Constantin A Dasanu

Summary

Publications

  1. ncbi Mediastinal choriocarcinoma presenting with syncope
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center, Hartford, USA
    Conn Med 77:473-5. 2013
  2. ncbi Aleukemic leukemia presenting with paranoid psychosis
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center, Hartford, USA
    Conn Med 77:537-9. 2013
  3. ncbi Gastrointestinal stromal tumor of small intestine and synchronous bilateral papillary renal cell carcinoma
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center, Hartford, USA
    Conn Med 77:405-7. 2013
  4. pmc Exogenous endothelial cells as accelerators of hematopoietic reconstitution
    J Christopher Mizer
    Regen BioPharma Inc, San Diego, CA, USA
    J Transl Med 10:231. 2012
  5. ncbi Smoking-induced monoclonal B-lymphocytosis in two female smokers: what are the odds?
    Constantin A Dasanu
    Medical Oncology and Blood Disorders, Hartford, CT, USA
    Conn Med 77:353-5. 2013
  6. doi Hair repigmentation associated with the use of lenalidomide: graying may not be an irreversible process!
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center, Hartford, CT 06105, USA
    J Oncol Pharm Pract 19:165-9. 2013
  7. ncbi Collision tumors: pancreatic adenocarcinoma and mantle cell lymphoma
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center Hartford, CT 06105, USA
    JOP 14:458-62. 2013
  8. doi Targeting macrophages in classical Hodgkin's lymphoma may seem rational, but is it safe?
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center, Hartford, CT 06105, USA
    J Oncol Pharm Pract 18:104-8. 2012
  9. ncbi Bevacizumab in lung cancer: lackluster performance and unjustified expense?
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center, USA
    J Oncol Pharm Pract 18:381-2. 2012
  10. ncbi Length of adjuvant imatinib therapy in GIST: weighing benefits, side effects and costs
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center, Hartford, CT 06105, USA
    J Oncol Pharm Pract 18:379-80. 2012

Collaborators

Detail Information

Publications80

  1. ncbi Mediastinal choriocarcinoma presenting with syncope
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center, Hartford, USA
    Conn Med 77:473-5. 2013
    ..He remains with no evidence of disease relapse 18 months later. Clinicians should consider the diagnosis of a mediastinal germ-cell tumor in a younger male patient presenting with a syncopal episode...
  2. ncbi Aleukemic leukemia presenting with paranoid psychosis
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center, Hartford, USA
    Conn Med 77:537-9. 2013
    ..As there is paucity of literature, diagnosis of MCL presenting with psychiatric symptoms remains a diagnostic challenge and warrants clinicians to be alert of this rare possibility...
  3. ncbi Gastrointestinal stromal tumor of small intestine and synchronous bilateral papillary renal cell carcinoma
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center, Hartford, USA
    Conn Med 77:405-7. 2013
    ..However, a unique feature in our GIST patient is the presence of synchronous (bilateral) papillary renal cell carcinomas...
  4. pmc Exogenous endothelial cells as accelerators of hematopoietic reconstitution
    J Christopher Mizer
    Regen BioPharma Inc, San Diego, CA, USA
    J Transl Med 10:231. 2012
    ....
  5. ncbi Smoking-induced monoclonal B-lymphocytosis in two female smokers: what are the odds?
    Constantin A Dasanu
    Medical Oncology and Blood Disorders, Hartford, CT, USA
    Conn Med 77:353-5. 2013
    ..Clinical scenarios in our patients suggest that the MBL might have been caused by chronic cigarette smoking. We further postulate that tobacco-induced B-lymphocytic proliferation may become neoplastic...
  6. doi Hair repigmentation associated with the use of lenalidomide: graying may not be an irreversible process!
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center, Hartford, CT 06105, USA
    J Oncol Pharm Pract 19:165-9. 2013
    ....
  7. ncbi Collision tumors: pancreatic adenocarcinoma and mantle cell lymphoma
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center Hartford, CT 06105, USA
    JOP 14:458-62. 2013
    ..To the best of our knowledge, collision tumors featuring mantle cell lymphoma and pancreatic adenocarcinoma have not been previously described in the scientific literature...
