of Washington, Seattle, WA 98195, USA
Novartis Found Symp 251:266-74; discussion 274-80, 281-97. 2003
..Early interventions that enhance social attention should result in changes in brain activity, as reflected in ERPs to face stimuli, with those children showing the greatest social improvement exhibiting more normal brain activity...
- Despite major challenges, autism research continues to offer hope
Geraldine Dawson
Arch Pediatr Adolesc Med 161:411-2. 2007
- Resting state cortical connectivity reflected in EEG coherence in individuals with autism
Michael Murias
University of Washington Autism Center, Seattle, Washington 98195, USA
Biol Psychiatry 62:270-3. 2007
..Theoretical conceptions of autism spectrum disorder (ASD) and experimental studies of cerebral blood flow suggest abnormalities in connections among distributed neural systems in ASD...
- Abnormal functional connectivity in autism spectrum disorders during face processing
Natalia M Kleinhans
Department of Radiology, University of Washington, Box 357115, Seattle, WA 98195, USA
Brain 131:1000-12. 2008
..These results suggest that abnormal neural connections within the limbic system may contribute to the social impairments observed in ASD...
- A replication of the Autism Diagnostic Observation Schedule (ADOS) revised algorithms
Katherine Gotham
University of Michigan Autism and Communication Disorders Center, 1111 East Catherine Street, Ann Arbor, MI 48109 2054, USA
J Am Acad Child Adolesc Psychiatry 47:642-51. 2008
..To replicate the factor structure and predictive validity of revised Autism Diagnostic Observation Schedule algorithms in an independent dataset (N = 1,282)...
- Becoming a face expert: a computerized face-training program for high-functioning individuals with autism spectrum disorders
Susan Faja
Department of Psychology, University of Washington, USA
Dev Neuropsychol 33:1-24. 2008
..These findings suggest that face processing ability and strategies in autism can be significantly improved through training...
- Fluorine magnetic resonance spectroscopy measurement of brain fluvoxamine and fluoxetine in pediatric patients treated for pervasive developmental disorders
Wayne L Strauss
Center on Human Development and Disability, University of Washington, Seattle, 98105-6099, USA
Am J Psychiatry 159:755-60. 2002
..It must be determined whether these findings can be generalized to other pediatric populations...
- Early recognition of 1-year-old infants with autism spectrum disorder versus mental retardation
Julie A Osterling
Center on Human Development and Disability, University of Washington, Seattle 98195, USA
Dev Psychopathol 14:239-51. 2002
..These results indicate that autism can be distinguished from mental retardation and typical development by 1 year of age...
- Stress hormone levels of children of depressed mothers
Sharon B Ashman
Department of Psychology, University of Washington, Seattle 98195, USA
Dev Psychopathol 14:333-49. 2002
..The results also provide preliminary evidence that exposure to maternal depression in the first 2 years of life may be related to children's cortisol levels later in life...
- Neural correlates of face and object recognition in young children with autism spectrum disorder, developmental delay, and typical development
Geraldine Dawson
Center on Human Development and Disability, University of Washington, Seattle 98195, USA
Child Dev 73:700-17. 2002
..These data suggest that autism is associated with face recognition impairment that is manifest early in life...
- Presence of large deletions in kindreds with autism
Chang-En Yu
Geriatrics Research Education and Clinical Center, Puget Sound Veterans Affairs Medical Center, University of Washington, Seattle 98108, USA
Am J Hum Genet 71:100-15. 2002
..An alternative hypothesis is that autism-susceptibility alleles elsewhere cause the deletions detected here, possibly by inducing errors during meiosis...
- Identification of a novel gene on chromosome 7q11.2 interrupted by a translocation breakpoint in a pair of autistic twins
Razia Sultana
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195, USA
Genomics 80:129-34. 2002
..Thus, although it is unlikely that AUTS2 is an autism susceptibility gene for idiopathic autism, it may be the gene responsible for the disorder in the twins studied here...
- Gray and white matter brain chemistry in young children with autism
Seth D Friedman
Department of Radiology, University of Washington School of Medicine, Seattle, WA 98105 6099, USA
Arch Gen Psychiatry 63:786-94. 2006
..The brain pathophysiological abnormalities underlying autism remain unclear. Neuroimaging and histological studies suggest cellular abnormalities early in the course of the disease...
- Defining the broader phenotype of autism: genetic, brain, and behavioral perspectives
Geraldine Dawson
Center of Human Development and Disability, University of Washington, Seattle 98195, USA
Dev Psychopathol 14:581-611. 2002
....
