Constantin A Dasanu

Summary

Publications

  1. ncbi request reprint Melanoma costs: a dynamic model comparing estimated overall costs of various clinical stages
    Doru Traian Alexandrescu
    University of California, San Diego, CA, USA
    Dermatol Online J 15:1. 2009
  2. pmc Expression of the epigenetic factor BORIS (CTCFL) in the human genome
    Rosalia De Necochea-Campion
    Division of Hematology and Oncology, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA
    J Transl Med 9:213. 2011
  3. pmc Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?
    Thomas E Ichim
    Department of Orthomolecular Studies, Riordan Clinic, 3100 N Hillside, Wichita, Kansas 67210, USA
    J Transl Med 9:25. 2011
  4. pmc Generalized cerebral atrophy seen on MRI in a naturally exposed animal model for Creutzfeldt-Jakob disease
    Alexia L McKnight
    University of Pennsylvania School of Veterinary Medicine, New Bolton Center, Kennett Square, PA 19348, USA
    J Transl Med 8:125. 2010
  5. pmc Circulating endothelial progenitor cells: a new approach to anti-aging medicine?
    Nina A Mikirova
    Bio Communications Research Institute, Wichita, Kansas, USA
    J Transl Med 7:106. 2009
  6. ncbi request reprint Cutaneous sarcoidosis and malignancy: An association between sarcoidosis with skin manifestations and systemic neoplasia
    Doru T Alexandrescu
    Georgetown Dermatology, Washington, DC, USA
    Dermatol Online J 17:2. 2011
  7. doi request reprint Serum globulins as marker of immune restoration after treatment with high-dose rituximab for chronic lymphocytic leukemia
    Doru T Alexandrescu
    Comprehensive Cancer Center, Our Lady of Mercy Medical Center, New York Medical College, 600 East 233rd Street, Bronx, NY 10466, USA
    Med Oncol 25:309-14. 2008
  8. ncbi request reprint Persistent cutaneous hyperpigmentation after tyrosine kinase inhibition with imatinib for GIST
    Doru T Alexandrescu
    Georgetown Dermatology, Washington, DC, USA
    Dermatol Online J 14:7. 2008
  9. doi request reprint Acute scurvy during treatment with interleukin-2
    D T Alexandrescu
    Department of Dermatology, Georgetown University, Washington Cancer Institute, Washington, DC 20010, USA
    Clin Exp Dermatol 34:811-4. 2009
  10. ncbi request reprint The cutaneous epidermal growth factor network: Can it be translated clinically to stimulate hair growth?
    Doru T Alexandrescu
    Georgetown Dermatology, Washington, DC, USA
    Dermatol Online J 15:1. 2009

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Melanoma costs: a dynamic model comparing estimated overall costs of various clinical stages
    Doru Traian Alexandrescu
    University of California, San Diego, CA, USA
    Dermatol Online J 15:1. 2009
    ..Futhermore, previous calculations have not been updated to reflect the modern tendencies in healthcare costs...
  2. pmc Expression of the epigenetic factor BORIS (CTCFL) in the human genome
    Rosalia De Necochea-Campion
    Division of Hematology and Oncology, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA
    J Transl Med 9:213. 2011
    ....
  3. pmc Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?
    Thomas E Ichim
    Department of Orthomolecular Studies, Riordan Clinic, 3100 N Hillside, Wichita, Kansas 67210, USA
    J Transl Med 9:25. 2011
    ....
  4. pmc Generalized cerebral atrophy seen on MRI in a naturally exposed animal model for Creutzfeldt-Jakob disease
    Alexia L McKnight
    University of Pennsylvania School of Veterinary Medicine, New Bolton Center, Kennett Square, PA 19348, USA
    J Transl Med 8:125. 2010
    ..This study attempts to answer the questions "Could MRI detect prion diseases before clinical symptoms appear?, and if so, with what confidence?"..
  5. pmc Circulating endothelial progenitor cells: a new approach to anti-aging medicine?
    Nina A Mikirova
    Bio Communications Research Institute, Wichita, Kansas, USA
    J Transl Med 7:106. 2009
    ..We conclude by discussing several clinically-relevant approaches to EPC mobilization and provide preliminary data on a food supplement, Stem-Kine, which enhanced EPC mobilization in human subjects...
