Dmitri R Davydov
Davydov D, Davydova N, Sineva E, Halpert J. Interactions among cytochromes P450 in microsomal membranes: oligomerization of cytochromes P450 3A4, 3A5, and 2E1 and its functional consequences. J Biol Chem. 2015;290:3850-64 pubmed publisher
..As a result of P450-P450 cross-talk, the catalytic properties of the cytochrome P450 ensemble cannot be predicted by simple summation of the properties of the individual P450 species. ..
Davydov D, Yang Z, Davydova N, Halpert J, Hubbell W. Conformational Mobility in Cytochrome P450 3A4 Explored by Pressure-Perturbation EPR Spectroscopy. Biophys J. 2016;110:1485-1498 pubmed publisher
..Our study demonstrates the high potential of pressure-perturbation strategies for studying protein conformational landscapes. ..
Davydov D, Davydova N, Rodgers J, Rushmore T, Jones J. Toward a systems approach to the human cytochrome P450 ensemble: interactions between CYP2D6 and CYP2E1 and their functional consequences. Biochem J. 2017;474:3523-3542 pubmed publisher