  8. doi Targeting macrophages in classical Hodgkin's lymphoma may seem rational, but is it safe?
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center, Hartford, CT 06105, USA
    J Oncol Pharm Pract 18:104-8. 2012
    ..The author believes RS cells should be targeted by the biologics, not the macrophages, and links his hopes with the existing investigational anti-CD30 therapies in relapsed/refractory classical HL...
  9. ncbi Bevacizumab in lung cancer: lackluster performance and unjustified expense?
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center, USA
    J Oncol Pharm Pract 18:381-2. 2012
    ..Integrating the conclusions of this study into clinical practice and further analysis of underlying physical, psychosocial, and economic hurdles of bevacizumab use in lung cancer patients are certainly justified...
  10. ncbi Length of adjuvant imatinib therapy in GIST: weighing benefits, side effects and costs
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center, Hartford, CT 06105, USA
    J Oncol Pharm Pract 18:379-80. 2012
    ..Further study of underlying economic, psychosocial, and physical barriers of longer vs shorter duration of adjuvant therapy in this patient population is probably warranted...
  11. doi Multiple myeloma and its therapies: to what extent do they contribute to the increased incidence of second malignant neoplasms?
    Constantin A Dasanu
    Medical Oncology and Blood Disorders, Gothic Park, Hartford, CT 06105, USA
    Curr Med Res Opin 28:1129-40. 2012
    ..The high risk of another cancer once one has been diagnosed is well known. Furthermore, a clear association exists between the use of some cytotoxic agents and chemotherapy-induced malignancies...
  12. doi Immune alterations in untreated and treated multiple myeloma
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center, Hartford, CT, USA
    J Oncol Pharm Pract 18:257-63. 2012
    ....
  13. ncbi Immune alterations and emerging immunotherapeutic approaches in lung cancer
    Constantin A Dasanu
    St Francis Hospital and Medical Center, Department of Hematology Oncology, Medical Oncology and Blood Disorders, Gothic Park, 43 Woodland Street, Suite G 80, Hartford, CT 06105, USA
    Expert Opin Biol Ther 12:923-37. 2012
    ..As discouraging results are commonly seen with the existing therapies in lung cancer, more innovative treatment strategies are needed...
  14. ncbi Cardiovascular toxicity associated with small molecule tyrosine kinase inhibitors currently in clinical use
    Constantin A Dasanu
    St Francis Hospital and Medical Center, Department of Hematology Oncology, Medical Oncology and Blood Disorders, LLP, Gothic Park, 43 Woodland Street, Suite G 80, Hartford, CT 06105, USA
    Expert Opin Drug Saf 11:445-57. 2012
    ..Tyrosine kinase inhibitors (TKIs) have changed the concepts of systemic therapy for a variety of advanced solid and hematologic malignancies. However, their toxicity can be significant, and includes both cardiac and non-cardiac effects...
  15. doi Newer developments in the therapeutics of the transitional cell carcinoma of renal pelvis
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center, Hartford, CT 06105, USA
    J Oncol Pharm Pract 18:97-103. 2012
    ..New targeted agents, alone or in combination with cytotoxic drugs, are currently being tested in clinical trials and may lead to new and exciting avenues for the therapy of this disease...
  16. doi Emerging therapeutic options for advanced enteropancreatic neuroendocrine tumors
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center, Hartford, CT 06105, USA
    Expert Opin Pharmacother 13:461-71. 2012
    ..Recent understanding of the molecular mechanisms of these tumors, especially the central role of tumor angiogenesis, has led to the identification of new therapeutic targets and agents directed at the molecular level...
  17. pmc Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?
    Thomas E Ichim
    Department of Orthomolecular Studies, Riordan Clinic, 3100 N Hillside, Wichita, Kansas 67210, USA
    J Transl Med 9:25. 2011
    ....
  18. pmc Generalized cerebral atrophy seen on MRI in a naturally exposed animal model for Creutzfeldt-Jakob disease
    Alexia L McKnight
    University of Pennsylvania School of Veterinary Medicine, New Bolton Center, Kennett Square, PA 19348, USA
    J Transl Med 8:125. 2010
    ..This study attempts to answer the questions "Could MRI detect prion diseases before clinical symptoms appear?, and if so, with what confidence?"..