  6. ncbi request reprint Cutaneous sarcoidosis and malignancy: An association between sarcoidosis with skin manifestations and systemic neoplasia
    Doru T Alexandrescu
    Georgetown Dermatology, Washington, DC, USA
    Dermatol Online J 17:2. 2011
    ..Because cutaneous manifestations are seen in 20-25 percent of cases of sarcoidosis, this association deserves further investigation...
  7. doi request reprint Serum globulins as marker of immune restoration after treatment with high-dose rituximab for chronic lymphocytic leukemia
    Doru T Alexandrescu
    Comprehensive Cancer Center, Our Lady of Mercy Medical Center, New York Medical College, 600 East 233rd Street, Bronx, NY 10466, USA
    Med Oncol 25:309-14. 2008
    ..Use of high doses of rituximab in CLL can avoid T-cell dysfunction and neutropenia, and is associated with humoral immunorestorative effects...
  8. ncbi request reprint Persistent cutaneous hyperpigmentation after tyrosine kinase inhibition with imatinib for GIST
    Doru T Alexandrescu
    Georgetown Dermatology, Washington, DC, USA
    Dermatol Online J 14:7. 2008
    ..Elucidation of the mechanisms of action of imatinib in the skin may open future directions for the treatment of pigmentary disorders...
  9. doi request reprint Acute scurvy during treatment with interleukin-2
    D T Alexandrescu
    Department of Dermatology, Georgetown University, Washington Cancer Institute, Washington, DC 20010, USA
    Clin Exp Dermatol 34:811-4. 2009
    ....
  10. ncbi request reprint The cutaneous epidermal growth factor network: Can it be translated clinically to stimulate hair growth?
    Doru T Alexandrescu
    Georgetown Dermatology, Washington, DC, USA
    Dermatol Online J 15:1. 2009
    ..A better characterization of the individual roles pertaining to the EGF family ligands and receptors, has the potential provide new strategies for the management of hair loss...
  11. ncbi request reprint Persistent hair growth during treatment with the EGFR inhibitor erlotinib
    Doru T Alexandrescu
    Georgetown Dermatology, Washington, DC, USA
    Dermatol Online J 15:4. 2009
    ..The persistence of trichomegaly in some patients brings into question the precise mechanism of this phenomenon and suggests the possibility of using EGFR inhibition therapeutically to stimulate hair growth...
  12. ncbi request reprint On the missing link between inflammation and cancer
    Doru T Alexandrescu
    Georgetown Dermatology, Washington, DC, USA
    Dermatol Online J 17:10. 2011
    ..Pathogenic links of inflammation with cancer are discussed, including inflammation, intrinsic immune dysfunction, cytokines and interleukins, angiogenetic factors, and epigenetic changes...
  13. doi request reprint Melanoma-specific marker expression in skin biopsy tissues as a tool to facilitate melanoma diagnosis
    Doru T Alexandrescu
    Georgetown Dermatology, Washington, DC, USA
    J Invest Dermatol 130:1887-92. 2010
    ..The role and potential utility of this molecular assay as an adjunct to the morphological diagnosis of melanoma are discussed...
  14. pmc Immunotherapy for melanoma: current status and perspectives
    Doru T Alexandrescu
    Division of Dermatology, University of California at San Diego, San Diego, CA, USA
    J Immunother 33:570-90. 2010
    ..The need to engineer better immune interactions and to boost positive feedback loops appear crucial for the future of melanoma therapy, which ultimately resides in our understanding of the complexity of immune responses in this disease...
  15. ncbi request reprint The influence of parental age and gender on anticipation in familial B-cell malignancies
    Doru T Alexandrescu
    New York Medical College, Comprehensive Cancer Center at Our Lady of Mercy, Medical Center, Bronx, NY 10466, USA
    Med Oncol 24:55-62. 2007
    ..Although less prominent than with neurological disease, this phenomenon indicates a possible germline inheritance of B-cell malignancies and a common genetic basis for HD and NHL...
