Genomes and Genes
Affiliation: Cancer Epigenetics and Biology Program (PEBC)
Location: Barcelona, Spain
Epithelial Mesenchymal Transition
- Telomeric associations in cigarette smokers exposed to low levels of X-raysC Paz-y-Mino
Departamento de Ciencias Biologicas, Laboratorio de Genética Molecular y Citogenética Humana, Pontificia Universidad Catolica del Ecuador, PO Box 17 1 2184, Quito, Ecuador
Mutat Res 490:77-80. 2001..1%). Our results suggest that probably there is not an additive or synergistic effect between X-rays and smoking, and that TA may be a useful cytogenetic marker for evaluating populations exposed to mutagens...
- Rolling the dice to discover the role of DICER in tumorigenesisVeronica Davalos
Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, Barcelona, 08908 Catalonia, Spain
Cancer Cell 21:717-9. 2012..characterize the effects of homozygous deletion of Dicer1. Using an in vivo mouse model, they show that genetic deletion of Dicer1 does not preclude tumor formation...
- Selective inhibition of microRNA accessibility by RBM38 is required for p53 activityNicolas Léveillé
Division of Gene Regulation, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Nat Commun 2:513. 2011..Thus, our results indicate a novel layer of p53 gene regulation, which is required for its tumour suppressive function...
- Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesisV Davalos
Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, Barcelona, Spain
Oncogene 31:2062-74. 2012..These findings indicate that the epigenetic silencing plasticity of the miR-200 family contributes to the evolving and adapting phenotypes of human tumors...
- Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processingSonia Melo
Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, 08908 L Hospitalet, Barcelona, Catalonia, Spain
Proc Natl Acad Sci U S A 108:4394-9. 2011..These results highlight the key role of disrupted miRNA expression patterns in tumorigenesis, and suggest a unique strategy for restoring the distorted microRNAome of cancer cells to a more physiological setting...
- A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cellsSonia A Melo
Bellvitge Biomedical Research Institute, Barcelona, Catalonia, Spain
Cancer Cell 18:303-15. 2010..Most importantly, the restoration of XPO5 functions reverses the impaired export of pre-miRNAs and has tumor-suppressor features...
- MicroRNAs and cancer epigenetics: a macrorevolutionVeronica Davalos
Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, Barcelona, Catalonia, Spain
Curr Opin Oncol 22:35-45. 2010....
- EPH receptors in cancerJulio Castaño
Drug Delivery and Targeting Group, Nanomedicine Program, Molecular Biology and Biochemistry Research Center CIBBIM, Vall d Hebron Hospital Research Institute, Barcelona, Spain
Histol Histopathol 23:1011-23. 2008..Accordingly, deregulation of EPH expression and signaling activity could be crucial for the tumorigenic process. This review focuses on EPH receptors' roles in oncogenic transformation and tumor progression...
- EPHB4 and survival of colorectal cancer patientsVeronica Davalos
Molecular Oncology Program, Institut Catala d Oncologia, Barcelona, Spain
Cancer Res 66:8943-8. 2006....
- Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basisP Laiho
Department of Medical Genetics and Molecular and Cancer Biology Research Program, Biomedicum Helsinki, University of Helsinki, Finland
Oncogene 26:312-20. 2007..The study also provides a platform to understand the molecular basis of serrated CRC and in long term may contribute to the development of specific treatment options for this tumor type...
- High EPHB2 mutation rate in gastric but not endometrial tumors with microsatellite instabilityV Davalos
Molecular Oncology Program, Molecular Oncology and Aging Group, Vall d Hebron Hospital Research Institute, Passeig Vall d Hebron, Barcelona, Spain
Oncogene 26:308-11. 2007..These results suggest a functional role for EPHB2 in gastric tumor progression, and emphasize the differences between the tumorigenic processes in MSI gastrointestinal and endometrial cancer...
- Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumorsHafid Alazzouzi
Molecular Oncology and Aging Group, Molecular Biology and Biochemistry Research Center CIBBIM, Valle Hebron Hospital Research Institute, Barcelona, Spain
Cancer Res 65:10170-3. 2005....
- SMAD4 levels and response to 5-fluorouracil in colorectal cancerPia Alhopuro
Department of Medical Genetics, Biomedicum Helsinki, Haartman Institute, University of Helsinki, Finland
Clin Cancer Res 11:6311-6. 2005....
- EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastomaMiguel Alaminos
Cancer Epigenetics Laboratory, Molecular Pathology Programme, Spanish National Cancer Centre, Madrid, Spain
Cancer Res 65:2565-71. 2005..03) and death of disease (Kendall tau, P = 0.03; r = 0.19). Thus, EMP3 is a good candidate for being the long-sought tumor suppressor gene located at 19q13 in gliomas and neuroblastomas...
- Clustering of gene hypermethylation associated with clinical risk groups in neuroblastomaMiguel Alaminos
Cancer Epigenetics Laboratory, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
J Natl Cancer Inst 96:1208-19. 2004..Transcriptional silencing of tumor suppressor genes mediated by hypermethylation of promoter CpG islands is a hallmark of human tumors. We addressed the clinical relevance of promoter hypermethylation in neuroblastoma...
- Human SMC2 protein, a core subunit of human condensin complex, is a novel transcriptional target of the WNT signaling pathway and a new therapeutic targetVeronica Davalos
Drug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine CIBBIM Nanomedicine, Vall d Hebron Institut de Recerca, Universitat Autonoma de Barcelona, Barcelona 08035 Spain
J Biol Chem 287:43472-81. 2012..02). Therefore, we propose that WNT signaling can directly activate SMC2 transcription as a key player in the mitotic cell division machinery. Furthermore, SMC2 represents a new target for oncological therapeutic intervention...