  19. doi Polycystic ovary syndrome: focus on platelets and prothrombotic risk
    Constantin A Dasanu
    Saint Francis Hospital and Medical Center, Hartford, CT, USA
    South Med J 104:174-8. 2011
    ..Systemic inflammation and reactive leukocytosis have also been described in PCOS. Recent research suggests the presence of an increased thrombotic risk in these patients...
  20. doi Bortezomib: friend or foe of hemolytic anemia?
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center, Hartford, CT, USA
    J Oncol Pharm Pract 17:233-5. 2011
    ..Concerted efforts of both basic and clinical researchers are necessary to further explore the safety and efficacy of this agent in nonmalignant disorders, including autoimmune disorders and anemias...
  21. doi Small cell lung cancer with paraneoplastic lipase production
    Constantin A Dasanu
    Department of Hematology Oncology, Saint Francis Hospital and Medical Center, Hartford, CT, USA
    South Med J 103:819-22. 2010
    ..In our patient, the paraneoplastic hyperlipasemia paralleled both the initial SCLC response to chemotherapy and its subsequent clinicoradiological relapse...
  22. ncbi Synchronous Tumors: Adenosquamous Carcinoma of Pancreas and GIST of Stomach
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center, Hartford, CT, USA
    J Gastrointest Cancer 42:186-9. 2011
    ..At the time of this publication, our patient, who received adjuvant chemoradiotherapy, remains disease-free 14 months after the abdominal surgery...
  23. ncbi Congenital combined deficiency of coagulation factors VII and II in a young adult
    Constantin A Dasanu
    Department of Hematology Oncology, Saint Francis Hospital and Medical Center, Gothic Park, 43 Woodland Street, Suite G 80, Hartford, CT 06105, USA
    Conn Med 74:581-3. 2010
    ....
  24. ncbi Alpha-thalassemia genetic testing: an important anemia diagnostic tool in patients of African heritage
    Constantin A Dasanu
    Department of Hematology Oncology, Saint Francis Hospital and Medical Center, Gothic Park, 43 Woodland Street, Suite G 80, Hartford, CT 06105, USA
    Conn Med 74:585-7. 2010
    ..We detected alpha-thalassemia gene deletions in 94 percent of these patients. Alpha-thalassemia genetic testing appears cost-effective in an otherwise unexplained, longstanding microcytic anemia in patients of African origin...
  25. ncbi Isolated thrombocytopenia: should we routinely screen for antiphospholipid antibodies?
    Constantin A Dasanu
    Department of Hematology Oncology, Saint Francis Hospital and Medical Center, Hartford, USA
    Conn Med 75:281-4. 2011
    ..Antiphospholipid (aPL) antibodies are thought to be present in at least 25% of immune thrombocytopenia patients. Conversely, more than 25% of patients with aPL antibody syndrome (APLAS) present with thrombocytopenia...
  26. ncbi Intrinsic and treatment-related immune alterations in chronic lymphocytic leukaemia and their impact for clinical practice
    Constantin A Dasanu
    Seattle Hematology Oncology, 2202 70th Ave West, University Place, WA 98466, USA
    Expert Opin Pharmacother 9:1481-94. 2008
    ..It has also been shown that the rate of second cancers is increased in chronic lymphocytic leukaemia...
  27. doi Newer developments in adult T-cell leukemia/lymphoma therapeutics
    Constantin A Dasanu
    St Francis Hospital and Medical Center, Department of Hematology Oncology, Hartford, CT, USA
    Expert Opin Pharmacother 12:1709-17. 2011
    ..Adult T-cell leukemia/lymphoma (ATL) is a rare disease with a unique geographic distribution. Conducting controlled randomized trials to assess the effective therapeutic strategies has therefore been a significant challenge to date...
  28. doi Emerging pharmacotherapeutic strategies for cholangiocarcinoma
    Constantin A Dasanu
    St Francis Hospital and Medical Center, Department of Hematology Oncology, Hartford, CT, USA
    Expert Opin Pharmacother 12:1865-74. 2011
    ....
  29. doi Complete heart block secondary to bortezomib use in multiple myeloma
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center, Hartford, CT, USA
    J Oncol Pharm Pract 17:282-4. 2011
    ..The author discusses further various heart rhythm and other autonomic nervous system abnormalities attributed to bortezomib in the existing literature...
