Melanoma costs: a dynamic model comparing estimated overall costs of various clinical stagesDoru Traian Alexandrescu
University of California, San Diego, CA, USA
Dermatol Online J 15:1. 2009
..Futhermore, previous calculations have not been updated to reflect the modern tendencies in healthcare costs...
Expression of the epigenetic factor BORIS (CTCFL) in the human genomeRosalia De Necochea-Campion
Division of Hematology and Oncology, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA
J Transl Med 9:213. 2011
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- Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?
Thomas E Ichim
Department of Orthomolecular Studies, Riordan Clinic, 3100 N Hillside, Wichita, Kansas 67210, USA
J Transl Med 9:25. 2011
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- Generalized cerebral atrophy seen on MRI in a naturally exposed animal model for Creutzfeldt-Jakob disease
Alexia L McKnight
University of Pennsylvania School of Veterinary Medicine, New Bolton Center, Kennett Square, PA 19348, USA
J Transl Med 8:125. 2010
..This study attempts to answer the questions "Could MRI detect prion diseases before clinical symptoms appear?, and if so, with what confidence?"..
- Circulating endothelial progenitor cells: a new approach to anti-aging medicine?
Nina A Mikirova
Bio Communications Research Institute, Wichita, Kansas, USA
J Transl Med 7:106. 2009
..We conclude by discussing several clinically-relevant approaches to EPC mobilization and provide preliminary data on a food supplement, Stem-Kine, which enhanced EPC mobilization in human subjects...
- Persistent cutaneous hyperpigmentation after tyrosine kinase inhibition with imatinib for GIST
Doru T Alexandrescu
Georgetown Dermatology, Washington, DC, USA
Dermatol Online J 14:7. 2008
..Elucidation of the mechanisms of action of imatinib in the skin may open future directions for the treatment of pigmentary disorders...
Acute scurvy during treatment with interleukin-2D T Alexandrescu
Department of Dermatology, Georgetown University, Washington Cancer Institute, Washington, DC 20010, USA
Clin Exp Dermatol 34:811-4. 2009
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- Serum globulins as marker of immune restoration after treatment with high-dose rituximab for chronic lymphocytic leukemia
Doru T Alexandrescu
Comprehensive Cancer Center, Our Lady of Mercy Medical Center, New York Medical College, 600 East 233rd Street, Bronx, NY 10466, USA
Med Oncol 25:309-14. 2008
..Use of high doses of rituximab in CLL can avoid T-cell dysfunction and neutropenia, and is associated with humoral immunorestorative effects...
- The cutaneous epidermal growth factor network: Can it be translated clinically to stimulate hair growth?
Doru T Alexandrescu
Georgetown Dermatology, Washington, DC, USA
Dermatol Online J 15:1. 2009
..A better characterization of the individual roles pertaining to the EGF family ligands and receptors, has the potential provide new strategies for the management of hair loss...
- Persistent hair growth during treatment with the EGFR inhibitor erlotinib
Doru T Alexandrescu
Georgetown Dermatology, Washington, DC, USA
Dermatol Online J 15:4. 2009
..The persistence of trichomegaly in some patients brings into question the precise mechanism of this phenomenon and suggests the possibility of using EGFR inhibition therapeutically to stimulate hair growth...
- Melanoma-specific marker expression in skin biopsy tissues as a tool to facilitate melanoma diagnosis
Doru T Alexandrescu
Georgetown Dermatology, Washington, DC, USA
J Invest Dermatol 130:1887-92. 2010
..The role and potential utility of this molecular assay as an adjunct to the morphological diagnosis of melanoma are discussed...
- Immunotherapy for melanoma: current status and perspectives
Doru T Alexandrescu
Division of Dermatology, University of California at San Diego, San Diego, CA, USA
J Immunother 33:570-90. 2010
..The need to engineer better immune interactions and to boost positive feedback loops appear crucial for the future of melanoma therapy, which ultimately resides in our understanding of the complexity of immune responses in this disease...
- Cutaneous sarcoidosis and malignancy: An association between sarcoidosis with skin manifestations and systemic neoplasia
Doru T Alexandrescu
Georgetown Dermatology, Washington, DC, USA
Dermatol Online J 17:2. 2011
..Because cutaneous manifestations are seen in 20-25 percent of cases of sarcoidosis, this association deserves further investigation...
