Beta-carotene, vitamin C, and vitamin E and cardiovascular diseasesG R Dagenais
Institut de Cardiologie de Quebec, Hopital Laval, 2725 Chemin Ste Foy, Ste Foy, Quebec, Canada, G1V 4G5
Curr Cardiol Rep 2:293-9. 2000
..Trials are in progress to determine whether a longer duration of administration of vitamin E or the association of vitamin E with cofactors may reduce cardiovascular events...
- Effects of ramipril on coronary events in high-risk persons: results of the Heart Outcomes Prevention Evaluation Study
G R Dagenais
Quebec Heart Institute, Laval University, Ste Foy, Canada
Circulation 104:522-6. 2001
....
- Revisiting the Canadian Cardiovascular Society grading of stable angina pectoris after a quarter of a century of use
Gilles R Dagenais
, , Ste-Foy, Canada
Can J Cardiol 18:941-4. 2002
- Increased occurrence of diabetes in people with ischemic cardiovascular disease and general and abdominal obesity
Gilles R Dagenais
Laval University Heart and Lung Institute, Ste Foy, Quebec, Canada
Can J Cardiol 19:1387-91. 2003
..Such a relationship has not been assessed in patients with ICVD who may have a different occurrence due to their disease and medications...
- Fluctuating inflammatory markers in patients with stable ischemic heart disease
Peter Bogaty
Quebec Heart Institute, Laval Hospital, Laval University, Quebec City, Quebec, Canada
Arch Intern Med 165:221-6. 2005
..However, little is known about how inflammatory markers fluctuate over time in patients with stable ischemic heart disease...
- Job strain and risk of acute recurrent coronary heart disease events
Corine Aboa Eboulé
Unité de recherche en santé des populations, Universite Laval, Quebec, Canada
JAMA 298:1652-60. 2007
..There is evidence that job strain increases the risk of a first coronary heart disease (CHD) event. However, little is known about its association with the risk of recurrent CHD events after a first myocardial infarction (MI)...
- Inflammatory markers and long-term risk of ischemic heart disease in men A 13-year follow-up of the Quebec Cardiovascular Study
Annie C St-Pierre
Department of Nutrition, Institute on Nutraceuticals and Functional Foods, Laval University, 2440 Hochelaga Blvd, Ste-Foy, Qu, Canada G1K 7P4
Atherosclerosis 182:315-21. 2005
..An inflammation score based on high plasma IL-6 and fibrinogen levels used in combination with traditional risk factors may improve our ability to adequately identify high risk individuals...
Effects of exogenous metabolic substrate modulation on exercise-induced myocardial ischemiaPeter Bogaty
Quebec Heart Institute Laval Hospital, Laval University, Quebec City, Quebec, Canada
Am Heart J 156:790-6. 2008
..The aim of the study is to compare the impact of intravenous glucose versus lipid versus saline on exercise-induced myocardial ischemia in patients with stable angina...
- Impact of cigarette smoking in high-risk patients participating in a clinical trial. A substudy from the Heart Outcomes Prevention Evaluation (HOPE) trial
Gilles R Dagenais
Laval University Heart and Lung Institute, Ste Foy, Quebec G1V 4G5, Canada
Eur J Cardiovasc Prev Rehabil 12:75-81. 2005
..In recent large cardiovascular trials done in stable patients, 14-31% of the participants were smokers; the consequences of smoking in these trials using medications known to reduce cardiovascular events, have not been assessed...
- Low-density lipoprotein subfractions and the long-term risk of ischemic heart disease in men: 13-year follow-up data from the Québec Cardiovascular Study
Annie C St-Pierre
Institute on Nutraceuticals and Fonctionnal Foods, Laval University, , Canada
Arterioscler Thromb Vasc Biol 25:553-9. 2005
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- Clinical utility of C-reactive protein measured at admission, hospital discharge, and 1 month later to predict outcome in patients with acute coronary disease. The RISCA (recurrence and inflammation in the acute coronary syndromes) study
Peter Bogaty
Quebec Heart Institute Laval Hospital, Laval University, Quebec City, Quebec, Canada
J Am Coll Cardiol 51:2339-46. 2008
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- Effect of plasma C-reactive protein levels in modulating the risk of coronary heart disease associated with small, dense, low-density lipoproteins in men (The Quebec Cardiovascular Study)
Annie C St-Pierre
Institute on Nutraceuticals and Fonctionnal Foods, Laval University, Ste-Foy, , Canada
Am J Cardiol 91:555-8. 2003
..6 vs 3.0). Thus, increased plasma CRP levels further elevate the risk of CHD associated with having small, dense LDL particles...
