Undurti Das

Summary

Publications

  1. ncbi request reprint Can perinatal supplementation of long-chain polyunsaturated fatty acids prevent hypertension in adult life?
    U N Das
    EFA Sciences LLC, Norwood, MA 02062, USA
    Hypertension 38:E6-8. 2001
  2. ncbi request reprint Is metabolic syndrome X a disorder of the brain with the initiation of low-grade systemic inflammatory events during the perinatal period?
    Undurti N Das
    Department of Molecular and Clinical Medicine, CARE Hospital, The Institute of Medical Sciences, Banjara Hills, Hyderabad 500 034, India UND Life Sciences, Shaker Heights, OH 44120, USA
    J Nutr Biochem 18:701-13. 2007
  3. pmc Can endogenous lipid molecules serve as predictors and prognostic markers of coronary heart disease?
    Undurti N Das
    UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
    Lipids Health Dis 7:19. 2008
  4. ncbi request reprint Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies
    Undurti N Das
    UND Life Sciences, Shaker Heights, OH 42100, USA
    Med Sci Monit 13:RA119-31. 2007
  5. ncbi request reprint Is pyruvate an endogenous anti-inflammatory molecule?
    Undurti N Das
    UND Life Sciences, Shaker Heights, Ohio, USA
    Nutrition 22:965-72. 2006
  6. pmc Current and emerging strategies for the treatment and management of systemic lupus erythematosus based on molecular signatures of acute and chronic inflammation
    Undurti N Das
    Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh, India UND Life Sciences, Shaker Heights, OH, USA
    J Inflamm Res 3:143-70. 2010
  7. doi request reprint Renal sympathetic denervation for resistant hypertension--an alternate view
    Undurti N Das
    UND Life Sciences, 2020 S 360th St, K 2020, Federal Way, WA 98003, USA Department of Medicine, GVP Hospital and Bio Science Research Centre, Campus of Gayatri Vidya Parishad College of Engineering, Visakhapatnam 530 048, India Electronic address
    Med Hypotheses 81:1135-6. 2013
  8. doi request reprint Autism as a disorder of deficiency of brain-derived neurotrophic factor and altered metabolism of polyunsaturated fatty acids
    Undurti N Das
    UND Life Sciences, Shaker Heights, OH, USA
    Nutrition 29:1175-85. 2013
  9. pmc Effect of essential fatty acids on glucose-induced cytotoxicity to retinal vascular endothelial cells
    Junhui Shen
    Laboratory of Clinical Visual Science, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China
    Lipids Health Dis 11:90. 2012
  10. doi request reprint Arachidonic acid and lipoxin A4 as possible endogenous anti-diabetic molecules
    Undurti N Das
    UND Life Sciences, 13800 Fairhill Road 321, Shaker Heights, OH 44120, USA
    Prostaglandins Leukot Essent Fatty Acids 88:201-10. 2013

Collaborators

Detail Information

Publications118 found, 100 shown here

  1. ncbi request reprint Can perinatal supplementation of long-chain polyunsaturated fatty acids prevent hypertension in adult life?
    U N Das
    EFA Sciences LLC, Norwood, MA 02062, USA
    Hypertension 38:E6-8. 2001
    ..It is suggested that adequate provision of long-chain polyunsaturated fatty acids during the critical periods of brain growth prevents the development of hypertension in later life...
  2. ncbi request reprint Is metabolic syndrome X a disorder of the brain with the initiation of low-grade systemic inflammatory events during the perinatal period?
    Undurti N Das
    Department of Molecular and Clinical Medicine, CARE Hospital, The Institute of Medical Sciences, Banjara Hills, Hyderabad 500 034, India UND Life Sciences, Shaker Heights, OH 44120, USA
    J Nutr Biochem 18:701-13. 2007
    ....
  3. pmc Can endogenous lipid molecules serve as predictors and prognostic markers of coronary heart disease?
    Undurti N Das
    UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
    Lipids Health Dis 7:19. 2008
    ..Thus, beneficial actions of EPA/DHA and aspirin in CHD could be attributed to the formation of LXs, resolvins, protectins, and nitrolipids and suggest that their plasma levels aid in the prediction and prognosis of CHD...
  4. ncbi request reprint Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies
    Undurti N Das
    UND Life Sciences, Shaker Heights, OH 42100, USA
    Med Sci Monit 13:RA119-31. 2007
    ..The low neurotoxicity of GLA to normal brain neurons and selective activity against tumor cells suggests that it could be an effective anti-glioma molecule...
  5. ncbi request reprint Is pyruvate an endogenous anti-inflammatory molecule?
    Undurti N Das
    UND Life Sciences, Shaker Heights, Ohio, USA
    Nutrition 22:965-72. 2006
    ..Similar beneficial actions have been seen in endotoxemia. These and other studies suggest that ethyl pyruvate could be of significant benefit in the treatment of patients who are critically ill and have sepsis/septic shock...
