M Meloun

Summary

Affiliation: University of Pardubice
Country: Czech Republic

Publications

  1. ncbi request reprint Transformation in the PC-aided biochemical data analysis
    M Meloun
    Department of Analytical Chemistry, Faculty of Chemical Technology, University Pardubice, Czech Republic
    Clin Chem Lab Med 38:553-9. 2000
  2. doi request reprint Minimizing the effects of multicollinearity in the polynomial regression of age relationships and sex differences in serum levels of pregnenolone sulfate in healthy subjects
    Milan Meloun
    Department of Analytical Chemistry, Faculty of Chemical Technology, Pardubice University, Pardubice, Czech Republic
    Clin Chem Lab Med 47:464-70. 2009
  3. ncbi request reprint Number of species in complexation equilibria of o-, m- and p-CAPAZOXS with Cd2+, Co2+, Ni2+, Pb2+ and Zn2+ ions by PCA of UV-vis spectra
    Milan Meloun
    Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, CZ 532 10 Pardubice, Czech Republic
    Talanta 71:115-22. 2007
  4. doi request reprint Precision limits and interval estimation in the calibration of 1-hydroxypyrene in urine and hexachlorbenzene in water, applying the regression triplet procedure on chromatographic data
    Milan Meloun
    Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, 532 10, Pardubice, Czech Republic
    Anal Bioanal Chem 390:1899-910. 2008
  5. ncbi request reprint The thermodynamic dissociation constants of four non-steroidal anti-inflammatory drugs by the least-squares nonlinear regression of multiwavelength spectrophotometric pH-titration data
    Milan Meloun
    Department of Analytical Chemistry, University of Pardubice, CZ 532 10 Pardubice, Czech Republic
    J Pharm Biomed Anal 45:552-64. 2007
  6. ncbi request reprint Benchmarking and validating algorithms that estimate pK(a) values of drugs based on their molecular structures
    Milan Meloun
    Department of Analytical Chemistry, Faculty of Chemical Technology, Pardubice University, 532 10, Pardubice, Czech Republic
    Anal Bioanal Chem 389:1267-81. 2007
  7. ncbi request reprint The thermodynamic dissociation constants of the anticancer drugs camptothecine, 7-ethyl-10-hydroxycamptothecine, 10-hydroxycamptothecine and 7-ethylcamptothecine by the least-squares nonlinear regression of multiwavelength spectrophotometric pH-titration
    Milan Meloun
    Department of Analytical Chemistry, University of Pardubice, CZ 532 10 Pardubice, Czech Republic
    Anal Chim Acta 584:419-32. 2007
  8. ncbi request reprint Reliability and uncertainty in the estimation of pKa by least squares nonlinear regression analysis of multiwavelength spectrophotometric pH titration data
    Milan Meloun
    Department of Analytical Chemistry, University of Pardubice, 532 10, Pardubice, Czech Republic
    Anal Bioanal Chem 387:941-55. 2007
  9. doi request reprint Reliability of dissociation constants and resolution capability of SQUAD(84) and SPECFIT/32 in the regression of multiwavelength spectrophotometric pH-titration data
    Milan Meloun
    Department of Analytical Chemistry, University of Pardubice, CZ 532 10 Pardubice, Czech Republic
    Spectrochim Acta A Mol Biomol Spectrosc 86:305-14. 2012
  10. ncbi request reprint Analysis of large and small samples of biochemical and clinical data
    M Meloun
    Department of Analytical Chemistry, Faculty of Chemical Technology, Pardubice University, Czech Republic
    Clin Chem Lab Med 39:53-61. 2001