- Can prolonged exercise-induced myocardial ischaemia be innocuous?
Martin Noel
Quebec Heart Institute, Laval Hospital, Laval University, 2725 Chemin Ste Foy, Ste Foy, Quebec, Canada G1V 4G5
Eur Heart J 28:1559-65. 2007
..To evaluate the innocuousness of intense and prolonged exercise training above the threshold for myocardial ischaemia (1 mm ST-segment depression)...
- Impact of prolonged cyclooxygenase-2 inhibition on inflammatory markers and endothelial function in patients with ischemic heart disease and raised C-reactive protein: a randomized placebo-controlled study
Peter Bogaty
Quebec Heart Institute Laval Hospital, Laval University, 2725 Chemin Ste Foy, Quebec City, Quebec, Canada G1V 4G5
Circulation 110:934-9. 2004
..We investigated the effect of prolonged COX-2 inhibition on inflammatory profile and endothelial function in patients with ischemic heart disease and high serum C-reactive protein (CRP) values...
- Apolipoprotein-B, low-density lipoprotein cholesterol, and the long-term risk of coronary heart disease in men
Annie C St-Pierre
Institute on Nutraceuticals and Functional Foods, Ste-Foy, , Canada
Am J Cardiol 97:997-1001. 2006
..04). In conclusion, plasma apo-B levels modulated the risk of CHD associated with LDL cholesterol over a 13-year follow-up...
- Prognostic impact of body weight and abdominal obesity in women and men with cardiovascular disease
Gilles R Dagenais
Department of Cardiology, Laval University Heart and Lung Institute, Ste Foy, Quebec, Canada
Am Heart J 149:54-60. 2005
..Increased body mass index (BMI) and abdominal adiposity increase the risk of cardiovascular disease (CVD) in persons free of these diseases, but their independent prognostic impact in persons with CVD has not been well defined...
- Effect of atorvastatin on exercise-induced myocardial ischemia in patients with stable angina pectoris
Peter Bogaty
Quebec Heart Institute, Laval Hospital, Ste Foy, Quebec, Canada
Am J Cardiol 92:1192-5. 2003
..Endothelial function improved progressively and C-reactive protein, P-selectin, and tissue plasminogen activator inhibitor levels decreased, but there was no decrease in exercise electrocardiographic ischemia...
- Different thresholds of myocardial ischemia in ramp and standard bruce protocol exercise tests in patients with positive exercise stress tests and angiographically demonstrated coronary arterial narrowing
Martin Noel
Quebec Heart Institute Laval Hospital, Laval Sainte University Foy, Quebec, Canada
Am J Cardiol 99:921-4. 2007
..This effect is unexplained by energy expenditure (VO2) or myocardial work (RPP) and is consistent with a "warm-up" ischemic mechanism...
- Impact of ramipril on the circadian periodicity of acute myocardial infarction
Gilles R Dagenais
University Heart and Lung Institute, Laval Hospital, and the Department of Medicine, Laval University, Quebec, Quebec, Canada
Am J Cardiol 98:758-60. 2006
..In conclusion, inhibiting angiotensin-converting enzyme decreased AMI over a 24-hour period, but this enzyme does not seem to play a major role in the circadian periodicity of this acute event...
- Prognostic impact of the presence and absence of angina on mortality and cardiovascular outcomes in patients with type 2 diabetes and stable coronary artery disease: results from the BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes)
Gilles R Dagenais
Quebec Heart and Lung University Institute, Quebec City, Quebec, Canada
J Am Coll Cardiol 61:702-11. 2013
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Effects of job strain on blood pressure: a prospective study of male and female white-collar workersChantal Guimont
, Quebec City, Quebec, Canada
Am J Public Health 96:1436-43. 2006
..The risk was of comparable magnitude to that observed for age and sedentary behavior. Men and women with low levels of social support at work appeared to be at higher risk for increases in blood pressure...
- Does correction of the friedewald formula using lipoprotein(a) change our estimation of ischemic heart disease risk? The Quebec Cardiovascular Study
Bernard Cantin
Quebec Heart Institute, Laval University, Canada
Atherosclerosis 163:261-7. 2002
..This study was undertaken to determine if correction of the Friedewald formula would result in a better evaluation of ischemic heart disease (IHD) risk...
- Effects of optimal medical treatment with or without coronary revascularization on angina and subsequent revascularizations in patients with type 2 diabetes mellitus and stable ischemic heart disease
Gilles R Dagenais
Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, QC, Canada
Circulation 123:1492-500. 2011
..In the same population, we tested whether the REV strategy was superior to the MED strategy in preventing worsening and new angina and subsequent coronary revascularizations...