  16. ncbi request reprint Fatal intra-alveolar hemorrhage after rituximab in a patient with non-Hodgkin lymphoma
    Doru T Alexandrescu
    Comprehensive Cancer Center, Our Lady of Mercy Medical Center, New York Medical College, Bronx, NY 10466, USA
    Leuk Lymphoma 45:2321-5. 2004
    ..A review of the pertinent literature is provided. The possible pathogenetic mechanisms, including the role of cytokines, cytotoxic T-lymphocytes and CD 20 positive T-cells in relation to the administration of rituximab are discussed...
  17. ncbi request reprint Metastatic melanoma: is biochemotherapy the future?
    Doru T Alexandrescu
    New York Medical College, Our Lady of Mercy Medical Center, Comprehensive Cancer Center, Bronx, NY 10466, USA
    Med Oncol 22:101-11. 2005
    ....
  18. ncbi request reprint Metastatic solid-pseudopapillary tumour of the pancreas: clinico-biological correlates and management
    D T Alexandrescu
    Comprehensive Cancer Center, Our Lady of Mercy Medical Center, Bronx, NY 10466, USA
    Clin Oncol (R Coll Radiol) 17:358-63. 2005
    ..However, the indolent clinical progression of solid-pseudopapillary tumours is similar to that of pancreatic neuroendocrine tumour...
  19. ncbi request reprint Unusually large colon cancer cutaneous and subcutaneous metastases occurring in resection scars
    Doru T Alexandrescu
    Comprehensive Cancer Center, New York Medical College, Our Lady of Mercy Medical Center, Bronx, NY 10466, USA
    Dermatol Online J 11:22. 2005
    ....
  20. ncbi request reprint Steroid-responsive inclusion body myositis associated with endometrial cancer
    D T Alexandrescu
    Comprehensive Cancer Center, Our Lady of Mercy Medical Center, Bronx, New York 10466, USA
    Clin Exp Rheumatol 23:93-6. 2005
    ..The factors that are associated with a response of IBM to steroids are discussed. An atypical, steroid-responsive form of the disease is delineated...
  21. ncbi request reprint Mitoxantrone, vinblastine and CCNU: long-term follow-up of patients treated for advanced and poor-prognosis Hodgkin's disease
    Doru T Alexandrescu
    Comprehensive Cancer Center, Our Lady of Mercy Medical Center, New York Medical College, NY 10446, USA
    Leuk Lymphoma 47:641-56. 2006
    ..Although significant, the toxicities associated with this regimen were manageable...
  22. ncbi request reprint Effect of treatment with a colloidal oatmeal lotion on the acneform eruption induced by epidermal growth factor receptor and multiple tyrosine-kinase inhibitors
    D T Alexandrescu
    Washington Cancer Institute and Lombardi Cancer Center, Georgetown Univeisty, Department of Internal Medicine, Washington Hospital Center, Washington, DC 20010, USA
    Clin Exp Dermatol 32:71-4. 2007
    ..Treatment with colloidal oatmeal lotion is efficient in controlling the rash associated with EGFR and multiple TKI, and allows continuation of the antineoplastic treatment...
  23. ncbi request reprint Strokes after intravenous gamma globulin: thrombotic phenomenon in patients with risk factors or just coincidence?
    Doru T Alexandrescu
    Comprehensive Cancer Center, New York Medical College, Our Lady of Mercy Medical Center, Bronx, New York 10466, USA
    Am J Hematol 78:216-20. 2005
    ..Clinical evaluation, with attention to history, a focused vascular work-up, and looking for markers of dehydration, can identify the high-risk patient for whom a careful analysis of the risk/benefit ratio is warranted...
  24. ncbi request reprint Unusual cutaneous involvement during plasma cell leukaemia phase in a multiple myeloma patient after treatment with thalidomide: a case report and review of the literature
    D T Alexandrescu
    New York Medical College, Our Lady of Mercy Medical Center, Comprehensive Cancer, Bronx, NY 10466, USA
    Clin Exp Dermatol 30:391-4. 2005
    ..The significance of the changes in adhesion molecules, especially CD138 and CD56, relevant to the development of cutaneous plasmacytomas is discussed...