  6. pmc Current and emerging strategies for the treatment and management of systemic lupus erythematosus based on molecular signatures of acute and chronic inflammation
    Undurti N Das
    Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh, India UND Life Sciences, Shaker Heights, OH, USA
    J Inflamm Res 3:143-70. 2010
    ..These strategies are likely to be useful not only in lupus but also in other conditions, such as rheumatoid arthritis, scleroderma, ischemia-reperfusion injury to the myocardium, ischemic heart disease, and sepsis...
  7. doi request reprint Renal sympathetic denervation for resistant hypertension--an alternate view
    Undurti N Das
    UND Life Sciences, 2020 S 360th St, K 2020, Federal Way, WA 98003, USA Department of Medicine, GVP Hospital and Bio Science Research Centre, Campus of Gayatri Vidya Parishad College of Engineering, Visakhapatnam 530 048, India Electronic address
    Med Hypotheses 81:1135-6. 2013
    ..Hence, it is suggested that efforts made to augment parasympathetic tone in addition to RDN may form a more effective strategy to reduce blood pressure in resistant hypertension than RDN alone. ..
  8. doi request reprint Autism as a disorder of deficiency of brain-derived neurotrophic factor and altered metabolism of polyunsaturated fatty acids
    Undurti N Das
    UND Life Sciences, Shaker Heights, OH, USA
    Nutrition 29:1175-85. 2013
    ..Based on these evidences, it is proposed that selective delivery of BDNF and methods designed to augment the production of anti-inflammatory cytokines and eicosanoids and PUFAs may prevent, arrest, or reverse the autism disease process. ..
  9. pmc Effect of essential fatty acids on glucose-induced cytotoxicity to retinal vascular endothelial cells
    Junhui Shen
    Laboratory of Clinical Visual Science, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China
    Lipids Health Dis 11:90. 2012
    ..Whether essential fatty acids (EFAs) α-linolenic acid and linoleic acid have similar beneficial effect remains poorly understood...
  10. doi request reprint Arachidonic acid and lipoxin A4 as possible endogenous anti-diabetic molecules
    Undurti N Das
    UND Life Sciences, 13800 Fairhill Road 321, Shaker Heights, OH 44120, USA
    Prostaglandins Leukot Essent Fatty Acids 88:201-10. 2013
    ..Thus, AA and lipoxins, resolvins and protectins may function as endogenous anti-diabetic molecules implying that their administration could be useful in the prevention and management of both types of diabetes mellitus...
  11. doi request reprint Polyunsaturated fatty acids and their metabolites in the pathobiology of schizophrenia
    Undurti N Das
    UND Life Sciences, 13800 Fairhill Road, Shaker Heights, OH 44120, USA
    Prog Neuropsychopharmacol Biol Psychiatry 42:122-34. 2013
    ..Furthermore, synthetic analogs of lipoxins, resolvins, and protectins may be of significant benefit in schizophrenia...
  12. doi request reprint Is sepsis a pro-resolution deficiency disorder?
    Undurti N Das
    UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
    Med Hypotheses 80:297-9. 2013
    ....
  13. doi request reprint Lipoxins, resolvins, and protectins in the prevention and treatment of diabetic macular edema and retinopathy
    Undurti N Das
    School of Biotechnology, Jawaharlal Nehru Technological University, Kakinada, India
    Nutrition 29:1-7. 2013
    ..In view of these evidences, I propose that lipoxins, resolvins, and protectins could be of significant benefit in the prevention and management of diabetic macular edema and retinopathy...
  14. doi request reprint Is multiple sclerosis a proresolution deficiency disorder?
    Undurti N Das
    UND Life Sciences, Shaker Heights, Ohio, USA
    Nutrition 28:951-8. 2012
    ..Hence, methods designed to enhance the production and/or administration of lipoxins, resolvins, and protectins may form a new approach in the prevention and treatment of multiple sclerosis and other similar autoimmune diseases...
  15. pmc Automated diagnosis of diabetic retinopathy and glaucoma using fundus and OCT images
    Arulmozhivarman Pachiyappan
    School of Electronics Engineering, VIT University, Vellore 632014 Tamil Nadu, India
    Lipids Health Dis 11:73. 2012
    ..The accuracy for optical disk detection is found to be 97.75%. The proposed system therefore is accurate, reliable and robust and can be realized...
  16. pmc Agonistic effect of polyunsaturated fatty acids (PUFAs) and its metabolites on brain-derived neurotrophic factor (BDNF) through molecular docking simulation
    Umashankar Vetrivel
    Department of Bioinformatics, Vision Research Foundation, Chennai 600006, India
    Lipids Health Dis 11:109. 2012
    ..To decipher the molecular mechanism through which PUFAs modulates BDNF's activity, molecular docking was performed for BDNF with PUFAs and its metabolites, with 4-Methyl Catechol as a control...
