The simulated microgravity environment maintains key metabolic functions and promotes aggregation of primary porcine hepatocytesK J Dabos
Liver Cell Biology Laboratory, Department of Internal Medicine, University of Edinburgh, Edinburgh, UK
Biochim Biophys Acta 1526:119-30. 2001
..The high aspect ratio vessel is suitable for long-term culture of porcine hepatocytes and it is worthwhile carrying out scale-up feasibility studies...
- Biochemical prognostic markers of outcome in non-paracetamol-induced fulminant hepatic failure
Konstantinos J Dabos
Centre of Liver and Digestive Disorders, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
Transplantation 77:200-5. 2004
..This study uses admission blood samples to identify early biochemical markers of clinical outcome in patients with non-paracetamol-induced FHF...
- Comparison of bioenergetic activity of primary porcine hepatocytes cultured in four different media
Konstantinos J Dabos
Liver Cell Biology Laboratory, Department of Hepatology, University of Edinburgh, Edinburgh EH16 4SU, Scotland, UK
Cell Transplant 13:213-29. 2004
..Medium 199 was best in ketogenesis. Overall, medium 199 was the best at driving energy metabolism from its constituent substrates and we think that it preferentially should be used in the culture of primary porcine hepatocytes...
- A biochemical prognostic model of outcome in paracetamol-induced acute liver injury
Konstantinos John Dabos
Department of Hepatology, Royal Infirmary of Edinburgh and Ultra High Field NMR Centre, Department of Chemistry, University of Edinburgh, Edinburgh, UK
Transplantation 80:1712-7. 2005
..The aim of this study was to develop a prognostic model of outcome for patients with paracetamol induced acute liver injury based on admission parameters..
The effect of mastic gum on Helicobacter pylori: a randomized pilot studyK J Dabos
Department of Gastroenterology, Chios General Hospital Skylitsion, Helenas Venizalou 2, 82100 Chios, Greece
Phytomedicine 17:296-9. 2010
..08) and in Group B (p=0.064). The difference was significant in Group D (p=0.01). All patients tolerated mastic gum well and no serious adverse events were reported. Mastic gum has bactericidal activity on H. pylori in vivo...
- Is Chios mastic gum effective in the treatment of functional dyspepsia? A prospective randomised double-blind placebo controlled trial
Konstantinos J Dabos
Department of Gastroenterology, Chios General Hospital Skylitsion, Chios, Greece
J Ethnopharmacol 127:205-9. 2010
..chia. It is a traditional natural remedy used throughout the eastern Mediterranean. The aim of this study was to assess the efficacy of Chios mastic gum in patients with functional dyspepsia...
- Regional variations in the concentrations of ketone bodies in cirrhosis and hepatic encephalopathy: a study in patients with TIPSS
Konstantinos J Dabos
Department of Hepatology, University of Edinburgh, Edinburgh, UK
Liver Int 31:707-11. 2011
..Little is known about the metabolism of acetoacetate and β-hydroxybutyrate in patients with cirrhosis and encephalopathy...
Impaired gluconeogenesis in a porcine model of paracetamol induced acute liver failureKonstantinos J Dabos
Liver Cell Biology Laboratory, Department of Hepatology, University of Edinburgh, Edinburgh, EH16 4SA, United Kingdom
World J Gastroenterol 17:1457-61. 2011
..To investigate glucose homeostasis and in particular gluconeogenesis in a large animal model of acute liver failure (ALF)...
- Development of an invasively monitored porcine model of acetaminophen-induced acute liver failure
Philip N Newsome
Centre for Liver Research, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, UK
BMC Gastroenterol 10:34. 2010
..Our aim was to develop a reproducible invasively-monitored porcine model of acetaminophen-induced ALF...
