Veronica Davalos

Summary

Affiliation: Cancer Epigenetics and Biology Program (PEBC)
Location: Barcelona, Spain
Summary:
Epigenetics
Cancer
miRNAs
Epithelial Mesenchymal Transition

Publications

  1. ncbi request reprint Telomeric associations in cigarette smokers exposed to low levels of X-rays
    C Paz-y-Mino
    Departamento de Ciencias Biologicas, Laboratorio de Genética Molecular y Citogenética Humana, Pontificia Universidad Catolica del Ecuador, PO Box 17 1 2184, Quito, Ecuador
    Mutat Res 490:77-80. 2001
  2. ncbi request reprint Rolling the dice to discover the role of DICER in tumorigenesis
    Veronica Davalos
    Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, Barcelona, 08908 Catalonia, Spain
    Cancer Cell 21:717-9. 2012
  3. pmc Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity
    Nicolas Léveillé
    Division of Gene Regulation, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nat Commun 2:513. 2011
  4. pmc Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis
    V Davalos
    Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, Barcelona, Spain
    Oncogene 31:2062-74. 2012
  5. pmc Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing
    Sonia Melo
    Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, 08908 L Hospitalet, Barcelona, Catalonia, Spain
    Proc Natl Acad Sci U S A 108:4394-9. 2011
  6. doi request reprint A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells
    Sonia A Melo
    Bellvitge Biomedical Research Institute, Barcelona, Catalonia, Spain
    Cancer Cell 18:303-15. 2010
  7. doi request reprint MicroRNAs and cancer epigenetics: a macrorevolution
    Veronica Davalos
    Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, Barcelona, Catalonia, Spain
    Curr Opin Oncol 22:35-45. 2010
  8. ncbi request reprint EPH receptors in cancer
    Julio Castaño
    Drug Delivery and Targeting Group, Nanomedicine Program, Molecular Biology and Biochemistry Research Center CIBBIM, Vall d Hebron Hospital Research Institute, Barcelona, Spain
    Histol Histopathol 23:1011-23. 2008
  9. ncbi request reprint EPHB4 and survival of colorectal cancer patients
    Veronica Davalos
    Molecular Oncology Program, Institut Catala d Oncologia, Barcelona, Spain
    Cancer Res 66:8943-8. 2006
  10. ncbi request reprint Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis
    P Laiho
    Department of Medical Genetics and Molecular and Cancer Biology Research Program, Biomedicum Helsinki, University of Helsinki, Finland
    Oncogene 26:312-20. 2007