  17. doi request reprint Radiation resistance, invasiveness and metastasis are inflammatory events that could be suppressed by lipoxin A4
    Undurti N Das
    UND Life Sciences, Shaker Heights, OH 44120, USA
    Prostaglandins Leukot Essent Fatty Acids 86:3-11. 2012
    ..Thus, methods designed to enhance endogenous lipoxin A(4) formation or its synthetic analogs may be useful in the management of cancer...
  18. pmc MicroRNA profile of polyunsaturated fatty acid treated glioma cells reveal apoptosis-specific expression changes
    Nóra Faragó
    Functional Genomics Laboratory, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary
    Lipids Health Dis 10:173. 2011
    ..Polyunsaturated fatty acids (PUFAs) such as γ-linolenic acid (GLA), arachidonic acid (AA) and docosahexaenoic acid (DHA) have cytotoxic action on glioma cells...
  19. pmc Linoleic acid suppresses colorectal cancer cell growth by inducing oxidant stress and mitochondrial dysfunction
    Xiaofeng Lu
    Department of Food Science and Nutrition, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310029, P R China
    Lipids Health Dis 9:106. 2010
    ..The relative resistance of LOVO cells to the cytotoxic action of LA is due to a reduction in the activation of caspase-3. Thus, LA induced cancer cell apoptosis by enhancing cellular oxidant status and inducing mitochondrial dysfunction...
  20. pmc Effect of ω-3 and ω-9 fatty acid rich oils on lipoxygenases and cyclooxygenases enzymes and on the growth of a mammary adenocarcinoma model
    Andrea Comba
    Instituto de Biologia Celular, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Argentina
    Lipids Health Dis 9:112. 2010
    ..We studied the effect of two diets enriched in 6% Walnut and Peanut oils that are rich in ω-3 and ω9 PUFAs respectively on a murine mammary gland adenocarcinoma as compared with the control (C) that received commercial diet...
  21. pmc Insulin and the critically ill
    Undurti N Das
    Crit Care 6:262-3. 2002
  22. doi request reprint Essential fatty acids and their metabolites as modulators of stem cell biology with reference to inflammation, cancer, and metastasis
    Undurti N Das
    School of Biotechnology, Jawaharlal Nehru Technological University, Kakinada 533 003, India
    Cancer Metastasis Rev 30:311-24. 2011
    ..Thus, there appears to be a close interaction among essential fatty acids, their bioactive products, and inflammation and cancer growth and its metastasis...
  23. pmc Transgenic fat-1 mouse as a model to study the pathophysiology of cardiovascular, neurological and psychiatric disorders
    Undurti N Das
    Jawaharlal Nehru Technological University, Kakinada 533 003, Andhra Pradesh, India
    Lipids Health Dis 8:61. 2009
    ..Identifying the anti-inflammatory compounds from n-3 fatty acids that suppress low-grade systemic inflammatory conditions and understanding their mechanism(s) of action may lead to newer therapeutic strategies...
  24. ncbi request reprint Hypothesis: can glucose-insulin-potassium regimen in combination with polyunsaturated fatty acids suppress lupus and other inflammatory conditions?
    U N Das
    EFA Sciences LLC, 1420 Providence Highway, Suite 266, Norwood, MA 02062, USA
    Prostaglandins Leukot Essent Fatty Acids 65:109-13. 2001
    ..Hence, it is suggested that a combination of insulin (in the form of glucose-insulin-potassium) and PUFAs may be of benefit in lupus and other inflammatory conditions...
  25. ncbi request reprint Can glucose-insulin-potassium regimen suppress inflammatory bowel disease?
    U N Das
    EFA Sciences LLC, Suite 266, 1420 Providence Highway, Norwood, MA 02062, USA
    Med Hypotheses 57:183-5. 2001
    ..This suggests that insulin can behave as an anti-inflammatory molecule. In view of this, it is suggested that insulin in combination with glucose and potassium may be of benefit in the management of inflammatory bowel disease...
  26. doi request reprint Obesity: genes, brain, gut, and environment
    Undurti N Das
    UND Life Sciences, Shaker Heights, Ohio, USA
    Nutrition 26:459-73. 2010
    ..Thus, there is a cross-talk among the gut, liver, pancreas, adipose tissue, and hypothalamus. Based on these evidences, it is clear that management of obesity needs a multifactorial approach...
  27. ncbi request reprint Essential fatty acids as possible mediators of the actions of statins
    U N Das
    EFA Sciences LLC, 1420 Providence Highway, Norwood, MA 02062, USA
    Prostaglandins Leukot Essent Fatty Acids 65:37-40. 2001
    ..In view of the similarity in their actions and as statins influence essential fatty acid metabolism, it is suggested that essential fatty acids and their metabolites may serve as second messengers of the actions of statins...