- On the missing link between inflammation and cancer
Doru T Alexandrescu
Georgetown Dermatology, Washington, DC, USA
Dermatol Online J 17:10. 2011
..Pathogenic links of inflammation with cancer are discussed, including inflammation, intrinsic immune dysfunction, cytokines and interleukins, angiogenetic factors, and epigenetic changes...
- The influence of parental age and gender on anticipation in familial B-cell malignancies
Doru T Alexandrescu
New York Medical College, Comprehensive Cancer Center at Our Lady of Mercy, Medical Center, Bronx, NY 10466, USA
Med Oncol 24:55-62. 2007
..Although less prominent than with neurological disease, this phenomenon indicates a possible germline inheritance of B-cell malignancies and a common genetic basis for HD and NHL...
- Unusual cutaneous involvement during plasma cell leukaemia phase in a multiple myeloma patient after treatment with thalidomide: a case report and review of the literature
D T Alexandrescu
New York Medical College, Our Lady of Mercy Medical Center, Comprehensive Cancer, Bronx, NY 10466, USA
Clin Exp Dermatol 30:391-4. 2005
..The significance of the changes in adhesion molecules, especially CD138 and CD56, relevant to the development of cutaneous plasmacytomas is discussed...
- Steroid-responsive inclusion body myositis associated with endometrial cancer
D T Alexandrescu
Comprehensive Cancer Center, Our Lady of Mercy Medical Center, Bronx, New York 10466, USA
Clin Exp Rheumatol 23:93-6. 2005
..The factors that are associated with a response of IBM to steroids are discussed. An atypical, steroid-responsive form of the disease is delineated...
- Metastatic melanoma: is biochemotherapy the future?
Doru T Alexandrescu
New York Medical College, Our Lady of Mercy Medical Center, Comprehensive Cancer Center, Bronx, NY 10466, USA
Med Oncol 22:101-11. 2005
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- Metastatic solid-pseudopapillary tumour of the pancreas: clinico-biological correlates and management
D T Alexandrescu
Comprehensive Cancer Center, Our Lady of Mercy Medical Center, Bronx, NY 10466, USA
Clin Oncol (R Coll Radiol) 17:358-63. 2005
..However, the indolent clinical progression of solid-pseudopapillary tumours is similar to that of pancreatic neuroendocrine tumour...
- Strokes after intravenous gamma globulin: thrombotic phenomenon in patients with risk factors or just coincidence?
Doru T Alexandrescu
Comprehensive Cancer Center, New York Medical College, Our Lady of Mercy Medical Center, Bronx, New York 10466, USA
Am J Hematol 78:216-20. 2005
..Clinical evaluation, with attention to history, a focused vascular work-up, and looking for markers of dehydration, can identify the high-risk patient for whom a careful analysis of the risk/benefit ratio is warranted...
- Unusually large colon cancer cutaneous and subcutaneous metastases occurring in resection scars
Doru T Alexandrescu
Comprehensive Cancer Center, New York Medical College, Our Lady of Mercy Medical Center, Bronx, NY 10466, USA
Dermatol Online J 11:22. 2005
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- Mitoxantrone, vinblastine and CCNU: long-term follow-up of patients treated for advanced and poor-prognosis Hodgkin's disease
Doru T Alexandrescu
Comprehensive Cancer Center, Our Lady of Mercy Medical Center, New York Medical College, NY 10446, USA
Leuk Lymphoma 47:641-56. 2006
..Although significant, the toxicities associated with this regimen were manageable...
- Effect of treatment with a colloidal oatmeal lotion on the acneform eruption induced by epidermal growth factor receptor and multiple tyrosine-kinase inhibitors
D T Alexandrescu
Washington Cancer Institute and Lombardi Cancer Center, Georgetown Univeisty, Department of Internal Medicine, Washington Hospital Center, Washington, DC 20010, USA
Clin Exp Dermatol 32:71-4. 2007
..Treatment with colloidal oatmeal lotion is efficient in controlling the rash associated with EGFR and multiple TKI, and allows continuation of the antineoplastic treatment...
- Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome associated with high-dose interleukin-2 for the treatment of metastatic melanoma
Doru T Alexandrescu
Comprehensive Cancer Center, Our Lady of Mercy Medical Center, New York Medical College, Bronx, New York 10466, USA
J Immunother 28:144-7. 2005
..coli O157, after IL-2 or IL-2-containing biochemotherapy, as well as in TTP caused by interferon-alpha. This cytokine profile could reflect a common cause, or just the presence of similar pathways involved...
