Bibhu Ranjan Das
Ahmad F, Avabhrath N, Natarajan S, Parikh J, Patole K, Das B. Molecular evaluation of BRAF V600 mutation and its association with clinicopathological characteristics: First findings from Indian malignant melanoma patients. Cancer Genet. 2019;231-232:46-53 pubmed publisher
..Our results demonstrated that the BRAF V600E mutation is a frequent event in Indian melanomas, and represents an important molecular target for novel therapeutic approaches. ..
Bhanushali A, Pradhan G, Contractor A, Das B. Frequency and association of disabled homolog 2-interacting protein (DAB2IP) variant rs7025486 G>A with coronary artery disease risk in Indian population. Indian Heart J. 2018;70 Suppl 3:S480-S482 pubmed publisher
..149; P 0.034) and controls >50 yrs (OR 3.430; P 0.080). The risk allele (A) was significantly associated with premature CAD. ..
Ahmad F, Nathani R, Venkat J, Bharda A, Vanere V, Bhatia S, et al
. Molecular evaluation of BRAF gene mutation in thyroid tumors: Significant association with papillary tumors and extra thyroidal extension indicating its role as a biomarker of aggressive disease. Exp Mol Pathol. 2018;105:380-386 pubmed publisher
..Furthermore, association of BRAF mutation with extra thyroidal extension indicates its aggressive nature and thus can provide insights into the progression of thyroid tumors from less aggressive to poorly differentiated subtype. ..
Ahmad F, Dalvi R, Mandava S, Das B. Molecular characterization of complex chromosomal rearrangement: first report of novel t(7;12) (q11;q22) as part of a complex karyotype in de novo AML-M2 case. Pathol Res Pract. 2014;210:1090-4 pubmed publisher
..To the best of our knowledge, this is the first report of identification of novel t(7;12) (q11;q22) as part of a complex karyotype in de novo AML-M2. ..
Das B, Bhaumik S, Ahmad F, Mandsaurwala A, Satam H. Molecular spectrum of somatic EGFR and KRAS gene mutations in non small cell lung carcinoma: determination of frequency, distribution pattern and identification of novel variations in Indian patients. Pathol Oncol Res. 2015;21:675-87 pubmed publisher
..To the best of our knowledge, this is the first Indian study to evaluate KRAS mutation. The current study also served to identify novel variations that added new insights into the genetic heterogeneity of NSCLC. ..
Bhanushali A, Patra P, Pradhan S, Khanka S, Singh S, Das B. Genetics of fetal hemoglobin in tribal Indian patients with sickle cell anemia. Transl Res. 2015;165:696-703 pubmed publisher
..Further interrogation of these genotypes with respect to pain crisis is warranted in this population, which may help in prognostication, as also a genome-wide association study, which may help uncover new loci controlling HbF levels. ..
Bhanushali A, Mandsaurwala A, Das B. Homozygous c.1160C>T (P38L) in the MECP2 gene in a female Rett syndrome patient. J Clin Neurosci. 2016;25:127-9 pubmed publisher
..This novel report reveals for the first time the homozygous presence of a mutation which has hitherto only been reported in males with MRX. ..
Ahmad F, Badwe A, Verma G, Bhatia S, Das B. Molecular evaluation of PIK3CA gene mutation in breast cancer: determination of frequency, distribution pattern and its association with clinicopathological findings in Indian patients. Med Oncol. 2016;33:74 pubmed publisher
..The frequency and distribution pattern of PIK3CA mutations is similar to global reports. Furthermore, identification of molecular markers has unique strengths and can provide insights into the pathogenic process of breast carcinomas. ..
Bhaumik S, Ahmad F, Das B. Somatic mutation analysis of KRAS, BRAF, HER2 and PTEN in EGFR mutation-negative non-small cell lung carcinoma: determination of frequency, distribution pattern and identification of novel deletion in HER2 gene from Indian patients. Med Oncol. 2016;33:117 pubmed publisher
..To the best of our knowledge, this is the first Indian study to evaluate KRAS, BRAF, HER2 and PTEN gene mutations. ..