  30. ncbi mTOR-blocking agents in advanced renal cancer: an emerging therapeutic option
    Constantin A Dasanu
    Saint Francis Hospital and Medical Center, Hematology and Medical Oncology, Gothic Park, 43 Woodland Street, Hartford, CT 06105, USA
    Expert Opin Investig Drugs 18:175-87. 2009
    ..A prominent member in its class of medications, temsirolimus has already been shown to improve overall survival in advanced kidney cancer, when compared with the previous standard, IFN-alpha...
  31. ncbi Bilateral Leser-Trélat sign mirroring lung adenocarcinoma with early metastases to the contralateral lung
    Constantin A Dasanu
    Georgetown University, Washington, DC, USA
    South Med J 102:216-8. 2009
    ..Our case suggests a unique interrelation between the paraneoplastic sign of Leser-Trélat and the tumor itself. The recognition of this phenomenon may contribute to an early diagnosis and prompt surgical treatment of occult cancers...
  32. ncbi Systemic lupus erythematosus associated with paclitaxel use in the treatment of ovarian cancer
    Constantin A Dasanu
    Seattle Hematology Oncology, Seattle, WA 98466, USA
    South Med J 101:1161-2. 2008
    ..To our knowledge, this is the first known case of a patient with serologically confirmed systemic lupus erythematosus secondary to paclitaxel use...
  33. doi A case of severe aplastic anemia secondary to treatment with lenalidomide for multiple myeloma
    Constantin A Dasanu
    Department of Hematology Oncology, Saint Francis Hospital and Medical Center, Hartford, CT, USA
    Eur J Haematol 82:231-4. 2009
    ..A gradual spontaneous recovery of normal hematopoiesis followed after the lenalidomide discontinuation...
  34. ncbi Gemcitabine: vascular toxicity and prothrombotic potential
    Constantin A Dasanu
    Practicing Hematologist and Medical Oncologist, University Place, 2202 70th Ave W, Suite 5, WA 98466, USA
    Expert Opin Drug Saf 7:703-16. 2008
    ..Gemcitabine has been associated with important thrombotic and vascular side effects. As indications for its use in oncology and hematology are expanding, comprehensive characterization of these complications becomes imperative...
  35. doi Acute retinal pigment epithelial detachment secondary to pamidronate administration
    Constantin A Dasanu
    J Oncol Pharm Pract 15:119-21. 2009
    ..We present here the first case of an acute retinal pigment epithelial detachment associated with pamidronate infusion in a 59-year-old patient with metastatic prostate cancer...
  36. doi Bilateral perinephric diffuse large B-cell lymphoma and synchronous renal oncocytoma
    Constantin A Dasanu
    Comprehensive Cancer Center at Our Lady of Mercy Medical Center, New York Medical College, Bronx, New York, USA
    South Med J 101:196-8. 2008
    ..Because of the patient's other medical conditions, systemic chemotherapy was not deemed feasible. Subsequently, the proliferation had a favorable response to single-agent monoclonal antibody rituximab...
  37. pmc Risk for second nonlymphoid neoplasms in chronic lymphocytic leukemia
    Constantin A Dasanu
    MedGenMed 9:35. 2007
    ..Increased awareness of this association is warranted. Future development of surveillance strategies may be needed for a growing population of surviving patients who are at risk for second nonlymphoid neoplasms...
  38. ncbi Yellow skin discoloration associated with sorafenib use for treatment of metastatic renal cell carcinoma
    Constantin A Dasanu
    New York Medical College, Comprehensive Cancer Center, Our Lady of Mercy Medical Center, 600 East 233rd Street, Bronx, NY 10466, USA
    South Med J 100:328-30. 2007
    ..A thorough clinicolaboratory investigation did not reveal any evidence of jaundice, B12 deficiency, anemia, carotenemia, hypothyroidism, or any other disorder of endocrine or metabolic etiology...
  39. ncbi A complex pattern of melanonychia and onycholysis after treatment with pemetrexed for lung cancer
    Constantin A Dasanu
    Our Lady of Mercy Cancer Center, New York Medical College, Bronx, NY, USA
    Skinmed 6:95-6. 2007
    ..When questioned, he denied taking any other drugs including other alternative medicine approaches or vitamin supplements, particularly retinoids, well known for causing severe nail dystrophy...
