Hriday K Das

Summary

Publications

  1. doi request reprint Repression of transcription of presenilin-1 inhibits γ-secretase independent ER Ca²⁺ leak that is impaired by FAD mutations
    Hriday K Das
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Neurochem 122:487-500. 2012
  2. ncbi request reprint Transcriptional regulation of the presenilin-1 gene controls gamma-secretase activity
    Sebum Lee
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, Texas 76107, USA
    Front Biosci (Elite Ed) 2:22-35. 2010
  3. ncbi request reprint ADR1 interacts with a down-stream positive element to activate PS1 transcription
    Hriday K Das
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    Front Biosci 13:3439-47. 2008
  4. ncbi request reprint The C-terminal region of CHD3/ZFH interacts with the CIDD region of the Ets transcription factor ERM and represses transcription of the human presenilin 1 gene
    Martine Pastorcic
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    FEBS J 274:1434-48. 2007
  5. doi request reprint Inhibition of basal activity of c-jun-NH2-terminal kinase (JNK) represses the expression of presenilin-1 by a p53-dependent mechanism
    Sebum Lee
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, Texas 76107, USA
    Brain Res 1207:19-31. 2008
  6. pmc Analysis of transcriptional modulation of the presenilin 1 gene promoter by ZNF237, a candidate binding partner of the Ets transcription factor ERM
    Martine Pastorcic
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Brain Res 1128:21-32. 2007
  7. ncbi request reprint Transcriptional regulation of the presenilin-1 gene: implication in Alzheimer's disease
    Hriday K Das
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas 76107, USA
    Front Biosci 13:822-32. 2008
  8. pmc Intraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis
    Moshiur Rahman
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76123, USA
    Brain Res 1448:117-28. 2012

Collaborators

  • Dong Ming Su
  • Sebum Lee
  • Martine Pastorcic
  • Moshiur Rahman
  • Avani A Mody
  • Zhijie Zhang

Detail Information

Publications8

  1. doi request reprint Repression of transcription of presenilin-1 inhibits γ-secretase independent ER Ca²⁺ leak that is impaired by FAD mutations
    Hriday K Das
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Neurochem 122:487-500. 2012
    ..Therefore, p53, ZNF237, and Chromodomain helicase DNA-binding protein 3 inhibit the function ER Ca²⁺ leak channels to regulate both ER and cytoplasmic Ca²⁺ levels and may potentially control Ca²⁺-signaling function of PS1...
  2. ncbi request reprint Transcriptional regulation of the presenilin-1 gene controls gamma-secretase activity
    Sebum Lee
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, Texas 76107, USA
    Front Biosci (Elite Ed) 2:22-35. 2010
    ..Therefore, regulation of PS1 transcription modulates gamma-secretase activity...
  3. ncbi request reprint ADR1 interacts with a down-stream positive element to activate PS1 transcription
    Hriday K Das
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    Front Biosci 13:3439-47. 2008
    ..These data suggest that a novel mammalian trans-activator protein ADR1 binds to the downstream element (+140 to +165) to activate PS1 transcription...
  4. ncbi request reprint The C-terminal region of CHD3/ZFH interacts with the CIDD region of the Ets transcription factor ERM and represses transcription of the human presenilin 1 gene
    Martine Pastorcic
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    FEBS J 274:1434-48. 2007
    ..Furthermore, data from chromatin immunoprecipitation (ChIP) indicate that CHD3/ZFH interacts with the PS1 promoter in vivo...
  5. doi request reprint Inhibition of basal activity of c-jun-NH2-terminal kinase (JNK) represses the expression of presenilin-1 by a p53-dependent mechanism
    Sebum Lee
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, Texas 76107, USA
    Brain Res 1207:19-31. 2008
    ....
  6. pmc Analysis of transcriptional modulation of the presenilin 1 gene promoter by ZNF237, a candidate binding partner of the Ets transcription factor ERM
    Martine Pastorcic
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Brain Res 1128:21-32. 2007
    ..Data from electrophoretic mobility shift assays indicate that ERM and possibly ZNF237 interact with a fragment of the PS1 promoter...
  7. ncbi request reprint Transcriptional regulation of the presenilin-1 gene: implication in Alzheimer's disease
    Hriday K Das
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas 76107, USA
    Front Biosci 13:822-32. 2008
    ..An in depth understanding of the regulatory mechanism of PS1 transcription can identify the targets that can potentially be used in therapeutic intervention of AD...
  8. pmc Intraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis
    Moshiur Rahman
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76123, USA
    Brain Res 1448:117-28. 2012
    ..These results provide insights for further study on PS1-mediated reduction of Notch 1 and APP processing for the treatment of Alzheimer's disease...