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Transformation in the PC-aided biochemical data analysis
    M Meloun
    Department of Analytical Chemistry, Faculty of Chemical Technology, University Pardubice, Czech Republic
    Clin Chem Lab Med 38:553-9. 2000
    ..After examination of statistical assumptions by diagnostic plots of an exploratory data analysis the best estimate of a mean value of 17-hydroxypregnenolone is derived...
  2. doi request reprint Minimizing the effects of multicollinearity in the polynomial regression of age relationships and sex differences in serum levels of pregnenolone sulfate in healthy subjects
    Milan Meloun
    Department of Analytical Chemistry, Faculty of Chemical Technology, Pardubice University, Pardubice, Czech Republic
    Clin Chem Lab Med 47:464-70. 2009
    ..It is known that circulating levels of PregS in human are relatively high depending primarily on age and adrenal activity...
  3. ncbi request reprint Number of species in complexation equilibria of o-, m- and p-CAPAZOXS with Cd2+, Co2+, Ni2+, Pb2+ and Zn2+ ions by PCA of UV-vis spectra
    Milan Meloun
    Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, CZ 532 10 Pardubice, Czech Republic
    Talanta 71:115-22. 2007
    ..The computational strategy is presented with goodness-of-fit tests and various regression diagnostics capable of proving the reliability of the chemical model proposed...
  4. doi request reprint Precision limits and interval estimation in the calibration of 1-hydroxypyrene in urine and hexachlorbenzene in water, applying the regression triplet procedure on chromatographic data
    Milan Meloun
    Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, 532 10, Pardubice, Czech Republic
    Anal Bioanal Chem 390:1899-910. 2008
    ..Results show that the approach developed provides improved estimates of analytical limits and that the single-concentration approaches currently in wide use are seriously flawed...
  5. ncbi request reprint The thermodynamic dissociation constants of four non-steroidal anti-inflammatory drugs by the least-squares nonlinear regression of multiwavelength spectrophotometric pH-titration data
    Milan Meloun
    Department of Analytical Chemistry, University of Pardubice, CZ 532 10 Pardubice, Czech Republic
    J Pharm Biomed Anal 45:552-64. 2007
    ..PALLAS and MARVIN predicted pK(a,pred) values with larger bias errors in comparison with the experimental value for all four drugs...
  6. ncbi request reprint Benchmarking and validating algorithms that estimate pK(a) values of drugs based on their molecular structures
    Milan Meloun
    Department of Analytical Chemistry, Faculty of Chemical Technology, Pardubice University, 532 10, Pardubice, Czech Republic
    Anal Bioanal Chem 389:1267-81. 2007
    ..The proposed accuracy test performed by the REGDIA program can also be applied to test the accuracy of other predicted values, such as log P, log D, aqueous solubility or certain physicochemical properties of drug molecules...
  7. ncbi request reprint The thermodynamic dissociation constants of the anticancer drugs camptothecine, 7-ethyl-10-hydroxycamptothecine, 10-hydroxycamptothecine and 7-ethylcamptothecine by the least-squares nonlinear regression of multiwavelength spectrophotometric pH-titration
    Milan Meloun
    Department of Analytical Chemistry, University of Pardubice, CZ 532 10 Pardubice, Czech Republic
    Anal Chim Acta 584:419-32. 2007
    ..Pallas and Marvin predict pK(a) being based on the structural formulae of drug compounds in agreement with the experimental value...
  8. ncbi request reprint Reliability and uncertainty in the estimation of pKa by least squares nonlinear regression analysis of multiwavelength spectrophotometric pH titration data
    Milan Meloun
    Department of Analytical Chemistry, University of Pardubice, 532 10, Pardubice, Czech Republic
    Anal Bioanal Chem 387:941-55. 2007
    ..The influences of various sources of uncertainty on the accuracy and precision are discussed using the example of the mixed dissociation constants of silybin, obtained using the SQUAD(84) and SPECFIT/32 regression programs...
  9. doi request reprint Reliability of dissociation constants and resolution capability of SQUAD(84) and SPECFIT/32 in the regression of multiwavelength spectrophotometric pH-titration data