  28. pmc Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules
    Undurti N Das
    UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
    Lipids Health Dis 7:37. 2008
    ....
  29. ncbi request reprint Is obesity an inflammatory condition?
    U N Das
    EFA Sciences LLC, Norwood, Massachusets 02062, USA
    Nutrition 17:953-66. 2001
    ....
  30. ncbi request reprint Is insulin an antiinflammatory molecule?
    U N Das
    From EFA Sciences LLC, Norwood, Massachusetts, USA
    Nutrition 17:409-13. 2001
    ....
  31. ncbi request reprint Abrupt and complete occlusion of tumor-feeding vessels by gamma-linolenic acid
    Undurti N Das
    EFA Sciences LLC, Norwood, Massachusetts, USA
    Nutrition 18:767-9. 2002
    ..For legal reasons this article has been removed by the publisher..
  32. ncbi request reprint Essential fatty acids, lipid peroxidation and apoptosis
    U N Das
    EFA Sciences, Inc, Techlead, Norwood, MA 02062, USA
    Prostaglandins Leukot Essent Fatty Acids 61:157-63. 1999
    ..Thus, these long-chain fatty acids may, infact act at the level of gene/oncogene expression in producing their cytotoxic action on tumour cells...
  33. ncbi request reprint Nutritional factors in the pathobiology of human essential hypertension
    U N Das
    EFA Sciences LLC, Norwood, Massachusetts 02062, USA
    Nutrition 17:337-46. 2001
    ..Therefore, alterations in the metabolism of essential fatty acids might be a predisposing factor to the development of essential hypertension and insulin resistance...
  34. pmc Effect of polyunsaturated fatty acids on drug-sensitive and resistant tumor cells in vitro
    Undurti N Das
    Jawaharlal Nehru Technological University, Kakinada 533 003, India
    Lipids Health Dis 10:159. 2011
    ..Thus, polyunsaturated fatty acids either by themselves or in combination with chemotherapeutic drugs have the potential as anti-cancer molecules...
  35. pmc Lipoxins as biomarkers of lupus and other inflammatory conditions
    Undurti N Das
    UND Life Sciences, 13800 Fairhill Road, 321 Shaker Heights, OH 44120, USA
    Lipids Health Dis 10:76. 2011
    ....
  36. ncbi request reprint L-arginine, NO and asymmetrical dimethylarginine in hypertension and type 2 diabetes
    Undurti N Das
    UND Life Sciences, 13800 Fairhill Road, 321 Shaker Heights, OH 44120, USA
    Front Biosci (Landmark Ed) 16:13-20. 2011
    ..These and other studies suggest that serum ADMA levels could be used to predict the development of hypertension and type 2 diabetes mellitus in those who are at high-risk to develop these diseases...
  37. ncbi request reprint Is insulin resistance a disorder of the brain?
    Undurti N Das
    Jawaharlal Nehru Technological University, Kakinada 533 003, India
    Front Biosci (Landmark Ed) 16:1-12. 2011
    ..These and other evidence suggest that insulin resistance may very well be a disease of the brain...
  38. doi request reprint Vagus nerve stimulation as a strategy to prevent and manage metabolic syndrome
    Undurti N Das
    School of Biotechnology, Jawaharlal Nehru Technological University, Kakinada 533 003, India
    Med Hypotheses 76:429-33. 2011
    ..Based on these evidences, it is proposed that vagus nerve stimulation could be of significant benefit in the management of the metabolic syndrome...
  39. pmc Can vagus nerve stimulation halt or ameliorate rheumatoid arthritis and lupus?
    Undurti N Das
    UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
    Lipids Health Dis 10:19. 2011
    ....
  40. doi request reprint Lipoxin A4 may function as an endogenous anti-arrhythmic molecule
    Undurti N Das
    School of Biotechnology, Jawaharlal Nehru Technological University, Kakinada 533 003, India
    Med Hypotheses 76:14-6. 2011
    ..Based on these evidences, I propose that lipoxins, resolvins and protectins function as endogenous anti-arrhythmic molecules and their stable synthetic analogs could be useful in the management of cardiac arrhythmias...
  41. pmc A defect in Δ6 and Δ5 desaturases may be a factor in the initiation and progression of insulin resistance, the metabolic syndrome and ischemic heart disease in South Asians
    Undurti N Das
    UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
    Lipids Health Dis 9:130. 2010
    ....
  42. ncbi request reprint Beneficial effect(s) of n-3 fatty acids in cardiovascular diseases: but, why and how?
    U N Das
    EFA Sciences LLC, 1420 Providence Highway, Norwood, MA 02062, USA
    Prostaglandins Leukot Essent Fatty Acids 63:351-62. 2000
    ....
