A simple inexpensive method for the production of tissue microarrays from needle biopsy specimens: examples with prostate cancerMilton W Datta
Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Appl Immunohistochem Mol Morphol 13:96-103. 2005
..This process can be extended to any type of needle biopsy specimen, increasing the number of studies and potential use of these tissues as a practical reality...
- Prostate cancer with low PSA levels
Milton W Datta
N Engl J Med 351:1802-3. 2004
- The role of tissue microarrays in prostate cancer biomarker discovery
Milton W Datta
Hospital Pathology Associates, Abbott Northwestern Hospital, University of Minnesota, Minneapolis, MN 55407, USA
Adv Anat Pathol 14:408-18. 2007
..The processes used here can be applied to any tumor type to improve patient diagnosis, prognosis, and treatment response prediction...
- An informatics model for tissue banks--lessons learned from the Cooperative Prostate Cancer Tissue Resource
Ashokkumar A Patel
Department of Pathology, Center for Pathology Informatics, Benedum Oncology Informatics Center, University of Pittsburgh, Pittsburgh, PA, USA
BMC Cancer 6:120. 2006
..Here we describe the CPCTR information management system architecture, common data element (CDE) development, query interfaces, data curation, and quality control...
- The development of common data elements for a multi-institute prostate cancer tissue bank: the Cooperative Prostate Cancer Tissue Resource (CPCTR) experience
Ashokkumar A Patel
Department of Pathology, Center for Pathology Informatics, Benedum Oncology Informatics Center, University of Pittsburgh, Pittsburgh, PA, USA
BMC Cancer 5:108. 2005
..To facilitate this effort, it was critical to arrive at agreed upon common data elements (CDEs) that could be used to collect demographic, pathologic, treatment and clinical outcome data...
- Expression analysis of kidney-specific cadherin in a wide spectrum of traditional and newly recognized renal epithelial neoplasms: diagnostic and histogenetic implications
Adam Kuehn
Department of Pathology, Emory University Hospital, Atlanta, GA, USA
Am J Surg Pathol 31:1528-33. 2007
....
- Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway
Milton W Datta
Department of Pathology, Emory University, Atlanta, GA 30322, USA
Mol Cancer 5:9. 2006
..Previously we have linked Perlecan to Hedgehog signaling in Drosophila. More recently, we have demonstrated the importance of Hedgehog signaling in humans for advanced prostate cancer...
- Cross-species global and subset gene expression profiling identifies genes involved in prostate cancer response to selenium
Michael Schlicht
Department of Pathology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA
BMC Genomics 5:58. 2004
..This method is made possible through the use of highly controlled spotted cDNA slide production and the use of comparative bioinformatics databases without the use of cross-species slide hybridizations...
- Intrahepatic portal hypertension secondary to metastatic carcinoma of the prostate
Tan Attila
Medical College of Wisconsin, 9200 W WisconsinAve, Milwaukee, WI, USA
WMJ 106:34-6. 2007
..We report a case of a patient with symptomatic portal hypertension due to diffuse metastatic prostate carcinoma infiltration of liver parenchyma that was not appreciated with routine imaging...
- Tissue microarrays from biopsy specimens
Milton W Datta
Hospital Pathology Associates and Department of Pathology, University of Minnesota, Minneapolis, MN, USA
Methods Mol Biol 664:103-11. 2010
..While the techniques are technically challenging, in the hands of investigators they can reveal new insights into biomarkers of disease...
- The cooperative prostate cancer tissue resource: a specimen and data resource for cancer researchers
Jonathan Melamed
Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
Clin Cancer Res 10:4614-21. 2004
..Interested investigators are encouraged to apply for use of this material (www.prostatetissues.org)...
- A simple computer program for calculating PSA recurrence in prostate cancer patients
Zhongyue Liao
Medical College of Wisconsin, Milwaukee, WI, 53226, U, S, A
BMC Urol 4:8. 2004
..This method needs to be simple and reproducible, and based on known aspects of PSA biology...
- Giant multilocular cystadenoma of the prostate responsive to GnRH antagonists
Milton W Datta
Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Urology 61:225. 2003
..The patient was stable without biochemical or radiologic evidence of progression during the last 2.5 years. This result offers a new treatment option for patients with this rare tumor...
- Use of a three-color cDNA microarray platform to measure and control support-bound probe for improved data quality and reproducibility
Martin J Hessner
The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, The Medical College of Wisconsin and Children s Hospital of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Nucleic Acids Res 31:e60. 2003
..Collectively, this strategy will improve microarray data and increase its utility as a sensitive screening tool...
- ChromSorter PC: a database of chromosomal regions associated with human prostate cancer
Ann Etim
Department of Pathology, Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
BMC Genomics 5:27. 2004
..The input material was based on a broad literature search with subsequent hand annotation of information relevant to prostate cancer...
- B.E.A.R. GeneInfo: a tool for identifying gene-related biomedical publications through user modifiable queries
Guohui Zhou
Department of Pathology and Bioinformatics Program, Medical College of Wisconsin, Milwaukee, WI, 53226, USA
BMC Bioinformatics 5:46. 2004
..In these situations having a tool for searching the biomedical literature using the list of identified genes while simultaneously defining additional search terms would be useful...
- Nox1 expression determines cellular reactive oxygen and modulates c-fos-induced growth factor, interleukin-8, and Cav-1
Rebecca S Arnold
Department of Urology, Winship Cancer Institute, Emory University School of Medicine, 1365 Clifton Rd, Building B, Atlanta, GA 30322, USA
Am J Pathol 171:2021-32. 2007
..0001). These studies indicate that Nox1 overexpression may function as a reversible signal for cellular proliferation with relevance for a common human tumor...
- Non-invasive bioluminescent detection of prostate cancer growth and metastasis in a bigenic transgenic mouse model
Chia Ling Hsieh
Molecular Urology and Therapeutic Program, Department of Urology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Prostate 67:685-91. 2007
....
- Perlecan signaling: helping hedgehog stimulate prostate cancer growth
Sumana Datta
Department of Biochemistry and Biophysics, MS 2128, Texas A and M University, College Station, TX 77843 2128, United States
Int J Biochem Cell Biol 38:1855-61. 2006
..Inhibitors of Perlecan function at either the protein or glycan level would be ideal drug candidates for anti-cancer therapies...
- Current trends in molecular classification of adult renal tumors
Andrew N Young
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Urology 67:873-80. 2006
- Sex-determining region Y box 4 is a transforming oncogene in human prostate cancer cells
Pengbo Liu
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Cancer Res 66:4011-9. 2006
..Stable transfection of SOX4 into nontransformed prostate cells enabled colony formation in soft agar, suggesting that, in the proper cellular context, SOX4 can be a transforming oncogene...
- Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling
Pilar Sanchez
Skirball Institute and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Proc Natl Acad Sci U S A 101:12561-6. 2004
..Our data demonstrate the dependence of prostate cancer on SHH-GLI function and suggest a novel therapeutic approach...
- Prostate cancer in patients with screening serum prostate specific antigen values less than 4.0 ng/dl: results from the cooperative prostate cancer tissue resource
Milton W Datta
Departments of Pathology, New York University School of Medicine, New York, New York, USA
J Urol 173:1546-51. 2005
..0 ng/ml had smaller, lower grade tumors and lower recurrence rates than patients with PSA 4.0 ng/ml or greater. This was not true for those older than 62 years and for black men...