  40. ncbi Distinct patterns of chromonychia, Beau's lines, and melanoderma seen with vincristine, adriamycin, dexamethasone therapy for multiple myeloma
    Constantin A Dasanu
    Department of Oncology, Our Lady of Mercy Medical Center, New York Medical College, Bronx, NY, USA
    Dermatol Online J 12:10. 2006
    ..All changes disappeared 4 months after the discontinuation of VAD chemotherapy, which further pointed out towards adriamycin and vincristine as possible etiologic agents...
  41. pmc Clear cell adenocarcinoma of the ovary associated with in utero diethylstilbestrol exposure: case report and clinical overview
    Constantin A Dasanu
    Saint Francis Hospital and Medical Center, Hartford, Connecticut, USA
    Medscape J Med 11:6. 2009
    ..This report describes the first clinical case of clear cell adenocarcinoma of the ovary linked to early diethylstilbestrol exposure in utero...
  42. doi Chronic lymphocytic leukemia presenting with cholecystitis-like symptoms and gallbladder wall invasion
    Constantin A Dasanu
    Department of Hematology Oncology and Pathology, Saint Francis Hospital and Medical Center, Hartford, CT, USA
    South Med J 103:482-4. 2010
    ..In this way, we would like to alert clinicians and pathologists alike to CLL as yet another cause of a cholecystitis-like symptomatology...
  43. doi Inherent and iatrogenic immune defects in hairy cell leukemia: revisited
    Constantin A Dasanu
    Saint Francis Hospital and Medical Center, Department of Hematology Oncology, Gothic Park, 43 Woodland Street, Hartford 06105, USA
    Expert Opin Drug Saf 9:55-64. 2010
    ..These alterations are responsible for an increased rate of infections and additional malignancies in HCL...
  44. doi Risk of additional cancers in untreated and treated hairy cell leukemia patients
    Constantin A Dasanu
    St Francis Hospital and Medical Center, Department of Hematology Oncology, Gothic Park, 43 Woodland Street, G 80, Hartford, CT 06105, USA
    Expert Opin Pharmacother 11:41-50. 2010
    ..The increased incidence of second cancers in HCL has been documented in large epidemiologic studies conducted in various locations on the globe...
  45. doi Prophylactic antivirals may be helpful in prevention of varicella-zoster virus reactivation in myeloma, but are they safe?
    Constantin A Dasanu
    Department of Hematology Oncology, Saint Francis Hospital and Medical Center, Hartford, CT, USA
    J Oncol Pharm Pract 16:266-8. 2010
    ..Therefore, prophylactic use of antivirals has been advocated by some authors. This article explores the potential risks and pitfalls linked to routine acyclovir prophylaxis in bortezomib-treated MM...
  46. doi H. pylori-associated gastric cancer in a husband-wife pair: a veritable family affair
    Constantin A Dasanu
    Saint Francis Hospital and Medical Center, Hartford, CT, USA
    South Med J 102:1158-60. 2009
    ..pylori strain, putting them at risk for developing the disease. Therefore, it may be justified to identify and eradicate the H. pylori infection in such family members early, before the neoplastic changes become irreversible...
  47. doi A case of prekallikrein deficiency resulting in severe recurrent mucosal hemorrhage
    Constantin A Dasanu
    Department of Hematology Oncology, St Francis Hospital and Medical Center, Hartford, CT 06105, USA
    Am J Med Sci 338:429-30. 2009
    ..We find it intriguing that our patient is of African heritage and presented with a moderate nasal bleeding tendency in her youth, followed by severe recurrent mucosal bleeding later in life...
  48. doi Carboplatin-gemcitabine in the therapy of advanced ovarian cancer: dose reduction consideration
    Constantin A Dasanu
    Department of Hematology and Oncology, Saint Francis Hospital and Medical Center, Hartford, CT, USA
    J Oncol Pharm Pract 16:63-6. 2010
    ..In conclusion, administration of carboplatin AUC = 4 and gemcitabine 750 mg/m(2) appears to be a safe and effective combination for the therapy of advanced/metastatic OC, with clinically tolerable hematological toxicity...