  43. pmc Critical advances in septicemia and septic shock
    U N Das
    EFA Sciences LLC, Norwood, Massachusetts 02062, USA
    Crit Care 4:290-6. 2000
    ..This suggests that it may be possible to predict the development of septicemia and septic shock in a given individual and take appropriate action both to prevent and treat them adequately...
  44. ncbi request reprint Is metabolic syndrome X an inflammatory condition?
    Undurti N Das
    EFA Sciences LLC, Norwood, MA 02062, USA
    Exp Biol Med (Maywood) 227:989-97. 2002
    ..It is suggested that metabolic syndrome X is a low-grade systemic inflammatory condition...
  45. ncbi request reprint Effect of gamma-linolenic acid and prostaglandins E1 on gamma-radiation and chemical-induced genetic damage to the bone marrow cells of mice
    Undurti N Das
    UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
    Prostaglandins Leukot Essent Fatty Acids 74:165-73. 2006
    ..PGE1 and its precursor GLA prevented gamma-radiation, DPH, BP, and 4-alpha-phorbol-induced genetic damage...
  46. ncbi request reprint Anti-inflammatory nature of exercise
    Undurti N Das
    EFA Sciences LLC, Norwood, Massachusetts, USA
    Nutrition 20:323-6. 2004
  47. ncbi request reprint Estrogen, statins, and polyunsaturated fatty acids: similarities in their actions and benefits-is there a common link?
    U N Das
    EFA Sciences LLC, Norwood, Massachusetts 02062, USA
    Nutrition 18:178-88. 2002
    ..To investigate whether there is any common link between estrogen, statins, and polyunsaturated fatty acids (PUFAs), which have similar actions and benefits...
  48. ncbi request reprint Insulin: an endogenous cardioprotector
    Undurti N Das
    EFA Sciences LLC, Norwood, Massachusetts 02062, USA
    Curr Opin Crit Care 9:375-83. 2003
    ....
  49. ncbi request reprint Essential Fatty acids - a review
    Undurti N Das
    UND Life Sciences, 13800 Fairhill Road, Shaker Heights, OH 44120, USA
    Curr Pharm Biotechnol 7:467-82. 2006
    ..Thus, EFAs and their derivatives have significant clinical implications...
  50. ncbi request reprint Perinatal supplementation of long-chain polyunsaturated fatty acids, immune response and adult diseases
    Undurti N Das
    UND Life Sciences, Walpole, MA 02081, USA
    Med Sci Monit 10:HY19-25. 2004
    ....
  51. ncbi request reprint From bench to the clinic: gamma-linolenic acid therapy of human gliomas
    Undurti N Das
    UND Life Sciences, 1083 Main Street, Walpole, MA 02081, USA corrected
    Prostaglandins Leukot Essent Fatty Acids 70:539-52. 2004
    ..In view of this, large-scale, double blind studies are needed to establish the usefulness of GLA in the treatment of malignant brain tumors...
  52. ncbi request reprint Acetylcholinesterase and butyrylcholinesterase as possible markers of low-grade systemic inflammation
    Undurti N Das
    UND Life Sciences, Shaker Heights, OH 44120, USA
    Med Sci Monit 13:RA214-21. 2007
    ..This suggests that increased plasma and tissue activities of acetylcholinesterase and butyrylcholinesterase seen in various clinical conditions could serve as a marker of low-grade systemic inflammation...
  53. ncbi request reprint Is type 2 diabetes mellitus a disorder of the brain?
    Undurti N Das
    EFA Sciences LLC, 1420 Providence Highway, Norwood, MA 02062, USA
    Nutrition 18:667-72. 2002
    ..Hence, supplementation of adequate amounts of long-chain polyunsaturated fatty acids during the third trimester of pregnancy to 2 y postterm can prevent or postpone the development of diabetes mellitus...
  54. ncbi request reprint Essential fatty acids as possible enhancers of the beneficial actions of probiotics
    U N Das
    EFA Sciences LLC, Norwood, Massachusetts 02062, USA
    Nutrition 18:786. 2002
    ..It is likely that breast-feeding and probiotics are two naturally occurring, appropriate events in early human life that have significant health benefits...
  55. ncbi request reprint A radical approach to cancer
    Undurti Das
    EFA Sciences LLC, Norwood, MA 02062, USA
    Med Sci Monit 8:RA79-92. 2002
    ..Thus, PUFAs, thalidomide and 2-methoxyoestradiol or their derivatives may offer a new radical approach to the treatment of cancer...
  56. ncbi request reprint Can perinatal supplementation of long-chain polyunsaturated fatty acids prevent diabetes mellitus?