  25. ncbi request reprint Kidney cancer therapy: new perspectives and avenues
    Doru T Alexandrescu
    Georgetown University, Washington Cancer Institute, 110 Irving Street, N W, Washington, DC 20010, USA
    Expert Opin Pharmacother 7:2481-93. 2006
    ..The use of small molecules, such as multitargeted tyrosine kinase inhibitors, the mTOR inhibitors and monoclonal antibodies, is dramatically changing the existing concepts of systemic treatment for metastatic kidney cancer...
  26. ncbi request reprint Chemotherapy-induced scleroderma: a pleiomorphic syndrome
    D T Alexandrescu
    Comprehensive Cancer Center, Our Lady of Mercy Medical Center, New York Medical College, Bronx, New York 10466, USA
    Clin Exp Dermatol 30:141-5. 2005
    ..Analysis of all similar case reports defines the particular features and clinical course of this phenomenon...
  27. ncbi request reprint Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome associated with high-dose interleukin-2 for the treatment of metastatic melanoma
    Doru T Alexandrescu
    Comprehensive Cancer Center, Our Lady of Mercy Medical Center, New York Medical College, Bronx, New York 10466, USA
    J Immunother 28:144-7. 2005
    ..coli O157, after IL-2 or IL-2-containing biochemotherapy, as well as in TTP caused by interferon-alpha. This cytokine profile could reflect a common cause, or just the presence of similar pathways involved...
  28. ncbi request reprint Trastuzumab/docetaxel-induced nail dystrophy
    Doru T Alexandrescu
    New York Medical College, Our Lady of Mercy Medical Center, Comprehensive Cancer Center, Department of Dermatology, Bronx, NY 10466, USA
    Int J Dermatol 45:1334-6. 2006
  29. ncbi request reprint Anticipation in families with Hodgkin's and non-Hodgkin's lymphoma in their pedigree
    Doru T Alexandrescu
    New York Medical College, Comprehensive Cancer Center at Our Lady of Mercy, Bronx, NY 10466, USA
    Leuk Lymphoma 47:2115-27. 2006
    ..These data suggest that anticipation occurs in families that exhibit both HL and NHL and that both neoplasms may have a common genetic basis...
  30. doi request reprint Tumor vaccines in 2010: need for integration
    David Koos
    Entest BioMedical, San Diego, CA, USA
    Cell Immunol 263:138-47. 2010
    ..In this review we describe major advances in our understanding of tumor escape from immunological pressure and provide some possible therapeutic scenarios for enhancement of efficacy in future cancer vaccine trials...
  31. ncbi request reprint Malignant melanoma in African-Americans
    Filamer D Kabigting
    Dermatology Clinical Trials Unit, University of California at San Diego, CA, USA
    Dermatol Online J 15:3. 2009
    ....
  32. pmc Exogenous endothelial cells as accelerators of hematopoietic reconstitution
    J Christopher Mizer
    Regen BioPharma Inc, San Diego, CA, USA
    J Transl Med 10:231. 2012
    ....
  33. ncbi request reprint Yellow skin discoloration associated with sorafenib use for treatment of metastatic renal cell carcinoma
    Constantin A Dasanu
    New York Medical College, Comprehensive Cancer Center, Our Lady of Mercy Medical Center, 600 East 233rd Street, Bronx, NY 10466, USA
    South Med J 100:328-30. 2007
    ..A thorough clinicolaboratory investigation did not reveal any evidence of jaundice, B12 deficiency, anemia, carotenemia, hypothyroidism, or any other disorder of endocrine or metabolic etiology...
  34. ncbi request reprint A complex pattern of melanonychia and onycholysis after treatment with pemetrexed for lung cancer
    Constantin A Dasanu
    Our Lady of Mercy Cancer Center, New York Medical College, Bronx, NY, USA
    Skinmed 6:95-6. 2007
    ..When questioned, he denied taking any other drugs including other alternative medicine approaches or vitamin supplements, particularly retinoids, well known for causing severe nail dystrophy...
  35. ncbi request reprint Distinct patterns of chromonychia, Beau's lines, and melanoderma seen with vincristine, adriamycin, dexamethasone therapy for multiple myeloma
    Constantin A Dasanu
    Department of Oncology, Our Lady of Mercy Medical Center, New York Medical College, Bronx, NY, USA
    Dermatol Online J 12:10. 2006
    ..All changes disappeared 4 months after the discontinuation of VAD chemotherapy, which further pointed out towards adriamycin and vincristine as possible etiologic agents...