  49. ncbi Persistent hair growth during treatment with the EGFR inhibitor erlotinib
    Doru T Alexandrescu
    Georgetown Dermatology, Washington, DC, USA
    Dermatol Online J 15:4. 2009
    ..The persistence of trichomegaly in some patients brings into question the precise mechanism of this phenomenon and suggests the possibility of using EGFR inhibition therapeutically to stimulate hair growth...
  50. ncbi Tumor fever, paraneoplastic leukocytosis and necrotic liver metastases: a triad worth remembering
    Constantin A Dasanu
    St Francis Hospital and Medical Center, Hartford, CT 06105, USA
    Conn Med 74:389-91. 2010
    ..We report two unique patients with adenocarcinoma of the lung associated with tumor fever, necrotic liver metastases and granulocyte-colony stimulating factor (G-CSF) driven leukocytosis...
  51. ncbi Plasmablastic haemato-lymphoid neoplasm with a complex genetic signature of Burkitt lymphoma responding to bortezomib
    Constantin A Dasanu
    Department of Hematology Oncology, Saint Francis Hospital and Medical Center, Hartford, CT, USA
    Hematol Oncol 31:164-6. 2013
    ..In addition, the patient responded to the treatment with bortezomib. Newer antimyeloma agents such as bortezomib have shown promise in the treatment of these neoplasms and should further be explored for their therapy...
  52. ncbi Persistent polyclonal B-cell lymphocytosis in chronic smokers: more than meets the eye
    Constantin A Dasanu
    Department of Hematology Oncology, Saint Francis Hospital and Medical Center, Hartford, USA
    Conn Med 76:69-72. 2012
    ..Persistent neutrophiliais awell-recognized phenomenon in some chronic cigarette smokers. In contrast, persistent polyclonal B-cell lymphocytosis (PPBL) is considered a rare entity affecting this patient population...
  53. ncbi On the missing link between inflammation and cancer
    Doru T Alexandrescu
    Georgetown Dermatology, Washington, DC, USA
    Dermatol Online J 17:10. 2011
    ..Pathogenic links of inflammation with cancer are discussed, including inflammation, intrinsic immune dysfunction, cytokines and interleukins, angiogenetic factors, and epigenetic changes...
  54. ncbi Persistent cutaneous hyperpigmentation after tyrosine kinase inhibition with imatinib for GIST
    Doru T Alexandrescu
    Georgetown Dermatology, Washington, DC, USA
    Dermatol Online J 14:7. 2008
    ..Elucidation of the mechanisms of action of imatinib in the skin may open future directions for the treatment of pigmentary disorders...
  55. ncbi Skin necrosis: a rare complication of protein S deficiency
    Ashif Jethava
    Department of Hospital Medicine, Saint Francis Hospital and Medical Center, Hartford, USA
    Conn Med 78:29-32. 2014
    ..She had a protracted clinical course resulting in gangrene and transmetatarsal amputation. Recognition of this rare complication and an earlyhematology referral may prevent dismal outcomes in patients with protein S deficiency...
  56. doi Immune alterations in malignant melanoma and current immunotherapy concepts
    Alexei Shimanovsky
    University of Connecticut Health Science Center, Department of Medicine, Farmington, 21 Temple Street 501, Hartford, CT 06103, USA
    Expert Opin Biol Ther 13:1413-27. 2013
    ..Innovative treatment strategies can be achieved through employing our knowledge of the melanoma-induced immune alterations...
  57. ncbi Hematology consult: high-sensitivity warfarin genotype
    Caitlin Schwer
    Department of Hematology Oncology, Saint Francis Hospital and Medical Center, Hartford, USA
    Conn Med 77:581-5. 2013
    ..Notwithstanding, randomized controlled trials are awaited to determine the true impact of this testing on clinical outcomes and its cost-effectiveness...
  58. ncbi Muehrcke's lines (Leukonychia striata) due to transretinoic acid therapy for acute promyelocytic leukemia
    Constantin A Dasanu
    Medical Oncology and Blood Disorders, Saint Francis Hospital and Medical Center, Hartford, CT, USA
    J Oncol Pharm Pract 19:377-9. 2013
    ..Physician awareness of transverse leukonychia is important in order to reassure the patients and avoid unnecessary (and often not inexpensive) diagnostic work-up...
