Fish consumption, mercury exposure, and their associations with scholastic achievement in the Seychelles Child Development StudyPhilip W Davidson
University of Rochester, School of Medicine and Dentistry, Department of Pediatrics, Rochester, NY 14642, USA
Neurotoxicology 31:439-47. 2010
..The adverse association of educational measures with postnatal exposure in males is intriguing, but will need to be confirmed by further studies examining factors that influence scholastic achievement...
- Fish consumption and prenatal methylmercury exposure: cognitive and behavioral outcomes in the main cohort at 17 years from the Seychelles child development study
Philip W Davidson
Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Neurotoxicology 32:711-7. 2011
..For some endpoints we found performance improved with increasing prenatal exposure to MeHg. Follow up studies indicate this association is related to the beneficial nutrients present in fish...
- Is susceptibility to prenatal methylmercury exposure from fish consumption non-homogeneous? Tree-structured analysis for the Seychelles Child Development Study
Li Shan Huang
Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Neurotoxicology 28:1237-44. 2007
..The regression tree results support previous analyses of outcomes in this cohort. However, this analysis raises the intriguing possibility that an effect may be non-homogeneous among children with different backgrounds and IQ levels...
- Prenatal exposure to dental amalgam: evidence from the Seychelles Child Development Study main cohort
GENE E WATSON
Eastman Institute for Oral Health, Department of Environmental Medicine, and Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester, N Y, USA
J Am Dent Assoc 142:1283-94. 2011
..Controversy surrounds whether fetal exposure to mercury vapor resulting from maternal dental amalgam restorations has neurodevelopmental consequences...
Methylmercury and neurodevelopment: longitudinal analysis of the Seychelles child development cohortPhilip W Davidson
The Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642, USA
Neurotoxicol Teratol 28:529-35. 2006
..These findings suggest that the associations observed between MeHg and developmental outcomes may vary with developmental stage...
- Benchmark concentrations for methyl mercury obtained from the 9-year follow-up of the Seychelles Child Development Study
Edwin van Wijngaarden
Department of Community and Preventive Medicine, 601 Elmwood Avenue, Box 644, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Neurotoxicology 27:702-9. 2006
..These estimates are somewhat lower than those obtained after 66 months of follow-up. The Seychelles Child Development Study continues to provide a firm scientific basis for the derivation of safe levels of MeHg consumption...
- Varying coefficient function models to explore interactions between maternal nutritional status and prenatal methylmercury toxicity in the Seychelles Child Development Nutrition Study
Miranda L Lynch
Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Environ Res 111:75-80. 2011
..The results encourage more emphasis on a holistic view of the risks and benefits of fish consumption as it relates to infant development...
- Exploring nonlinear association between prenatal methylmercury exposure from fish consumption and child development: evaluation of the Seychelles Child Development Study nine-year data using semiparametric additive models
Li Shan Huang
Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Environ Res 97:100-8. 2005
..We conclude that this reanalysis supports the primary linear analysis, showing little evidence for a prenatal adverse effect...
- Does prenatal methylmercury exposure from fish consumption affect blood pressure in childhood?
Sally W Thurston
Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States
Neurotoxicology 28:924-30. 2007
..We examined this relationship in the Seychelles Islands to determine if it was present in a society exposed primarily to MeHg from consuming ocean fish...
- Association between prenatal exposure to methylmercury and visuospatial ability at 10.7 years in the seychelles child development study
Philip W Davidson
University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Neurotoxicology 29:453-9. 2008
..04), but not when the single outlier was removed (p=0.07). In a population whose exposure to MeHg is from fish consumption, we continue to find no consistent adverse association between MeHg and visual motor coordination...
- A longitudinal analysis of prenatal exposure to methylmercury and fatty acids in the Seychelles
Abbie Stokes-Riner
University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Neurotoxicol Teratol 33:325-8. 2011
..These findings suggest that the effects of MeHg and LCPUFA may vary with age over the first few years of life. We address this by including outcomes at two ages and adjusting for the child's age at testing...
- Interpreting epidemiological evidence in the presence of multiple endpoints: an alternative analytic approach using the 9-year follow-up of the Seychelles child development study
Edwin van Wijngaarden
Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA
Int Arch Occup Environ Health 82:1031-41. 2009
..These studies evaluate a large number of developmental tests. We propose an alternative analysis strategy that reduces the number of comparisons tested in these studies...
- Bayesian models for multiple outcomes nested in domains
Sally W Thurston
University of Rochester, Department of Biostatistics and Computational Biology, 601 Elmwood Avenue, Box 630, Rochester, New York 14642, USA
Biometrics 65:1078-86. 2009
..Simulation studies examine the model performance under alternative scenarios. Our results demonstrate that a sizeable increase in power is possible...
- Neurodevelopmental effects of maternal nutritional status and exposure to methylmercury from eating fish during pregnancy
Philip W Davidson
University of Rochester School of Medicine and Dentistry, Box 671, URMC, 601 Elmwood Avenue, Rochester, NY 14642, USA
Neurotoxicology 29:767-75. 2008
..These findings suggest a possible confounding role of maternal nutrition in studies examining associations between prenatal MeHg exposures and developmental outcomes in children...
- Prenatal exposure to methylmercury and child development: influence of social factors
Philip W Davidson
Strong Center for Developmental Disabilities, Department of Pediatrics, Box 671, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
Neurotoxicol Teratol 26:553-9. 2004
..We performed a similar analysis of the 66-month evaluations to determine if the modifying influences of social and environmental factors were consistent with those previously observed...
- Development and validation of a test battery to assess subtle neurodevelopmental differences in children
Philip W Davidson
University of Rochester School of Medicine, Rochester, NY, USA
Neurotoxicology 27:951-69. 2006
..Further studies are needed to confirm the capability of the RTB to detect subtle changes associated with neurotoxic exposures...
- Socioeconomic position and cognitive function in the Seychelles: a life course analysis
Roni W Kobrosly
Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Neuroepidemiology 36:162-8. 2011
..In this study, we sought to confirm the relation between early-life socioeconomic position (SEP) and adult cognitive function, and to examine potential mediation by contemporaneous SEP...
- Nutrient and methyl mercury exposure from consuming fish
Gary J Myers
Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
J Nutr 137:2805-8. 2007
..Preliminary findings from this study suggest that the beneficial influence of nutrients from fish may counter any adverse effects of MeHg on the developing nervous system...
- Prenatal exposure to dental amalgam in the Seychelles Child Development Nutrition Study: associations with neurodevelopmental outcomes at 9 and 30 months
GENE E WATSON
Eastman Institute for Oral Health, and Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA
Neurotoxicology 33:1511-7. 2012
..Maternal amalgams expose the developing fetus to mercury vapor. Mercury vapor can be toxic, but uncertainty remains whether prenatal amalgam exposure is associated with neurodevelopmental consequences in offspring...
- Maternal fish consumption benefits children's development
Gary J Myers
Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
Lancet 369:537-8. 2007
- Using measurement error models to assess effects of prenatal and postnatal methylmercury exposure in the Seychelles Child Development Study
Li Shan Huang
Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 630, Rochester, NY 14642, USA
Environ Res 93:115-22. 2003
..Our reanalysis indicated that adjustment for measurement errors in explanatory variables had no appreciable effect on the original results...
- Mercury exposure and child development outcomes
Philip W Davidson
Strong Center for Developmental Disabilities, Golisano Children s Hospital at Strong, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Pediatrics 113:1023-9. 2004
..Our intent is to focus the debate about mercury on 1) additional research that should be sought and 2) defining the principal issues that public policy makers face...