- Anticipation in families with Hodgkin's and non-Hodgkin's lymphoma in their pedigree
Doru T Alexandrescu
New York Medical College, Comprehensive Cancer Center at Our Lady of Mercy, Bronx, NY 10466, USA
Leuk Lymphoma 47:2115-27. 2006
..These data suggest that anticipation occurs in families that exhibit both HL and NHL and that both neoplasms may have a common genetic basis...
- Trastuzumab/docetaxel-induced nail dystrophy
Doru T Alexandrescu
New York Medical College, Our Lady of Mercy Medical Center, Comprehensive Cancer Center, Department of Dermatology, Bronx, NY 10466, USA
Int J Dermatol 45:1334-6. 2006
- Chemotherapy-induced scleroderma: a pleiomorphic syndrome
D T Alexandrescu
Comprehensive Cancer Center, Our Lady of Mercy Medical Center, New York Medical College, Bronx, New York 10466, USA
Clin Exp Dermatol 30:141-5. 2005
..Analysis of all similar case reports defines the particular features and clinical course of this phenomenon...
- Fatal intra-alveolar hemorrhage after rituximab in a patient with non-Hodgkin lymphoma
Doru T Alexandrescu
Comprehensive Cancer Center, Our Lady of Mercy Medical Center, New York Medical College, Bronx, NY 10466, USA
Leuk Lymphoma 45:2321-5. 2004
..A review of the pertinent literature is provided. The possible pathogenetic mechanisms, including the role of cytokines, cytotoxic T-lymphocytes and CD 20 positive T-cells in relation to the administration of rituximab are discussed...
- Kidney cancer therapy: new perspectives and avenues
Doru T Alexandrescu
Georgetown University, Washington Cancer Institute, 110 Irving Street, N W, Washington, DC 20010, USA
Expert Opin Pharmacother 7:2481-93. 2006
..The use of small molecules, such as multitargeted tyrosine kinase inhibitors, the mTOR inhibitors and monoclonal antibodies, is dramatically changing the existing concepts of systemic treatment for metastatic kidney cancer...
- Tumor vaccines in 2010: need for integration
David Koos
Entest BioMedical, San Diego, CA, USA
Cell Immunol 263:138-47. 2010
..In this review we describe major advances in our understanding of tumor escape from immunological pressure and provide some possible therapeutic scenarios for enhancement of efficacy in future cancer vaccine trials...
- Malignant melanoma in African-Americans
Filamer D Kabigting
Dermatology Clinical Trials Unit, University of California at San Diego, CA, USA
Dermatol Online J 15:3. 2009
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- Exogenous endothelial cells as accelerators of hematopoietic reconstitution
J Christopher Mizer
Regen BioPharma Inc, San Diego, CA, USA
J Transl Med 10:231. 2012
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- Yellow skin discoloration associated with sorafenib use for treatment of metastatic renal cell carcinoma
Constantin A Dasanu
New York Medical College, Comprehensive Cancer Center, Our Lady of Mercy Medical Center, 600 East 233rd Street, Bronx, NY 10466, USA
South Med J 100:328-30. 2007
..A thorough clinicolaboratory investigation did not reveal any evidence of jaundice, B12 deficiency, anemia, carotenemia, hypothyroidism, or any other disorder of endocrine or metabolic etiology...
- A complex pattern of melanonychia and onycholysis after treatment with pemetrexed for lung cancer
Constantin A Dasanu
Our Lady of Mercy Cancer Center, New York Medical College, Bronx, NY, USA
Skinmed 6:95-6. 2007
..When questioned, he denied taking any other drugs including other alternative medicine approaches or vitamin supplements, particularly retinoids, well known for causing severe nail dystrophy...
- Distinct patterns of chromonychia, Beau's lines, and melanoderma seen with vincristine, adriamycin, dexamethasone therapy for multiple myeloma
Constantin A Dasanu
Department of Oncology, Our Lady of Mercy Medical Center, New York Medical College, Bronx, NY, USA
Dermatol Online J 12:10. 2006
..All changes disappeared 4 months after the discontinuation of VAD chemotherapy, which further pointed out towards adriamycin and vincristine as possible etiologic agents...