  59. ncbi Adenosquamous carcinoma of the pancreas: a distinct clinicopathologic entity
    Guru Trikudanathan
    Department of Internal Medicine, University of Connecticut Medical Center, Farmington, CT, USA
    South Med J 103:903-10. 2010
    ..As a result, its molecular and genetic makeup could be exploited for both diagnostic and therapeutic quests in the future...
  60. ncbi Kidney cancer therapy: new perspectives and avenues
    Doru T Alexandrescu
    Georgetown University, Washington Cancer Institute, 110 Irving Street, N W, Washington, DC 20010, USA
    Expert Opin Pharmacother 7:2481-93. 2006
    ..The use of small molecules, such as multitargeted tyrosine kinase inhibitors, the mTOR inhibitors and monoclonal antibodies, is dramatically changing the existing concepts of systemic treatment for metastatic kidney cancer...
  61. ncbi Association between Helicobacter pylori infection and pancreatic cancer. A cumulative meta-analysis
    Guru Trikudanathan
    Department of Internal Medicine, University of Connecticut Medical Center, Farmington, CT, USA
    JOP 12:26-31. 2011
    ..Notwithstanding, its etiological association with pancreatic cancer remains inconclusive. Studies focusing on the relationship between H. pylori infection and pancreatic cancer risk have yielded conflicting results...
  62. ncbi Cutaneous sarcoidosis and malignancy: An association between sarcoidosis with skin manifestations and systemic neoplasia
    Doru T Alexandrescu
    Georgetown Dermatology, Washington, DC, USA
    Dermatol Online J 17:2. 2011
    ..Because cutaneous manifestations are seen in 20-25 percent of cases of sarcoidosis, this association deserves further investigation...
  63. ncbi Details of left ventricular remodeling and the mechanism of paradoxical ventricular septal motion after coronary artery bypass graft surgery
    Ion Codreanu
    Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, United Kingdom
    J Invasive Cardiol 23:276-82. 2011
    ..The purpose of this study was to obtain new details of three-dimensional left ventricular wall motion related to ventricular remodeling in patients undergoing coronary artery bypass graft (CABG) surgery...
  64. pmc Chasing the reflected wave back into the heart: a new hypothesis while the jury is still out
    Ion Codreanu
    Department of Physiology, Anatomy, and Genetics, University of Oxford, UK
    Vasc Health Risk Manag 7:365-73. 2011
    ..The aim of this study was to obtain detailed information on regional ventricular wall motion patterns corresponding to the propagation of the reflected aortic wave on ventricular segments...
  65. doi Management of advanced and/or metastatic carcinoid tumors: historical perspectives and emerging therapies
    Nina Nandy
    University of Connecticut Medical Center, Department of Internal Medicine, Hartford, CT 06103, USA
    Expert Opin Pharmacother 14:1649-58. 2013
    ..Given the heterogeneity of these tumors, there is no clear therapeutic agent or combination that confers a significant advantage over others...
  66. ncbi The cutaneous epidermal growth factor network: Can it be translated clinically to stimulate hair growth?
    Doru T Alexandrescu
    Georgetown Dermatology, Washington, DC, USA
    Dermatol Online J 15:1. 2009
    ..A better characterization of the individual roles pertaining to the EGF family ligands and receptors, has the potential provide new strategies for the management of hair loss...
  67. ncbi Evolving pharmacotherapeutic strategies for small bowel adenocarcinoma
    Guru Trikudanathan
    University of Connecticut Medical Center, Department of Internal Medicine, Farmington, CT, USA
    Expert Opin Pharmacother 11:1695-704. 2010
    ..Few studies in the literature adequately address the role of chemotherapy in SBA. The regimens used in colon and gastric cancers have been tried in SBA with varying degrees of success...
  68. doi An unusual presentation of a carcinoid tumor of the common bile duct
    Ashif Jethava
    Department of Hematology Oncology, Saint Francis Hospital and Medical Center, Hartford, CT, USA
    JOP 14:85-7. 2013
    ..Carcinoid tumors arising from the bile ducts account for only a small fraction of biliary tract cancers...