  36. doi request reprint Hepatoid variant of pancreatic cancer: insights from a case and literature review
    Shounak Majumder
    Department of Internal Medicine, University of Connecticut Farmington, CT 06030, USA
    JOP 14:442-5. 2013
    ..Hepatoid" cancer refers to an extrahepatic neoplasm with hepatocellular differentiation. The stomach is the most common site and pancreatic origin is distinctly uncommon...
  37. doi request reprint Mesenchymal stem cells as anti-inflammatories: implications for treatment of Duchenne muscular dystrophy
    Thomas E Ichim
    Medistem Inc, San Diego, CA 92122, USA
    Cell Immunol 260:75-82. 2010
    ..We conclude by describing one practical scenario of stem cell therapy for DMD...
  38. ncbi request reprint Bilateral Leser-Trélat sign mirroring lung adenocarcinoma with early metastases to the contralateral lung
    Constantin A Dasanu
    Georgetown University, Washington, DC, USA
    South Med J 102:216-8. 2009
    ..Our case suggests a unique interrelation between the paraneoplastic sign of Leser-Trélat and the tumor itself. The recognition of this phenomenon may contribute to an early diagnosis and prompt surgical treatment of occult cancers...
  39. doi request reprint Rapidly progressive colonic dysplasia/neoplasia in a series of treated lung cancer patients: Is paclitaxel involved?
    Antarpreet Kaur
    Department of Internal Medicine, University of Connecticut Medical Center, Farmington, CT 06030, USA
    J Oncol Pharm Pract 19:82-5. 2013
    ..We herein describe the first series of lung cancer patients who developed colonic polyps/colon cancer either during or immediately following chemotherapy with paclitaxel, suggesting a possible role of this agent in their pathogenesis...
  40. doi request reprint Immune alterations and immunotherapy prospects in head and neck cancer
    Vincent Varilla
    University of Connecticut Medical Center, Department of Internal Medicine, Hartford, CT 06106, USA
    Expert Opin Biol Ther 13:1241-56. 2013
    ..Serious side effects and only a limited success with traditional therapies in HNSCC dictate the need for newer therapies...
  41. doi request reprint Targeting the HER2 pathway for the therapy of lower esophageal and gastric adenocarcinoma
    Antarpreet Kaur
    University of Connecticut Medical Center, Department of Internal Medicine, Farmington, CT 06030, USA
    Expert Opin Pharmacother 12:2493-503. 2011
    ..The mysteries of complex molecular pathways of tumorigenesis are only beginning to be unraveled. Overexpression of HER2 receptors has been associated with adverse outcomes in certain malignant solid tumors...
  42. doi request reprint Bilateral perinephric diffuse large B-cell lymphoma and synchronous renal oncocytoma
    Constantin A Dasanu
    Comprehensive Cancer Center at Our Lady of Mercy Medical Center, New York Medical College, Bronx, New York, USA
    South Med J 101:196-8. 2008
    ..Because of the patient's other medical conditions, systemic chemotherapy was not deemed feasible. Subsequently, the proliferation had a favorable response to single-agent monoclonal antibody rituximab...
  43. doi request reprint Incidence of second primary malignancies in patients with treated head and neck cancer: a comprehensive review of literature
    Jonessa Ann S Atienza
    University of Connecticut, Department of Internal Medicine, Farmington, CT 06030, USA
    Curr Med Res Opin 28:1899-909. 2012
    ..Furthermore, a clear set of surveillance strategies for second primary aero-digestive cancers in these patients exists...
  44. ncbi request reprint Catastrophic arteriovenous thromboembolism as initial manifestation of pancreatic cancer
    Shounak Majumder
    Department of Internal Medicine, University of Connecticut, Farmington, CT 06030, USA
    JOP 13:231-4. 2012
    ..However, simultaneous arterial and venous thromboses affecting multiple organs at the time of initial diagnosis is rare, with an incidence of less than 1%...