- The Quebec Heart Institute: 50 years of excellence in cardiology
Gilles R Dagenais
Quebec Heart Institute, Laval Hospital, Sainte Foy, Quebec
Can J Cardiol 23:5B-8B. 2007
..The first 50 years of the Quebec Heart Institute are depicted in this overview, which will also introduce this special supplement to The Canadian Journal of Cardiology...
- Association of fibrinogen and lipoprotein(a) as a coronary heart disease risk factor in men (The Quebec Cardiovascular Study)
Bernard Cantin
Quebec Heart Institute, Ste Foy, Quebec, Canada
Am J Cardiol 89:662-6. 2002
..5; 95% CI 1.2 to 5.1; p = 0.0132). In this population, high fibrinogen levels associated with high Lp(a) levels significantly increased the risk of CHD...
- A multivariate model for predicting mortality in patients with heart failure and systolic dysfunction
James M Brophy
Division of Cardiology and Clinical Epidemiology, McGill University Health Center, Montreal, Quebec, Canada
Am J Med 116:300-4. 2004
..Heart failure is a leading cause of morbidity and mortality, but there are no reliable models based on readily available clinical variables to predict outcomes in patients taking angiotensin-converting enzyme (ACE) inhibitors...
- What induces the warm-up ischemia/angina phenomenon: exercise or myocardial ischemia?
Peter Bogaty
Quebec Heart Institute Laval Hospital, 2725 Chemin Ste Foy, Ste Foy, Quebec, Canada G1V 4G5
Circulation 107:1858-63. 2003
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- Psychologic distress in postmyocardial infarction patients who have returned to work
Chantal Brisson
Unité de recherche en santé des populations, Centre Hospitalier Universitaire de Quebec, Hôpital Saint Sacrement, 1050 Chemin Sainte Foy, Quebec, Quebec, Canada G1S 4L8
Psychosom Med 67:59-63. 2005
..To assess the prevalence of psychologic distress in women and men returning to work after a myocardial infarction (MI) and to compare this prevalence with the prevalence observed among men and women of the general working population...
- Plasma free fatty acid levels and the risk of ischemic heart disease in men: prospective results from the Québec Cardiovascular Study
Matteo Pirro
Department of Food Science and Nutrition, Lipid Research Center, R-9600 CHUL Research Center, 2705 Laurier Boulevard, Ste-Foy, G1V 4G2, Quebec, Canada
Atherosclerosis 160:377-84. 2002
..However, a single fasting measurement of plasma FFA levels does not appear to improve our ability to predict IHD onset in men when information on other risk factors is considered...
- Insulin resistance syndrome, body mass index and the risk of ischemic heart disease
Annie C St-Pierre
Institute on Nutraceuticals and Functional Foods, Lipid Research Centre, Ste-Foy, Que
CMAJ 172:1301-5. 2005
..70-5.32). INTERPRETATION: Although obesity is an important risk factor for ischemic heart disease, variations in BMI alone poorly reflect the risk of ischemic heart disease associated with features of insulin resistance syndrome...
- Long-term effects of ramipril on cardiovascular events and on diabetes: results of the HOPE study extension
Jackie Bosch
Division of Cardiology, Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Circulation 112:1339-46. 2005
..6 years of follow-up and (2) observed in subgroups based on risk and ancillary treatments...
- Concordance/discordance between plasma apolipoprotein B levels and the cholesterol indexes of atherosclerotic risk
Allan D Sniderman
Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Montreal, , Canada
Am J Cardiol 91:1173-7. 2003
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- Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial
Eva Lonn
Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario
JAMA 293:1338-47. 2005
..CONCLUSION: In patients with vascular disease or diabetes mellitus, long-term vitamin E supplementation does not prevent cancer or major cardiovascular events and may increase the risk for heart failure...
- Challenges for the Canadian Cardiovascular Society in the 1990s
Gilles R Dagenais
Institut Universitaire de Cardiologie et Pneumologie, , , Canada
Can J Cardiol 23:913-4. 2007
- Can the Canadian Cardiovascular Society grading scale of angina influence clinical management and predict outcomes?
Gilles R Dagenais
Can J Cardiol 20:310. 2004
- Moderate alcohol consumption is more cardioprotective in men with the metabolic syndrome
Iris Gigleux
Institute on Nutraceuticals and Functional Foods Quebec City, QC, Canada
J Nutr 136:3027-32. 2006
..22). These results confirm that moderate daily alcohol consumption has cardioprotective properties and suggest that the effects may be more important in subjects with a deteriorated risk profile, such as those with the metabolic syndrome...