  69. doi Immune alterations and immunotherapy prospects in head and neck cancer
    Vincent Varilla
    University of Connecticut Medical Center, Department of Internal Medicine, Hartford, CT 06106, USA
    Expert Opin Biol Ther 13:1241-56. 2013
    ..Serious side effects and only a limited success with traditional therapies in HNSCC dictate the need for newer therapies...
  70. doi Newer developments in the immunotherapy of malignant melanoma
    Benjamin Maslin
    Department of Medicine, Yale University School of Medicine, New Haven, CT, USA
    J Oncol Pharm Pract 20:3-10. 2014
    ..Consequently, these experimental immunotherapy agents may soon become important items in the anti-melanoma armamentarium. ..
  71. ncbi Primary respiratory failure due to inclusion body myositis: think outside the box
    Ashif Jethava
    Department of Hospital Medicine, Saint Francis Hospital and Medical Center, Hartford, USA
    Conn Med 77:155-8. 2013
    ..We postulate that muscle biopsy may be warranted in select patients suffering from a protracted muscle weakness...
  72. ncbi Adult biphasic pulmonary blastoma
    Ashif Jethava
    Department of Hospital Medicine, Saint Francis Hospital and Medical Center, Hartford, USA
    Conn Med 77:19-22. 2013
    ..Although a rare occurrence after the age of 20, pulmonary blastoma should remain in the differential diagnosis of a lung mass in an adult...
  73. ncbi Hepatoid variant of pancreatic cancer: insights from a case and literature review
    Shounak Majumder
    Department of Internal Medicine, University of Connecticut Farmington, CT 06030, USA
    JOP 14:442-5. 2013
    ..Hepatoid" cancer refers to an extrahepatic neoplasm with hepatocellular differentiation. The stomach is the most common site and pancreatic origin is distinctly uncommon...
  74. ncbi Acute Wernicke encephalopathy and sensorineural hearing loss complicating bariatric surgery
    Ashif Jethava
    Department of Hospital Medicine, Saint Francis Hospital and Medical Center, Hartford CT, USA
    Conn Med 76:603-5. 2012
    ....
  75. ncbi Anaphylactic reactions with intravenous vitamin K: lessons from the bedside
    Ashif Jethava
    Department of Hospital Medicine, Saint Francis Hospital and Medical Center, Hartford, USA
    Conn Med 76:549-50. 2012
    ..Vigilance with the intravenous formulation of this agent should always be sought in order to prevent fatal outcomes, especially in patients with severe comorbidities...
  76. doi Immune alterations in untreated and treated myelodysplastic syndrome
    Prerna Mewawalla
    University of Connecticut, Department of Medicine, 24 Park Pl, Apt 20A, Hartford, Farmington, CT 06106, USA
    Expert Opin Drug Saf 10:351-61. 2011
    ..As a result, their clinical implications remain largely unknown. In addition, an increased incidence of various autoimmune conditions has been documented in MDS patients...
  77. ncbi Catastrophic arteriovenous thromboembolism as initial manifestation of pancreatic cancer
    Shounak Majumder
    Department of Internal Medicine, University of Connecticut, Farmington, CT 06030, USA
    JOP 13:231-4. 2012
    ..However, simultaneous arterial and venous thromboses affecting multiple organs at the time of initial diagnosis is rare, with an incidence of less than 1%...
  78. doi Hodgkin lymphoma as Richter transformation in chronic lymphocytic leukaemia: a retrospective analysis of world literature
    Bruno Bockorny
    Department of Internal Medicine, University of Connecticut Medical Center, Farmington, CT 06030 1235, USA
    Br J Haematol 156:50-66. 2012
    ..The role of immunosuppression and Epstein-Barr virus infection in the aetiopathogenesis of this entity remains to be clarified...
  79. doi Secondary erythrocytosis produced by the tyrosine kinase inhibitors sunitinib and sorafenib
    Doru T Alexandrescu
    J Clin Oncol 26:4047-8. 2008
  80. doi Sunitinib-associated lymphocytic thyroiditis without circulating antithyroid antibodies
    Doru T Alexandrescu
    Thyroid 18:809-12. 2008