- A randomized, double-blind, placebo-controlled trial of porcine versus synthetic secretin for reducing symptoms of autism
Alan S Unis
Department of Psychiatry and Behavioral Science, University of Washington, Seattle, WA 98195, USA
J Am Acad Child Adolesc Psychiatry 41:1315-21. 2002
..CONCLUSIONS: No evidence that either biologic or synthetic secretin provided amelioration of symptoms beyond placebo was observed. This held true when children with and without gastrointestinal problems were examined separately...
- Mapping autism risk loci using genetic linkage and chromosomal rearrangements
Peter Szatmari
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
Nat Genet 39:319-28. 2007
..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs...
- Early social, imitation, play, and language abilities of young non-autistic siblings of children with autism
Karen Toth
UW Autism Center and Center on Human Development and Disability, University of Washington, Seattle, USA
J Autism Dev Disord 37:145-57. 2007
..These results suggest that the development of young non-autistic siblings is affected at an early age and, thus, should be closely monitored, with appropriate interventions implemented as needed...
- Neurocognitive and electrophysiological evidence of altered face processing in parents of children with autism: implications for a model of abnormal development of social brain circuitry in autism
Geraldine Dawson
University of Washington Autism Center and Center on Human Development and Disability, Seattle 98195, USA
Dev Psychopathol 17:679-97. 2005
..The hypothesis that genetic-mediated dysfunction of the dopamine reward system, especially its functioning in social contexts, might account for altered face processing in individuals with autism and their relatives is discussed...
- Individuals with autism spectrum disorder show normal responses to a fear potential startle paradigm
Raphael Bernier
Center on Human Development and Disability, University of Washington, Seattle 98195, USA
J Autism Dev Disord 35:575-83. 2005
..These results suggest that this aspect of amygdala function, namely fear conditioning and potentiation of the startle response, is intact in individuals with autism...
- Variation in early developmental course in autism and its relation with behavioral outcome at 3-4 years of age
Emily Werner
Department of Psychology and UW Autism Center, University of Washington, Seattle, WA 98195, USA
J Autism Dev Disord 35:337-50. 2005
..late onset of symptoms, and with vs. without a history of loss of skills (regression) were not found to differ on standardized tests of verbal and nonverbal IQ and observational measures of autism symptom severity...
- Validation of the phenomenon of autistic regression using home videotapes
Emily Werner
UW Autism Center and Department of Psychology and Psychiatry, University of Washington, Seattle, WA 98195, USA
Arch Gen Psychiatry 62:889-95. 2005
..To date, there has been no objective validation of the phenomenon of autistic regression early in life...
- Understanding the nature of face processing impairment in autism: insights from behavioral and electrophysiological studies
Geraldine Dawson
University of Washington Autism Center, University of Washington, Seattle 98195, USA
Dev Neuropsychol 27:403-24. 2005
..This article discusses implications for intervention...
- Early regression in social communication in autism spectrum disorders: a CPEA Study
Rhiannon Luyster
Autism and Communication Disorders Center, University of Michigan, Ann Arbor 48109-2054, USA
Dev Neuropsychol 27:311-36. 2005
..A significant minority of children with autism without word loss showed a very similar pattern of loss of social-communication skills, a pattern not observed in the children with developmental delays or typical development...
- Links between social and linguistic processing of speech in preschool children with autism: behavioral and electrophysiological measures
Patricia K Kuhl
Center on Human Development and Disabilities and Department of Speech and Hearing Sciences, University of Washington, Seattle, WA 98195, USA
Dev Sci 8:F1-F12. 2005
..The data support the hypothesis of an association between social and linguistic processing in children with ASD...
- Young children with autism show atypical brain responses to fearful versus neutral facial expressions of emotion
Geraldine Dawson
Department of Psychology, University of Washington, Seattle, 98195, USA
Dev Sci 7:340-59. 2004
..These data suggest that children with ASD, as young as 3 years of age, show a disordered pattern of neural responses to emotional stimuli...
- Genetic investigation of quantitative traits related to autism: use of multivariate polygenic models with ascertainment adjustment
Yun Ju Sung
Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195-7720, USA
Am J Hum Genet 76:68-81. 2005
..92). This finding suggests a shared genetic basis of these two traits and that they may be most promising for future gene mapping and for extending pedigrees by phenotyping additional relatives...