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Telomeric associations in cigarette smokers exposed to low levels of X-rays
    C Paz-y-Mino
    Departamento de Ciencias Biologicas, Laboratorio de Genética Molecular y Citogenética Humana, Pontificia Universidad Catolica del Ecuador, PO Box 17 1 2184, Quito, Ecuador
    Mutat Res 490:77-80. 2001
    ..1%). Our results suggest that probably there is not an additive or synergistic effect between X-rays and smoking, and that TA may be a useful cytogenetic marker for evaluating populations exposed to mutagens...
  2. ncbi request reprint Rolling the dice to discover the role of DICER in tumorigenesis
    Veronica Davalos
    Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, Barcelona, 08908 Catalonia, Spain
    Cancer Cell 21:717-9. 2012
    ..characterize the effects of homozygous deletion of Dicer1. Using an in vivo mouse model, they show that genetic deletion of Dicer1 does not preclude tumor formation...
  3. pmc Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity
    Nicolas Léveillé
    Division of Gene Regulation, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nat Commun 2:513. 2011
    ..Thus, our results indicate a novel layer of p53 gene regulation, which is required for its tumour suppressive function...
  4. pmc Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis
    V Davalos
    Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, Barcelona, Spain
    Oncogene 31:2062-74. 2012
    ..These findings indicate that the epigenetic silencing plasticity of the miR-200 family contributes to the evolving and adapting phenotypes of human tumors...
  5. pmc Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing
    Sonia Melo
    Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, 08908 L Hospitalet, Barcelona, Catalonia, Spain
    Proc Natl Acad Sci U S A 108:4394-9. 2011
    ..These results highlight the key role of disrupted miRNA expression patterns in tumorigenesis, and suggest a unique strategy for restoring the distorted microRNAome of cancer cells to a more physiological setting...
  6. doi request reprint A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells
    Sonia A Melo
    Bellvitge Biomedical Research Institute, Barcelona, Catalonia, Spain
    Cancer Cell 18:303-15. 2010
    ..Most importantly, the restoration of XPO5 functions reverses the impaired export of pre-miRNAs and has tumor-suppressor features...
  7. doi request reprint MicroRNAs and cancer epigenetics: a macrorevolution
    Veronica Davalos
    Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, Barcelona, Catalonia, Spain
    Curr Opin Oncol 22:35-45. 2010
    ....
  8. ncbi request reprint EPH receptors in cancer
    Julio Castaño
    Drug Delivery and Targeting Group, Nanomedicine Program, Molecular Biology and Biochemistry Research Center CIBBIM, Vall d Hebron Hospital Research Institute, Barcelona, Spain
    Histol Histopathol 23:1011-23. 2008
    ..Accordingly, deregulation of EPH expression and signaling activity could be crucial for the tumorigenic process. This review focuses on EPH receptors' roles in oncogenic transformation and tumor progression...
  9. ncbi request reprint EPHB4 and survival of colorectal cancer patients
    Veronica Davalos
    Molecular Oncology Program, Institut Catala d Oncologia, Barcelona, Spain
    Cancer Res 66:8943-8. 2006
    ....
  10. ncbi request reprint Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis
    P Laiho
    Department of Medical Genetics and Molecular and Cancer Biology Research Program, Biomedicum Helsinki, University of Helsinki, Finland
    Oncogene 26:312-20. 2007
    ..The study also provides a platform to understand the molecular basis of serrated CRC and in long term may contribute to the development of specific treatment options for this tumor type...
  11. ncbi request reprint High EPHB2 mutation rate in gastric but not endometrial tumors with microsatellite instability
    V Davalos
    Molecular Oncology Program, Molecular Oncology and Aging Group, Vall d Hebron Hospital Research Institute, Passeig Vall d Hebron, Barcelona, Spain
    Oncogene 26:308-11. 2007
    ..These results suggest a functional role for EPHB2 in gastric tumor progression, and emphasize the differences between the tumorigenic processes in MSI gastrointestinal and endometrial cancer...
  12. ncbi request reprint Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors
    Hafid Alazzouzi
    Molecular Oncology and Aging Group, Molecular Biology and Biochemistry Research Center CIBBIM, Valle Hebron Hospital Research Institute, Barcelona, Spain
    Cancer Res 65:10170-3. 2005
    ....
  13. ncbi request reprint SMAD4 levels and response to 5-fluorouracil in colorectal cancer
    Pia Alhopuro
    Department of Medical Genetics, Biomedicum Helsinki, Haartman Institute, University of Helsinki, Finland
    Clin Cancer Res 11:6311-6. 2005
    ....
  14. ncbi request reprint EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma
    Miguel Alaminos
    Cancer Epigenetics Laboratory, Molecular Pathology Programme, Spanish National Cancer Centre, Madrid, Spain
    Cancer Res 65:2565-71. 2005
    ..03) and death of disease (Kendall tau, P = 0.03; r = 0.19). Thus, EMP3 is a good candidate for being the long-sought tumor suppressor gene located at 19q13 in gliomas and neuroblastomas...
  15. ncbi request reprint Clustering of gene hypermethylation associated with clinical risk groups in neuroblastoma
    Miguel Alaminos
    Cancer Epigenetics Laboratory, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    J Natl Cancer Inst 96:1208-19. 2004
    ..Transcriptional silencing of tumor suppressor genes mediated by hypermethylation of promoter CpG islands is a hallmark of human tumors. We addressed the clinical relevance of promoter hypermethylation in neuroblastoma...
  16. pmc Human SMC2 protein, a core subunit of human condensin complex, is a novel transcriptional target of the WNT signaling pathway and a new therapeutic target
    Veronica Davalos
    Drug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine CIBBIM Nanomedicine, Vall d Hebron Institut de Recerca, Universitat Autonoma de Barcelona, Barcelona 08035 Spain
    J Biol Chem 287:43472-81. 2012
    ..02). Therefore, we propose that WNT signaling can directly activate SMC2 transcription as a key player in the mitotic cell division machinery. Furthermore, SMC2 represents a new target for oncological therapeutic intervention...