Jan Novotny

Summary

Country: Czech Republic

Publications

  1. pmc Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases
    Stefanie Huhn
    Department of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Med Genet 13:94. 2012
  2. ncbi request reprint Comparative analysis of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in colorectal cancer and surrounding normal tissue
    M Zimovjanova
    Department of Oncology, General Teaching Hospital, 12880 Prague, Czech Republic
    Neoplasma 52:208-10. 2005
  3. ncbi request reprint Breast cancer risk assessment in the Czech female population--an adjustment of the original Gail model
    Jan Novotny
    Department of Oncology, General Teaching Hospital, Prague, Czech Republic
    Breast Cancer Res Treat 95:29-35. 2006
  4. pmc A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer
    Daniele Campa
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Med Genet 11:88. 2010
  5. pmc Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    BMC Gastroenterol 10:112. 2010
  6. doi request reprint Association of serum bilirubin and promoter variations in HMOX1 and UGT1A1 genes with sporadic colorectal cancer
    Alena Jiraskova
    4th Department of Internal Medicine, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Int J Cancer 131:1549-55. 2012
  7. pmc High proportion of recurrent germline mutations in the BRCA1 gene in breast and ovarian cancer patients from the Prague area
    Petr Pohlreich
    Department of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Breast Cancer Res 7:R728-36. 2005
  8. doi request reprint Polymorphisms in miRNA-binding sites of nucleotide excision repair genes and colorectal cancer risk
    Alessio Naccarati
    Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Prague, Czech Republic
    Carcinogenesis 33:1346-51. 2012
  9. doi request reprint Single nucleotide polymorphisms in the multidrug resistance gene 1 (ABCB1): effects on its expression and clinicopathological characteristics in breast cancer patients
    Radka Vaclavikova
    Biotransformation Group, Center of Occupational Health, National Institute of Public Health, Prague, Czech Republic
    Pharmacogenet Genomics 18:263-73. 2008
  10. ncbi request reprint The CHEK2 c.1100delC germline mutation rarely contributes to breast cancer development in the Czech Republic
    Zdenek Kleibl
    Department of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, U nemocnice 5, Prague, 12853, Czech Republic
    Breast Cancer Res Treat 90:165-7. 2005

Collaborators

Detail Information

Publications13

  1. pmc Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases
    Stefanie Huhn
    Department of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Med Genet 13:94. 2012
    ..A two-stage case-control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases...
  2. ncbi request reprint Comparative analysis of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in colorectal cancer and surrounding normal tissue
    M Zimovjanova
    Department of Oncology, General Teaching Hospital, 12880 Prague, Czech Republic
    Neoplasma 52:208-10. 2005
    ..87; 2.32 and 4.50 for tumors and 2.14; 2.63 and 11.64 for normal tissue. We did not find any significant differences in TS, TP and DPD gene expression between colorectal tumor and surrounding mucosa...
  3. ncbi request reprint Breast cancer risk assessment in the Czech female population--an adjustment of the original Gail model
    Jan Novotny
    Department of Oncology, General Teaching Hospital, Prague, Czech Republic
    Breast Cancer Res Treat 95:29-35. 2006
    ..Such models can help clinicians to choose appropriate preventive and therapeutic interventions for each patient. Unfortunately, the validity of these models has not been tested outside the USA...
  4. pmc A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer
    Daniele Campa
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Med Genet 11:88. 2010
    ..TAS2R14 is one of the better characterized members of the taste receptor family and has several polymorphic variants. Several substances that have been shown to activate TAS2R14 are powerful toxic and carcinogenic agents...
  5. pmc Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    BMC Gastroenterol 10:112. 2010
    ..Accumulating evidence also indicates a role of ghrelin in cancer development...
  6. doi request reprint Association of serum bilirubin and promoter variations in HMOX1 and UGT1A1 genes with sporadic colorectal cancer
    Alena Jiraskova
    4th Department of Internal Medicine, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Int J Cancer 131:1549-55. 2012
    ..001). In conclusion, UGT1A1*28 allele carrier status might be a protective factor against the development of CRC in the male population, whereas low serum bilirubin levels are associated with an increased risk of CRC in both genders...
  7. pmc High proportion of recurrent germline mutations in the BRCA1 gene in breast and ovarian cancer patients from the Prague area
    Petr Pohlreich
    Department of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Breast Cancer Res 7:R728-36. 2005
    ..The purpose of our study was to estimate the incidence and spectrum of pathogenic mutations in BRCA1/2 genes in high-risk Czech families...
  8. doi request reprint Polymorphisms in miRNA-binding sites of nucleotide excision repair genes and colorectal cancer risk
    Alessio Naccarati
    Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Prague, Czech Republic
    Carcinogenesis 33:1346-51. 2012
    ..Variation in miRNA target binding sites in the 3'untranslated region of NER genes may be important for modulating colorectal cancer risk, with a different relevance according to tumor location...
  9. doi request reprint Single nucleotide polymorphisms in the multidrug resistance gene 1 (ABCB1): effects on its expression and clinicopathological characteristics in breast cancer patients
    Radka Vaclavikova
    Biotransformation Group, Center of Occupational Health, National Institute of Public Health, Prague, Czech Republic
    Pharmacogenet Genomics 18:263-73. 2008
    ..The main aim of this study was to assess the prognostic value of ABCB1 genotype and phenotype in breast cancer...
  10. ncbi request reprint The CHEK2 c.1100delC germline mutation rarely contributes to breast cancer development in the Czech Republic
    Zdenek Kleibl
    Department of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, U nemocnice 5, Prague, 12853, Czech Republic
    Breast Cancer Res Treat 90:165-7. 2005
    ..1100delC mutation varies among different populations. Based on our results, genotyping of CHEK2 c.1100delC mutation in clinical settings in the Czech Republic could not be recommended...
  11. doi request reprint NBN 657del5 heterozygous mutations and colorectal cancer risk in the Czech Republic
    Barbara Pardini
    Institute of Experimental Medicine, Academy of Sciences of Czech Republic, Prague, Czech Republic
    Mutat Res 666:64-7. 2009
    ..The present results do not provide any evidence that the exceeding risk of CRC in this population is attributable to the high frequency of heterozygous carriage of the NBN 657del5...
  12. ncbi request reprint KIT receptor is expressed in more than 50% of early-stage malignant melanoma: a retrospective study of 261 patients
    Filip Janku
    Department of Oncology, First Faculty of Medicine, General Teaching Hospital, Charles University, Prague, Czech Republic
    Melanoma Res 15:251-6. 2005
    ..The therapeutic impact of KIT expression in malignant melanoma is uncertain. Results of ongoing pilot phase II studies may validate the efficacy of imatinib mesylate in malignant melanoma expressing KIT...
  13. ncbi request reprint Symptomatic control of hypoglycaemia with prednisone in refractory metastatic pancreatic insulinoma
    Jan Novotny
    Department of Oncology, First Faculty of Medicine, General Teaching Hospital, Charles University, 128 08 Praha 2, Czech Republic
    Support Care Cancer 13:760-2. 2005
    ..5 mg with excellent symptomatic effects. In conclusion, prednisone therapy may be considered as a valid option to achieve symptomatic control in hormonally active therapeutically resistant insulinomas...