- Challenges in evaluating psychosocial interventions for Autistic Spectrum Disorders
Catherine Lord
University of Michigan, Austim and Communication Disorders Center 1111, Ann Arbor 48109, USA
J Autism Dev Disord 35:695-708; discussion 709-11. 2005
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- Familial autoimmune thyroid disease as a risk factor for regression in children with Autism Spectrum Disorder: a CPEA Study
Cynthia A Molloy
Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Ohio 45229 3039, USA
J Autism Dev Disord 36:317-24. 2006
..89; 95% CI: 1.17, 3.10). The only specific autoimmune disorder found to be associated with regression was autoimmune thyroid disease (adjusted OR=2.09; 95% CI: 1.28, 3.41)...
- Corpus callosum morphometrics in young children with autism spectrum disorder
Inbal Boger-Megiddo
Department of Radiology, 5C-1, Children's Hospital and Regional Medical Center, 4800 Sand Point Way NE, Seattle, WA, 98105, USA
J Autism Dev Disord 36:733-9. 2006
..Results could reflect decreased inter-hemispheric connectivity or cerebral enlargement due to increase in tissues less represented in the corpus callosum in ASD...
- Rate of head growth decelerates and symptoms worsen in the second year of life in autism
Geraldine Dawson
Autism Center, University of Washington, Seattle, Washington, USA
Biol Psychiatry 61:458-64. 2007
..Longitudinal studies of head circumference growth in infants later diagnosed with autism are needed to understand the accelerated head growth in this disorder...
- Early social attention impairments in autism: social orienting, joint attention, and attention to distress
Geraldine Dawson
Department of Psychology, Center on Human Development and Disability, University of Washington, Seattle, WA, USA
Dev Psychol 40:271-83. 2004
..These results help to clarify the nature of social attention impairments in autism, offer clues to developmental mechanisms, and suggest targets for early intervention...
- ERP evidence of atypical face processing in young children with autism
Sara J Webb
Psychiatry and Behavioral Sciences, Box 357920 CHDD, Seattle, WA 98195, USA
J Autism Dev Disord 36:881-90. 2006
..These findings indicate that children with ASD have a disordered pattern of brain responses to faces and objects at an early age...
- Designing research studies on psychosocial interventions in autism
Tristram Smith
Department of Pediatrics, Strong Center for Developmental Disabilities, University of Rochester Medical Center, 601 Elmwood, Box 671, Rochester, NY 14642, USA
J Autism Dev Disord 37:354-66. 2007
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- Quantitative assessment of autism symptom-related traits in probands and parents: Broader Phenotype Autism Symptom Scale
Geraldine Dawson
University of Washington Autism Center and Department of Psychology, University of Washington, Seattle, WA 98195, USA
J Autism Dev Disord 37:523-36. 2007
..BPASS scores were not correlated with ethnicity or parent education; however, some domains were correlated with IQ. The BPASS holds promise as a quantitative phenotypic assessment for genetic studies...
- Early predictors of communication development in young children with autism spectrum disorder: joint attention, imitation, and toy play
Karen Toth
Department of Psychology, UW Autism Center, CHDD, University of Washington 357920, Seattle, WA 98195, USA
J Autism Dev Disord 36:993-1005. 2006
..5 years. The implications of these results for understanding the nature and course of language development in autism and for the development of targeted early interventions are discussed...
- Neurocognitive function and joint attention ability in young children with autism spectrum disorder versus developmental delay
Geraldine Dawson
Center on Human Development and Disability, University of Washington, Seattle 98195, USA
Child Dev 73:345-58. 2002
..The ventromedial prefrontal cortex is hypothesized to play a role in the development of joint attention and possibly some aspects of the autistic syndrome...
- Amygdalar volume and behavioral development in autism
Jeffrey Munson
University of Washington Autism Center, University of Washington, Seattle, USA
Arch Gen Psychiatry 63:686-93. 2006
..These results provide additional evidence that amygdalar development is implicated in the behavioral impairments found in autism...
- Is there a 'regressive phenotype' of Autism Spectrum Disorder associated with the measles-mumps-rubella vaccine? A CPEA Study
Jennifer Richler
University of Michigan, Ann Arbor, 48109 2054, USA
J Autism Dev Disord 36:299-316. 2006
..There was no evidence that onset of autistic symptoms or of regression was related to measles-mumps-rubella vaccination. The implications of these findings for the existence of a 'regressive phenotype' of ASD are discussed...
- Event-related brain potentials reveal anomalies in temporal processing of faces in autism spectrum disorder
James McPartland
UW Autism Center, University of Washington, Seattle, USA
J Child Psychol Psychiatry 45:1235-45. 2004
..CONCLUSIONS: These data provide evidence for slowed neural speed of face processing in autism and highlight the role of speed of processing in face processing impairments in autism...