    Milan Meloun
    Department of Analytical Chemistry, University of Pardubice, CZ 532 10 Pardubice, Czech Republic
    Spectrochim Acta A Mol Biomol Spectrosc 86:305-14. 2012
    ..The magnitude of instrumental error s(inst)(A) only slightly affects the shape of a Cattel's scree graph s(k)(A)=f(k) to determine the true number of light-absorbing species in the equilibrium mixture...
  10. ncbi request reprint Analysis of large and small samples of biochemical and clinical data
    M Meloun
    Department of Analytical Chemistry, Faculty of Chemical Technology, Pardubice University, Czech Republic
    Clin Chem Lab Med 39:53-61. 2001
    ..The proposed methodology is demonstrated in two case studies, a large sample analysis of mean pregnenolone concentrations in the umbilical blood of newborns, and a small sample analysis of mean haptoglobin concentrations in human serum...
  11. ncbi request reprint Exploratory biochemical data analysis: a comparison of two sample means and diagnostic displays
    M Meloun
    Department of Analytical Chemistry, Faculty of Chemical Technology, Pardubice University, Czech Republic
    Clin Chem Lab Med 39:244-55. 2001
    ..The results indicate that androgens are not significantly related to the intensity of acne, and that SHBG is higher in patients with more severe forms of acne...
  12. ncbi request reprint Assessment of the mean-value of 17-hydroxypregnenolone in the umbilical blood of newborns by the exploratory analysis of biochemical data
    Milan Meloun
    Department of Analytical Chemistry, Faculty of Chemical Technology, Pardubice University, CZ 532 10 Pardubice, Czech Republic
    Comput Methods Programs Biomed 70:187-97. 2003
    ..The Box-Cox transformation improves a sample symmetry. The proposed procedure gives reliable estimates of a mean-value for an asymmetric distribution of 17-hydroxypregnenolone when the arithmetic mean can not be used...
  13. ncbi request reprint New methodology of influential point detection in regression model building for the prediction of metabolic clearance rate of glucose
    Milan Meloun
    Department of Analytical Chemistry, Faculty of Chemical Technology, Pardubice University, Pardubice, Czech Republic
    Clin Chem Lab Med 42:311-22. 2004
    ..MCRg reflects insulin sensitivity filtering-off the effect of blood glucose. The prediction of clamp parameters should enable us to avoid the demanding clamp examination, which is connected with a higher load and risk for patients...
  14. ncbi request reprint The analysis of soil cores polluted with certain metals using the Box-Cox transformation
    Milan Meloun
    Department of Analytical Chemistry, University of Pardubice, CZ532 10 Pardubice, Czech Republic
    Environ Pollut 137:273-80. 2005
    ....
  15. ncbi request reprint Antioxidant vitamin levels do not exhibit negative correlation with the extent of acute myocardial infarction
    V Muzakova
    Faculty of Chemical Technology, University of Pardubice, Strossova 239, 530 03 Pardubice, Czech Republic
    Physiol Res 54:623-9. 2005
    ....
  16. doi request reprint Evaluation of oxidative stress and inflammation in obese adults with metabolic syndrome
    Jiri Skalicky
    Department of Clinical Biochemistry and Diagnostics, Regional Hospital of Pardubice, Pardubice, Czech Republic
    Clin Chem Lab Med 46:499-505. 2008
    ..The aim of our study was to evaluate the level of oxidative stress and inflammation in obese adults with and without metabolic syndrome...
  17. ncbi request reprint Descriptive growth model of the height of stapes in the fetus: a histopathological study of the temporal bone
    Viktor Chrobok
    Department of Otorhinolaryngology, General Hospital, 532 03 Pardubice, Czech Republic
    Eur Arch Otorhinolaryngol 261:25-9. 2004
    ..The average height of stapes was 1.05 mm in the 13th week and 2.6 mm in the 24th week. Later, after the 25th week, the growth of the height of stapes was slower, and the average height in the 30th week was 3.0 mm...
  18. ncbi request reprint Reinstatement of serum pregnanolone isomers and progesterone during alcohol detoxification therapy in premenopausal women
    Martin Hill
    Institute of EndocrinologyCharles University, Prague, Czech Republic
    Alcohol Clin Exp Res 29:1010-7. 2005
    ....