- Bilateral Leser-Trélat sign mirroring lung adenocarcinoma with early metastases to the contralateral lung
Constantin A Dasanu
Georgetown University, Washington, DC, USA
South Med J 102:216-8. 2009
..Our case suggests a unique interrelation between the paraneoplastic sign of Leser-Trélat and the tumor itself. The recognition of this phenomenon may contribute to an early diagnosis and prompt surgical treatment of occult cancers...
- Mesenchymal stem cells as anti-inflammatories: implications for treatment of Duchenne muscular dystrophy
Thomas E Ichim
Medistem Inc, San Diego, CA 92122, USA
Cell Immunol 260:75-82. 2010
..We conclude by describing one practical scenario of stem cell therapy for DMD...
- Bilateral perinephric diffuse large B-cell lymphoma and synchronous renal oncocytoma
Constantin A Dasanu
Comprehensive Cancer Center at Our Lady of Mercy Medical Center, New York Medical College, Bronx, New York, USA
South Med J 101:196-8. 2008
..Because of the patient's other medical conditions, systemic chemotherapy was not deemed feasible. Subsequently, the proliferation had a favorable response to single-agent monoclonal antibody rituximab...
- Targeting the HER2 pathway for the therapy of lower esophageal and gastric adenocarcinoma
Antarpreet Kaur
University of Connecticut Medical Center, Department of Internal Medicine, Farmington, CT 06030, USA
Expert Opin Pharmacother 12:2493-503. 2011
..A variety of monoclonal antibodies and tyrosine kinase inhibitors with affinity for HER2 are in development and may improve further the outcomes of these malignancies...
- Catastrophic arteriovenous thromboembolism as initial manifestation of pancreatic cancer
Shounak Majumder
Department of Internal Medicine, University of Connecticut, Farmington, CT 06030, USA
JOP 13:231-4. 2012
..However, simultaneous arterial and venous thromboses affecting multiple organs at the time of initial diagnosis is rare, with an incidence of less than 1%...
- Adenosquamous carcinoma of the pancreas: a distinct clinicopathologic entity
Guru Trikudanathan
Department of Internal Medicine, University of Connecticut Medical Center, Farmington, CT, USA
South Med J 103:903-10. 2010
..As a result, its molecular and genetic makeup could be exploited for both diagnostic and therapeutic quests in the future...
- Association between Helicobacter pylori infection and pancreatic cancer. A cumulative meta-analysis
Guru Trikudanathan
Department of Internal Medicine, University of Connecticut Medical Center, Farmington, CT, USA
JOP 12:26-31. 2011
..Notwithstanding, its etiological association with pancreatic cancer remains inconclusive. Studies focusing on the relationship between H. pylori infection and pancreatic cancer risk have yielded conflicting results...
- Evolving pharmacotherapeutic strategies for small bowel adenocarcinoma
Guru Trikudanathan
University of Connecticut Medical Center, Department of Internal Medicine, Farmington, CT, USA
Expert Opin Pharmacother 11:1695-704. 2010
..Few studies in the literature adequately address the role of chemotherapy in SBA. The regimens used in colon and gastric cancers have been tried in SBA with varying degrees of success...
- Risk factors for gallbladder cancer and cholangiocarcinoma: similarities, differences and updates
Tarun Rustagi
Department of Internal Medicine, University of Connecticut, Farmington, CT 06032, USA
J Gastrointest Cancer 43:137-47. 2012
..Far-ranging variation in the incidence of gallbladder cancer (GBC) and cholangiocarcinoma (CCA) in different geographic regions on the globe may reflect the risk factor distribution for these tumors..
- Hodgkin lymphoma as Richter transformation in chronic lymphocytic leukaemia: a retrospective analysis of world literature
Bruno Bockorny
Department of Internal Medicine, University of Connecticut Medical Center, Farmington, CT 06030 1235, USA
Br J Haematol 156:50-66. 2012
..The role of immunosuppression and Epstein-Barr virus infection in the aetiopathogenesis of this entity remains to be clarified...
- Lasers, stem cells, and COPD
Feng Lin
Entest BioMedical, San Diego, CA, USA
J Transl Med 8:16. 2010
..The combination of LLL together with allogeneic and autologous stem cells, as well as post-mobilization directing of stem cells will be discussed...
- Autoimmune phenomena in untreated and treated marginal zone lymphoma
Joanna Grabska
University of Connecticut Medical Center, Department of Internal Medicine, 263 Farmington Avenue, Farmington, CT 06030, USA
Expert Opin Pharmacother 12:2369-79. 2011
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