    U N Das
    EFA Sciences LLC, Norwood, Massachusetts 02062, USA
    Eur J Clin Nutr 57:218-26. 2003
    ..Based on this, it is proposed that provision of adequate amounts of long chain polyunsaturated fatty acids during the critical periods of brain growth and development can prevent or postpone the development diabetes mellitus...
  57. ncbi request reprint Pathophysiology of metabolic syndrome X and its links to the perinatal period
    Undurti N Das
    UND Life Sciences, Walpole, Massachusetts, USA
    Nutrition 21:762-73. 2005
    ....
  58. ncbi request reprint Do polyunsaturated fatty acids behave like an endogenous "polypill"?
    Undurti N Das
    UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
    Med Hypotheses 70:430-4. 2008
    ....
  59. ncbi request reprint A perinatal strategy to prevent coronary heart disease
    Undurti N Das
    EFA Sciences LLC, Norwood, Massachusetts 02062, USA
    Nutrition 19:1022-7. 2003
    ..Based on this evidence, I suggest that provision of LCPUFAs during critical periods of growth, especially from the second trimester of pregnancy to age 5 y, prevents CHD in adult life...
  60. ncbi request reprint Long-chain polyunsaturated fatty acids in memory formation and consolidation: further evidence and discussion
    Undurti N Das
    EFA Sciences LLC, Norwood, Massachusetts 02062, USA
    Nutrition 19:988-93. 2003
  61. ncbi request reprint COX-2 inhibitors and metabolism of essential fatty acids
    Undurti N Das
    UND Life Sciences, Cleveland Heights, OH 44106, USA
    Med Sci Monit 11:RA233-7. 2005
    ..EPA, DHA, and AA augment eNO formation that has anti-atherosclerotic action. Hence, combining EFAs with COX-2 inhibitors will prevent thrombotic cardiovascular events...
  62. ncbi request reprint Folic acid says NO to vascular diseases
    Undurti N Das
    EFA Sciences LLC, Norwood, Massachusetts, USA
    Nutrition 19:686-92. 2003
    ....
  63. ncbi request reprint Long-chain polyunsaturated fatty acids in the growth and development of the brain and memory
    U N Das
    EFA Sciences LLC, Norwood, Massachusetts 02062, USA
    Nutrition 19:62-5. 2003
  64. ncbi request reprint Nutritional deficiencies and the prevalence of syndrome X in South Asians
    Undurti N Das
    EFA Sciences LLC, Norwood, Massachusetts 02062, USA
    Nutrition 18:282. 2002
  65. ncbi request reprint Can memory be improved? A discussion on the role of ras, GABA, acetylcholine, NO, insulin, TNF-alpha, and long-chain polyunsaturated fatty acids in memory formation and consolidation
    Undurti N Das
    EFA Sciences LLC, 1420 Providence Highway, Suite 266, Norwood, MA 02062, USA
    Brain Dev 25:251-61. 2003
    ....
  66. ncbi request reprint A defect in the activity of Delta6 and Delta5 desaturases may be a factor predisposing to the development of insulin resistance syndrome
    Undurti N Das
    UND Life Sciences, 1083 Main Street, Walpole, MA 02081, USA
    Prostaglandins Leukot Essent Fatty Acids 72:343-50. 2005
    ..Thus, calorie restriction or reduced food intake has a role not only in the pathobiology of insulin resistance, but also in other associated conditions such as obesity, type II diabetes mellitus, ageing, and longevity...
  67. ncbi request reprint Current advances in sepsis and septic shock with particular emphasis on the role of insulin
    Undurti N Das
    EFA Sciences LLC, Norwood, MA 02062, USA
    Med Sci Monit 9:RA181-92. 2003
    ..Hence, their combined use may be of significant benefit in sepsis and septic shock...
  68. pmc Can essential fatty acids reduce the burden of disease(s)?
    Undurti N Das
    UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
    Lipids Health Dis 7:9. 2008
    ..Hence, supplementation of EFAs could reduce burden of these disease(s)...
  69. pmc Is insulin an endogenous cardioprotector?
    Undurti N Das
    EFA Sciences LLC, Norwood, Massachusetts, USA
    Crit Care 6:389-93. 2002
    ..Adequate attention should be given to maintaining euglycemia (plasma glucose <or= 110 mg/dl) in order to reduce infarct size and improve cardiac function while using a glucose-insulin-potassium cocktail...
  70. ncbi request reprint Essential fatty acids in Huntington's disease
    Undurti N Das
    UND Life Sciences, Walpole, Massachusetts 02081, USA
    Nutrition 20:942-7. 2004
    ..In view of the encouraging results with essential fatty acids in Huntington's disease, it is proposed that their possible use in other neurodegenerative conditions need to be explored...