  45. ncbi request reprint Association between Helicobacter pylori infection and pancreatic cancer. A cumulative meta-analysis
    Guru Trikudanathan
    Department of Internal Medicine, University of Connecticut Medical Center, Farmington, CT, USA
    JOP 12:26-31. 2011
    ..Notwithstanding, its etiological association with pancreatic cancer remains inconclusive. Studies focusing on the relationship between H. pylori infection and pancreatic cancer risk have yielded conflicting results...
  46. doi request reprint Adenosquamous carcinoma of the pancreas: a distinct clinicopathologic entity
    Guru Trikudanathan
    Department of Internal Medicine, University of Connecticut Medical Center, Farmington, CT, USA
    South Med J 103:903-10. 2010
    ..As a result, its molecular and genetic makeup could be exploited for both diagnostic and therapeutic quests in the future...
  47. doi request reprint Evolving pharmacotherapeutic strategies for small bowel adenocarcinoma
    Guru Trikudanathan
    University of Connecticut Medical Center, Department of Internal Medicine, Farmington, CT, USA
    Expert Opin Pharmacother 11:1695-704. 2010
    ..Few studies in the literature adequately address the role of chemotherapy in SBA. The regimens used in colon and gastric cancers have been tried in SBA with varying degrees of success...
  48. doi request reprint Second primary pancreatic adenocarcinoma three years after successfully treated index esophageal cancer
    Nina Nandy
    Department of Internal Medicine, University of Connecticut Farmington CT, USA
    JOP 15:46-8. 2014
    ..However, the number of long-term esophageal cancer survivors has been increasing due to advances in early detection and therapy...
  49. doi request reprint Management of advanced and/or metastatic carcinoid tumors: historical perspectives and emerging therapies
    Nina Nandy
    University of Connecticut Medical Center, Department of Internal Medicine, Hartford, CT 06103, USA
    Expert Opin Pharmacother 14:1649-58. 2013
    ..Given the heterogeneity of these tumors, there is no clear therapeutic agent or combination that confers a significant advantage over others...
  50. doi request reprint Pralatrexate : evaluation of clinical efficacy and toxicity in T-cell lymphoma
    Alexei Shimanovsky
    University of Connecticut, Department of Internal Medicine, 263 Farmington Avenue, Farmington, CT 06030, USA
    Expert Opin Pharmacother 14:515-23. 2013
    ..Its clinical efficacy as a single agent in relapsed or refractory peripheral T-cell lymphoma (PTCL) has been established in randomized trials. Treatment with this agent is generally safe...
  51. doi request reprint Risk factors for gallbladder cancer and cholangiocarcinoma: similarities, differences and updates
    Tarun Rustagi
    Department of Internal Medicine, University of Connecticut, Farmington, CT 06032, USA
    J Gastrointest Cancer 43:137-47. 2012
    ..Far-ranging variation in the incidence of gallbladder cancer (GBC) and cholangiocarcinoma (CCA) in different geographic regions on the globe may reflect the risk factor distribution for these tumors..
  52. doi request reprint Hodgkin lymphoma as Richter transformation in chronic lymphocytic leukaemia: a retrospective analysis of world literature
    Bruno Bockorny
    Department of Internal Medicine, University of Connecticut Medical Center, Farmington, CT 06030 1235, USA
    Br J Haematol 156:50-66. 2012
    ..The role of immunosuppression and Epstein-Barr virus infection in the aetiopathogenesis of this entity remains to be clarified...
  53. pmc Lasers, stem cells, and COPD
    Feng Lin
    Entest BioMedical, San Diego, CA, USA
    J Transl Med 8:16. 2010
    ..The combination of LLL together with allogeneic and autologous stem cells, as well as post-mobilization directing of stem cells will be discussed...
  54. doi request reprint Autoimmune phenomena in untreated and treated marginal zone lymphoma
    Joanna Grabska
    University of Connecticut Medical Center, Department of Internal Medicine, 263 Farmington Avenue, Farmington, CT 06030, USA
    Expert Opin Pharmacother 12:2369-79. 2011
    ..However, these autoimmune conditions have not been comprehensively systematized to date. As a result, their clinical implications remain largely unknown...