James Y Dai
Dai J, Wang B, Wang X, Cheng A, Kolb S, Stanford J, et al
. Vigorous Physical Activity Is Associated with Lower Risk of Metastatic-Lethal Progression in Prostate Cancer and Hypomethylation in the CRACR2A Gene. Cancer Epidemiol Biomarkers Prev. 2018;: pubmed publisher
Dai J, de Dieu Tapsoba J, Buas M, Onstad L, Levine D, Risch H, et al
. A newly identified susceptibility locus near FOXP1 modifies the association of gastroesophageal reflux with Barrett's esophagus. Cancer Epidemiol Biomarkers Prev. 2015;24:1739-47 pubmed publisher
..The novel gene-exposure interaction discovered in this study provides new insights into the etiology of esophageal adenocarcinoma. ..
Dai J, LeBlanc M, Goodman P, Lucia M, Thompson I, Tangen C. Case-only Methods Identified Genetic Loci Predicting a Subgroup of Men with Reduced Risk of High-grade Prostate Cancer by Finasteride. Cancer Prev Res (Phila). 2018;: pubmed publisher
..In conclusion, case-only methods identified SNPs that modified the effect of finasteride on the risk of high-grade prostate cancer and predicted a subgroup of men who had reduced cancer risk by finasteride. ..
Wang X, Li X, Cheng Y, Sun X, Sun X, Self S, et al
. Copy number alterations detected by whole-exome and whole-genome sequencing of esophageal adenocarcinoma. Hum Genomics. 2015;9:22 pubmed publisher
..WGS is superior to WES in that it can offer finer resolution for the detection, though if the interest is on recurrent CNAs, WES can be preferable to WGS for its cost-effectiveness. ..
Dai J, Tapsoba J, Buas M, Risch H, Vaughan T. Constrained Score Statistics Identify Genetic Variants Interacting with Multiple Risk Factors in Barrett's Esophagus. Am J Hum Genet. 2016;99:352-65 pubmed publisher
..These findings deepen understanding of the genetic and environmental architecture of Barrett's esophagus and esophageal adenocarcinoma. ..