  71. ncbi request reprint Tumoricidal and anti-angiogenic actions of gamma-linolenic acid and its derivatives
    Undurti N Das
    UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
    Curr Pharm Biotechnol 7:457-66. 2006
    ..Since GLA is an endogenous naturally occurring molecule and has no significant side effects, it calls for more studies to exploit its potential as a novel anti-cancer drug...
  72. ncbi request reprint Essential fatty acids: biochemistry, physiology and pathology
    Undurti N Das
    UND Life Sciences, Shaker Heights, OH 44120, USA
    Biotechnol J 1:420-39. 2006
    ..Thus, EFAs and their derivatives have varied biological actions and seem to be involved in several physiological and pathological processes...
  73. ncbi request reprint The lipids that matter from infant nutrition to insulin resistance
    U N Das
    EFA Sciences LLC, 1420 Providence Highway, Norwood, MA 02062, USA
    Prostaglandins Leukot Essent Fatty Acids 67:1-12. 2002
    ..Hence, promoting prolonged breast feeding and/or supplementing LCPUFAs during the critical stages of development may be beneficial in preventing insulin resistance...
  74. ncbi request reprint Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer's disease--but how and why?
    Undurti N Das
    UND Life Sciences, 13800 Fairhill Road 321, Shaker Heights, OH 44120, USA
    Prostaglandins Leukot Essent Fatty Acids 78:11-9. 2008
    ..These results suggest that a combination of EPA, DHA, AA and folic acid could be of significant benefit in dementia, depression, and Alzheimer's disease and improve cognitive function...
  75. ncbi request reprint Occlusion of infusion vessels on gamma-linolenic acid infusion
    Undurti N Das
    EFA Sciences LLC, 1420 Providence Highway, Suite 266, Norwood, MA 02062, USA
    Prostaglandins Leukot Essent Fatty Acids 70:23-32. 2004
    ..A significant reduction in the size of the tumor was also observed in these patients. LGIOC showed occlusion of tumor-feeding vessels after infusion, and further studies are needed to confirm these preliminary results...
  76. pmc Gene expression profile in obesity and type 2 diabetes mellitus
    Undurti N Das
    UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
    Lipids Health Dis 6:35. 2007
    ..These results suggest that genes concerned with carbohydrate, lipid and amino acid metabolic pathways, neuronal function and inflammation play a significant role in the pathobiology of obesity and type 2 diabetes...
  77. ncbi request reprint Nitric oxide as the mediator of the antiosteoporotic actions of estrogen, statins, and essential fatty acids
    Undurti N Das
    EFA Sciences, Norwood, Massachusetts 02062, USA
    Exp Biol Med (Maywood) 227:88-93. 2002
    ..If so, it will be interesting to study whether nitric oxide donors and/or nitric oxide precursors can be given together with estrogen, statins, or essential fatty acids to potentiate their benefit in osteoporosis...
  78. ncbi request reprint Pyruvate is an endogenous anti-inflammatory and anti-oxidant molecule
    Undurti N Das
    UND Life Sciences, Shaker Heights, OH, USA
    Med Sci Monit 12:RA79-84. 2006
    ..This may have relevance to the use of glucose-insulin-potassium regimen in these clinical conditions, sepsis, and cancer...
  79. ncbi request reprint A defect in the activity of Delta6 and Delta5 desaturases may be a factor in the initiation and progression of atherosclerosis
    Undurti N Das
    UND Life Sciences, Shaker Heights, OH 44120, USA
    Prostaglandins Leukot Essent Fatty Acids 76:251-68. 2007
    ..In view of this, it is suggested that Delta6 and Delta5 desaturases could serve as biological target(s) for the discovery and development of pharmaceuticals to treat atherosclerosis...
  80. ncbi request reprint Can perinatal supplementation of long-chain polyunsaturated fatty acids prevents schizophrenia in adult life?
    Undurti N Das
    UND Life Sciences, 1083 Main Street, Walpole, MA 02081, USA
    Med Sci Monit 10:HY33-7. 2004
    ..If this hypothesis is true, it implies that perinatal supplementation of appropriate amounts of LCPUFAs in the right combination is helpful in the prevention of schizophrenia in adult life...
  81. ncbi request reprint Elevated butyrylcholinesterase and acetylcholinesterase may predict the development of type 2 diabetes mellitus and Alzheimer's disease
    Allam A Rao
    Department of Computer Sciences and Systems Engineering, Andhra University, Visakhapatnam 530 003, India
    Med Hypotheses 69:1272-6. 2007
    ..In view of this, we propose that butyrylcholinesterase and acetylcholinesterase will not only serve as therapeutic targets but also may serve as markers to predict the development of type 2 diabetes mellitus and Alzheimer's disease...
  82. ncbi request reprint Metabolic syndrome X: an inflammatory condition?
