Wnt pathway and IL-17: novel regulators of joint remodeling in rheumatic diseases. Looking beyond the RANK-RANKL-OPG axisDimitrios Daoussis
Consultant Rheumatologist, Division of Rheumatology, Department of Internal Medicine, Patras University Hospital, University of Patras Medical School, Patras, Greece
Semin Arthritis Rheum 39:369-83. 2010
..This review focuses on the recent information about the pathophysiology of the Wingless (Wnt) pathway and interleukin-17 (IL-17) in relation of their role in bone and joint remodeling...
B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skinDimitrios Daoussis
Division of Rheumatology, Department of Internal Medicine, Patras University Hospital, University of Patras Medical School, Patras, Rion, 26504, Greece
Arthritis Res Ther 14:R145. 2012
..We aimed at exploring whether RTX exerts its beneficial effects on fibrosis through attenuation of platelet-derived growth factor receptor (PDGFR) pathway activation...
Effect of long-term treatment with rituximab on pulmonary function and skin fibrosis in patients with diffuse systemic sclerosisDimitrios Daoussis
Department of Internal Medicine, University of Patras Medical School, Patras, Greece
Clin Exp Rheumatol 30:S17-22. 2012
..To assess the safety and efficacy of long-term treatment with rituximab (RTX) in patients with systemic sclerosis (SSc)...
- Treatment of systemic sclerosis-associated calcinosis: a case report of rituximab-induced regression of CREST-related calcinosis and review of the literature
Dimitrios Daoussis
Division of Rheumatology, Department of Internal Medicine, Patras University Hospital, University of Patras Medical School, Patras, Greece
Semin Arthritis Rheum 41:822-9. 2012
..Calcinosis is frequently encountered in patients with systemic sclerosis (SSc) and may be associated with significant morbidity. No treatment has shown so far an unequivocal beneficial effect...
- The emerging role of Dickkopf-1 in bone biology: is it the main switch controlling bone and joint remodeling?
Dimitrios Daoussis
Division of Rheumatology, Department of Internal Medicine, Patras University Hospital, University of Patras Medical School, Patras, Greece
Semin Arthritis Rheum 41:170-7. 2011
..Dickkopf-1 (DKK-1), an inhibitor of the Wnt pathway, has recently emerged as an important player in several critical aspects of bone biology...
- Rituximab in the treatment of systemic sclerosis-associated interstitial lung disease: Comment on the article by Yoo
Dimitrios Daoussis
Division of Rheumatology, Department of Internal Medicine, Patras University Hospital, University of Patras Medical School, 26504, Rion, Patras, Greece
Rheumatol Int 31:841-2. 2011
..Clinical studies as well have provided preliminary data pointing to the direction that B-cell depletion with rituximab might be a therapeutic option for patients with this debilitating disease...
- Evidence that Dkk-1 is dysfunctional in ankylosing spondylitis
Dimitrios Daoussis
Department of Internal Medicine, Division of Rheumatology, Patras University Hospital, University of Patras, Patras, Greece
Arthritis Rheum 62:150-8. 2010
..Dkk-1 is an inhibitory molecule that regulates the Wnt pathway, which controls osteoblastogenesis. This study was undertaken to explore the potential role of Dkk-1 in ankylosing spondylitis (AS), a prototypical bone-forming disease...
- Is there a role for B-cell depletion as therapy for scleroderma? A case report and review of the literature
Dimitrios Daoussis
Division of Rheumatology, Department of Internal Medicine, Patras University Hospital, University of Patras Medical School, Patras, Greece
Semin Arthritis Rheum 40:127-36. 2010
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- Uric acid is a strong independent predictor of renal dysfunction in patients with rheumatoid arthritis
Dimitrios Daoussis
Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Pensnett Road, Dudley, West Midlands, UK
Arthritis Res Ther 11:R116. 2009
..In this study we investigated whether UA associates with renal dysfunction in patients with RA and whether such an association is independent or mediated through other comorbidities or risk factors for renal impairment...
- Experience with rituximab in scleroderma: results from a 1-year, proof-of-principle study
Dimitrios Daoussis
Division of Rheumatology, Department of Internal Medicine, Patras University Hospital, 26504 Rion, Patras, Greece
Rheumatology (Oxford) 49:271-80. 2010
..To assess the efficacy of rituximab (RTX) in SSc...
- Microalbuminuria in rheumatoid arthritis in the post penicillamine/gold era: association with hypertension, but not therapy or inflammation
Dimitrios Daoussis
Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Pensnett Road, Dudley, West Midlands, DY1 2HQ, UK
Clin Rheumatol 30:477-84. 2011
..Given the association of MA with MetS, future prospective studies are needed to establish the use of MA as a screening tool for RA patients at increased CVD risk...
- B-cell depletion therapy in systemic sclerosis: experimental rationale and update on clinical evidence
Dimitrios Daoussis
Division of Rheumatology, Department of Internal Medicine, Patras University Hospital, University of Patras Medical School, Rion, 26504 Patras, Greece
Int J Rheumatol 2011:214013. 2011
..Definite conclusions regarding the clinical efficacy of RTX in SSc cannot be drawn but further exploration with a multicenter, randomized study is warranted...
- Bony ears
Dimitrios Daoussis
University of Patras Medical School, Patras University Hospital, Patras, Greece
Arthritis Rheum 58:611. 2008