    Undurti N Das
    Reflexis Systems, Inc, 1420 Providence Highway, Suite 266, Norwood, MA 02062, USA
    Curr Hypertens Rep 6:66-73. 2004
    ..Hence, instituting anti-inflammatory measures might be beneficial in preventing or halting the progress of metabolic syndrome X in high-risk populations...
  83. ncbi request reprint Pathobiology of metabolic syndrome X in obese and non-obese South Asian Indians: further discussion and some suggestions
    Undurti N Das
    Nutrition 19:560-2. 2003
  84. ncbi request reprint Prevention of chemically induced diabetes mellitus in experimental animals by polyunsaturated fatty acids
    I Krishna Mohan
    EFA Sciences LLC, Norwood, Massachusetts 02062, USA
    Nutrition 17:126-51. 2001
    ....
  85. ncbi request reprint Differential effect of saturated, monounsaturated, and polyunsaturated fatty acids on alloxan-induced diabetes mellitus
    Y Suresh
    UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
    Prostaglandins Leukot Essent Fatty Acids 74:199-213. 2006
    ..Furthermore, AA restored the anti-oxidant status to normal range in various tissues. These results suggest that AA protects pancreatic beta cells against alloxan-induced diabetes in experimental animals by attenuating oxidant stress...
  86. ncbi request reprint Is angiotensin-II an endogenous pro-inflammatory molecule?
    Undurti N Das
    UND Life Sciences, Walpole, MA 02081, USA
    Med Sci Monit 11:RA155-162. 2005
    ....
  87. ncbi request reprint Metabolic alterations during inflammation and its modulation by central actions of omega-3 fatty acids
    Undurti N Das
    EFA Sciences LLC, Norwood, Massachusetts 02062, USA
    Curr Opin Clin Nutr Metab Care 6:413-9. 2003
    ....
  88. ncbi request reprint Insulin and inflammation: further evidence and discussion
    Undurti N Das
    Nutrition 18:526-7. 2002
  89. ncbi request reprint Nutrition, physical activity, and obesity
    Undurti N Das
    Lancet 360:1249-50. 2002
  90. ncbi request reprint Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: The ATTICA Study
    Christina Chrysohoou
    First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece
    J Am Coll Cardiol 44:152-8. 2004
    ..We studied the effect of the Mediterranean diet on plasma levels of C-reactive protein (CRP), white blood cell counts, interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, amyloid A, fibrinogen, and homocysteine...
  91. ncbi request reprint Insulin in the critically ill with focus on cytokines, reactive oxygen species, HLA-DR expression
    Undurti N Das
    UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
    J Assoc Physicians India 55:56-65. 2007
    ....
  92. ncbi request reprint Bioinformatics analysis of functional protein sequences reveals a role for brain-derived neurotrophic factor in obesity and type 2 diabetes mellitus
    Allam Appa Rao
    Department of Computer Science and Systems Engineering, Andhra University, Visakhapatnam 530 003, India
    Med Hypotheses 70:424-9. 2008
    ..Hence, methods developed to selectively deliver BDNF to appropriate hypothalamic neurons may form a novel approach in their treatment...
  93. ncbi request reprint Diet, exercise, and C-reactive protein levels in people with abdominal obesity: the ATTICA epidemiological study
    Christos Pitsavos
    Unit of Preventive Cardiology Epidemiology, First Cardiology Clinic, School of Medicine, University of Athens, Greece
    Angiology 58:225-33. 2007
    ....
  94. ncbi request reprint Exercise and inflammation
    Undurti N Das
    Eur Heart J 27:1385; author reply 1385-6. 2006
  95. ncbi request reprint Glucose, insulin, and acute myocardial infarction
    Undurti N Das
    Eur Heart J 27:2141-2; author reply 2142-3. 2006
  96. ncbi request reprint Long-chain polyunsaturated fatty acids interact with nitric oxide, superoxide anion, and transforming growth factor-beta to prevent human essential hypertension
    U N Das
    EFA Sciences LLC, Norwood, MA 02062, USA
    Eur J Clin Nutr 58:195-203. 2004
    ..Hence, it is proposed that availability of adequate amounts of LCPUFAs during the critical periods of growth prevents the development of hypertension in adulthood...
  97. ncbi request reprint Hypertension as a low-grade systemic inflammatory condition that has its origins in the perinatal period
    U N Das
    UND Life Sciences, 13800 Fairhill Road, Shaker Heights, OH 44120, USA
    J Assoc Physicians India 54:133-42. 2006
    ....
  98. ncbi request reprint Angiotensin-II behaves as an endogenous pro-inflammatory molecule
    U N Das
    UND Life Sciences, 1083 Main Street, Walpole, MA 02081, USA
    J Assoc Physicians India 53:472-6. 2005
    ..Furthermore, structural analogues of ACE inhibitors and angiotensin-II receptor blockers could be developed that possess anti-inflammatory actions without significant action on the cardiovascular system...